FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kurian GA and Paddikkala J | Role of Mitochondrial Enzymes and Sarcoplasmic ATPase in Cardioprotection Mediated by Aqueous Extract of Desmodium gangeticum (L) DC Root on Ischemic Reperfusion Injury. | 2010 | Indian J Pharm Sci | pmid:21969747 |
Yamada K et al. | A lipase inhibitor monoterpene and monoterpene glycosides from Monarda punctata. | 2010 | Phytochemistry | pmid:20832830 |
Hirai S et al. | Functional food targeting the regulation of obesity-induced inflammatory responses and pathologies. | 2010 | Mediators Inflamm. | pmid:20508825 |
Han Y et al. | Ectopic expression of apple F3'H genes contributes to anthocyanin accumulation in the Arabidopsis tt7 mutant grown under nitrogen stress. | 2010 | Plant Physiol. | pmid:20357139 |
Meydani M and Hasan ST | Dietary polyphenols and obesity. | 2010 | Nutrients | pmid:22254051 |
Torres-Piedra M et al. | A comparative study of flavonoid analogues on streptozotocin-nicotinamide induced diabetic rats: quercetin as a potential antidiabetic agent acting via 11beta-hydroxysteroid dehydrogenase type 1 inhibition. | 2010 | Eur J Med Chem | pmid:20346546 |
Halbwirth H | The creation and physiological relevance of divergent hydroxylation patterns in the flavonoid pathway. | 2010 | Int J Mol Sci | pmid:20386656 |
Jeong HJ et al. | Chungsim-Yeunja-Tang decreases the inflammatory response in peripheral blood mononuclear cells from patients with cerebral infarction through an NF-κB dependent mechanism. | 2010 | J Neuroinflammation | pmid:21108840 |
Xia EQ et al. | Biological activities of polyphenols from grapes. | 2010 | Int J Mol Sci | pmid:20386657 |
Kundu S and Roy D | Structural study of biologically significant ligands with major birch pollen allergen Betv1 by docking and molecular dynamics simulation. | 2010 | Bioinformation | pmid:20978606 |
Ansó E et al. | Flavonoids inhibit hypoxia-induced vascular endothelial growth factor expression by a HIF-1 independent mechanism. | 2010 | Biochem. Pharmacol. | pmid:20153296 |
Ghasemzadeh A et al. | Effect of different light intensities on total phenolics and flavonoids synthesis and anti-oxidant activities in young ginger varieties (Zingiber officinale Roscoe). | 2010 | Int J Mol Sci | pmid:21152306 |
Yen JH et al. | Glycine tomentella Hayata inhibits IL-1β and IL-6 production, inhibits MMP-9 activity, and enhances RAW264.7 macrophage clearance of apoptotic cells. | 2010 | J. Biomed. Sci. | pmid:21054849 |
Medjakovic S et al. | Potential health-modulating effects of isoflavones and metabolites via activation of PPAR and AhR. | 2010 | Nutrients | pmid:22254019 |
Xiang H et al. | Synthesis and biological evaluation of isoflavone fatty acid esters with potential weight loss and hypolipidemic activities. | 2010 | Bioorg. Med. Chem. | pmid:20392645 |
Wang P et al. | Structural basis for certain naturally occurring bioflavonoids to function as reducing co-substrates of cyclooxygenase I and II. | 2010 | PLoS ONE | pmid:20808785 |
Liao Z et al. | Antidiabetic effect of flavones from Cirsium japonicum DC in diabetic rats. | 2010 | Arch. Pharm. Res. | pmid:20361298 |
Khoo BY et al. | Apoptotic effects of chrysin in human cancer cell lines. | 2010 | Int J Mol Sci | pmid:20559509 |
Ono E et al. | Co-pigmentation and flavonoid glycosyltransferases in blue Veronica persica flowers. | 2010 | Phytochemistry | pmid:20223486 |
Villaflores OB et al. | Phytoconstituents from Alpinia purpurata and their in vitro inhibitory activity against Mycobacterium tuberculosis. | 2010 | Pharmacogn Mag | pmid:21120040 |
Prajapati RP et al. | Phytochemical and pharmacological review of Lagenaria sicereria. | 2010 | J Ayurveda Integr Med | pmid:21731373 |
Kim MJ et al. | TNF-α induces expression of urokinase-type plasminogen activator and β-catenin activation through generation of ROS in human breast epithelial cells. | 2010 | Biochem. Pharmacol. | pmid:20804741 |
Vidyalakshmi K et al. | Antinociceptive effect of certain dihydroxy flavones in mice. | 2010 | Pharmacol. Biochem. Behav. | pmid:20346369 |
Madeira PJ et al. | Electrospray ionization Fourier transform ion cyclotron resonance mass spectrometric and semi-empirical calculations study of five isoflavone aglycones. | 2010 | Rapid Commun. Mass Spectrom. | pmid:21072799 |
