FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kuffel MJ et al. | Activation of the antitumor agent aminoflavone (NSC 686288) is mediated by induction of tumor cell cytochrome P450 1A1/1A2. | 2002 | Mol. Pharmacol. | pmid:12065765 |
Rawel HM et al. | Interactions of different phenolic acids and flavonoids with soy proteins. | 2002 | Int. J. Biol. Macromol. | pmid:12063116 |
Lin YM et al. | Chalcones and flavonoids as anti-tuberculosis agents. | 2002 | Bioorg. Med. Chem. | pmid:12057669 |
Hadjokas NE et al. | Arginine to lysine 108 substitution in recombinant CYP1A2 abolishes methoxyresorufin metabolism in lymphoblastoid cells. | 2002 | Br. J. Pharmacol. | pmid:12023936 |
Matsui T et al. | Luteolin, a flavone, does not suppress postprandial glucose absorption through an inhibition of alpha-glucosidase action. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12005074 |
Kragh M et al. | Acute effects of vascular modifying agents in solid tumors assessed by noninvasive laser Doppler flowmetry and near infrared spectroscopy. | 2002 May-Jun | Neoplasia | pmid:11988846 |
Isobe T et al. | [Antibacterial constituents against Helicobacter pylori of Brazilian medicinal plant, Pariparoba]. | 2002 | Yakugaku Zasshi | pmid:11968842 |
Rajendran NN et al. | Modulation by insulin rather than blood glucose of the pain threshold in acute physiological and flavone induced antinociception in mice. | 2001 | Indian J. Exp. Biol. | pmid:11883508 |
Cai H et al. | A straightforward means of coupling preparative high-performance liquid chromatography and mass spectrometry. | 2002 | Rapid Commun. Mass Spectrom. | pmid:11870892 |
Fang J and Beattie DS | Novel FMN-containing rotenone-insensitive NADH dehydrogenase from Trypanosoma brucei mitochondria: isolation and characterization. | 2002 | Biochemistry | pmid:11863445 |
Frangne N et al. | Flavone glucoside uptake into barley mesophyll and Arabidopsis cell culture vacuoles. Energization occurs by H(+)-antiport and ATP-binding cassette-type mechanisms. | 2002 | Plant Physiol. | pmid:11842175 |
Kulevanova S et al. | HPLC identification and determination of flavone aglycones in Helichrysum plicatum DC. (Asteraceae). | 2000 | Pharmazie | pmid:11828624 |
Tunçbilek M et al. | Synthesis and antioxidant properties of some new flavone derivatives on lipid peroxidation in the rat liver. | 2000 | Pharmazie | pmid:11828615 |
Cook SA and Shiemke AK | Evidence that a type-2 NADH:quinone oxidoreductase mediates electron transfer to particulate methane monooxygenase in methylococcus capsulatus. | 2002 | Arch. Biochem. Biophys. | pmid:11811946 |
Chung MI et al. | Synthesis, antiplatelet and vasorelaxing effects of monooxygenated flavones and flavonoxypropanolamines. | 2001 | J. Pharm. Pharmacol. | pmid:11804390 |
Otake Y and Walle T | Oxidation of the flavonoids galangin and kaempferide by human liver microsomes and CYP1A1, CYP1A2, and CYP2C9. | 2002 | Drug Metab. Dispos. | pmid:11792676 |
Duportail G et al. | Neutral fluorescence probe with strong ratiometric response to surface charge of phospholipid membranes. | 2001 | FEBS Lett. | pmid:11718715 |
Kestell P et al. | Measurement of plasma 5-hydroxyindoleacetic acid as a possible clinical surrogate marker for the action of antivascular agents. | 2001 | Clin. Chim. Acta | pmid:11718691 |
Lee SE et al. | Inhibitory effects of naturally occurring compounds on aflatoxin B(1) biotransformation. | 2001 | J. Agric. Food Chem. | pmid:11714299 |
Hirvonen T et al. | Flavonol and flavone intake and the risk of cancer in male smokers (Finland). | 2001 | Cancer Causes Control | pmid:11714106 |
Andrade-Cetto A and Wiedenfeld H | Hypoglycemic effect of Cecropia obtusifolia on streptozotocin diabetic rats. | 2001 | J Ethnopharmacol | pmid:11694359 |
Saarinen N et al. | No evidence for the in vivo activity of aromatase-inhibiting flavonoids. | 2001 | J. Steroid Biochem. Mol. Biol. | pmid:11595503 |
