FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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pmid:21176927 | ||||
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Duan K et al. | LC-MS/MS determination and pharmacokinetic study of five flavone components after solvent extraction/acid hydrolysis in rat plasma after oral administration of Verbena officinalis L. extract. | 2011 | J Ethnopharmacol | pmid:21220003 |
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Jin J et al. | Design, synthesis and biological evaluation of new arylpiperazine derivatives bearing a flavone moiety as α1-adrenoceptor antagonists. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21236664 |
Fan Y et al. | Epimedium polysaccharide and propolis flavone can synergistically inhibit the cellular infectivity of NDV and improve the curative effect of ND in chicken. | 2011 | Int. J. Biol. Macromol. | pmid:21238483 |
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Kurian G et al. | A Novel Approach for Oral Delivery of Insulin via Desmodium gangeticum Aqueous Root Extract. | 2010 | J Young Pharm | pmid:21264119 |
Zuk M et al. | Flavonoid engineering of flax potentiate its biotechnological application. | 2011 | BMC Biotechnol. | pmid:21276227 |
Rachchh MA and Jain SM | Gastroprotective effect of Benincasa hispida fruit extract. | 2008 | Indian J Pharmacol | pmid:21279184 |
Larroque-Lombard AL et al. | Synthesis and studies on three-compartment flavone-containing combi-molecules designed to target EGFR, DNA, and MEK. | 2011 | Chem Biol Drug Des | pmid:21294849 |
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Marinova MD and Tchorbanov BP | Preparation of antioxidant enzymatic hydrolysates from honeybee-collected pollen using plant enzymes. | 2011 | Enzyme Res | pmid:21318132 |
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Hämäläinen M et al. | Effects of flavonoids on prostaglandin E2 production and on COX-2 and mPGES-1 expressions in activated macrophages. | 2011 | Planta Med. | pmid:21341175 |
Schmidt A et al. | Polymethylated myricetin in trichomes of the wild tomato species Solanum habrochaites and characterization of trichome-specific 3'/5'- and 7/4'-myricetin O-methyltransferases. | 2011 | Plant Physiol. | pmid:21343428 |
Masoodi TA and Alhamdanz AH | Inhibitory effect of flavonoids on mutant H-Rasp protein. | 2010 | Bioinformation | pmid:21346872 |
Guo SS et al. | [The cytology mechanism of anti-parainfluenza virus infection of total flavone of Scutellaria barbata]. | 2009 | Yao Xue Xue Bao | pmid:21351467 |
Bredebach M et al. | Three 2-oxoglutarate-dependent dioxygenase activities of Equisetum arvense L. forming flavone and flavonol from (2S)-naringenin. | 2011 | Phytochemistry | pmid:21353683 |
Semwal RB et al. | Chemical constituents from the stem bark of Symplocos paniculata Thunb. with antimicrobial, analgesic and anti-inflammatory activities. | 2011 | J Ethnopharmacol | pmid:21354288 |
Pick A et al. | Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP). | 2011 | Bioorg. Med. Chem. | pmid:21354800 |
Kumar S et al. | Pharmacological evaluation of Bioactive Principle of Turnera aphrodisiaca. | 2008 | Indian J Pharm Sci | pmid:21369434 |
Shi G et al. | Molecular characteristics and antitumor capacity of Glycan extracted from Cynomorium songaricum. | 2011 | Int. J. Biol. Macromol. | pmid:21396396 |
Zhang JW et al. | Structural elucidation of a new flavone from Sarcopyramis nepalensis. | 2011 | J Asian Nat Prod Res | pmid:21409688 |
Rasoanaivo P et al. | Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions. | 2011 | Malar. J. | pmid:21411015 |
Manhita A et al. | Extracting natural dyes from wool--an evaluation of extraction methods. | 2011 | Anal Bioanal Chem | pmid:21416400 |
Novy P et al. | In vitro synergistic effects of baicalin with oxytetracycline and tetracycline against Staphylococcus aureus. | 2011 | J. Antimicrob. Chemother. | pmid:21421582 |
Kim JY et al. | Isolation of cholinesterase-inhibiting flavonoids from Morus lhou. | 2011 | J. Agric. Food Chem. | pmid:21434689 |
Kochevenko A and Fernie AR | The genetic architecture of branched-chain amino acid accumulation in tomato fruits. | 2011 | J. Exp. Bot. | pmid:21436187 |