Joe EJ et al. | Engineering of flavonoid O-methyltransferase for a novel regioselectivity. | 2010 | Mol. Cells | pmid:20680484 |
Sharma RD et al. | Possible implication of oxidative stress in anti filarial effect of certain traditionally used medicinal plants in vitro against Brugia malayi microfilariae. | 2010 | Pharmacognosy Res | pmid:21713137 |
Pichichero E et al. | Acacia honey and chrysin reduce proliferation of melanoma cells through alterations in cell cycle progression. | 2010 | Int. J. Oncol. | pmid:20811719 |
Shimada T et al. | Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives. | 2010 | Chem. Res. Toxicol. | pmid:21053930 |
Shukla S and Gupta S | Apigenin: a promising molecule for cancer prevention. | 2010 | Pharm. Res. | pmid:20306120 |
Zhou JM et al. | Structure-function relationships of wheat flavone O-methyltransferase: Homology modeling and site-directed mutagenesis. | 2010 | BMC Plant Biol. | pmid:20670441 |
Tamura S et al. | New inhibitors for expression of IgE receptor on human mast cell. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20202836 |
Kurian G et al. | A Novel Approach for Oral Delivery of Insulin via Desmodium gangeticum Aqueous Root Extract. | 2010 | J Young Pharm | pmid:21264119 |
Yi Lau GT and Leung LK | The dietary flavonoid apigenin blocks phorbol 12-myristate 13-acetate-induced COX-2 transcriptional activity in breast cell lines. | 2010 | Food Chem. Toxicol. | pmid:20691240 |
Kumar GS et al. | Synthesis and biological evaluation of novel benzyl-substituted flavones as free radical (DPPH) scavengers and α-glucosidase inhibitors. | 2010 | J Asian Nat Prod Res | pmid:21061220 |
de Pascual-Teresa S et al. | Flavanols and anthocyanins in cardiovascular health: a review of current evidence. | 2010 | Int J Mol Sci | pmid:20480037 |
Ghasemzadeh A et al. | Synthesis of phenolics and flavonoids in ginger (Zingiber officinale Roscoe) and their effects on photosynthesis rate. | 2010 | Int J Mol Sci | pmid:21151455 |
Goettel W and Messing J | Divergence of gene regulation through chromosomal rearrangements. | 2010 | BMC Genomics | pmid:21118519 |
Guttikonda SK et al. | Whole genome co-expression analysis of soybean cytochrome P450 genes identifies nodulation-specific P450 monooxygenases. | 2010 | BMC Plant Biol. | pmid:21062474 |
Attimarad M | Liquid Chromatographic Determination of Flavoxate HCl in Pharmaceutical Formulation. | 2010 | J Young Pharm | pmid:21042486 |
Demiroglu-Zergeroglu A et al. | The investigation of effects of quercetin and its combination with Cisplatin on malignant mesothelioma cells in vitro. | 2010 | J. Biomed. Biotechnol. | pmid:20508819 |
Zou GA et al. | Flavonoids from the stems of Croton caudatus Geisel. var. tomentosus Hook. | 2010 | Molecules | pmid:20335965 |
Ragab FA et al. | Synthesis and anticonvulsant activity of certain substituted furochromone, benzofuran and flavone derivatives. | 2010 | Chem. Pharm. Bull. | pmid:20823592 |
Stark JL et al. | Solution structure and function of YndB, an AHSA1 protein from Bacillus subtilis. | 2010 | Proteins | pmid:20818668 |
Chung KS et al. | Eupafolin, a flavonoid isolated from Artemisia princeps, induced apoptosis in human cervical adenocarcinoma HeLa cells. | 2010 | Mol Nutr Food Res | pmid:20397191 |
Schubert M et al. | Two novel disaccharides, rutinose and methylrutinose, are involved in carbon metabolism in Datisca glomerata. | 2010 | Planta | pmid:19915863 |
Goodger JQ et al. | Isolation of intact sub-dermal secretory cavities from Eucalyptus. | 2010 | Plant Methods | pmid:20807444 |
Kim JM et al. | Morin modulates the oxidative stress-induced NF-kappaB pathway through its anti-oxidant activity. | 2010 | Free Radic. Res. | pmid:20187708 |
Zhang A et al. | Augmented inhibition of angiogenesis by combination of HER2 antibody chA21 and trastuzumab in human ovarian carcinoma xenograft. | 2010 | J Ovarian Res | pmid:20723224 |
Du Y et al. | CYP93G2 is a flavanone 2-hydroxylase required for C-glycosylflavone biosynthesis in rice. | 2010 | Plant Physiol. | pmid:20647377 |
