FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kitajima-Ihara T and Yagi T | Rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria: the enzyme expressed in Escherichia coli acts as a member of the respiratory chain in the host cells. | 1998 | FEBS Lett. | pmid:9462835 |
Kuo SM | Transepithelial transport and accumulation of flavone in human intestinal Caco-2 cells. | 1998 | Life Sci. | pmid:9877222 |
Zhai S et al. | Inhibition of methoxyresorufin demethylase activity by flavonoids in human liver microsomes. | 1998 | Life Sci. | pmid:9718089 |
Qian S and Chen L | [Studies on the chemical constituents of Citrus reticulata]. | 1998 | Zhong Yao Cai | pmid:12567525 |
Belinky PA et al. | The antioxidative effects of the isoflavan glabridin on endogenous constituents of LDL during its oxidation. | 1998 | Atherosclerosis | pmid:9568736 |
Bai F et al. | Promoter activation and following induction of the p21/WAF1 gene by flavone is involved in G1 phase arrest in A549 lung adenocarcinoma cells. | 1998 | FEBS Lett. | pmid:9804172 |
Collins BM et al. | The estrogenic and antiestrogenic activities of phytochemicals with the human estrogen receptor expressed in yeast. | 1997 | Steroids | pmid:9090797 |
Hollman PC and Katan MB | Absorption, metabolism and health effects of dietary flavonoids in man. | 1997 | Biomed. Pharmacother. | pmid:9436520 |
Harlow GR and Halpert JR | Alanine-scanning mutagenesis of a putative substrate recognition site in human cytochrome P450 3A4. Role of residues 210 and 211 in flavonoid activation and substrate specificity. | 1997 | J. Biol. Chem. | pmid:9038138 |
Lin L et al. | [A study on the quality of various species of Dalbergia]. | 1997 | Zhong Yao Cai | pmid:12572437 |
Canivenc-Lavier MC et al. | Comparative effects of flavonoids and model inducers on drug-metabolizing enzymes in rat liver. | 1996 | Toxicology | pmid:8931757 |
Chaumontet C et al. | Lack of tumor-promoting effects of flavonoids: studies on rat liver preneoplastic foci and on in vivo and in vitro gap junctional intercellular communication. | 1996 | Nutr Cancer | pmid:8910908 |
Karton Y et al. | Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. | 1996 | J. Med. Chem. | pmid:8691424 |
Critchfield JW et al. | Inhibition of HIV activation in latently infected cells by flavonoid compounds. | 1996 | AIDS Res. Hum. Retroviruses | pmid:8825617 |
Siess MH et al. | Time course of induction of rat hepatic drug-metabolizing enzyme activities following dietary administration of flavonoids. | 1996 | J Toxicol Environ Health | pmid:8968409 |
Ji XD et al. | Interactions of flavonoids and other phytochemicals with adenosine receptors. | 1996 | J. Med. Chem. | pmid:8576921 |
Nijhoff WA et al. | Enhancement of rat hepatic and gastrointestinal glutathione and glutathione S-transferases by alpha-angelicalactone and flavone. | 1995 | Carcinogenesis | pmid:7697820 |
Shin W et al. | Structure-taste correlations in sweet dihydrochalcone, sweet dihydroisocoumarin, and bitter flavone compounds. | 1995 | J. Med. Chem. | pmid:7473560 |
Liu H and Wehmeyer KR | Supercritical fluid extraction as a sample preparation technique for the direct isolation of drugs from plasma prior to analysis. | 1994 | J. Chromatogr. B, Biomed. Appl. | pmid:7952070 |
