FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Hunyadi A et al. | Direct semi-synthesis of the anticancer lead-drug protoapigenone from apigenin, and synthesis of further new cytotoxic protoflavone derivatives. | 2011 | PLoS ONE | pmid:21912610 |
Vitcheva V et al. | Hepatoprotective effects of saponarin, isolated from Gypsophila trichotoma Wend. on cocaine-induced oxidative stress in rats. | 2011 | Redox Rep. | pmid:21722413 |
Wang Y et al. | Screening Antitumor Compounds Psoralen and Isopsoralen from Psoralea corylifolia L. Seeds. | 2011 | Evid Based Complement Alternat Med | pmid:19131395 |
Liu LZ et al. | Acacetin inhibits VEGF expression, tumor angiogenesis and growth through AKT/HIF-1α pathway. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21893035 |
Singh S et al. | 2-(4-Chloro-phen-yl)chromen-4-one. | 2011 | Acta Crystallogr Sect E Struct Rep Online | pmid:22199687 |
Zandi K et al. | Antiviral activity of four types of bioflavonoid against dengue virus type-2. | 2011 | Virol. J. | pmid:22201648 |
Kothandan G et al. | Docking and 3D-QSAR (quantitative structure activity relationship) studies of flavones, the potent inhibitors of p-glycoprotein targeting the nucleotide binding domain. | 2011 | Eur J Med Chem | pmid:21723648 |
Vila-Real H et al. | Enzymatic Synthesis of the Flavone Glucosides, Prunin and Isoquercetin, and the Aglycones, Naringenin and Quercetin, with Selective α-L-Rhamnosidase and β-D-Glucosidase Activities of Naringinase. | 2011 | Enzyme Res | pmid:21941631 |
Bhavsar AS et al. | A review on recent advances in dry eye: Pathogenesis and management. | 2011 | Oman J Ophthalmol | pmid:21897618 |
Manna P et al. | Phytomedicinal Role of Pithecellobium dulce against CCl(4)-mediated Hepatic Oxidative Impairments and Necrotic Cell Death. | 2011 | Evid Based Complement Alternat Med | pmid:21869899 |
Lee KN et al. | Prevention of NSAID-associated gastroduodenal injury in healthy volunteers-a randomized, double-blind, multicenter study comparing DA-9601 with misoprostol. | 2011 | J. Korean Med. Sci. | pmid:21860559 |
Tahanian E et al. | Flavonoids targeting of IκB phosphorylation abrogates carcinogen-induced MMP-9 and COX-2 expression in human brain endothelial cells. | 2011 | Drug Des Devel Ther | pmid:21625419 |
Guo AJ et al. | Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/beta-catenin signaling pathway. | 2011 | J. Biol. Chem. | pmid:21652696 |
Nerurkar PV et al. | Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation. | 2011 | J Neuroinflammation | pmid:21639917 |
Ono M and Saji H | SPECT Imaging Agents for Detecting Cerebral β-Amyloid Plaques. | 2011 | Int J Mol Imaging | pmid:21603239 |
Seo S et al. | Cyanide, a coproduct of plant hormone ethylene biosynthesis, contributes to the resistance of rice to blast fungus. | 2011 | Plant Physiol. | pmid:21075959 |
Wootten D et al. | Modulation of the glucagon-like peptide-1 receptor signaling by naturally occurring and synthetic flavonoids. | 2011 | J. Pharmacol. Exp. Ther. | pmid:21075839 |
Lewin G et al. | Synthesis of antiproliferative flavones from calycopterin, major flavonoid of Calycopteris floribunda Lamk. | 2011 | Bioorg. Med. Chem. | pmid:21146994 |
Flemmig J et al. | Olea europaea leaf (Ph.Eur.) extract as well as several of its isolated phenolics inhibit the gout-related enzyme xanthine oxidase. | 2011 | Phytomedicine | pmid:21144719 |
Vitalini S et al. | Primula spectabilis Tratt. aerial parts: morphology, volatile compounds and flavonoids. | 2011 | Phytochemistry | pmid:21612805 |
Yin Y et al. | Jaceosidin inhibits contact hypersensitivity in mice via down-regulating IFN-γ/STAT1/T-bet signaling in T cells. | 2011 | Eur. J. Pharmacol. | pmid:21093428 |
Enomoto R et al. | Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects. | 2011 | Cancer Chemother. Pharmacol. | pmid:20658136 |
Varma A et al. | Andrographolide: a new plant-derived antineoplastic entity on horizon. | 2011 | Evid Based Complement Alternat Med | pmid:19752167 |
Xue L et al. | Pd-carbene catalyzed carbonylation reactions of aryl iodides. | 2011 | Dalton Trans | pmid:21677940 |
Schumacher M et al. | Potential role of P-gp for flavone-induced diminished apoptosis and increased adenoma size in the small intestine of APC(min/+) mice. | 2011 | Cancer Invest. | pmid:21649465 |
