FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Fisher RF et al. | Extended Region of Nodulation Genes in Rhizobium meliloti 1021. II. Nucleotide Sequence, Transcription Start Sites and Protein Products. | 1987 | Genetics | pmid:17246400 |
Kapulnik Y et al. | Flavone limitations to root nodulation and symbiotic nitrogen fixation in alfalfa. | 1987 | Plant Physiol. | pmid:16665583 |
Weiss GR et al. | New anticancer agents. | 1987 | Cancer Chemother Biol Response Modif | pmid:2484330 |
Rubin J et al. | Flavone-8-acetic acid inhibits ristocetin-induced platelet agglutination and prolongs bleeding time. | 1987 | Lancet | pmid:2889983 |
Bibby MC et al. | Factors involved in the anti-cancer activity of the investigational agents LM985 (flavone acetic acid ester) and LM975 (flavone acetic acid). | 1987 | Br. J. Cancer | pmid:3814485 |
Dodion P et al. | Sensitivity of normal human bone marrow myeloid progenitor cells to anthracycline, cisplatin, anthracene and flavone acetic acid derivatives, and its relevance for the prediction of human plasma concentrations of anticancer drugs. | 1987 | Eur J Cancer Clin Oncol | pmid:3436354 |
Ching LM and Baguley BC | Induction of natural killer cell activity by the antitumour compound flavone acetic acid (NSC 347 512). | 1987 | Eur J Cancer Clin Oncol | pmid:3665989 |
Abdalla SS and Abu Zarga MH | Effects of cirsimaritin, a flavone isolated from Artemisia judaica, on isolated guinea-pig ileum. | 1987 | Planta Med. | pmid:3671552 |
Kerr DJ et al. | Phase I and pharmacokinetic study of flavone acetic acid. | 1987 | Cancer Res. | pmid:3677106 |
Capolongo LS et al. | Antiproliferative properties of flavone acetic acid (NSC 347512) (LM 975), a new anticancer agent. | 1987 | Eur J Cancer Clin Oncol | pmid:3678316 |
O'Dwyer PJ et al. | Flavone acetic acid (LM 975, NSC 347512). A novel antitumor agent. | 1987 | Cancer Chemother. Pharmacol. | pmid:3545524 |
Saxena M et al. | A New Flavone from Sapium insigne. | 1986 | Planta Med. | pmid:17345426 |
Jiménez MJ et al. | Anti-Inflammatory Activity of a Flavone from Sideritis leucantha. | 1986 | Planta Med. | pmid:17345496 |
Larson RL and Bussard JB | Microsomal flavonoid 3'-monooxygenase from maize seedlings. | 1986 | Plant Physiol. | pmid:16664648 |
Double JA et al. | Pharmacokinetics and anti-tumour activity of LM985 in mice bearing transplantable adenocarcinomas of the colon. | 1986 | Br. J. Cancer | pmid:3778803 |
Kerr DJ et al. | Phase I and pharmacokinetic study of LM985 (flavone acetic acid ester). | 1986 | Cancer Res. | pmid:3698028 |
Zaharko DS et al. | Therapeutic and pharmacokinetic relationships of flavone acetic acid: an agent with activity against solid tumors. | 1986 | Cancer Treat Rep | pmid:3791254 |
Plowman J et al. | Flavone acetic acid: a novel agent with preclinical antitumor activity against colon adenocarcinoma 38 in mice. | 1986 | Cancer Treat Rep | pmid:3708611 |
Vernet A and Siess MH | Comparison of the effects of various flavonoids on ethoxycoumarin deethylase activity of rat intestinal and hepatic microsomes. | 1986 | Food Chem. Toxicol. | pmid:3491024 |
Drewinko B and Yang LY | The activity of flavone acetic acid (NSC 347512) on human colon cancer cells in vitro. | 1986 | Invest New Drugs | pmid:3583640 |
Corbett TH et al. | Activity of flavone acetic acid (NSC-347512) against solid tumors of mice. | 1986 | Invest New Drugs | pmid:3546183 |
Barberán FA et al. | Highly Methylated 6-Hydroxyflavones and Other Flavonoids from Thymus piperella. | 1985 | Planta Med. | pmid:17342612 |
Li XF | [Effects of flavone II of Piper wallichii on the isolated rabbit heart]. | 1985 | Zhong Yao Tong Bao | pmid:2934172 |