Ching LM et al. | Induction of tumor necrosis factor-alpha messenger RNA in human and murine cells by the flavone acetic acid analogue 5,6-dimethylxanthenone-4-acetic acid (NSC 640488). | 1994 | Cancer Res. | pmid:8313372 |
Tamura M et al. | Effects of flavonoid compounds on the activity of NADPH diaphorase prepared from the mouse brain. | 1994 | Jpn. J. Pharmacol. | pmid:7990275 |
Monici M et al. | Flavone photoreactivity. UV-induced reactions in organic solvents and micellar systems. | 1993 | J. Photochem. Photobiol. B, Biol. | pmid:8271117 |
Valenti P et al. | Benzo-gamma-pyrone analogues of geiparvarin: synthesis and biological evaluation against B16 melanoma cells. | 1993 | Anticancer Drug Des. | pmid:8251042 |
Barrellier MT | [Lymphedema: is there a treatment?]. | 1992 Jan-Feb | Rev Med Interne | pmid:1410875 |
Liu H and Wehmeyer KR | Solid-phase extraction with supercritical fluid elution as a sample preparation technique for the ultratrace analysis of flavone in blood plasma. | 1992 | J. Chromatogr. | pmid:1400746 |
Le Bon AM et al. | Inhibition of microsome-mediated binding of benzo[a]pyrene to DNA by flavonoids either in vitro or after dietary administration to rats. | 1992 | Chem. Biol. Interact. | pmid:1643669 |
Siess MH et al. | Dietary modification of drug-metabolizing enzyme activities: dose-response effect of flavonoids. | 1992 | J Toxicol Environ Health | pmid:1602520 |
Minagawa N et al. | Possible involvement of superoxide anion in the induction of cyanide-resistant respiration in Hansenula anomala. | 1992 | FEBS Lett. | pmid:1318225 |
Morita K et al. | Stimulatory actions of bioflavonoids on tyrosine uptake into cultured bovine adrenal chromaffin cells. | 1990 | Biochem. Biophys. Res. Commun. | pmid:1977385 |
Ibrahim AR and Abul-Hajj YJ | Microbiological transformation of flavone and isoflavone. | 1990 | Xenobiotica | pmid:2346033 |
Desoize B et al. | Response of primary tumour, spontaneous metastases and recurrence of Lewis lung carcinoma (3LL) to flavone acetic acid (FAA, LM975). | 1989 Nov-Dec | Anticancer Res. | pmid:2627123 |
Lee DW and Park KH | Testosterone metabolism by microsomal cytochrome P-450 in liver of rats treated with some inducers. | 1989 | Int. J. Biochem. | pmid:2502444 |
Ferrari F et al. | Structures of three new flavone derivatives, brosimones G, H, and I, from Brosimopsis oblongifolia. | 1989 | Planta Med. | pmid:17262259 |
Hirano T et al. | Effects of synthetic and naturally occurring flavonoids on Na+,K+-ATPase: aspects of the structure-activity relationship and action mechanism. | 1989 | Life Sci. | pmid:2552245 |
Cummings J and Smyth JF | Flavone 8-acetic acid: our current understanding of its mechanism of action in solid tumours. | 1989 | Cancer Chemother. Pharmacol. | pmid:2667786 |
Kerr DJ and Kaye SB | Flavone acetic acid--preclinical and clinical activity. | 1989 | Eur J Cancer Clin Oncol | pmid:2680512 |
Bonnay M et al. | [Flavone acetic acid and LY 186641 interfere in various ways in Jaffé's reaction]. | 1989 | Bull Cancer | pmid:2620109 |
Tranchand B et al. | [Phase I pharmacokinetics of flavone-acetic acid]. | 1989 | Bull Cancer | pmid:2620114 |
Hill S et al. | Vascular collapse after flavone acetic acid: a possible mechanism of its anti-tumour action. | 1989 | Eur J Cancer Clin Oncol | pmid:2591434 |
Ching LM and Baguley BC | Hyporesponsiveness of macrophages from C3H/HeJ (endotoxin-resistant) mice to the antitumour agent flavone acetic acid (NSC 347512). | 1989 | Eur J Cancer Clin Oncol | pmid:2591444 |