Philpott M et al. | The antitumour agent 5,6-dimethylxanthenone-4-acetic acid acts in vitro on human mononuclear cells as a co-stimulator with other inducers of tumour necrosis factor. | 2001 | Eur. J. Cancer | pmid:11576850 |
Seo HJ and Surh YJ | Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human promyelocytic leukemia cells. | 2001 | Mutat. Res. | pmid:11551495 |
Mcmullen MD et al. | The biological basis of epistasis between quantitative trait loci for flavone and 3-deoxyanthocyanin synthesis in maize (Zea mays L.). | 2001 | Genome | pmid:11550903 |
Collins-Burow BM et al. | Estrogenic and antiestrogenic activities of flavonoid phytochemicals through estrogen receptor binding-dependent and -independent mechanisms. | 2000 | Nutr Cancer | pmid:11525602 |
Kumazawa T et al. | Synthesis of 8-C-glucosylflavones. | 2001 | Carbohydr. Res. | pmid:11513825 |
Park BK et al. | Inhibition of TPA-induced cyclooxygenase-2 expression and skin inflammation in mice by wogonin, a plant flavone from Scutellaria radix. | 2001 | Eur. J. Pharmacol. | pmid:11502282 |
Pepper C et al. | Flavopiridol circumvents Bcl-2 family mediated inhibition of apoptosis and drug resistance in B-cell chronic lymphocytic leukaemia. | 2001 | Br. J. Haematol. | pmid:11472347 |
Stochmal A et al. | Acylated apigenin glycosides from alfalfa (Medicago sativa L.) var. Artal. | 2001 | Phytochemistry | pmid:11454348 |
MarÃn FR and Del RÃo JA | Selection of hybrids and edible citrus species with a high content in the diosmin functional compound. Modulating effect of plant growth regulators on contents. | 2001 | J. Agric. Food Chem. | pmid:11453775 |
Kim SJ | Effect of biflavones of Ginkgo biloba against UVB-induced cytotoxicity in vitro. | 2001 | J. Dermatol. | pmid:11449670 |
Tabak C et al. | Chronic obstructive pulmonary disease and intake of catechins, flavonols, and flavones: the MORGEN Study. | 2001 | Am. J. Respir. Crit. Care Med. | pmid:11435239 |
Krakauer T et al. | The flavonoid baicalin inhibits superantigen-induced inflammatory cytokines and chemokines. | 2001 | FEBS Lett. | pmid:11434925 |
Schrag ML and Wienkers LC | Covalent alteration of the CYP3A4 active site: evidence for multiple substrate binding domains. | 2001 | Arch. Biochem. Biophys. | pmid:11414684 |
Fabre N et al. | Determination of flavone, flavonol, and flavanone aglycones by negative ion liquid chromatography electrospray ion trap mass spectrometry. | 2001 | J. Am. Soc. Mass Spectrom. | pmid:11401161 |
D'arc Felicio J et al. | Biflavonoids from Ouratea multiflora. | 2001 | Fitoterapia | pmid:11395278 |
Huang X et al. | 3D-QSAR model of flavonoids binding at benzodiazepine site in GABAA receptors. | 2001 | J. Med. Chem. | pmid:11384234 |
Lim SS et al. | Synthesis of flavonoids and their effects on aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues. | 2001 | J. Pharm. Pharmacol. | pmid:11370705 |
Velázquez I and Pardo JP | Kinetic characterization of the rotenone-insensitive internal NADH: ubiquinone oxidoreductase of mitochondria from Saccharomyces cerevisiae. | 2001 | Arch. Biochem. Biophys. | pmid:11370674 |
Chi YS et al. | Effect of wogonin, a plant flavone from Scutellaria radix, on the suppression of cyclooxygenase-2 and the induction of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells. | 2001 | Biochem. Pharmacol. | pmid:11322923 |
Tanaka S et al. | Influence of natural and synthetic compounds on cell surface expression of cell adhesion molecules, ICAM-1 and VCAM-1. | 2001 | Planta Med. | pmid:11301853 |
Kanwar JR et al. | Vascular attack by 5,6-dimethylxanthenone-4-acetic acid combined with B7.1 (CD80)-mediated immunotherapy overcomes immune resistance and leads to the eradication of large tumors and multiple tumor foci. | 2001 | Cancer Res. | pmid:11280751 |
Galietta LJ et al. | Novel CFTR chloride channel activators identified by screening of combinatorial libraries based on flavone and benzoquinolizinium lead compounds. | 2001 | J. Biol. Chem. | pmid:11262417 |
Recanatini M et al. | A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase. | 2001 | J. Med. Chem. | pmid:11262078 |