Hii CS and Howell SL | Effects of flavonoids on insulin secretion and 45Ca2+ handling in rat islets of Langerhans. | 1985 | J. Endocrinol. | pmid:3900267 |
Alworth WL and Slaga TJ | Effects of ellipticine, flavone, and 7,8-benzoflavone upon 7,12-dimethylbenz[a]anthracene, 7,14-dimethyldibenzo[a,h]anthracene and dibenzo[a,h]anthracene initiated skin tumors in mice. | 1985 | Carcinogenesis | pmid:3921269 |
Sziklai I and Ribári O | The effect of flavone treatment on human otosclerotic ossicle organ cultures. | 1985 | Arch Otorhinolaryngol | pmid:4038152 |
Friedman FK et al. | Flavone modulators of rat hepatic aryl hydrocarbon hydroxylase. | 1985 | Pharmacology | pmid:4059325 |
Tóth L et al. | [Analysis of flavone derivatives by polyamide layer chromatography]. | 1984 | Acta Pharm Hung | pmid:6711313 |
Elliger CA et al. | Mutagenicity of flavones, chromones and acetophenones in Salmonella typhimurium. New structure-activity relationships. | 1984 | Mutat. Res. | pmid:6363915 |
Ficarra P et al. | Analysis of 2-phenyl-chromon derivatives and chlorogenic acid. II. High-performance thin layer chromatography and high-performance liquid chromatography in flowers, leaves and buds extractives of Crataegus oxyacantha L. | 1984 | Farmaco Prat | pmid:6542533 |
Nose K | Inhibition by flavonoids of RNA synthesis in permeable WI-38 cells and of transcription by RNA polymerase II. | 1984 | Biochem. Pharmacol. | pmid:6508836 |
Agosin M | The aerobic metabolism of metronidazole by Trypanosoma cruzi epimastigotes. | 1983 | Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. | pmid:6138198 |
He ZY | [Preliminary study on the treatment of coronary heart disease with total flavone of Caulis piperis Futokadsurae]. | 1983 | Zhong Xi Yi Jie He Za Zhi | pmid:6227404 |
Nomura T et al. | Constituents of the Chinese crude drug "sÄng-bái-pÃ" (Morus root bark). | 1983 | Planta Med. | pmid:17405088 |
Paulin JJ et al. | Ultrastructural modifications during the metabolism of metronidazole by Trypanosoma cruzi. | 1983 | J. Submicrosc. Cytol. | pmid:6361276 |
Ghosh DK et al. | Microsomal benzo(a)pyrene hydroxylase in Aspergillus ochraceus TS: assay and characterization of the enzyme system. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6409103 |
Dutta D et al. | Induction of benzo(a)pyrene hydroxylase in Aspergillus ochraceus TS: evidences of multiple forms of cytochrome P-450. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6626210 |
Matern U et al. | Further characterization and regulation of malonyl-coenzyme A: flavonoid glucoside malonyltransferases from parsley cell suspension cultures. | 1983 | Arch. Biochem. Biophys. | pmid:6639051 |
Hausen BM et al. | 5,8-dihydroxyflavone (primetin) the contact sensitizer of Primula mistassinica Michaux. | 1983 | Arch. Dermatol. Res. | pmid:6660907 |
Odebiyi OO | Isolation of a new flavone and some essential oils with antimicrobial and antifungal properties from the stem bark of Jatropha podagrica. | 1982 | Planta Med. | pmid:17396821 |
Hurabielle M et al. | [Flavonoids of Artemisia campestris, ssp. glutinosa]. | 1982 | Planta Med. | pmid:17396957 |
Okuda J et al. | Inhibition of aldose reductases from rat and bovine lenses by flavonoids. | 1982 | Biochem. Pharmacol. | pmid:6818971 |
Lasker JM et al. | In vivo activation of zoxazolamine metabolism by flavone. | 1982 | Science | pmid:7089530 |
Forgacs P et al. | [Flavones and Sesquiterpene Lactones of Volutarella divaricata]. | 1981 | Planta Med. | pmid:17401976 |
Hildebrandt AG et al. | Studies on the mechanism of stimulation of microsomal H2O2 formation and benzo(a)pyrene hydroxylation by substrates and flavone. | 1981 | Adv. Exp. Med. Biol. | pmid:6283811 |
Viswanathan T and Alworth WL | Effects of 1-arylpyrroles and naphthoflavones upon cytochrome P-450 dependent monooxygenase activities. | 1981 | J. Med. Chem. | pmid:7277387 |
