FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

Cross Reference

Introduction

To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with FLAVONE?

FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with FLAVONE

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Adenoma D000236 40 associated lipids
Asthma D001249 52 associated lipids
Body Weight D001835 333 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cystitis D003556 23 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Edema D004487 152 associated lipids
Encephalitis D004660 15 associated lipids
Glioma D005910 112 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hyperlipidemias D006949 73 associated lipids
Hypertension D006973 115 associated lipids
Leukemia P388 D007941 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lymphedema D008209 4 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Melanoma D008545 69 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Pain D010146 64 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Osteosarcoma D012516 50 associated lipids
Stomach Ulcer D013276 75 associated lipids
Weight Loss D015431 56 associated lipids
Per page 10 20 50 | Total 32

PubChem Associated disorders and diseases

What pathways are associated with FLAVONE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with FLAVONE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with FLAVONE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with FLAVONE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with FLAVONE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with FLAVONE?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Disease model

Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Animal Disease Models

Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with FLAVONE

Download all related citations
Per page 10 20 50 100 | Total 1492
Authors Title Published Journal PubMed Link
Liu Q et al. Metabolism profile of scutellarin in urine following oral administration to rats by ultra performance liquid chromatography coupled to time-of-flight mass spectrometry. 2009 Talanta pmid:19782195
Yenjai C et al. Structural modification of 5,7-dimethoxyflavone from Kaempferia parviflora and biological activities. 2009 Arch. Pharm. Res. pmid:19784571
Kwak HS et al. Marked individual variation in isoflavone metabolism after a soy challenge can modulate the skeletal effect of isoflavones in premenopausal women. 2009 J. Korean Med. Sci. pmid:19794985
Chang TL Inhibitory effect of flavonoids on 26S proteasome activity. 2009 J. Agric. Food Chem. pmid:19795881
Zhang HM et al. [Analysis of Belamcanda chinensis with space flight mutagenesis by FTIR]. 2009 Guang Pu Xue Yu Guang Pu Fen Xi pmid:19798954
Zhao JH et al. Chemical chaperone and inhibitor discovery: potential treatments for protein conformational diseases. 2007 Perspect Medicin Chem pmid:19812735
Kasai N et al. Atypical kinetics of cytochromes P450 catalysing 3'-hydroxylation of flavone from the white-rot fungus Phanerochaete chrysosporium. 2010 J. Biochem. pmid:19819902
Tan M et al. Synthesis, cytotoxic activity, and DNA binding properties of copper (II) complexes with hesperetin, naringenin, and apigenin. 2009 Bioinorg Chem Appl pmid:19830248
Geng X et al. High selective purification of flavonoids from natural plants based on polymeric adsorbent with hydrogen-bonding interaction. 2009 J Chromatogr A pmid:19837412
Jandera P and Hájek T Utilization of dual retention mechanism on columns with bonded PEG and diol stationary phases for adjusting the separation selectivity of phenolic and flavone natural antioxidants. 2009 J Sep Sci pmid:19839014
Duchowicz PR et al. QSAR analysis on Spodoptera litura antifeedant activities for flavone derivatives. 2009 Sci. Total Environ. pmid:19846206
Galla G et al. Computational annotation of genes differentially expressed along olive fruit development. 2009 BMC Plant Biol. pmid:19852839
Seo J et al. Time-dependent density functional theory-assisted absolute configuration determination of cis-dihydrodiol metabolite produced from isoflavone by biphenyl dioxygenase. 2010 Anal. Biochem. pmid:19854147
Rajesh G et al. Effect of hydroxyl substitution of flavone on angiogenesis and free radical scavenging activities: a structure-activity relationship studies using computational tools. 2010 Eur J Pharm Sci pmid:19874890
