FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Larson RL and Bussard JB | Microsomal flavonoid 3'-monooxygenase from maize seedlings. | 1986 | Plant Physiol. | pmid:16664648 |
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Stipcevic T et al. | Effect of different flavonoids on collagen synthesis in human fibroblasts. | 2006 | Plant Foods Hum Nutr | pmid:16642409 |
Wurglics M and Schubert-Zsilavecz M | Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. | 2006 | Clin Pharmacokinet | pmid:16640452 |
Gupta A et al. | Influence of sea buckthorn (Hippophae rhamnoides L.) flavone on dermal wound healing in rats. | 2006 | Mol. Cell. Biochem. | pmid:16633732 |
Niho N et al. | Inhibition of intestinal carcinogenesis by a new flavone derivative, chafuroside, in oolong tea. | 2006 | Cancer Sci. | pmid:16630115 |
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Stintzing FC et al. | Thermal degradation kinetics of isoflavone aglycones from soy and red clover. | 2006 | Mol Nutr Food Res | pmid:16598813 |
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Sundararajan R et al. | Cytisus scoparius link--a natural antioxidant. | 2006 | BMC Complement Altern Med | pmid:16542432 |
Capasso R et al. | Inhibition of rat vas deferens contractions by flavonoids in-vitro. | 2006 | J. Pharm. Pharmacol. | pmid:16536906 |
Herath W et al. | Microbial metabolism. Part 6. Metabolites of 3- and 7-hydroxyflavones. | 2006 | Chem. Pharm. Bull. | pmid:16508185 |
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Le Bon AM et al. | Inhibition of microsome-mediated binding of benzo[a]pyrene to DNA by flavonoids either in vitro or after dietary administration to rats. | 1992 | Chem. Biol. Interact. | pmid:1643669 |
Yang Y et al. | Dietary rescue of fumble--a Drosophila model for pantothenate-kinase-associated neurodegeneration. | 2005 | J. Inherit. Metab. Dis. | pmid:16435199 |
Bradshaw PC and Pfeiffer DR | Loss of NAD(H) from swollen yeast mitochondria. | 2006 | BMC Biochem. | pmid:16433924 |
Li BH et al. | Structure-activity relationship of polyphenols that inhibit fatty acid synthase. | 2005 | J. Biochem. | pmid:16428296 |
Meyer H et al. | Bioavailability of apigenin from apiin-rich parsley in humans. | 2006 | Ann. Nutr. Metab. | pmid:16407641 |
Sun JL et al. | Immunologic enhancement of compound Chinese herbal medicinal ingredients and their efficacy comparison with compound Chinese herbal medicines. | 2006 | Vaccine | pmid:16378665 |
Rayyan S et al. | Flavone C-glycosides from leaves of Oxalis triangularis. | 2005 | J. Agric. Food Chem. | pmid:16366694 |
Zgórka G | Retention behavior of silica-bonded and novel polymeric reversed-phase sorbents in studies on flavones as chemotaxonomic markers of Scutellaria L. genus. | 2006 | J Chromatogr A | pmid:16364344 |
Varga Z et al. | Structure prerequisite for antioxidant activity of silybin in different biochemical systems in vitro. | 2006 | Phytomedicine | pmid:16360937 |
Kite GC et al. | Data-directed scan sequence for the general assignment of C-glycosylflavone O-glycosides in plant extracts by liquid chromatography-ion trap mass spectrometry. | 2006 | J Chromatogr A | pmid:16360661 |
Capodice JL et al. | Complementary and alternative medicine for chronic prostatitis/chronic pelvic pain syndrome. | 2005 | Evid Based Complement Alternat Med | pmid:16322807 |
Wenzel U et al. | Increased mitochondrial palmitoylcarnitine/carnitine countertransport by flavone causes oxidative stress and apoptosis in colon cancer cells. | 2005 | Cell. Mol. Life Sci. | pmid:16314920 |
Melidou M et al. | Protection against nuclear DNA damage offered by flavonoids in cells exposed to hydrogen peroxide: the role of iron chelation. | 2005 | Free Radic. Biol. Med. | pmid:16298684 |
