FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Dei S et al. | Design and synthesis of aminoester heterodimers containing flavone or chromone moieties as modulators of P-glycoprotein-based multidrug resistance (MDR). | 2018 | Bioorg. Med. Chem. | pmid:29162309 |
Vetrani C et al. | Association between different dietary polyphenol subclasses and the improvement in cardiometabolic risk factors: evidence from a randomized controlled clinical trial. | 2018 | Acta Diabetol | pmid:29151225 |
Bibby MC et al. | Reduction of tumor blood flow by flavone acetic acid: a possible component of therapy. | 1989 | J. Natl. Cancer Inst. | pmid:2911084 |
Wu ES et al. | Flavones. 2. Synthesis and structure-activity relationship of flavodilol and its analogues, a novel class of antihypertensive agents with catecholamine depleting properties. | 1989 | J. Med. Chem. | pmid:2909730 |
Relling MV et al. | Anticancer drugs as inhibitors of two polymorphic cytochrome P450 enzymes, debrisoquin and mephenytoin hydroxylase, in human liver microsomes. | 1989 | Cancer Res. | pmid:2908853 |
Xie H et al. | Total flavone of Desmodium styracifolium relieved apoptosis and autophagy of COM-induced HK-2 cells by regulating KIM-1 via p38/MAPK pathway. | 2018 | Mol. Cell. Biochem. | pmid:29071538 |
Yu FL et al. | NIR Rapid Assessments of Blumea balsamifera (Ai-na-xiang) in China. | 2017 | Molecules | pmid:29035305 |
Chung YC et al. | Pratol, an O-Methylated Flavone, Induces Melanogenesis in B16F10 Melanoma Cells via p-p38 and p-JNK Upregulation. | 2017 | Molecules | pmid:29019920 |
Davis HP et al. | Immune thrombocytopenia caused by flavone-8-acetic acid. | 1988 | Lancet | pmid:2893207 |
Verweij J et al. | Rapid alkalinisation for flavone acetic acid administration: a potentially hazardous procedure. | 1988 | Lancet | pmid:2893206 |
Kamata R et al. | Agonistic effects of diverse xenobiotics on the constitutive androstane receptor as detected in a recombinant yeast-cell assay. | 2018 | Toxicol In Vitro | pmid:28927721 |
Huang QH et al. | Isoprenylated phenolic compounds with PTP1B inhibition from Morus alba. | 2017 | Fitoterapia | pmid:28916258 |
Rubin J et al. | Flavone-8-acetic acid inhibits ristocetin-induced platelet agglutination and prolongs bleeding time. | 1987 | Lancet | pmid:2889983 |
Kim J et al. | In vitro characterization of CYP102G4 from Streptomyces cattleya: A self-sufficient P450 naturally producing indigo. | 2018 | Biochim Biophys Acta Proteins Proteom | pmid:28821467 |
Feng XT et al. | Protective role of Pollen Typhae total flavone against the palmitic acid-induced impairment of glucose-stimulated insulin secretion involving GPR40 signaling in INS-1 cells. | 2017 | Int. J. Mol. Med. | pmid:28731171 |
Miyata Y et al. | In vitro studies on nobiletin isolated from citrus plants and the bioactive metabolites, inhibitory action against gelatinase enzymatic activity and the molecular mechanisms in human retinal Müller cell line. | 2017 | Biomed. Pharmacother. | pmid:28623785 |
Das S et al. | Antioxidant flavone analog functionalized fluorescent silica nanoparticles: Synthesis and exploration of their possible use as biomolecule sensor. | 2017 | Colloids Surf B Biointerfaces | pmid:28601757 |
Al-Rimawi F et al. | ANALYSIS OF PHENOLIC AND FLAVONOIDS OF WILD EPHEDRA ALATA PLANT EXTRACTS BY LC/PDA AND LC/MS AND THEIR ANTIOXIDANT ACTIVITY. | 2017 | Afr J Tradit Complement Altern Med | pmid:28573229 |
Berczyński P et al. | Synthesis and in vitro antioxidant activity study of some new piperazinyl flavone compounds. | 2017 | Luminescence | pmid:28569387 |
Montenegro CA et al. | In Silico Study and Bioprospection of the Antibacterial and Antioxidant Effects of Flavone and Its Hydroxylated Derivatives. | 2017 | Molecules | pmid:28538688 |