Jin M et al. Suppressive effects of T-412, a flavone on interleukin-4 production in T cells. 2009 Biol. Pharm. Bull. pmid:19881301
Fekrazad HM et al. A phase I study of flavopiridol in combination with gemcitabine and irinotecan in patients with metastatic cancer. 2010 Am. J. Clin. Oncol. pmid:19884803
Baek I et al. Flavone Attenuates Vascular Contractions by Inhibiting RhoA/Rho Kinase Pathway. 2009 Korean J. Physiol. Pharmacol. pmid:19885038
Ibanez S et al. Plant chemical defence: a partner control mechanism stabilising plant--seed-eating pollinator mutualisms. 2009 BMC Evol. Biol. pmid:19887006
Qian LB et al. Luteolin reduces high glucose-mediated impairment of endothelium-dependent relaxation in rat aorta by reducing oxidative stress. 2010 Pharmacol. Res. pmid:19892019
Szliszka E et al. Ethanolic Extract of Propolis Augments TRAIL-Induced Apoptotic Death in Prostate Cancer Cells. 2011 Evid Based Complement Alternat Med pmid:19892808
Schubert M et al. Two novel disaccharides, rutinose and methylrutinose, are involved in carbon metabolism in Datisca glomerata. 2010 Planta pmid:19915863
Zhang ZF et al. Separation and purification of two flavone glucuronides from Erigeron multiradiatus (Lindl.) Benth with macroporous resins. 2009 J. Biomed. Biotechnol. pmid:19918373
Julião Lde S et al. Flavones and phenylpropanoids from a sedative extract of Lantana trifolia L. 2010 Phytochemistry pmid:19922967
Büchner FL et al. Fruits and vegetables consumption and the risk of histological subtypes of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). 2010 Cancer Causes Control pmid:19924549
Mays JR et al. The synthesis and evaluation of flavone and isoflavone chimeras of novobiocin and derrubone. 2010 Bioorg. Med. Chem. pmid:19932969
Oyama T et al. Dietary tricin suppresses inflammation-related colon carcinogenesis in male Crj: CD-1 mice. 2009 Cancer Prev Res (Phila) pmid:19934339
Bacher M et al. Complete 1H and 13C NMR data assignment of new constituents from Severinia buxifolia. 2010 Magn Reson Chem pmid:19937908
Veitch NC et al. Flavonoid glycosides of the black locust tree, Robinia pseudoacacia (Leguminosae). 2010 Phytochemistry pmid:19948349
Marczak Ł et al. Fragmentation pathways of acylated flavonoid diglucuronides from leaves of Medicago truncatula. 2010 May-Jun Phytochem Anal pmid:19950391
Liu Z et al. Protective effect of chrysoeriol against doxorubicin-induced cardiotoxicity in vitro. 2009 Chin. Med. J. pmid:19951587
Uchi H et al. A clinical trial of kampo formulae for the treatment of symptoms of yusho, a poisoning caused by dioxins and related organochlorine compounds. 2011 Evid Based Complement Alternat Med pmid:19996156
Gunnarsson D et al. Effects of dietary phytoestrogens on plasma testosterone and triiodothyronine (T3) levels in male goat kids. 2009 Acta Vet. Scand. pmid:20003293
Du Y et al. Identification of flavone phytoalexins and a pathogen-inducible flavone synthase II gene (SbFNSII) in sorghum. 2010 J. Exp. Bot. pmid:20007684
Morant M et al. Metabolomic, transcriptional, hormonal, and signaling cross-talk in superroot2. 2010 Mol Plant pmid:20008451
Yin J et al. Antioxidant and antidiabetic activities of extracts from Cirsium japonicum roots. 2008 Nutr Res Pract pmid:20016726
Bao K et al. Selective demethylation and debenzylation of aryl ethers by magnesium iodide under solvent-free conditions and its application to the total synthesis of natural products. 2009 Org. Biomol. Chem. pmid:20024102
An L et al. Total flavonoids extracted from xiaobuxin-tang on the hyperactivity of hypothalamic-pituitary-adrenal axis in chronically stressed rats. 2011 Evid Based Complement Alternat Med pmid:20028718
Tayarani-Najaran Z et al. Analyzing Cytotoxic and Apoptogenic Properties of Scutellaria litwinowii Root Extract on Cancer Cell Lines. 2011 Evid Based Complement Alternat Med pmid:20028719
Vijayaraghavan R et al. Comparative evaluation of some flavonoids and tocopherol acetate against the systemic toxicity induced by sulphur mustard. 2008 Indian J Pharmacol pmid:20040938
Froyen EB et al. Regulation of phase II enzymes by genistein and daidzein in male and female Swiss Webster mice. 2009 J Med Food pmid:20041775
Smit N et al. The hunt for natural skin whitening agents. 2009 Int J Mol Sci pmid:20054473
Tanaka Y et al. Recent progress of flower colour modification by biotechnology. 2009 Int J Mol Sci pmid:20054474
