FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Chi YS et al. | Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression. | 2003 | Biochem. Pharmacol. | pmid:14505806 |
Carcache-Blanco EJ et al. | Constituents of the stem bark of Pongamia pinnata with the potential to induce quinone reductase. | 2003 | J. Nat. Prod. | pmid:14510596 |
Rudek MA et al. | Clinical pharmacology of flavopiridol following a 72-hour continuous infusion. | 2003 | Ann Pharmacother | pmid:14519054 |
Govindarajan R et al. | Studies on the antioxidant activities of Desmodium gangeticum. | 2003 | Biol. Pharm. Bull. | pmid:14519948 |
Shibata H et al. | Flavone markedly affects phenotypic expression of beta-lactam resistance in methicillin-resistant Staphylococcus aureus strains isolated clinically. | 2003 | Biol. Pharm. Bull. | pmid:14519958 |
Peterson J et al. | Flavonoid intake and breast cancer risk: a case--control study in Greece. | 2003 | Br. J. Cancer | pmid:14520456 |
Schwalm K et al. | Flavonoid-related regulation of auxin accumulation in Agrobacterium tumefaciens-induced plant tumors. | 2003 | Planta | pmid:14523649 |
Mackenzie CA et al. | Gonadal differentiation in frogs exposed to estrogenic and antiestrogenic compounds. | 2003 | Environ. Toxicol. Chem. | pmid:14552012 |
Uyemura SA et al. | Oxidative phosphorylation and rotenone-insensitive malate- and NADH-quinone oxidoreductases in Plasmodium yoelii yoelii mitochondria in situ. | 2004 | J. Biol. Chem. | pmid:14561763 |
Lin HY et al. | Inhibition of lipopolysaccharide-induced nitric oxide production by flavonoids in RAW264.7 macrophages involves heme oxygenase-1. | 2003 | Biochem. Pharmacol. | pmid:14563492 |
Fang H et al. | Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor. | 2003 | Chem. Res. Toxicol. | pmid:14565775 |
Kim SY et al. | Cis-2', 3'-dihydrodiol production on flavone B-ring by biphenyl dioxygenase from Pseudomonas pseudoalcaligenes KF707 expressed in Escherichia coli. | 2003 | Antonie Van Leeuwenhoek | pmid:14574103 |
Lee S et al. | Solubility enhancement of a hydrophobic flavonoid, luteolin by the complexation with cyclosophoraoses isolated from Rhizobium meliloti. | 2003 | Antonie Van Leeuwenhoek | pmid:14574115 |
Tudella VG et al. | In situ evidence of an alternative oxidase and an uncoupling protein in the respiratory chain of Aspergillus fumigatus. | 2004 | Int. J. Biochem. Cell Biol. | pmid:14592541 |
Cho H et al. | Modulation of the activity of pro-inflammatory enzymes, COX-2 and iNOS, by chrysin derivatives. | 2004 | Pharmacol. Res. | pmid:14597150 |
Haraguchi H et al. | A flavone from Manilkara indica as a specific inhibitor against aldose reductase in vitro. | 2003 | Planta Med. | pmid:14598214 |
Cai H et al. | Determination of the flavone tricin in human plasma by high-performance liquid chromatography. | 2003 | Biomed. Chromatogr. | pmid:14598326 |
Albach DC et al. | Acylated flavone glycosides from Veronica. | 2003 | Phytochemistry | pmid:14599528 |
Almada-Ruiz E et al. | Fungicidal potential of methoxylated flavones from citrus for in vitro control of Colletotrichum gloeosporioides, causal agent of anthracnose disease in tropical fruits. | 2003 | Pest Manag. Sci. | pmid:14620052 |
Ajay M et al. | Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta. | 2003 | Life Sci. | pmid:14623031 |