Said SA | Two new special flavones from Uvaria accuminata. | 2011 | Nat. Prod. Res. | pmid:21644179 |
Seo J et al. | Flavonoids biotransformation by bacterial non-heme dioxygenases, biphenyl and naphthalene dioxygenase. | 2011 | Appl. Microbiol. Biotechnol. | pmid:21626021 |
Chou ST et al. | Zanthoxylum ailanthoides Sieb and Zucc. extract inhibits growth and induces cell death through G2/M-phase arrest and activation of apoptotic signals in colo 205 human colon adenocarcinoma cells. | 2011 | Anticancer Res. | pmid:21617225 |
Boyle SP et al. | Evaluation of quality control strategies in Scutellaria herbal medicines. | 2011 | J Pharm Biomed Anal | pmid:21163602 |
Cai WJ et al. | Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. | 2011 | PLoS ONE | pmid:22216122 |
Mafuvadze B et al. | Apigenin blocks induction of vascular endothelial growth factor mRNA and protein in progestin-treated human breast cancer cells. | 2010 Sep-Oct | Menopause | pmid:20551847 |
Marczak Å et al. | Fragmentation pathways of acylated flavonoid diglucuronides from leaves of Medicago truncatula. | 2010 May-Jun | Phytochem Anal | pmid:19950391 |
Acharya A et al. | Redox regulation in cancer: a double-edged sword with therapeutic potential. | 2010 Jan-Feb | Oxid Med Cell Longev | pmid:20716925 |
Carneiro CD et al. | Effect of flavonoids on 2'-deoxyguanosine and DNA oxidation caused by singlet molecular oxygen. | 2010 Aug-Sep | Food Chem. Toxicol. | pmid:20561949 |
Julião Lde S et al. | Flavones and phenylpropanoids from a sedative extract of Lantana trifolia L. | 2010 | Phytochemistry | pmid:19922967 |
Rayyan S et al. | Flavone C-glycosides from seeds of fenugreek, Trigonella foenum-graecum L. | 2010 | J. Agric. Food Chem. | pmid:20486688 |
Cabrera M et al. | Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. | 2010 | Bioorg. Med. Chem. | pmid:20639112 |
Zhao C et al. | [Study on extraction of anti-diabetes active constituents from Potentilla chinesis]. | 2010 | Zhong Yao Cai | pmid:20575426 |
Gülcemal D et al. | Phenolic Glycosides with antiproteasomal activity from Centaurea urvillei DC. subsp. urvillei. | 2010 | Carbohydr. Res. | pmid:20937505 |
Winkelmann I et al. | Flavone induces changes in intermediary metabolism that prevent microadenoma formation in colonic tissue of carcinogen-treated mice. | 2010 | Mol Nutr Food Res | pmid:20564477 |
Basile A et al. | Antibacterial and antifungal properties of acetonic extract of Feijoa sellowiana fruits and its effect on Helicobacter pylori growth. | 2010 | J Med Food | pmid:20136454 |
Seo J et al. | Location of flavone B-ring controls regioselectivity and stereoselectivity of naphthalene dioxygenase from Pseudomonas sp. strain NCIB 9816-4. | 2010 | Appl. Microbiol. Biotechnol. | pmid:20091026 |
D'Archivio M et al. | Bioavailability of the polyphenols: status and controversies. | 2010 | Int J Mol Sci | pmid:20480022 |
Wang SQ et al. | Flavonoids from Dracocephalum tanguticum and their cardioprotective effects against doxorubicin-induced toxicity in H9c2 cells. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20932762 |
Kuete V and Efferth T | Cameroonian medicinal plants: pharmacology and derived natural products. | 2010 | Front Pharmacol | pmid:21833168 |
Chatuphonprasert W et al. | Potent modification of inducible CYP1A1 expression by flavonoids. | 2010 | Biol. Pharm. Bull. | pmid:20930378 |
Kundu S and Roy D | Structural study of biologically significant ligands with major birch pollen allergen Betv1 by docking and molecular dynamics simulation. | 2010 | Bioinformation | pmid:20978606 |
Jayaraman P et al. | Activity and interactions of antibiotic and phytochemical combinations against Pseudomonas aeruginosa in vitro. | 2010 | Int. J. Biol. Sci. | pmid:20941374 |
Mukai R et al. | Suppression mechanisms of flavonoids on aryl hydrocarbon receptor-mediated signal transduction. | 2010 | Arch. Biochem. Biophys. | pmid:20450880 |
Meng X et al. | Effects of Various Flavonoids on the α-Synuclein Fibrillation Process. | 2010 | Parkinsons Dis | pmid:20976092 |
