FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Rostom SA et al. | Synthesis and biological evaluation of some polymethoxylated fused pyridine ring systems as antitumor agents. | 2009 | Arch. Pharm. (Weinheim) | pmid:19714673 |
Hausen BM et al. | 5,8-dihydroxyflavone (primetin) the contact sensitizer of Primula mistassinica Michaux. | 1983 | Arch. Dermatol. Res. | pmid:6660907 |
Matern U et al. | Further characterization and regulation of malonyl-coenzyme A: flavonoid glucoside malonyltransferases from parsley cell suspension cultures. | 1983 | Arch. Biochem. Biophys. | pmid:6639051 |
Mukai R et al. | Suppression mechanisms of flavonoids on aryl hydrocarbon receptor-mediated signal transduction. | 2010 | Arch. Biochem. Biophys. | pmid:20450880 |
JURD L et al. | The flavonoid constituents of Spirodela oligorrhiza. II. The flavone constituents. | 1957 | Arch. Biochem. Biophys. | pmid:13425623 |
Tammela P et al. | Permeability characteristics and membrane affinity of flavonoids and alkyl gallates in Caco-2 cells and in phospholipid vesicles. | 2004 | Arch. Biochem. Biophys. | pmid:15111127 |
Henry EC and Gasiewicz TA | Molecular determinants of species-specific agonist and antagonist activity of a substituted flavone towards the aryl hydrocarbon receptor. | 2008 | Arch. Biochem. Biophys. | pmid:18294953 |
Schrag ML and Wienkers LC | Covalent alteration of the CYP3A4 active site: evidence for multiple substrate binding domains. | 2001 | Arch. Biochem. Biophys. | pmid:11414684 |
Velázquez I and Pardo JP | Kinetic characterization of the rotenone-insensitive internal NADH: ubiquinone oxidoreductase of mitochondria from Saccharomyces cerevisiae. | 2001 | Arch. Biochem. Biophys. | pmid:11370674 |
Cook SA and Shiemke AK | Evidence that a type-2 NADH:quinone oxidoreductase mediates electron transfer to particulate methane monooxygenase in methylococcus capsulatus. | 2002 | Arch. Biochem. Biophys. | pmid:11811946 |
Sutter A et al. | Oxidation of flavanone to flavone with cell-free extracts from young parsley leaves. | 1975 | Arch. Biochem. Biophys. | pmid:242261 |
Hänsel R and Ohlendorf D | [A new flavone from Achyrocline satureoides unsubstituted in ring B]. | 1971 | Arch Pharm Ber Dtsch Pharm Ges | pmid:5290613 |
Brieskorn CH and Biechele W | [Flavones from Salvia officinalis L. 22. Components of Salvia off. L]. | 1971 | Arch Pharm Ber Dtsch Pharm Ges | pmid:5284536 |
Sziklai I and Ribári O | The effect of flavone treatment on human otosclerotic ossicle organ cultures. | 1985 | Arch Otorhinolaryngol | pmid:4038152 |
Mohammadi-Motlagh HR et al. | Anticancer and anti-inflammatory activities of shallot (Allium ascalonicum) extract. | 2011 | Arch Med Sci | pmid:22291731 |
Seo J et al. | Location of flavone B-ring controls regioselectivity and stereoselectivity of naphthalene dioxygenase from Pseudomonas sp. strain NCIB 9816-4. | 2010 | Appl. Microbiol. Biotechnol. | pmid:20091026 |
He XZ et al. | Regioselective synthesis of plant (iso)flavone glycosides in Escherichia coli. | 2008 | Appl. Microbiol. Biotechnol. | pmid:18568307 |
Leonard E et al. | Expression of a soluble flavone synthase allows the biosynthesis of phytoestrogen derivatives in Escherichia coli. | 2006 | Appl. Microbiol. Biotechnol. | pmid:16025328 |
Seo J et al. | Flavonoids biotransformation by bacterial non-heme dioxygenases, biphenyl and naphthalene dioxygenase. | 2011 | Appl. Microbiol. Biotechnol. | pmid:21626021 |
Erhart LM et al. | Flavone initiates a hierarchical activation of the caspase-cascade in colon cancer cells. | 2005 | Apoptosis | pmid:15909122 |