Chabot GG et al. | Pharmacodynamics and causes of dose-dependent pharmacokinetics of flavone-8-acetic acid (LM-975; NSC-347512) in mice. | 1989 | Cancer Chemother. Pharmacol. | pmid:2597279 |
Ching LM and Baguley BC | Reduction of cytotoxic effector cell activity in colon 38 tumours following treatment with flavone acetic acid. | 1989 | Eur J Cancer Clin Oncol | pmid:2597283 |
Baguley BC et al. | Comparison of the effects of flavone acetic acid, fostriecin, homoharringtonine and tumour necrosis factor alpha on colon 38 tumours in mice. | 1989 | Eur J Cancer Clin Oncol | pmid:2702981 |
Lewis CR et al. | Autonomic neuropathy following treatment with flavone acetic acid. | 1989 | Eur J Cancer Clin Oncol | pmid:2703010 |
Nagai T et al. | Inhibition of mouse liver sialidase by plant flavonoids. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2775264 |
Sun JR and Brown JM | Enhancement of the antitumor effect of flavone acetic acid by the bioreductive cytotoxic drug SR 4233 in a murine carcinoma. | 1989 | Cancer Res. | pmid:2790784 |
Cassidy J et al. | Could interspecies differences in the protein binding of flavone acetic acid contribute to the failure to predict lack of efficacy in patients? | 1989 | Cancer Chemother. Pharmacol. | pmid:2713962 |
Ertan R et al. | Synthesis of new annellated flavonoid derivatives possessing spasmolytic activity--VII. | 1989 | Arch. Pharm. (Weinheim) | pmid:2751412 |
Chabot GG et al. | Flavone acetic acid (LM-975; NSC-347512) activation to cytotoxic species in vivo and in vitro. | 1989 | Cancer Chemother. Pharmacol. | pmid:2758556 |
Cummings J et al. | Characterization of the major metabolites of flavone acetic acid and comparison of their disposition in humans and mice. | 1989 | Cancer Res. | pmid:2731178 |
Bibby MC et al. | Influence of site on the chemosensitivity of transplantable murine colon tumours to flavone acetic acid (LM975, NSC 347512). | 1989 | Cancer Chemother. Pharmacol. | pmid:2731316 |
Rabinovitz M | Flavone-8-acetic acid and the natural flavonoids. | 1989 | J. Natl. Cancer Inst. | pmid:2733041 |
Zwi LJ et al. | Blood flow failure as a major determinant in the antitumor action of flavone acetic acid. | 1989 | J. Natl. Cancer Inst. | pmid:2733044 |
Roy D and Liehr JG | Metabolic oxidation of diethylstilbestrol to diethylstilbestrol-4',4"-quinone in Syrian hamsters. | 1989 | Carcinogenesis | pmid:2736717 |
Ching LM and Baguley BC | Effect of flavone acetic acid (NSC 347,512) on splenic cytotoxic effector cells and their role in tumour necrosis. | 1989 | Eur J Cancer Clin Oncol | pmid:2737219 |
Atwell GJ et al. | Synthesis and anti-tumour activity of topologically-related analogues of flavoneacetic acid. | 1989 | Anticancer Drug Des. | pmid:2803464 |
Kerr DJ et al. | Phase II trials of flavone acetic acid in advanced malignant melanoma and colorectal carcinoma. | 1989 | Br. J. Cancer | pmid:2803908 |
Murray JC et al. | Flavone acetic acid induces a coagulopathy in mice. | 1989 | Br. J. Cancer | pmid:2803949 |
Relling MV et al. | Anticancer drugs as inhibitors of two polymorphic cytochrome P450 enzymes, debrisoquin and mephenytoin hydroxylase, in human liver microsomes. | 1989 | Cancer Res. | pmid:2908853 |