Jeng YJ et al. | Subchronic exposure to phytoestrogens alone and in combination with diethylstilbestrol - pituitary tumor induction in Fischer 344 rats. | 2010 | Nutr Metab (Lond) | pmid:20459739 |
Ci X et al. | Regulation of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 cells by 2''-hydroxy-3''-en-anhydroicaritin involves down-regulation of NF-kappaB and MAPK expression. | 2010 | Int. Immunopharmacol. | pmid:20462523 |
Madeira PJ et al. | Electrospray ionization Fourier transform ion cyclotron resonance mass spectrometric and semi-empirical calculations study of five isoflavone aglycones. | 2010 | Rapid Commun. Mass Spectrom. | pmid:21072799 |
Qian LB et al. | Luteolin reduces high glucose-mediated impairment of endothelium-dependent relaxation in rat aorta by reducing oxidative stress. | 2010 | Pharmacol. Res. | pmid:19892019 |
Sasaki K et al. | Functional divergence within class B MADS-box genes TfGLO and TfDEF in Torenia fournieri Lind. | 2010 | Mol. Genet. Genomics | pmid:20872230 |
Zhang Y et al. | Dietary flavonol and flavone intakes and their major food sources in Chinese adults. | 2010 | Nutr Cancer | pmid:21058200 |
Kumar GS et al. | Synthesis and biological evaluation of novel benzyl-substituted flavones as free radical (DPPH) scavengers and α-glucosidase inhibitors. | 2010 | J Asian Nat Prod Res | pmid:21061220 |
de Pascual-Teresa S et al. | Flavanols and anthocyanins in cardiovascular health: a review of current evidence. | 2010 | Int J Mol Sci | pmid:20480037 |
Treutter D | Managing phenol contents in crop plants by phytochemical farming and breeding-visions and constraints. | 2010 | Int J Mol Sci | pmid:20479987 |
Huang CH et al. | Natural flavone kaempferol suppresses chemokines expression in human monocyte THP-1 cells through MAPK pathways. | 2010 | J. Food Sci. | pmid:21535503 |
Xu B and Chang SK | Phenolic substance characterization and chemical and cell-based antioxidant activities of 11 lentils grown in the northern United States. | 2010 | J. Agric. Food Chem. | pmid:20058926 |
Attimarad M | Liquid Chromatographic Determination of Flavoxate HCl in Pharmaceutical Formulation. | 2010 | J Young Pharm | pmid:21042486 |
Charkoudian LK et al. | In living color: bacterial pigments as an untapped resource in the classroom and beyond. | 2010 | PLoS Biol. | pmid:20957190 |
Lakhan SE and Vieira KF | Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review. | 2010 | Nutr J | pmid:20929532 |
Fransen HP et al. | Assessment of health claims, content, and safety of herbal supplements containing Ginkgo biloba. | 2010 | Food Nutr Res | pmid:20927202 |
Wang XH et al. | Screen of micro-organisms for inducing the production of dragon's blood by leaf of Dracaena cochinchinensis. | 2010 | Lett. Appl. Microbiol. | pmid:20860774 |
Suttana W et al. | Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols. | 2010 | Mol. Cancer | pmid:20438634 |
Chen CC et al. | Calcium- and phosphatidylinositol 3-kinase/Akt-dependent activation of endothelial nitric oxide synthase by apigenin. | 2010 | Life Sci. | pmid:21034748 |
Gao LM and Meléndez E | Cytotoxic properties of titanocenyl amides on breast cancer cell line mcf-7. | 2010 | Met Based Drugs | pmid:20454639 |
Kyrgidis A et al. | Melanoma: Stem cells, sun exposure and hallmarks for carcinogenesis, molecular concepts and future clinical implications. | 2010 | J Carcinog | pmid:20442802 |
Zhuang P et al. | Effects of flavone on the oxidation-induced injury of retinal pigment epithelium cells. | 2010 | Int J Ophthalmol | pmid:22553529 |
Zhuang P et al. | Effect of flavone on the ocular blood flow and formation of choroidal neovascularization. | 2010 | Int J Ophthalmol | pmid:22553528 |
Semalty M et al. | Semecarpus anacardium Linn.: A review. | 2010 | Pharmacogn Rev | pmid:22228947 |
Wera M et al. | 2-(4-Fluoro-phen-yl)-3-hy-droxy-4H-chromen-4-one. | 2010 | Acta Crystallogr Sect E Struct Rep Online | pmid:21589426 |
van Tonder JH et al. | Racemic tricarbonyl[(4a,5,6,7,8,8a-η)-2-phenyl-3,4-dihydro-2H-1-benzopyran]chromium(0). | 2010 | Acta Crystallogr Sect E Struct Rep Online | pmid:21588503 |
Janeczko T et al. | 2-(4-Bromo-phen-yl)-6-methyl-4H-1-benzopyran-4-one (4'-bromo-6-methyl-flavone). | 2010 | Acta Crystallogr Sect E Struct Rep Online | pmid:21580767 |