Bregestovski P et al. Genetically encoded optical sensors for monitoring of intracellular chloride and chloride-selective channel activity. 2009 Front Mol Neurosci pmid:20057911
Xu B and Chang SK Phenolic substance characterization and chemical and cell-based antioxidant activities of 11 lentils grown in the northern United States. 2010 J. Agric. Food Chem. pmid:20058926
Dirscherl K et al. Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype. 2010 J Neuroinflammation pmid:20074346
Walle T Methylation of dietary flavones increases their metabolic stability and chemopreventive effects. 2009 Int J Mol Sci pmid:20087474
Jandera P et al. Dual hydrophilic interaction-RP retention mechanism on polar columns: structural correlations and implementation for 2-D separations on a single column. 2010 J Sep Sci pmid:20087874
Seo J et al. Location of flavone B-ring controls regioselectivity and stereoselectivity of naphthalene dioxygenase from Pseudomonas sp. strain NCIB 9816-4. 2010 Appl. Microbiol. Biotechnol. pmid:20091026
Echeverry C et al. Pretreatment with natural flavones and neuronal cell survival after oxidative stress: a structure-activity relationship study. 2010 J. Agric. Food Chem. pmid:20095615
Gokara M et al. Molecular interaction studies of trimethoxy flavone with human serum albumin. 2010 PLoS ONE pmid:20098677
Ramful D et al. Bioactive phenolics and antioxidant propensity of flavedo extracts of Mauritian citrus fruits: potential prophylactic ingredients for functional foods application. 2010 Toxicology pmid:20100535
Kaneko T et al. Inhibition of prostaglandin E2 production by flavone and its related compounds. In Vivo pmid:20133976
Saleem A et al. A RP-HPLC-DAD-APCI/MSD method for the characterisation of medicinal Ericaceae used by the Eeyou Istchee Cree First Nations. Phytochem Anal pmid:20135709
Basile A et al. Antibacterial and antifungal properties of acetonic extract of Feijoa sellowiana fruits and its effect on Helicobacter pylori growth. 2010 J Med Food pmid:20136454
Ansó E et al. Flavonoids inhibit hypoxia-induced vascular endothelial growth factor expression by a HIF-1 independent mechanism. 2010 Biochem. Pharmacol. pmid:20153296
Mbouangouere RN et al. Piptaderol from Piptadenia africana. 2007 Afr J Tradit Complement Altern Med pmid:20161892
Cheung FW et al. Geoditin A induces oxidative stress and apoptosis on human colon HT29 cells. 2010 Mar Drugs pmid:20161972
McKeage MJ and Baguley BC Disrupting established tumor blood vessels: an emerging therapeutic strategy for cancer. 2010 Cancer pmid:20166210
Kim JM et al. Morin modulates the oxidative stress-induced NF-kappaB pathway through its anti-oxidant activity. 2010 Free Radic. Res. pmid:20187708
Chang TL et al. 5,6,3',4'-Tetrahydroxy-7-methoxyflavone as a novel potential proteasome inhibitor. 2010 Planta Med. pmid:20195959
Song WY et al. Effect of ethanol extracts from red pepper seeds on antioxidative defense system and oxidative stress in rats fed high-fat . high-cholesterol diet. 2010 Nutr Res Pract pmid:20198203
Akhtar TA et al. Photosynthetic redox imbalance influences flavonoid biosynthesis in Lemna gibba. 2010 Plant Cell Environ. pmid:20199616
Galabov AS Virucidal agents in the eve of manorapid synergy. 2007 GMS Krankenhhyg Interdiszip pmid:20200679
Tamura S et al. New inhibitors for expression of IgE receptor on human mast cell. 2010 Bioorg. Med. Chem. Lett. pmid:20202836
Zhang A et al. Anti-HER-2 engineering antibody ChA21 inhibits growth and induces apoptosis of SK-OV-3 cells. 2010 J. Exp. Clin. Cancer Res. pmid:20214830
Yashiroda Y et al. A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor. 2010 Biochem. Biophys. Res. Commun. pmid:20214890
Wang J et al. Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation. 2010 PLoS ONE pmid:20221395
Wang C et al. [Advances in chemical components and pharmacology of genus Gentiana]. 2009 Zhongguo Zhong Yao Za Zhi pmid:20222408
Ono E et al. Co-pigmentation and flavonoid glycosyltransferases in blue Veronica persica flowers. 2010 Phytochemistry pmid:20223486
Parravicini C et al. Forced unbinding of GPR17 ligands from wild type and R255I mutant receptor models through a computational approach. 2010 BMC Struct. Biol. pmid:20233425
Shukla S and Gupta S Apigenin: a promising molecule for cancer prevention. 2010 Pharm. Res. pmid:20306120
Xiao J et al. Structure-affinity relationship of flavones on binding to serum albumins: effect of hydroxyl groups on ring A. 2010 Mol Nutr Food Res pmid:20306480