Mladěnka P et al. | In vitro analysis of iron chelating activity of flavonoids. | 2011 | J. Inorg. Biochem. | pmid:21450273 |
Pham MH et al. | Identification and induction of cytochrome P450s involved in the metabolism of flavone-8-acetic acid in mice. | 2011 | Drug Metab Lett | pmid:21457135 |
Li LJ et al. | Flavans from the leaf of Ilex centrochinensis. | 2011 | J Asian Nat Prod Res | pmid:21462042 |
Zhao J et al. | MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula. | 2011 | Plant Cell | pmid:21467581 |
Zhang J et al. | Studies on the active components and antioxidant activities of the extracts of Mimosa pudica Linn. from southern China. | 2011 | Pharmacogn Mag | pmid:21472077 |
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Neves MP et al. | Prenylated derivatives of baicalein and 3,7-dihydroxyflavone: synthesis and study of their effects on tumor cell lines growth, cell cycle and apoptosis. | 2011 | Eur J Med Chem | pmid:21496973 |
Etinski M et al. | Time-dependent approaches for the calculation of intersystem crossing rates. | 2011 | J Chem Phys | pmid:21513373 |
Wera M et al. | 3-Hy-droxy-2-(4-meth-oxy-phen-yl)-4H-chromen-4-one. | 2011 | Acta Crystallogr Sect E Struct Rep Online | pmid:21523104 |
Zhou T et al. | Study of polyethylene glycol as a green solvent in the microwave-assisted extraction of flavone and coumarin compounds from medicinal plants. | 2011 | J Chromatogr A | pmid:21531418 |
Huang CH et al. | Natural flavone kaempferol suppresses chemokines expression in human monocyte THP-1 cells through MAPK pathways. | 2010 | J. Food Sci. | pmid:21535503 |
Park NI et al. | Enhancement of flavone levels through overexpression of chalcone isomerase in hairy root cultures of Scutellaria baicalensis. | 2011 | Funct. Integr. Genomics | pmid:21538138 |
Vandeputte OM et al. | The flavanone naringenin reduces the production of quorum sensing-controlled virulence factors in Pseudomonas aeruginosa PAO1. | 2011 | Microbiology (Reading, Engl.) | pmid:21546585 |
Baguley BC | Preclinical efficacy of vascular disrupting agents in non-small-cell lung cancer. | 2011 | Clin Lung Cancer | pmid:21550553 |
Khan MS et al. | Methylated chrysin induces co-ordinated attenuation of the canonical Wnt and NF-kB signaling pathway and upregulates apoptotic gene expression in the early hepatocarcinogenesis rat model. | 2011 | Chem. Biol. Interact. | pmid:21554863 |
Lin CC et al. | Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. | 2011 | Int. J. Oncol. | pmid:21573491 |
Jeon JG et al. | Natural products in caries research: current (limited) knowledge, challenges and future perspective. | 2011 | Caries Res. | pmid:21576957 |
van Tonder JH et al. | Tricarbon-yl(η-flavone)chromium(0). | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21578102 |
Aree T et al. | 5,7-Dimeth-oxy-2-(4-methoxy-phen-yl)-4H-1-benzopyran-4-one methanol solvate monohydrate. | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21578297 |
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Xiong HP et al. | 5,7-Dihydr-oxy-3,6,8-trimethoxy-flavone. | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21578970 |
Janeczko T et al. | 2-(4-Bromo-phen-yl)-6-methyl-4H-1-benzopyran-4-one (4'-bromo-6-methyl-flavone). | 2010 | Acta Crystallogr Sect E Struct Rep Online | pmid:21580767 |
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Liu B and Yang BL | Poly[(μ-5,7-dihydr-oxy-4-oxo-2-phenyl-4H-chromene-8-sulfonato)potassium(I)]. | 2008 | Acta Crystallogr Sect E Struct Rep Online | pmid:21581534 |
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van Tonder JH et al. | Racemic tricarbonyl[(4a,5,6,7,8,8a-η)-2-phenyl-3,4-dihydro-2H-1-benzopyran]chromium(0). | 2010 | Acta Crystallogr Sect E Struct Rep Online | pmid:21588503 |
Wera M et al. | 2-(4-Fluoro-phen-yl)-3-hy-droxy-4H-chromen-4-one. | 2010 | Acta Crystallogr Sect E Struct Rep Online | pmid:21589426 |
Yao N et al. | Novel flavonoids with antiproliferative activities against breast cancer cells. | 2011 | J. Med. Chem. | pmid:21599001 |
Ono M and Saji H | SPECT Imaging Agents for Detecting Cerebral β-Amyloid Plaques. | 2011 | Int J Mol Imaging | pmid:21603239 |
Vitalini S et al. | Primula spectabilis Tratt. aerial parts: morphology, volatile compounds and flavonoids. | 2011 | Phytochemistry | pmid:21612805 |