Ono M et al. | Radioiodinated flavones for in vivo imaging of beta-amyloid plaques in the brain. | 2005 | J. Med. Chem. | pmid:16279784 |
Wang F et al. | Neuroactive flavonoids interacting with GABAA receptor complex. | 2005 | Curr Drug Targets CNS Neurol Disord | pmid:16266290 |
Mavel S et al. | Synthesis and biological evaluation of a series of flavone derivatives as potential radioligands for imaging the multidrug resistance-associated protein 1 (ABCC1/MRP1). | 2006 | Bioorg. Med. Chem. | pmid:16263302 |
Yoon JH and Baek SJ | Molecular targets of dietary polyphenols with anti-inflammatory properties. | 2005 | Yonsei Med. J. | pmid:16259055 |
Moon BH et al. | Complete assignment of (1)H and (13)C NMR data of dihydroxyflavone derivatives. | 2006 | Magn Reson Chem | pmid:16259053 |
Kim H et al. | Effects of naturally occurring compounds on fibril formation and oxidative stress of beta-amyloid. | 2005 | J. Agric. Food Chem. | pmid:16248550 |
Sandabe UK et al. | Phytochemical screening and effect of aqueous extract of Ficus sycomorus L. (Moraceae) stembark on muscular activity in laboratory animals. | 2006 | J Ethnopharmacol | pmid:16243463 |
Girish KS and Kemparaju K | Inhibition of Naja naja venom hyaluronidase by plant-derived bioactive components and polysaccharides. | 2005 | Biochemistry Mosc. | pmid:16212553 |
Cappelli C et al. | Computational study of conformational and chiroptical properties of (2R,3S,4R)-(+)-3,3',4,4',7-flavanpentol. | 2005 | Chirality | pmid:16196026 |
Kovacic P | Fundamental, electron transfer mechanism by pyrylium-type ions for the anticancer drugs 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA). | 2005 | Curr Med Chem Anticancer Agents | pmid:16178775 |
Cai H et al. | The rice bran constituent tricin potently inhibits cyclooxygenase enzymes and interferes with intestinal carcinogenesis in ApcMin mice. | 2005 | Mol. Cancer Ther. | pmid:16170019 |
UydeÅŸ-DoÄŸan BS et al. | The comparison of the relaxant effects of two methoxylated flavones in rat aortic rings. | 2005 | Vascul. Pharmacol. | pmid:16169284 |
Ozbey S et al. | Antibacterial 4-amino-N-(5-methylisoxazol-3-yl)-N-[(4-oxo-2-phenyl-4H-1-benzopyran-6-yl)methyl]benzenesulfonamide. | 2005 | Acta Crystallogr C | pmid:16143780 |
Martens S and Mithöfer A | Flavones and flavone synthases. | 2005 | Phytochemistry | pmid:16137727 |
Xie F et al. | The osteoprotective effect of Herba epimedii (HEP) extract in vivo and in vitro. | 2005 | Evid Based Complement Alternat Med | pmid:16136213 |
Huong DT et al. | A new flavone and cytotoxic activity of flavonoid constituents isolated from Miliusa balansae (Annonaceae). | 2005 | Pharmazie | pmid:16124409 |
Woodman OL et al. | Vasorelaxant and antioxidant activity of flavonols and flavones: structure-activity relationships. | 2005 | J. Cardiovasc. Pharmacol. | pmid:16116335 |
Zheng W et al. | [Study on extraction of zhuyun 3# by supercritical CO2]. | 2005 | Zhong Yao Cai | pmid:16104514 |
Shiono M et al. | Phytochemistry: structure of the blue cornflower pigment. | 2005 | Nature | pmid:16094358 |
Leonard E et al. | Expression of a soluble flavone synthase allows the biosynthesis of phytoestrogen derivatives in Escherichia coli. | 2006 | Appl. Microbiol. Biotechnol. | pmid:16025328 |
Siess MH et al. | Dietary modification of drug-metabolizing enzyme activities: dose-response effect of flavonoids. | 1992 | J Toxicol Environ Health | pmid:1602520 |
Takeda K et al. | Components of protocyanin, a blue pigment from the blue flowers of Centaurea cyanus. | 2005 | Phytochemistry | pmid:16005311 |
Verschoyle RD et al. | Preliminary safety evaluation of the putative cancer chemopreventive agent tricin, a naturally occurring flavone. | 2006 | Cancer Chemother. Pharmacol. | pmid:16001171 |