Huang MT et al. | Specificity in the activation and inhibition by flavonoids of benzo[a]pyrene hydroxylation by cytochrome P-450 isozymes from rabbit liver microsomes. | 1981 | J. Biol. Chem. | pmid:6270135 |
Keller G and Leuenberger PM | [Aldose-reductase inhibitors and cataract formation (author's transl)]. | 1980 | Klin Monbl Augenheilkd | pmid:6775130 |
Alworth WL et al. | Stimulation of mammalian epoxide hydrase activity by flavones. | 1980 | Xenobiotica | pmid:7415221 |
Rossi M et al. | Molecular structures of 5,6- and 7,8-benzoflavones, inhibitors of aryl hydrocarbon hydroxylase. | 1980 | Cancer Res. | pmid:7388828 |
Iinuma M and Matsuura S | [Synthetic studies of the flavone derivatives. VII. Synthesis of 6,8-dimethoxyflavone derivatives and their 13C-NMR (author's transl)]. | 1980 | Yakugaku Zasshi | pmid:7463312 |
Takido M et al. | [On the revised structure of skullcapflavone I, a flavone compound in the roots of Scutellaria baicalensis Georgi (Wogon) (author's transl)]. | 1979 | Yakugaku Zasshi | pmid:480145 |
Zhang BH et al. | [The effects of the total flavone of Ku-shen on cardiac arrhythmias (author's transl)]. | 1979 | Yao Xue Xue Bao | pmid:532643 |
Iinuma M and Matsuura S | [Synthetic studies of the flavone derivatives. VI. The synthesis of skullcapflavone I, II and related flavones (author's transl)]. | 1979 | Yakugaku Zasshi | pmid:536899 |
Quéval P and Beaumatin J | [Study of the inductor effect of 5,6-benzoflavone on the activity of pulmonary benzopyrene monoxidase. Comparison with other chemical or physical agents]. | 1979 | C. R. Acad. Sci., D, Sci. Nat. | pmid:111845 |
Heller W et al. | Enzymes of General Phenylpropanoid Metabolism and of Flavonoid Glycoside Biosynthesis in Parsley: Differential Inducibility by Light during the Growth of Cell Suspension Cultures. | 1979 | Plant Physiol. | pmid:16660968 |
Buset H and Scheline RR | Identification of urinary metabolites of flavanone in the rat. | 1979 | Biomed. Mass Spectrom. | pmid:476285 |
Udupa SR and Chadha MS | Microbiological transformations of flavonoids: Part V--Transformation of flavone. | 1978 | Indian J. Biochem. Biophys. | pmid:738753 |
Narain NK | Flavonoids from Vernonia fasciculata Michx. Isolation of genkwanin and a new flavone disaccharide, fasciculatin. | 1977 | J. Chem. Soc. Perkin Trans. I | pmid:559004 |
Teubert H et al. | [Flavonols and flavones of vegetables. VIII. Flavones of carrot leaves (author's transl)]. | 1977 | Z Lebensm Unters Forsch | pmid:595898 |
Ebel J and Hahlbrock K | Enzymes of flavone and flavonol-glycoside biosynthesis. Coordinated and selective induction in cell-suspension cultures of Petroselinum hortense. | 1977 | Eur. J. Biochem. | pmid:862617 |
Konno C et al. | Morusinol, isoprenoid flavone from Morus root barks. | 1977 | Planta Med. | pmid:905426 |
Matusuura S et al. | [Synthesis studies of the flavone derivates. III. Photochemical reaction of chalcone derivative (author's transl)]. | 1976 | Yakugaku Zasshi | pmid:986458 |
Ogawa M and Ogihara Y | [Studies on the constituents of Enkianthus nudipes. IV. A new flavone glucoside from the stems (author's transl)]. | 1975 | Yakugaku Zasshi | pmid:1237562 |
Da Re P et al. | Beta-adrenergic blocking agents of the flavone group. [(author's transl)]. | 1975 | Arch. Pharm. (Weinheim) | pmid:236740 |
Sutter A et al. | Oxidation of flavanone to flavone with cell-free extracts from young parsley leaves. | 1975 | Arch. Biochem. Biophys. | pmid:242261 |
Dorneanu V et al. | [Determination of flavone derivatives. I. Quantitative determination of condensation products of rutin with epsiolon-aminocaproic acid]. | 1974 Oct-Dec | Rev Med Chir Soc Med Nat Iasi | pmid:4453725 |