Wu ES et al. | Flavones. 2. Synthesis and structure-activity relationship of flavodilol and its analogues, a novel class of antihypertensive agents with catecholamine depleting properties. | 1989 | J. Med. Chem. | pmid:2909730 |
Bibby MC et al. | Reduction of tumor blood flow by flavone acetic acid: a possible component of therapy. | 1989 | J. Natl. Cancer Inst. | pmid:2911084 |
Lonchampt M et al. | Protective effect of a purified flavonoid fraction against reactive oxygen radicals. In vivo and in vitro study. | 1989 | Arzneimittelforschung | pmid:2818676 |
Bourdillat B et al. | Mechanism of action of hispidulin, a natural flavone, on human platelets. | 1988 | Prog. Clin. Biol. Res. | pmid:2845433 |
Urba WJ et al. | Enhancement of natural killer activity in human peripheral blood by flavone acetic acid. | 1988 | J. Natl. Cancer Inst. | pmid:2452890 |
Weiss GR et al. | New anticancer agents. | 1988 | Cancer Chemother Biol Response Modif | pmid:2484323 |
Hornung RL et al. | Augmentation of natural killer activity, induction of IFN and development tumor immunity during the successful treatment of established murine renal cancer using flavone acetic acid and IL-2. | 1988 | J. Immunol. | pmid:2460546 |
Verweij J et al. | Rapid alkalinisation for flavone acetic acid administration: a potentially hazardous procedure. | 1988 | Lancet | pmid:2893206 |
Davis HP et al. | Immune thrombocytopenia caused by flavone-8-acetic acid. | 1988 | Lancet | pmid:2893207 |
Yamazoe Y et al. | Metabolic activation of a protein pyrolysate promutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by rat liver microsomes and purified cytochrome P-450. | 1988 | Carcinogenesis | pmid:3121205 |
Yamazoe Y et al. | Metabolic activation of pyrolysate arylamines by human liver microsomes; possible involvement of a P-488-H type cytochrome P-450. | 1988 | Jpn. J. Cancer Res. | pmid:3147272 |
Armand J et al. | Flavonoids: a new class of anticancer agents? Preclinical and clinical data of flavone acetic acid. | 1988 | Prog. Clin. Biol. Res. | pmid:3051027 |
Pratesi G et al. | Response of chemically induced primary colon tumours of the mouse to flavone acetic acid (NSC 347 512). | 1988 | Br. J. Cancer | pmid:3166904 |
Weiss RB et al. | Phase I and clinical pharmacology study of intravenous flavone acetic acid (NSC 347512). | 1988 | Cancer Res. | pmid:3167843 |
Bibby MC et al. | Experimental anti-tumor effects of flavone acetic acid (LM975). | 1988 | Prog. Clin. Biol. Res. | pmid:3174695 |
Bibby MC et al. | Unique chemosensitivity of MAC 16 tumours to flavone acetic acid (LM975, NSC 347512). | 1988 | Br. J. Cancer | pmid:3179187 |
Ching LM and Baguley BC | Enhancement of in vitro cytotoxicity of mouse peritoneal exudate cells by flavone acetic acid (NSC 347512). | 1988 | Eur J Cancer Clin Oncol | pmid:3181272 |
Damia G et al. | Dose-dependent pharmacokinetics of flavone acetic acid in mice. | 1988 | Cancer Chemother. Pharmacol. | pmid:3396145 |
Evelhoch JL et al. | Flavone acetic acid (NSC 347512)-induced modulation of murine tumor physiology monitored by in vivo nuclear magnetic resonance spectroscopy. | 1988 | Cancer Res. | pmid:3409216 |
Gouyette A et al. | Flavone acetic acid: a nonlinear pharmacokinetic model. | 1988 | Cancer Chemother. Pharmacol. | pmid:3409441 |
Abdalla S et al. | Effects of hispidulin, a flavone isolated from Inula viscosa, on isolated guinea-pig smooth muscle. | 1988 | Gen. Pharmacol. | pmid:3410278 |