Bankova V | Chemical diversity of propolis and the problem of standardization. | 2005 | J Ethnopharmacol | pmid:15993016 |
Wang TC et al. | Synthesis, antiproliferative, and antiplatelet activities of oxime- and methyloxime-containing flavone and isoflavone derivatives. | 2005 | Bioorg. Med. Chem. | pmid:15990314 |
Kachlicki P et al. | Profiling isoflavone conjugates in root extracts of lupine species with LC/ESI/MSn systems. | 2005 | J Mass Spectrom | pmid:15971291 |
Kwon HM et al. | Anti-inflammatory inhibition of endothelial cell adhesion molecule expression by flavone derivatives. | 2005 | J. Agric. Food Chem. | pmid:15969490 |
Machha A and Mustafa MR | Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta. | 2005 | J. Cardiovasc. Pharmacol. | pmid:15965352 |
Park H et al. | Synthesis and inhibition of PGE2 production of 6,8-disubstituted chrysin derivatives. | 2005 | Eur J Med Chem | pmid:15963606 |
Jahaniani F et al. | Xanthomicrol is the main cytotoxic component of Dracocephalum kotschyii and a potential anti-cancer agent. | 2005 | Phytochemistry | pmid:15949825 |
Ko WC et al. | Mechanisms of relaxant action of luteolin in isolated guinea pig trachea. | 2005 | Planta Med. | pmid:15931576 |
Ahmed-Belkacem A et al. | Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2. | 2005 | Cancer Res. | pmid:15930306 |
Jeyabal PV et al. | Apigenin inhibits oxidative stress-induced macromolecular damage in N-nitrosodiethylamine (NDEA)-induced hepatocellular carcinogenesis in Wistar albino rats. | 2005 | Mol. Carcinog. | pmid:15924350 |
Åania-Pietrzak B et al. | Modulation of MRP1 protein transport by plant, and synthetically modified flavonoids. | 2005 | Life Sci. | pmid:15916776 |
Iori F et al. | Theoretical quantitative structure-activity relationships of flavone ligands interacting with cytochrome P450 1A1 and 1A2 isozymes. | 2005 | Bioorg. Med. Chem. | pmid:15914008 |
Nakagawa-Goto K et al. | Total synthesis and bioactivity of unique flavone desmosdumotin B and its analogs. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15913998 |
Rothwell JA et al. | Experimental determination of octanol-water partition coefficients of quercetin and related flavonoids. | 2005 | J. Agric. Food Chem. | pmid:15913295 |
Erhart LM et al. | Flavone initiates a hierarchical activation of the caspase-cascade in colon cancer cells. | 2005 | Apoptosis | pmid:15909122 |
Budzianowski J et al. | Lipophilic flavones of Primula veris L. from field cultivation and in vitro cultures. | 2005 | Phytochemistry | pmid:15896373 |
Ebert B et al. | Induction of phase-1 metabolizing enzymes by oltipraz, flavone and indole-3-carbinol enhance the formation and transport of benzo[a]pyrene sulfate conjugates in intestinal Caco-2 cells. | 2005 | Toxicol. Lett. | pmid:15890477 |
Simons AL et al. | Human gut microbial degradation of flavonoids: structure-function relationships. | 2005 | J. Agric. Food Chem. | pmid:15884869 |
Carrara M et al. | Mono- or di-fluorinated analogues of flavone-8-acetic acid: synthesis and in vitro biological activity. | 2005 Mar-Apr | Anticancer Res. | pmid:15868960 |
Fernández SP et al. | Synergistic interaction between hesperidin, a natural flavonoid, and diazepam. | 2005 | Eur. J. Pharmacol. | pmid:15840404 |
Sasaki K et al. | Effect of flavones on rat brain and lung matrix metalloproteinase activity measured by film in-situ zymography. | 2005 | J. Pharm. Pharmacol. | pmid:15831206 |
Han Y | Ginkgo terpene component has an anti-inflammatory effect on Candida albicans-caused arthritic inflammation. | 2005 | Int. Immunopharmacol. | pmid:15829420 |
Cai H et al. | Determination of the putative cancer chemopreventive flavone tricin in plasma and tissues of mice by HPLC with UV--visible detection. | 2005 | Biomed. Chromatogr. | pmid:15828058 |
