FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Hayeshi R et al. | The potential inhibitory effect of antiparasitic drugs and natural products on P-glycoprotein mediated efflux. | 2006 | Eur J Pharm Sci | pmid:16846720 |
Mavel S et al. | Synthesis and biological evaluation of a series of flavone derivatives as potential radioligands for imaging the multidrug resistance-associated protein 1 (ABCC1/MRP1). | 2006 | Bioorg. Med. Chem. | pmid:16263302 |
Chemler JA et al. | Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae. | 2006 | Microb. Cell Fact. | pmid:16719921 |
Berthier A et al. | Effect of 7-O-beta-D-glucopyranosylchrysin and its aglycone chrysin isolated from Podocytisus caramanicus on estrogen receptor alpha transcriptional activity. | 2007 | Planta Med. | pmid:17948189 |
Yan H et al. | Treating senile dementia with traditional Chinese medicine. | 2007 | Clin Interv Aging | pmid:18044136 |
Stracke R et al. | Differential regulation of closely related R2R3-MYB transcription factors controls flavonol accumulation in different parts of the Arabidopsis thaliana seedling. | 2007 | Plant J. | pmid:17419845 |
Ebert B et al. | Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate. | 2007 | Toxicol. Sci. | pmid:17077187 |
Han X et al. | Isolation of high-purity casticin from Artemisia annua L. by high-speed counter-current chromatography. | 2007 | J Chromatogr A | pmid:17374377 |
Patel D et al. | Apigenin and cancer chemoprevention: progress, potential and promise (review). | 2007 | Int. J. Oncol. | pmid:17143534 |
Cai H et al. | Tissue distribution in mice and metabolism in murine and human liver of apigenin and tricin, flavones with putative cancer chemopreventive properties. | 2007 | Cancer Chemother. Pharmacol. | pmid:17089164 |
Lohner K et al. | Flavonoids alter P-gp expression in intestinal epithelial cells in vitro and in vivo. | 2007 | Mol Nutr Food Res | pmid:17295420 |
Walle UK and Walle T | Bioavailable flavonoids: cytochrome P450-mediated metabolism of methoxyflavones. | 2007 | Drug Metab. Dispos. | pmid:17709371 |
Mitchell AE et al. | Isozyme- and gender-specific induction of glutathione S-transferases by flavonoids. | 2007 | Arch. Toxicol. | pmid:17503020 |
Cabrera M et al. | Synthetic chalcones, flavanones, and flavones as antitumoral agents: biological evaluation and structure-activity relationships. | 2007 | Bioorg. Med. Chem. | pmid:17383189 |
Patanasethanont D et al. | Effects of Kaempferia parviflora extracts and their flavone constituents on P-glycoprotein function. | 2007 | J Pharm Sci | pmid:17031860 |
Hämäläinen M et al. | Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. | 2007 | Mediators Inflamm. | pmid:18274639 |
Tsuji PA and Walle T | Benzo[a]pyrene-induced cytochrome P450 1A and DNA binding in cultured trout hepatocytes - inhibition by plant polyphenols. | 2007 | Chem. Biol. Interact. | pmid:17583686 |
do Nascimento AM and de Oliveira DC | A new 5-deoxyflavone glycoside from the aerial parts of Calea clausseniana. | 2007 | Carbohydr. Res. | pmid:17420009 |
Ajay M et al. | Modulation of vascular reactivity in normal, hypertensive and diabetic rat aortae by a non-antioxidant flavonoid. | 2007 | Pharmacol. Res. | pmid:17317209 |
Geraets L et al. | Flavone as PARP-1 inhibitor: its effect on lipopolysaccharide induced gene-expression. | 2007 | Eur. J. Pharmacol. | pmid:17643414 |
Jung SM et al. | Reduction of urate crystal-induced inflammation by root extracts from traditional oriental medicinal plants: elevation of prostaglandin D2 levels. | 2007 | Arthritis Res. Ther. | pmid:17612394 |
Bontempo P et al. | Feijoa sellowiana derived natural Flavone exerts anti-cancer action displaying HDAC inhibitory activities. | 2007 | Int. J. Biochem. Cell Biol. | pmid:17604209 |
Walle T et al. | Cancer chemopreventive properties of orally bioavailable flavonoids--methylated versus unmethylated flavones. | 2007 | Biochem. Pharmacol. | pmid:17250812 |
Ramajayam R et al. | Synthesis and antiproliferative activity of some diaryldiazepines and diarylpyrimidines. | 2007 | J Enzyme Inhib Med Chem | pmid:18237024 |
Murakami S et al. | Purification and characterization of three neutral extracellular isoperoxidases from rye leaves. | 2007 | Phytochemistry | pmid:17266998 |