Chou ST et al. | Zanthoxylum ailanthoides Sieb and Zucc. extract inhibits growth and induces cell death through G2/M-phase arrest and activation of apoptotic signals in colo 205 human colon adenocarcinoma cells. | 2011 | Anticancer Res. | pmid:21617225 |
Zhao E and Mu Q | Phytoestrogen biological actions on Mammalian reproductive system and cancer growth. | 2011 Jan-Mar | Sci Pharm | pmid:21617769 |
Tahanian E et al. | Flavonoids targeting of IκB phosphorylation abrogates carcinogen-induced MMP-9 and COX-2 expression in human brain endothelial cells. | 2011 | Drug Des Devel Ther | pmid:21625419 |
Seo J et al. | Flavonoids biotransformation by bacterial non-heme dioxygenases, biphenyl and naphthalene dioxygenase. | 2011 | Appl. Microbiol. Biotechnol. | pmid:21626021 |
Lei W et al. | Molecular cloning and expression profiling of a chalcone synthase gene from hairy root cultures of Scutellaria viscidula Bunge. | 2010 | Genet. Mol. Biol. | pmid:21637484 |
Nerurkar PV et al. | Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation. | 2011 | J Neuroinflammation | pmid:21639917 |
Said SA | Two new special flavones from Uvaria accuminata. | 2011 | Nat. Prod. Res. | pmid:21644179 |
Schumacher M et al. | Potential role of P-gp for flavone-induced diminished apoptosis and increased adenoma size in the small intestine of APC(min/+) mice. | 2011 | Cancer Invest. | pmid:21649465 |
Guo AJ et al. | Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/beta-catenin signaling pathway. | 2011 | J. Biol. Chem. | pmid:21652696 |
Jiang DP et al. | Effects of scutellarin on MUC5AC mucin production induced by human neutrophil elastase or interleukin 13 on airway epithelial cells. | 2011 | J. Korean Med. Sci. | pmid:21655064 |
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Subbarao PG and Ashok P | Antihyperlipidemic effect of Trichilia connaroides in hypercholesterolemic rats and its possible mechanism. | 2011 | J Pharm Bioallied Sci | pmid:21687351 |
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Li D et al. | Transcriptional profiling of Medicago truncatula under salt stress identified a novel CBF transcription factor MtCBF4 that plays an important role in abiotic stress responses. | 2011 | BMC Plant Biol. | pmid:21718548 |
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Prajapati RP et al. | Phytochemical and pharmacological review of Lagenaria sicereria. | 2010 | J Ayurveda Integr Med | pmid:21731373 |
Wang XX et al. | Simultaneous structural identification of natural products in fractions of crude extract of the rare endangered plant Anoectochilus roxburghii using H NMR/RRLC-MS parallel dynamic spectroscopy. | 2011 | Int J Mol Sci | pmid:21731458 |
Maher P et al. | Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes. | 2011 | PLoS ONE | pmid:21738623 |
Bojić M et al. | Evaluation of antiaggregatory activity of flavonoid aglycone series. | 2011 | Nutr J | pmid:21745360 |
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Wei H et al. | Neuropective constituents from the rhizomes of Abacopteris penangiana. | 2011 | J Asian Nat Prod Res | pmid:21751838 |
Gohain M et al. | Racemic tricarbon-yl[7-meth-oxy-2-(η-phen-yl)chromane]-chromium(0). | 2011 | Acta Crystallogr Sect E Struct Rep Online | pmid:21753961 |
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Ohno S et al. | A bHLH transcription factor, DvIVS, is involved in regulation of anthocyanin synthesis in dahlia (Dahlia variabilis). | 2011 | J. Exp. Bot. | pmid:21765172 |
Lima de Medeiros BJ et al. | Liver protective activity of a hydroethanolic extract of Arrabidaea chica (Humb. and Bonpl.) B. Verl. (pariri). | 2011 | Pharmacognosy Res | pmid:21772750 |
Polier G et al. | Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1. | 2011 | Cell Death Dis | pmid:21776020 |
Tan W et al. | Anti-cancer natural products isolated from chinese medicinal herbs. | 2011 | Chin Med | pmid:21777476 |
Yang C et al. | Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-κB/COX-2 pathway. | 2011 | PLoS ONE | pmid:21779360 |
Han S et al. | Herbal extract THI improves metabolic abnormality in mice fed a high-fat diet. | 2011 | Nutr Res Pract | pmid:21779522 |
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