Gassmann K et al. | Species-specific differential AhR expression protects human neural progenitor cells against developmental neurotoxicity of PAHs. | 2010 | Environ. Health Perspect. | pmid:20570779 |
Du Y et al. | Identification of flavone phytoalexins and a pathogen-inducible flavone synthase II gene (SbFNSII) in sorghum. | 2010 | J. Exp. Bot. | pmid:20007684 |
Morreel K et al. | Mass spectrometry-based sequencing of lignin oligomers. | 2010 | Plant Physiol. | pmid:20554692 |
Filak LK et al. | Organometallic indolo[3,2-c]quinolines versus indolo[3,2-d]benzazepines: synthesis, structural and spectroscopic characterization, and biological efficacy. | 2010 | J. Biol. Inorg. Chem. | pmid:20369265 |
Lei W et al. | Molecular cloning and expression profiling of a chalcone synthase gene from hairy root cultures of Scutellaria viscidula Bunge. | 2010 | Genet. Mol. Biol. | pmid:21637484 |
Parravicini C et al. | Forced unbinding of GPR17 ligands from wild type and R255I mutant receptor models through a computational approach. | 2010 | BMC Struct. Biol. | pmid:20233425 |
Zhang A et al. | Anti-HER-2 engineering antibody ChA21 inhibits growth and induces apoptosis of SK-OV-3 cells. | 2010 | J. Exp. Clin. Cancer Res. | pmid:20214830 |
Akhtar TA et al. | Photosynthetic redox imbalance influences flavonoid biosynthesis in Lemna gibba. | 2010 | Plant Cell Environ. | pmid:20199616 |
Khalafalah AK et al. | Chemical constituents of Tephrosia purpurea. | 2010 | Pharmacognosy Res | pmid:21808544 |
McKeage MJ and Baguley BC | Disrupting established tumor blood vessels: an emerging therapeutic strategy for cancer. | 2010 | Cancer | pmid:20166210 |
Cheung FW et al. | Geoditin A induces oxidative stress and apoptosis on human colon HT29 cells. | 2010 | Mar Drugs | pmid:20161972 |
Perez-Vizcaino F and Duarte J | Flavonols and cardiovascular disease. | 2010 | Mol. Aspects Med. | pmid:20837053 |
Yang JM et al. | Hispidulin sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by AMPK activation leading to Mcl-1 block in translation. | 2010 | J. Agric. Food Chem. | pmid:20734985 |
Lin YC et al. | Hispidulin potently inhibits human glioblastoma multiforme cells through activation of AMP-activated protein kinase (AMPK). | 2010 | J. Agric. Food Chem. | pmid:20698539 |
Büchner FL et al. | Fruits and vegetables consumption and the risk of histological subtypes of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). | 2010 | Cancer Causes Control | pmid:19924549 |
Aparicio S | A systematic computational study on flavonoids. | 2010 | Int J Mol Sci | pmid:20559499 |
Song WY et al. | Effect of ethanol extracts from red pepper seeds on antioxidative defense system and oxidative stress in rats fed high-fat . high-cholesterol diet. | 2010 | Nutr Res Pract | pmid:20198203 |
Mays JR et al. | The synthesis and evaluation of flavone and isoflavone chimeras of novobiocin and derrubone. | 2010 | Bioorg. Med. Chem. | pmid:19932969 |
Dirscherl K et al. | Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype. | 2010 | J Neuroinflammation | pmid:20074346 |
Choi CW et al. | Yeast α-glucosidase inhibition by isoflavones from plants of Leguminosae as an in vitro alternative to acarbose. | 2010 | J. Agric. Food Chem. | pmid:20734984 |
Valdameri G et al. | Importance of the core structure of flavones in promoting inhibition of the mitochondrial respiratory chain. | 2010 | Chem. Biol. Interact. | pmid:20654598 |
Hanhineva K et al. | Impact of dietary polyphenols on carbohydrate metabolism. | 2010 | Int J Mol Sci | pmid:20480025 |
Lewin G et al. | Semisynthesis of natural flavones inhibiting tubulin polymerization, from hesperidin. | 2010 | J. Nat. Prod. | pmid:20356063 |
Schrader KK | Plant Natural compounds with antibacterial activity towards common pathogens of pond-cultured channel catfish (Ictalurus punctatus). | 2010 | Toxins (Basel) | pmid:22069655 |
Mitra I et al. | Chemometric modeling of free radical scavenging activity of flavone derivatives. | 2010 | Eur J Med Chem | pmid:20800321 |
Alvarez G et al. | Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity. | 2010 | Eur J Med Chem | pmid:20889239 |