Yadava RN and Tiwari L | New antifungal flavone glycoside from Butea monosperma O. Kuntze. | 2007 | J Enzyme Inhib Med Chem | pmid:17847718 |
Bovicelli P et al. | Efficient synthesis of polyoxygenated flavones from naturally occurring flavanones. | 2007 | J. Pharm. Pharmacol. | pmid:18053332 |
Wan L et al. | Quantitative determination of apigenin and its metabolism in rat plasma after intravenous bolus administration by HPLC coupled with tandem mass spectrometry. | 2007 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:17561454 |
Jung J et al. | Inhibition of estrogen action by 2-phenylchromone as AhR agonist in MCF-7 cells. | 2007 | Life Sci. | pmid:17950758 |
Allouche Y et al. | How heating affects extra virgin olive oil quality indexes and chemical composition. | 2007 | J. Agric. Food Chem. | pmid:17935291 |
Diniz A et al. | Permeability profile estimation of flavonoids and other phenolic compounds by biopartitioning micellar capillary chromatography. | 2007 | J. Agric. Food Chem. | pmid:17927146 |
Pham MH et al. | Characterization of monohydroxylated derivatives of the anticancer agent flavone-8-acetic acid by liquid chromatography with on-line UV and mass spectrometry. | 2007 | Rapid Commun. Mass Spectrom. | pmid:17891752 |
Guo M et al. | Iron-binding properties of plant phenolics and cranberry's bio-effects. | 2007 | Dalton Trans | pmid:17992280 |
Wu Y et al. | [Effects of the total flavone of radix puerariae on apoptotic cell and apoptotic related-gene in atherosclerotic plaques of apoE gene deficiency mice]. | 2007 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:17711723 |
Liu S et al. | Anticancer activity and quantitative analysis of flavone of Cirsium japonicum DC. | 2007 | Nat. Prod. Res. | pmid:17680503 |
Yushchenko DA et al. | Sensing of adenosine-5'-triphosphate anion in aqueous solutions and mitochondria by a fluorescent 3-hydroxyflavone dye. | 2007 | Anal. Biochem. | pmid:17568555 |
Rodrigues J et al. | An unusual C6-C6" linked flavonoid from Miconia cabucu (Melastomataceae). | 2007 | Phytochemistry | pmid:17540417 |
Sarkar M and Samanta A | Photophysical and density functional studies of the interaction of a flavone derivative with the halides. | 2007 | J Phys Chem B | pmid:17523624 |
Ohtani H et al. | Effects of various methoxyflavones on vincristine uptake and multidrug resistance to vincristine in P-gp-overexpressing K562/ADM cells. | 2007 | Pharm. Res. | pmid:17492365 |
Meyer JD et al. | Quantitative trait loci for maysin synthesis in maize (Zea mays L.) lines selected for high silk maysin content. | 2007 | Theor. Appl. Genet. | pmid:17486311 |
Patanasethanont D et al. | Modulation of function of multidrug resistance associated-proteins by Kaempferia parviflora extracts and their components. | 2007 | Eur. J. Pharmacol. | pmid:17481606 |
Govindarajan R et al. | Effect of Desmodium gangeticum extract on blood glucose in rats and on insulin secretion in vitro. | 2007 | Planta Med. | pmid:17431824 |
Aboul-Enein HY et al. | Scavenging effects of phenolic compounds on reactive oxygen species. | 2007 | Biopolymers | pmid:17373654 |
Ono M | [Molecular imaging of beta-amyloid plaques in the brain]. | 2007 | Brain Nerve | pmid:17370649 |
Duarte-Almeida JM et al. | Antiproliferative and antioxidant activities of a tricin acylated glycoside from sugarcane (Saccharum officinarum) juice. | 2007 | Phytochemistry | pmid:17350657 |
Winkelmann I et al. | The suppression of aberrant crypt multiplicity in colonic tissue of 1,2-dimethylhydrazine-treated C57BL/6J mice by dietary flavone is associated with an increased expression of Krebs cycle enzymes. | 2007 | Carcinogenesis | pmid:17347140 |
Cacciola F et al. | Comprehensive two-dimensional liquid chromatography with parallel gradients for separation of phenolic and flavone antioxidants. | 2007 | J Chromatogr A | pmid:17331519 |
Boumendjel A et al. | Acridone derivatives: design, synthesis, and inhibition of breast cancer resistance protein ABCG2. | 2007 | Bioorg. Med. Chem. | pmid:17317193 |
Shukla S et al. | Blockade of beta-catenin signaling by plant flavonoid apigenin suppresses prostate carcinogenesis in TRAMP mice. | 2007 | Cancer Res. | pmid:17638904 |
Borges-Argáez R et al. | Cytotoxic and antiprotozoal activity of flavonoids from Lonchocarpus spp. | 2007 | Phytomedicine | pmid:17291734 |
