FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Hornung RL et al. | Augmentation of natural killer activity, induction of IFN and development tumor immunity during the successful treatment of established murine renal cancer using flavone acetic acid and IL-2. | 1988 | J. Immunol. | pmid:2460546 |
Bibby MC et al. | Experimental anti-tumor effects of flavone acetic acid (LM975). | 1988 | Prog. Clin. Biol. Res. | pmid:3174695 |
Bibby MC et al. | Unique chemosensitivity of MAC 16 tumours to flavone acetic acid (LM975, NSC 347512). | 1988 | Br. J. Cancer | pmid:3179187 |
Ching LM and Baguley BC | Enhancement of in vitro cytotoxicity of mouse peritoneal exudate cells by flavone acetic acid (NSC 347512). | 1988 | Eur J Cancer Clin Oncol | pmid:3181272 |
Damia G et al. | Dose-dependent pharmacokinetics of flavone acetic acid in mice. | 1988 | Cancer Chemother. Pharmacol. | pmid:3396145 |
Chen JC et al. | [Anti-arrhythmic action of 4'-methyl-7-([2-hydroxy-3-(beta-propinamidoethyl)amino]propoxy) flavone hydrochloride (SIPI-644)]. | 1988 | Zhongguo Yao Li Xue Bao | pmid:3188948 |
Fisher RF et al. | Specific binding of proteins from Rhizobium meliloti cell-free extracts containing NodD to DNA sequences upstream of inducible nodulation genes. | 1988 | Genes Dev. | pmid:3288541 |
Hayashi T et al. | A cytotoxic flavone from Scoparia dulcis L. | 1988 | Chem. Pharm. Bull. | pmid:3246045 |
Abbiati GA et al. | Receptor binding studies of the flavone, REC 15/2053, and other bladder spasmolytics. | 1988 | Pharm. Res. | pmid:3247311 |
Wiltrout RH et al. | Flavone-8-acetic acid augments systemic natural killer cell activity and synergizes with IL-2 for treatment of murine renal cancer. | 1988 | J. Immunol. | pmid:3258894 |
Rabinovitz M | The structure of flavone-8-acetic acid, a chemotherapeutic agent, and its application to drug design. | 1988 | J. Enzym. Inhib. | pmid:3236069 |
Robbins RC | Flavones in citrus exhibit antiadhesive action on platelets. | 1988 | Int J Vitam Nutr Res | pmid:3243696 |
Armitage JP et al. | Comparison of the chemotactic behaviour of Rhizobium leguminosarum with and without the nodulation plasmid. | 1988 | Mol. Microbiol. | pmid:3210967 |
Bourdillat B et al. | Mechanism of action of hispidulin, a natural flavone, on human platelets. | 1988 | Prog. Clin. Biol. Res. | pmid:2845433 |
Gao F et al. | Sesquiterpene lactones and flavonoids from Helianthus species. | 1987 Jan-Feb | J. Nat. Prod. | pmid:3598595 |
Rubin J et al. | Flavone-8-acetic acid inhibits ristocetin-induced platelet agglutination and prolongs bleeding time. | 1987 | Lancet | pmid:2889983 |
Dodion P et al. | Sensitivity of normal human bone marrow myeloid progenitor cells to anthracycline, cisplatin, anthracene and flavone acetic acid derivatives, and its relevance for the prediction of human plasma concentrations of anticancer drugs. | 1987 | Eur J Cancer Clin Oncol | pmid:3436354 |
Ching LM and Baguley BC | Induction of natural killer cell activity by the antitumour compound flavone acetic acid (NSC 347 512). | 1987 | Eur J Cancer Clin Oncol | pmid:3665989 |
Abdalla SS and Abu Zarga MH | Effects of cirsimaritin, a flavone isolated from Artemisia judaica, on isolated guinea-pig ileum. | 1987 | Planta Med. | pmid:3671552 |
Kerr DJ et al. | Phase I and pharmacokinetic study of flavone acetic acid. | 1987 | Cancer Res. | pmid:3677106 |