Fang H et al. | Structure-activity relationships for a large diverse set of natural, synthetic, and environmental estrogens. | 2001 | Chem. Res. Toxicol. | pmid:11258977 |
Marder M et al. | Molecular modeling and QSAR analysis of the interaction of flavone derivatives with the benzodiazepine binding site of the GABA(A) receptor complex. | 2001 | Bioorg. Med. Chem. | pmid:11249125 |
Summanen J et al. | Effects of simple aromatic compounds and flavonoids on Ca2+ fluxes in rat pituitary GH(4)C(1) cells. | 2001 | Eur. J. Pharmacol. | pmid:11239912 |
Klein M et al. | The ABC-like vacuolar transporter for rye mesophyll flavone glucuronides is not species-specific. | 2001 | Phytochemistry | pmid:11219807 |
Rajendran NN et al. | Antinociceptive pattern of flavone and its mechanism as tested by formalin assay. | 2000 | Indian J. Exp. Biol. | pmid:11218837 |
Siess MH et al. | Mechanisms involved in the chemoprevention of flavonoids. | 2000 | Biofactors | pmid:11216486 |
Akao T et al. | Baicalin, the predominant flavone glucuronide of scutellariae radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form. | 2000 | J. Pharm. Pharmacol. | pmid:11197087 |
Quéval P and Beaumatin J | [Study of the inductor effect of 5,6-benzoflavone on the activity of pulmonary benzopyrene monoxidase. Comparison with other chemical or physical agents]. | 1979 | C. R. Acad. Sci., D, Sci. Nat. | pmid:111845 |
Manthey JA et al. | Biological properties of citrus flavonoids pertaining to cancer and inflammation. | 2001 | Curr. Med. Chem. | pmid:11172671 |
Rossi M et al. | Molecular structure and activity toward DNA of baicalein, a flavone constituent of the Asian herbal medicine "Sho-saiko-to". | 2001 | J. Nat. Prod. | pmid:11170661 |
Guz NR et al. | Flavonolignan and flavone inhibitors of a Staphylococcus aureus multidrug resistance pump: structure-activity relationships. | 2001 | J. Med. Chem. | pmid:11170636 |
Dertinger SD et al. | Aryl hydrocarbon receptor signaling plays a significant role in mediating benzo[a]pyrene- and cigarette smoke condensate-induced cytogenetic damage in vivo. | 2001 | Carcinogenesis | pmid:11159756 |
Goto S and Handa S | Antithrombotic effects of flavonoid. | 2001 | Circulation | pmid:11157735 |
Lebeau J et al. | Beneficial effects of different flavonoids, on functional recovery after ischemia and reperfusion in isolated rat heart. | 2001 | Bioorg. Med. Chem. Lett. | pmid:11140725 |
Hirvonen T et al. | Intake of flavonols and flavones and risk of coronary heart disease in male smokers. | 2001 | Epidemiology | pmid:11138821 |
Tomazela DM et al. | Pyrano chalcones and a flavone from Neoraputia magnifica and their Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase-inhibitory activities. | 2000 | Phytochemistry | pmid:11130676 |
da Silva EL et al. | Inhibitory effect of flavonoids on low-density lipoprotein peroxidation catalyzed by mammalian 15-lipoxygenase. | 2000 | IUBMB Life | pmid:10995031 |
Kubo I et al. | Flavonols from Heterotheca inuloides: tyrosinase inhibitory activity and structural criteria. | 2000 | Bioorg. Med. Chem. | pmid:10976523 |
Valenti P et al. | Synthesis and biological activity of some rigid analogues of flavone-8-acetic acid. | 2000 | Bioorg. Med. Chem. | pmid:10968283 |
BozdaÄŸ O et al. | Synthesis and hypoglycemic activity of some new flavone derivatives. 3rd communication: 3'-flavonyl-2,4-thiazolidinediones. | 2000 | Arzneimittelforschung | pmid:10965419 |
El-Subbagh HI et al. | Synthesis and biological evaluation of certain alpha,beta-unsaturated ketones and their corresponding fused pyridines as antiviral and cytotoxic agents. | 2000 | J. Med. Chem. | pmid:10956199 |
Shao ZM et al. | Genistein's "ER-dependent and independent" actions are mediated through ER pathways in ER-positive breast carcinoma cell lines. | 2000 Jul-Aug | Anticancer Res. | pmid:10953303 |
Harris SR et al. | Oxidative stress contributes to the anti-proliferative effects of flavone acetic acid on endothelial cells. | 2000 Jul-Aug | Anticancer Res. | pmid:10953282 |