Sarkar K et al. | Antibody response against neem leaf preparation recognizes carcinoembryonic antigen. | 2007 | Int. Immunopharmacol. | pmid:17276888 |
Iida N et al. | A new flavone xyloside and two new flavan-3-ol glucosides from Juniperus communis var. depressa. | 2007 | Chem. Biodivers. | pmid:17256732 |
Burns DC et al. | A combined nuclear magnetic resonance and computational study of monohydroxyflavones applied to product ion mass spectra. | 2007 | Rapid Commun. Mass Spectrom. | pmid:17216597 |
Fossen T et al. | Covalent anthocyanin-flavone dimer from leaves of Oxalis triangularis. | 2007 | Phytochemistry | pmid:17182069 |
Tremblay AM and Giguère V | The NR3B subgroup: an ovERRview. | 2007 | Nucl Recept Signal | pmid:18174917 |
Auffret G et al. | Synthesis and antimalarial evaluation of a series of piperazinyl flavones. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17166718 |
Chen J et al. | Phospholipase C/diacylglycerol kinase-mediated signalling is required for benzothiadiazole-induced oxidative burst and hypersensitive cell death in rice suspension-cultured cells. | 2007 | Protoplasma | pmid:17111096 |
Ono M et al. | Synthesis and characterization of styrylchromone derivatives as beta-amyloid imaging agents. | 2007 | Bioorg. Med. Chem. | pmid:17035032 |
Jeon SB et al. | Flavone inhibits vascular contraction by decreasing phosphorylation of the myosin phosphatase target subunit. | 2007 | Clin. Exp. Pharmacol. Physiol. | pmid:17880363 |
Doronicheva N et al. | Chemical structure-dependent differential effects of flavonoids on the catalase activity as evaluated by a chemiluminescent method. | 2007 | Biol. Pharm. Bull. | pmid:17268053 |
Kikuchi K et al. | Flavonoids induce germination of basidiospores of the ectomycorrhizal fungus Suillus bovinus. | 2007 | Mycorrhiza | pmid:17516095 |
Huang GC et al. | Wogonin but not Nor-wogonin inhibits lipopolysaccharide and lipoteichoic acid-induced iNOS gene expression and NO production in macrophages. | 2007 | Int. Immunopharmacol. | pmid:17570322 |
Kunnumakkara AB et al. | Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis. | 2007 | Blood | pmid:17332240 |
Lin J et al. | Dietary intakes of flavonols and flavones and coronary heart disease in US women. | 2007 | Am. J. Epidemiol. | pmid:17379619 |
Kim MJ et al. | Jaceosidin induces apoptosis in ras-transformed human breast epithelial cells through generation of reactive oxygen species. | 2007 | Ann. N. Y. Acad. Sci. | pmid:17404061 |
Lee HS et al. | In vitro metabolism of eupatilin by multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes. | 2007 | Xenobiotica | pmid:17701830 |
Gates MA et al. | A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer. | 2007 | Int. J. Cancer | pmid:17471564 |
Galabov AS | Virucidal agents in the eve of manorapid synergy. | 2007 | GMS Krankenhhyg Interdiszip | pmid:20200679 |
Rossi A et al. | Inhibition of inducible nitric oxide synthase expression by an acetonic extract from Feijoa sellowiana Berg. fruits. | 2007 | J. Agric. Food Chem. | pmid:17550270 |
Akao T et al. | Efflux of baicalin, a flavone glucuronide of Scutellariae Radix, on Caco-2 cells through multidrug resistance-associated protein 2. | 2007 | J. Pharm. Pharmacol. | pmid:17227625 |
Fukuda I et al. | Interaction between the aryl hydrocarbon receptor and its antagonists, flavonoids. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17560542 |
DomÃnguez M et al. | Pensteminoside, an unusual catalpol-type iridoid from Penstemon gentianoides HBK (Plantaginaceae). | 2007 | Phytochemistry | pmid:17507063 |
Manna SK et al. | Morin (3,5,7,2',4'-Pentahydroxyflavone) abolishes nuclear factor-kappaB activation induced by various carcinogens and inflammatory stimuli, leading to suppression of nuclear factor-kappaB-regulated gene expression and up-regulation of apoptosis. | 2007 | Clin. Cancer Res. | pmid:17404114 |
Snijman PW et al. | The antimutagenic activity of the major flavonoids of rooibos (Aspalathus linearis): some dose-response effects on mutagen activation-flavonoid interactions. | 2007 | Mutat. Res. | pmid:17537670 |
Ahmed N et al. | Synthesis, characterization, and estrogen receptor binding affinity of flavone-, indole-, and furan-estradiol conjugates. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17379515 |