Baikar S and Malpathak N | Secondary metabolites as DNA topoisomerase inhibitors: A new era towards designing of anticancer drugs. | 2010 | Pharmacogn Rev | pmid:22228937 |
Ono M et al. | 99mTc/Re complexes based on flavone and aurone as SPECT probes for imaging cerebral β-amyloid plaques. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20797860 |
Xu H et al. | Molecular cloning and characterization of phenylalanine ammonia-lyase, cinnamate 4-hydroxylase and genes involved in flavone biosynthesis in Scutellaria baicalensis. | 2010 | Bioresour. Technol. | pmid:20708926 |
Sabarinathan D et al. | Naringenin promote apoptosis in cerebrally implanted C6 glioma cells. | 2010 | Mol. Cell. Biochem. | pmid:20717707 |
Hanhineva K et al. | Impact of dietary polyphenols on carbohydrate metabolism. | 2010 | Int J Mol Sci | pmid:20480025 |
Dobritsa AA et al. | LAP5 and LAP6 encode anther-specific proteins with similarity to chalcone synthase essential for pollen exine development in Arabidopsis. | 2010 | Plant Physiol. | pmid:20442277 |
Hong TB et al. | Potential effects of chrysin on MDA-MB-231 cells. | 2010 | Int J Mol Sci | pmid:20479999 |
Perumal Samy R and Gopalakrishnakone P | Therapeutic Potential of Plants as Anti-microbials for Drug Discovery. | 2010 | Evid Based Complement Alternat Med | pmid:18955349 |
Lakshmi V et al. | Antifilarial activity in vitro and in vivo of some flavonoids tested against Brugia malayi. | 2010 | Acta Trop. | pmid:20609356 |
Baguley BC and McKeage MJ | ASA404: a tumor vascular-disrupting agent with broad potential for cancer therapy. | 2010 | Future Oncol | pmid:21062153 |
Gautam N et al. | In-situ absorption, protein binding and pharmacokinetic studies of S002-853, a novel antidiabetic and antidyslipidaemic flavone derivative in rats. | 2010 | J. Pharm. Pharmacol. | pmid:20609062 |
Cesla P et al. | Separation of phenolic acids and flavone natural antioxidants by two-dimensional method combining liquid chromatography and micellar electrokinetic capillary chromatography. | 2010 | Electrophoresis | pmid:20593394 |
Fan Y et al. | Epimedium polysaccharide and propolis flavone can synergistically stimulate lymphocyte proliferation in vitro and enhance the immune responses to ND vaccine in chickens. | 2010 | Int. J. Biol. Macromol. | pmid:20562020 |
Liu XH et al. | Synthesis and molecular docking studies of novel 2-chloro-pyridine derivatives containing flavone moieties as potential antitumor agents. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20538457 |
Tian Y et al. | Anti-HBV active flavone glucosides from Euphorbia humifusa Willd. | 2010 | Fitoterapia | pmid:20450964 |
Hori A and Naganuma K | Fully and partially fluorinated flavone derivatives. | 2010 | Acta Crystallogr C | pmid:20442510 |
Wang H et al. | Xeno-oestrogens and phyto-oestrogens are alternative ligands for the androgen receptor. | 2010 | Asian J. Androl. | pmid:20436506 |
Ramful D et al. | Bioactive phenolics and antioxidant propensity of flavedo extracts of Mauritian citrus fruits: potential prophylactic ingredients for functional foods application. | 2010 | Toxicology | pmid:20100535 |
Echeverry C et al. | Pretreatment with natural flavones and neuronal cell survival after oxidative stress: a structure-activity relationship study. | 2010 | J. Agric. Food Chem. | pmid:20095615 |
Bacher M et al. | Complete 1H and 13C NMR data assignment of new constituents from Severinia buxifolia. | 2010 | Magn Reson Chem | pmid:19937908 |
Jandera P et al. | Dual hydrophilic interaction-RP retention mechanism on polar columns: structural correlations and implementation for 2-D separations on a single column. | 2010 | J Sep Sci | pmid:20087874 |
Kasai N et al. | Atypical kinetics of cytochromes P450 catalysing 3'-hydroxylation of flavone from the white-rot fungus Phanerochaete chrysosporium. | 2010 | J. Biochem. | pmid:19819902 |
Rajesh G et al. | Effect of hydroxyl substitution of flavone on angiogenesis and free radical scavenging activities: a structure-activity relationship studies using computational tools. | 2010 | Eur J Pharm Sci | pmid:19874890 |
Veitch NC et al. | Flavonoid glycosides of the black locust tree, Robinia pseudoacacia (Leguminosae). | 2010 | Phytochemistry | pmid:19948349 |