Nielsen SE et al. | Biotransformation of the citrus flavone tangeretin in rats. Identification of metabolites with intact flavane nucleus. | 2000 | Food Chem. Toxicol. | pmid:10930694 |
Wenzel U et al. | Dietary flavone is a potent apoptosis inducer in human colon carcinoma cells. | 2000 | Cancer Res. | pmid:10919656 |
BozdaÄŸ O et al. | Synthesis and hypoglycemic activity of some new flavone derivatives. 2nd communication: 4'-flavonyl-2,4-thiazolidinediones. | 2000 | Arzneimittelforschung | pmid:10918947 |
Aitken RA et al. | Synthesis and antitumour activity of new derivatives of flavone-8-acetic acid (FAA). Part 4: Variation of the basic structure. | 2000 | Arch. Pharm. (Weinheim) | pmid:10909190 |
La Casa C et al. | Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions. | 2000 | J Ethnopharmacol | pmid:10904145 |
Viola H et al. | 6,3'-dibromoflavone and 6-nitro-3'-bromoflavone: new additions to the 6,3'-disubstituted flavone family of high-affinity ligands of the brain benzodiazepine binding site with agonistic properties. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10873666 |
Dertinger SD et al. | Effect of 3'-methoxy-4'-nitroflavone on benzo[a]pyrene toxicity. Aryl hydrocarbon receptor-dependent and -independent mechanisms. | 2000 | Biochem. Pharmacol. | pmid:10825463 |
Schwinger RH et al. | Crataegus special extract WS 1442 increases force of contraction in human myocardium cAMP-independently. | 2000 | J. Cardiovasc. Pharmacol. | pmid:10813370 |
Maulik SK et al. | Effect of flavone in a canine model of myocardial stunning. | 1999 | Indian J. Exp. Biol. | pmid:10783754 |
Perez RM et al. | Isolation and hypoglycemic activity of 5, 7,3'-trihydroxy-3,6,4'-trimethoxyflavone from Brickellia veronicaefolia. | 2000 | Phytomedicine | pmid:10782487 |
Liu IX et al. | Baicalin synergy with beta-lactam antibiotics against methicillin-resistant Staphylococcus aureus and other beta-lactam-resistant strains of S. aureus. | 2000 | J. Pharm. Pharmacol. | pmid:10757427 |
Sue M et al. | Purification and characterization of a hydroxamic acid glucoside beta-glucosidase from wheat (Triticum aestivum L.) seedlings. | 2000 | Planta | pmid:10750901 |
Motwani M et al. | Flavopiridol, a cyclin-dependent kinase inhibitor, prevents spindle inhibitor-induced endoreduplication in human cancer cells. | 2000 | Clin. Cancer Res. | pmid:10741717 |
Wollenweber E et al. | Epicuticular flavonoids of some Scrophulariaceae. | 2000 Jan-Feb | Z. Naturforsch., C, J. Biosci. | pmid:10739092 |
Arriaga AM et al. | Constituents of Bowdichia virgilioides. | 2000 | Fitoterapia | pmid:10727826 |
Ma YL et al. | Internal glucose residue loss in protonated O-diglycosyl flavonoids upon low-energy collision-induced dissociation. | 2000 | J. Am. Soc. Mass Spectrom. | pmid:10689666 |
Viola H et al. | 6-Chloro-3'-nitroflavone is a potent ligand for the benzodiazepine binding site of the GABA(A) receptor devoid of intrinsic activity. | 2000 | Pharmacol. Biochem. Behav. | pmid:10672984 |
Ramelet AA | Pharmacologic aspects of a phlebotropic drug in CVI-associated edema. | 2000 | Angiology | pmid:10667639 |
Li Y et al. | Induction of apoptosis and inhibition of c-erbB-2 in breast cancer cells by flavopiridol. | 2000 | Clin. Cancer Res. | pmid:10656453 |
Mruk JS et al. | Flavone-8-acetic acid (Flavonoid) profoundly reduces platelet-dependent thrombosis and vasoconstriction after deep arterial injury In vivo. | 2000 | Circulation | pmid:10645930 |
Houghten RA et al. | Mixture-based synthetic combinatorial libraries. | 1999 | J. Med. Chem. | pmid:10508425 |
Reiners JJ et al. | Suppression of cell cycle progression by flavonoids: dependence on the aryl hydrocarbon receptor. | 1999 | Carcinogenesis | pmid:10426807 |
Carvalho JC et al. | Anti-inflammatory activity of flavone and some of its derivates from Virola michelli Heckel. | 1999 | J Ethnopharmacol | pmid:10197753 |
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