Matsuura S and Kunii T | [Synthetic studies of the flavone derivatives. II. Synthesis of cirsimaritin (author's transl)]. | 1974 | Yakugaku Zasshi | pmid:4473114 |
Cavé A et al. | [Pachypodol (5,4'-dihydroxy 3,7,3'-trimethoxy flavone or 3,7,3'-quercetol trimethylether), a new flavonoid isolated from Pachypodanthium confine Engler and Diels (annonaceae)]. | 1973 | C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. | pmid:4201538 |
Cutroneo KR et al. | Induction of benzpyrene hydroxylase by flavone and its derivatives in fetal rat liver explants. | 1972 | Biochem. Pharmacol. | pmid:5064734 |
Imre S | [Additional anthraquinone and flavone compounds from the leaves of Digitalis viridiflora. 3. Flavone and anthraquinone dyes of digitalis species]. | 1972 | Planta Med. | pmid:5047478 |
Hänsel R and Ohlendorf D | [A new flavone from Achyrocline satureoides unsubstituted in ring B]. | 1971 | Arch Pharm Ber Dtsch Pharm Ges | pmid:5290613 |
Brieskorn CH and Biechele W | [Flavones from Salvia officinalis L. 22. Components of Salvia off. L]. | 1971 | Arch Pharm Ber Dtsch Pharm Ges | pmid:5284536 |
KOEPPEN BH et al. | The flavone C-glycosides and flavonol O-glycosides of Aspalathus acuminatus (rooibos tea). | 1962 | Biochem. J. | pmid:14457727 |
NORTHOVER BJ and SUBRAMANIAN G | A study of possible mediators of inflammatory reactions in the mouse foot. | 1962 | Br J Pharmacol Chemother | pmid:14480419 |
JURD L et al. | The flavonoid constituents of Spirodela oligorrhiza. II. The flavone constituents. | 1957 | Arch. Biochem. Biophys. | pmid:13425623 |
MARSH CA | Glucuronide metabolism in plants. II. The isolation of flavone glucosiduronic acids from plants. | 1955 | Biochem. J. | pmid:14351142 |
ANREP GV et al. | The spasmolytic action of flavone. | 1953 | J. Pharm. Pharmacol. | pmid:13035698 |
BOHR DF et al. | The effects of various flavone glucosides on the rate of passage of Evans blue through the damaged capillary wall. | 1949 | J. Pharmacol. Exp. Ther. | pmid:15391936 |
Iwashina T et al. | Analysis of flavonoids in pubescence of soybean near-isogenic lines for pubescence color loci. | J. Hered. | pmid:16985083 | |
Cui XQ et al. | A new Diels-Alder type adduct and two new flavones from the stem bark of Morus yunanensis Koidz. | J Asian Nat Prod Res | pmid:18348061 | |
Jin L et al. | Chemical constituents from Belamcanda chinensis. | J Asian Nat Prod Res | pmid:18058385 | |
Yao N et al. | Synthesis of flavonoid analogues as scaffolds for natural product-based combinatorial libraries. | J Comb Chem | pmid:17487987 | |
Kumar R et al. | A new chromone from Cassia nodosa. | J Asian Nat Prod Res | pmid:17135042 | |
Gidda SK and Varin L | Biochemical and molecular characterization of flavonoid 7-sulfotransferase from Arabidopsis thaliana. | Plant Physiol. Biochem. | pmid:17095238 | |
Marrero-Ponce Y | Linear indices of the "molecular pseudograph's atom adjacency matrix": definition, significance-interpretation, and application to QSAR analysis of flavone derivatives as HIV-1 integrase inhibitors. | J Chem Inf Comput Sci | pmid:15554670 | |
Souza J et al. | A study on the antipicornavirus activity of flavonoid compounds (flavones) by using quantum chemical and chemometric methods. | J Chem Inf Comput Sci | pmid:15154785 | |
Saleem A et al. | A RP-HPLC-DAD-APCI/MSD method for the characterisation of medicinal Ericaceae used by the Eeyou Istchee Cree First Nations. | Phytochem Anal | pmid:20135709 | |
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Cao H et al. | Microbial biotransformation of bioactive flavonoids. | Biotechnol. Adv. | pmid:25447420 | |
Kaneko T et al. | Inhibition of prostaglandin E2 production by flavone and its related compounds. | In Vivo | pmid:20133976 |