Kanth BK et al. | Homology modeling, binding site identification and docking in flavone hydroxylase CYP105P2 in Streptomyces peucetius ATCC 27952. | 2010 | Comput Biol Chem | pmid:20889382 |
Xiao J et al. | Structure-affinity relationship of flavones on binding to serum albumins: effect of hydroxyl groups on ring A. | 2010 | Mol Nutr Food Res | pmid:20306480 |
Chang TL et al. | 5,6,3',4'-Tetrahydroxy-7-methoxyflavone as a novel potential proteasome inhibitor. | 2010 | Planta Med. | pmid:20195959 |
Zeng YW et al. | [The zonal characteristics and cultivated types difference of functional components in brown rice for core collection of Yunnan rice]. | 2010 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:21322246 |
Lakshmi V et al. | Antifilarial activity in vitro and in vivo of some flavonoids tested against Brugia malayi. | 2010 | Acta Trop. | pmid:20609356 |
Goettert M et al. | Biological evaluation and structural determinants of p38α mitogen-activated-protein kinase and c-Jun-N-terminal kinase 3 inhibition by flavonoids. | 2010 | Chembiochem | pmid:21108268 |
Wang J et al. | Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation. | 2010 | PLoS ONE | pmid:20221395 |
Yang Y et al. | Binding research on flavones as ligands of β-amyloid aggregates by fluorescence and their 3D-QSAR, docking studies. | 2010 | J. Mol. Graph. Model. | pmid:21094069 |
Baguley BC and McKeage MJ | ASA404: a tumor vascular-disrupting agent with broad potential for cancer therapy. | 2010 | Future Oncol | pmid:21062153 |
Zhang C et al. | Functional characterization of cis-acting elements mediating flavone-inducible expression of CYP321A1. | 2010 | Insect Biochem. Mol. Biol. | pmid:20854909 |
Zhang Y et al. | Reproducibility and relative validity of a food frequency questionnaire to assess intake of dietary flavonol and flavone in Chinese university campus population. | 2010 | Nutr Res | pmid:20851305 |
Nessa F et al. | Xanthine oxidase inhibitory activities of extracts and flavonoids of the leaves of Blumea balsamifera. | 2010 | Pharm Biol | pmid:20738223 |
Liu H et al. | New synthetic flavone derivatives induce apoptosis of hepatocarcinoma cells. | 2010 | Bioorg. Med. Chem. | pmid:20674374 |
Shaker E et al. | Anti-inflammatory and anti-ulcer activity of the extract from Alhagi maurorum (camelthorn). | 2010 | Food Chem. Toxicol. | pmid:20633591 |
Gautam N et al. | In-situ absorption, protein binding and pharmacokinetic studies of S002-853, a novel antidiabetic and antidyslipidaemic flavone derivative in rats. | 2010 | J. Pharm. Pharmacol. | pmid:20609062 |
Guendel I et al. | Inhibition of human immunodeficiency virus type-1 by cdk inhibitors. | 2010 | AIDS Res Ther | pmid:20334651 |
Valant-Vetschera KM et al. | Chemodiversity of exudate flavonoids in Dionysia (Primulaceae): a comparative study. | 2010 | Phytochemistry | pmid:20378133 |
Gokara M et al. | Molecular interaction studies of trimethoxy flavone with human serum albumin. | 2010 | PLoS ONE | pmid:20098677 |
Chen Q et al. | Measurement of total flavone content in snow lotus (Saussurea involucrate) using near infrared spectroscopy combined with interval PLS and genetic algorithm. | 2010 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:20338806 |
Yashiroda Y et al. | A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20214890 |
Ramful D et al. | Bioactive phenolics and antioxidant propensity of flavedo extracts of Mauritian citrus fruits: potential prophylactic ingredients for functional foods application. | 2010 | Toxicology | pmid:20100535 |
Echeverry C et al. | Pretreatment with natural flavones and neuronal cell survival after oxidative stress: a structure-activity relationship study. | 2010 | J. Agric. Food Chem. | pmid:20095615 |
Bacher M et al. | Complete 1H and 13C NMR data assignment of new constituents from Severinia buxifolia. | 2010 | Magn Reson Chem | pmid:19937908 |
Jandera P et al. | Dual hydrophilic interaction-RP retention mechanism on polar columns: structural correlations and implementation for 2-D separations on a single column. | 2010 | J Sep Sci | pmid:20087874 |
Kasai N et al. | Atypical kinetics of cytochromes P450 catalysing 3'-hydroxylation of flavone from the white-rot fungus Phanerochaete chrysosporium. | 2010 | J. Biochem. | pmid:19819902 |