Jeong MA et al. | Jaceosidin, a pharmacologically active flavone derived from Artemisia argyi, inhibits phorbol-ester-induced upregulation of COX-2 and MMP-9 by blocking phosphorylation of ERK-1 and -2 in cultured human mammary epithelial cells. | 2007 | Ann. N. Y. Acad. Sci. | pmid:17404058 |
Enomoto R et al. | Wogonin prevents immunosuppressive action but not anti-inflammatory effect induced by glucocorticoid. | 2007 | Ann. N. Y. Acad. Sci. | pmid:17404053 |
Lee E et al. | Wogonin, a plant flavone, potentiates etoposide-induced apoptosis in cancer cells. | 2007 | Ann. N. Y. Acad. Sci. | pmid:17404065 |
Zhao JH et al. | Chemical chaperone and inhibitor discovery: potential treatments for protein conformational diseases. | 2007 | Perspect Medicin Chem | pmid:19812735 |
Young J et al. | Antimicrobial effects of flavone analogues and their structure-activity relationships. | 2007 | J. Microbiol. Biotechnol. | pmid:18050960 |
Gao D et al. | Hypoglycemic effects and mechanisms of action of Cortex Lycii Radicis on alloxan-induced diabetic mice. | 2007 | Yakugaku Zasshi | pmid:17917429 |
Jung SH et al. | Aldose reductase and advanced glycation endproducts inhibitory effect of Phyllostachys nigra. | 2007 | Biol. Pharm. Bull. | pmid:17666823 |
Trusheva B et al. | Different extraction methods of biologically active components from propolis: a preliminary study. | 2007 | Chem Cent J | pmid:17880743 |
Enomoto R et al. | Wogonin prevents glucocorticoid-induced thymocyte apoptosis without diminishing its anti-inflammatory action. | 2007 | J. Pharmacol. Sci. | pmid:17690528 |
Pham MH et al. | Identification of new flavone-8-acetic acid metabolites using mouse microsomes and comparison with human microsomes. | 2007 | Drug Metab. Dispos. | pmid:17664249 |
Zeng Y et al. | Baicalin reduces the severity of experimental autoimmune encephalomyelitis. | 2007 | Braz. J. Med. Biol. Res. | pmid:17653455 |
Zamora RodrÃguez ZB et al. | Antioxidant mechanism is involved in the gastroprotective effects of ozonized sunflower oil in ethanol-induced ulcers in rats. | 2007 | Mediators Inflamm. | pmid:17497036 |
Zhang J et al. | Flavone synthases from Medicago truncatula are flavanone-2-hydroxylases and are important for nodulation. | 2007 | Plant Physiol. | pmid:17434990 |
Burns DC et al. | A predictive tool for assessing (13)C NMR chemical shifts of flavonoids. | 2007 | Magn Reson Chem | pmid:17729229 |
Ullmannova V and Popescu NC | Inhibition of cell proliferation, induction of apoptosis, reactivation of DLC1, and modulation of other gene expression by dietary flavone in breast cancer cell lines. | 2007 | Cancer Detect. Prev. | pmid:17418982 |
Chen S and Li X | Transposable elements are enriched within or in close proximity to xenobiotic-metabolizing cytochrome P450 genes. | 2007 | BMC Evol. Biol. | pmid:17381843 |
Hinnen P and Eskens FA | Vascular disrupting agents in clinical development. | 2007 | Br. J. Cancer | pmid:17375046 |
Joshi KS et al. | P276-00, a novel cyclin-dependent inhibitor induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models. | 2007 | Mol. Cancer Ther. | pmid:17363487 |
Perry JD et al. | Evaluation of novel chromogenic substrates for the detection of bacterial beta-glucosidase. | 2007 | J. Appl. Microbiol. | pmid:17241346 |
Innocenti G et al. | In vitro estrogenic activity of Achillea millefolium L. | 2007 | Phytomedicine | pmid:16860978 |
Pikulski M et al. | Tunable transition metal-ligand complexation for enhanced elucidation of flavonoid diglycosides by electrospray ionization mass spectrometry. | 2007 | J. Am. Soc. Mass Spectrom. | pmid:17112735 |
Mbouangouere RN et al. | Piptaderol from Piptadenia africana. | 2007 | Afr J Tradit Complement Altern Med | pmid:20161892 |
Vijayaraghavan R et al. | Comparative evaluation of some flavonoids and tocopherol acetate against the systemic toxicity induced by sulphur mustard. | 2008 | Indian J Pharmacol | pmid:20040938 |
Mursu J et al. | Flavonoid intake and the risk of ischaemic stroke and CVD mortality in middle-aged Finnish men: the Kuopio Ischaemic Heart Disease Risk Factor Study. | 2008 | Br. J. Nutr. | pmid:18377681 |
Li GM et al. | [Effects of elevated carbon dioxide and ozone on the growth and secondary metabolism of spring wheat]. | 2008 | Ying Yong Sheng Tai Xue Bao | pmid:18808021 |