Hornung RL et al. | Immunomodulation of natural killer cell activity by flavone acetic acid: occurrence via induction of interferon alpha/beta. | 1988 | J. Natl. Cancer Inst. | pmid:3418728 |
Oberpichler H et al. | Effects of Ginkgo biloba constituents related to protection against brain damage caused by hypoxia. | 1988 | Pharmacol Res Commun | pmid:3420139 |
Bissery MC et al. | Flavone acetic acid (NSC 347512)-induced DNA damage in Glasgow osteogenic sarcoma in vivo. | 1988 | Cancer Res. | pmid:3422592 |
Finlay GJ et al. | Effect of flavone acetic acid on Lewis lung carcinoma: evidence for an indirect effect. | 1988 | J. Natl. Cancer Inst. | pmid:3351960 |
Giavazzi R et al. | Response to flavone acetic acid (NSC 347512) of primary and metastatic human colorectal carcinoma xenografts. | 1988 | Br. J. Cancer | pmid:3355765 |
Gachályi A et al. | Mobilization of 85Sr by flavone derivatives (morin and ipriflavone) in normal and pregnant rats. | 1988 | Radiobiol Radiother (Berl) | pmid:3186955 |
Chen JC et al. | [Anti-arrhythmic action of 4'-methyl-7-([2-hydroxy-3-(beta-propinamidoethyl)amino]propoxy) flavone hydrochloride (SIPI-644)]. | 1988 | Zhongguo Yao Li Xue Bao | pmid:3188948 |
Fisher RF et al. | Specific binding of proteins from Rhizobium meliloti cell-free extracts containing NodD to DNA sequences upstream of inducible nodulation genes. | 1988 | Genes Dev. | pmid:3288541 |
Hayashi T et al. | A cytotoxic flavone from Scoparia dulcis L. | 1988 | Chem. Pharm. Bull. | pmid:3246045 |
Abbiati GA et al. | Receptor binding studies of the flavone, REC 15/2053, and other bladder spasmolytics. | 1988 | Pharm. Res. | pmid:3247311 |
Wiltrout RH et al. | Flavone-8-acetic acid augments systemic natural killer cell activity and synergizes with IL-2 for treatment of murine renal cancer. | 1988 | J. Immunol. | pmid:3258894 |
Rabinovitz M | The structure of flavone-8-acetic acid, a chemotherapeutic agent, and its application to drug design. | 1988 | J. Enzym. Inhib. | pmid:3236069 |
Robbins RC | Flavones in citrus exhibit antiadhesive action on platelets. | 1988 | Int J Vitam Nutr Res | pmid:3243696 |
Armitage JP et al. | Comparison of the chemotactic behaviour of Rhizobium leguminosarum with and without the nodulation plasmid. | 1988 | Mol. Microbiol. | pmid:3210967 |
Gao F et al. | Sesquiterpene lactones and flavonoids from Helianthus species. | 1987 Jan-Feb | J. Nat. Prod. | pmid:3598595 |
Rubin J et al. | Flavone-8-acetic acid inhibits ristocetin-induced platelet agglutination and prolongs bleeding time. | 1987 | Lancet | pmid:2889983 |
Dodion P et al. | Sensitivity of normal human bone marrow myeloid progenitor cells to anthracycline, cisplatin, anthracene and flavone acetic acid derivatives, and its relevance for the prediction of human plasma concentrations of anticancer drugs. | 1987 | Eur J Cancer Clin Oncol | pmid:3436354 |
Ching LM and Baguley BC | Induction of natural killer cell activity by the antitumour compound flavone acetic acid (NSC 347 512). | 1987 | Eur J Cancer Clin Oncol | pmid:3665989 |
Abdalla SS and Abu Zarga MH | Effects of cirsimaritin, a flavone isolated from Artemisia judaica, on isolated guinea-pig ileum. | 1987 | Planta Med. | pmid:3671552 |
Kerr DJ et al. | Phase I and pharmacokinetic study of flavone acetic acid. | 1987 | Cancer Res. | pmid:3677106 |