Sawada Y and Ayabe S | Multiple mutagenesis of P450 isoflavonoid synthase reveals a key active-site residue. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15809082 |
Kanho H et al. | Biotransformation of benzaldehyde-type and acetophenone-type derivatives by Pharbitis nil hairy roots. | 2005 | Chem. Pharm. Bull. | pmid:15802832 |
Wenzel U et al. | Melatonin potentiates flavone-induced apoptosis in human colon cancer cells by increasing the level of glycolytic end products. | 2005 | Int. J. Cancer | pmid:15800915 |
Malolanarasimhan K et al. | Synthesis and biological study of a flavone acetic acid analogue containing an azido reporting group designed as a multifunctional binding site probe. | 2005 | Bioorg. Med. Chem. | pmid:15781383 |
Ngadjui BT et al. | Prenylated chalcones, flavone and other constituents of the twigs of Dorstenia angusticornis and Dorstenia barteri var. subtriangularis. | 2005 | Phytochemistry | pmid:15771891 |
Zhang J and Brodbelt JS | Silver complexation and tandem mass spectrometry for differentiation of isomeric flavonoid diglycosides. | 2005 | Anal. Chem. | pmid:15762583 |
Kagawa H et al. | Oxidation and rearrangements of flavanones by mammalian cytochrome P450. | 2004 | Xenobiotica | pmid:15742975 |
Wenzig E et al. | Flavonolignans from Avena sativa. | 2005 | J. Nat. Prod. | pmid:15730266 |
Likhitwitayawuid K et al. | Phenolics with antiviral activity from Millettia erythrocalyx and Artocarpus lakoocha. | 2005 | Nat. Prod. Res. | pmid:15715263 |
Göker H et al. | Synthesis and potent antimicrobial activity of some novel 2-phenyl or methyl-4H-1-benzopyran-4-ones carrying amidinobenzimidazoles. | 2005 | Bioorg. Med. Chem. | pmid:15698788 |
Zhang J et al. | Threshold dissociation and molecular modeling of transition metal complexes of flavonoids. | 2005 | J. Am. Soc. Mass Spectrom. | pmid:15694764 |
Garritano S et al. | Assessment of estrogenic activity of flavonoids from Mediterranean plants using an in vitro short-term test. | 2005 | Phytomedicine | pmid:15693722 |
Lu H et al. | Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin. | 2005 | J. Med. Chem. | pmid:15689157 |
Horvath CR et al. | Identification and quantification of eight flavones in root and shoot tissues of the medicinal plant huang-qin (Scutellaria baicalensis Georgi) using high-performance liquid chromatography with diode array and mass spectrometric detection. | 2005 | J Chromatogr A | pmid:15679157 |
Watanabe J et al. | Coumarin and flavone derivatives from estragon and thyme as inhibitors of chemical mediator release from RBL-2H3 Cells. | 2005 | Biosci. Biotechnol. Biochem. | pmid:15665459 |
Madan V et al. | Requirement of the vesicular system for membrane permeabilization by Sindbis virus. | 2005 | Virology | pmid:15661162 |
Griffin RJ et al. | Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro. | 2005 | J. Med. Chem. | pmid:15658870 |
Furuya H et al. | Some flavonoids and DHEA-S prevent the cis-effect of expanded CTG repeats in a stable PC12 cell transformant. | 2005 | Biochem. Pharmacol. | pmid:15652241 |
Xiao R et al. | Dietary exposure to soy or whey proteins alters colonic global gene expression profiles during rat colon tumorigenesis. | 2005 | Mol. Cancer | pmid:15644144 |
Boyer J et al. | In vitro digestion and lactase treatment influence uptake of quercetin and quercetin glucoside by the Caco-2 cell monolayer. | 2005 | Nutr J | pmid:15644141 |
Singh RP et al. | Acacetin inhibits cell growth and cell cycle progression, and induces apoptosis in human prostate cancer cells: structure-activity relationship with linarin and linarin acetate. | 2005 | Carcinogenesis | pmid:15637089 |