FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Li LZ et al. | Flavonoids and other constituents from Aletris spicata and their chemotaxonomic significance. | 2014 | Nat. Prod. Res. | pmid:24896299 |
Yan J et al. | GmFNSII-controlled soybean flavone metabolism responds to abiotic stresses and regulates plant salt tolerance. | 2014 | Plant Cell Physiol. | pmid:24192294 |
Barreca D et al. | First evidence of C- and O-glycosyl flavone in blood orange (Citrus sinensis (L.) Osbeck) juice and their influence on antioxidant properties. | 2014 | Food Chem | pmid:24295703 |
Raghav N and Garg S | SAR studies of o-hydroxychalcones and their cyclized analogs and study them as novel inhibitors of cathepsin B and cathepsin H. | 2014 | Eur J Pharm Sci | pmid:24780403 |
Berczyński P et al. | Studies on the antioxidant activity of some thiazolidinedione, imidazolidinedione and rhodanine derivatives having a flavone core. | 2014 | Luminescence | pmid:24733694 |
Venditti A et al. | A C-methylated resacetophenone from Cistus monspeliensis L. | 2014 | Fitoterapia | pmid:24685506 |
Lin SH and Shih YW | Antitumor effects of the flavone chalcone: inhibition of invasion and migration through the FAK/JNK signaling pathway in human gastric adenocarcinoma AGS cells. | 2014 | Mol. Cell. Biochem. | pmid:24510324 |
Fan Y et al. | The design of propolis flavone microemulsion and its effect on enhancing the immunity and antioxidant activity in mice. | 2014 | Int. J. Biol. Macromol. | pmid:24463267 |
Liu B et al. | A step toward simplified detection of serum albumin on SDS-PAGE using an environment-sensitive flavone sensor. | 2015 | Chem. Commun. (Camb.) | pmid:26068596 |
Hu J et al. | Genome-wide analysis of DNA methylation in photoperiod- and thermo-sensitive male sterile rice Peiai 64S. | 2015 | BMC Genomics | pmid:25887533 |
Weng Z et al. | The novel flavone tetramethoxyluteolin is a potent inhibitor of human mast cells. | 2015 | J. Allergy Clin. Immunol. | pmid:25498791 |
Nakamura K et al. | Effects of Hydroxy Groups in the A-Ring on the Anti-proteasome Activity of Flavone. | 2015 | Biol. Pharm. Bull. | pmid:25810454 |
Yao X et al. | The changes in quality ingredients of Qi chrysanthemum flowers treated with elevated UV-B radiation at different growth stages. | 2015 | J. Photochem. Photobiol. B, Biol. | pmid:25792150 |
Wang RL et al. | A novel cytochrome P450 CYP6AB14 gene in Spodoptera litura (Lepidoptera: Noctuidae) and its potential role in plant allelochemical detoxification. | 2015 | J. Insect Physiol. | pmid:25783953 |
Zhu W et al. | Flavone inhibits nitric oxide synthase (NOS) activity, nitric oxide production and protein S-nitrosylation in breast cancer cells. | 2015 | Biochem. Biophys. Res. Commun. | pmid:25680459 |
Zheng ZP et al. | Preparation, characterization, and preliminary antibrowning evaluations of norartocarpetin microemulsions. | 2015 | J. Agric. Food Chem. | pmid:25603116 |
Ting Y et al. | Influence of processing parameters on morphology of polymethoxyflavone in emulsions. | 2015 | J. Agric. Food Chem. | pmid:25537008 |
Berim A et al. | Identification of a unique 2-oxoglutarate-dependent flavone 7-O-demethylase completes the elucidation of the lipophilic flavone network in basil. | 2015 | Plant Cell Physiol. | pmid:25378691 |
Jung Y et al. | Plant-derived flavones as inhibitors of aurora B kinase and their quantitative structure-activity relationships. | 2015 | Chem Biol Drug Des | pmid:25298094 |
Kammalla AK et al. | Comparative pharmacokinetic interactions of Quercetin and Rutin in rats after oral administration of European patented formulation containing Hipphophae rhamnoides and Co-administration of Quercetin and Rutin. | 2015 | Eur J Drug Metab Pharmacokinet | pmid:24888486 |