Guendel I et al. Inhibition of human immunodeficiency virus type-1 by cdk inhibitors. 2010 AIDS Res Ther pmid:20334651
Zou GA et al. Flavonoids from the stems of Croton caudatus Geisel. var. tomentosus Hook. 2010 Molecules pmid:20335965
Chen Q et al. Measurement of total flavone content in snow lotus (Saussurea involucrate) using near infrared spectroscopy combined with interval PLS and genetic algorithm. 2010 Spectrochim Acta A Mol Biomol Spectrosc pmid:20338806
Vidyalakshmi K et al. Antinociceptive effect of certain dihydroxy flavones in mice. 2010 Pharmacol. Biochem. Behav. pmid:20346369
Torres-Piedra M et al. A comparative study of flavonoid analogues on streptozotocin-nicotinamide induced diabetic rats: quercetin as a potential antidiabetic agent acting via 11beta-hydroxysteroid dehydrogenase type 1 inhibition. 2010 Eur J Med Chem pmid:20346546
Lewin G et al. Semisynthesis of natural flavones inhibiting tubulin polymerization, from hesperidin. 2010 J. Nat. Prod. pmid:20356063
Han Y et al. Ectopic expression of apple F3'H genes contributes to anthocyanin accumulation in the Arabidopsis tt7 mutant grown under nitrogen stress. 2010 Plant Physiol. pmid:20357139
Liao Z et al. Antidiabetic effect of flavones from Cirsium japonicum DC in diabetic rats. 2010 Arch. Pharm. Res. pmid:20361298
Cai H et al. Pharmacokinetics in mice and metabolism in murine and human liver fractions of the putative cancer chemopreventive agents 3',4',5',5,7-pentamethoxyflavone and tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone). 2011 Cancer Chemother. Pharmacol. pmid:20364427
Filak LK et al. Organometallic indolo[3,2-c]quinolines versus indolo[3,2-d]benzazepines: synthesis, structural and spectroscopic characterization, and biological efficacy. 2010 J. Biol. Inorg. Chem. pmid:20369265
Valant-Vetschera KM et al. Chemodiversity of exudate flavonoids in Dionysia (Primulaceae): a comparative study. 2010 Phytochemistry pmid:20378133
Halbwirth H The creation and physiological relevance of divergent hydroxylation patterns in the flavonoid pathway. 2010 Int J Mol Sci pmid:20386656
Xia EQ et al. Biological activities of polyphenols from grapes. 2010 Int J Mol Sci pmid:20386657
Xiang H et al. Synthesis and biological evaluation of isoflavone fatty acid esters with potential weight loss and hypolipidemic activities. 2010 Bioorg. Med. Chem. pmid:20392645
Chung KS et al. Eupafolin, a flavonoid isolated from Artemisia princeps, induced apoptosis in human cervical adenocarcinoma HeLa cells. 2010 Mol Nutr Food Res pmid:20397191
Knjazeva T and Kaljurand M Capillary electrophoresis frontal analysis for the study of flavonoid interactions with human serum albumin. 2010 Anal Bioanal Chem pmid:20422159
Kosmider B et al. Structure-activity relationship and apoptosis induction in A549 cells by the potential anticancer compound cis-bis(3-aminoflavone)dichloroplatinum(II). 2010 Arzneimittelforschung pmid:20422947
Neveu V et al. Phenol-Explorer: an online comprehensive database on polyphenol contents in foods. 2010 Database (Oxford) pmid:20428313
Picon PD et al. Randomized clinical trial of a phytotherapic compound containing Pimpinella anisum, Foeniculum vulgare, Sambucus nigra, and Cassia augustifolia for chronic constipation. 2010 BMC Complement Altern Med pmid:20433751
Wang H et al. Xeno-oestrogens and phyto-oestrogens are alternative ligands for the androgen receptor. 2010 Asian J. Androl. pmid:20436506
Suttana W et al. Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols. 2010 Mol. Cancer pmid:20438634
Dobritsa AA et al. LAP5 and LAP6 encode anther-specific proteins with similarity to chalcone synthase essential for pollen exine development in Arabidopsis. 2010 Plant Physiol. pmid:20442277
Hori A and Naganuma K Fully and partially fluorinated flavone derivatives. 2010 Acta Crystallogr C pmid:20442510
Kyrgidis A et al. Melanoma: Stem cells, sun exposure and hallmarks for carcinogenesis, molecular concepts and future clinical implications. 2010 J Carcinog pmid:20442802
Mukai R et al. Suppression mechanisms of flavonoids on aryl hydrocarbon receptor-mediated signal transduction. 2010 Arch. Biochem. Biophys. pmid:20450880
Tian Y et al. Anti-HBV active flavone glucosides from Euphorbia humifusa Willd. 2010 Fitoterapia pmid:20450964
Gao LM and Meléndez E Cytotoxic properties of titanocenyl amides on breast cancer cell line mcf-7. 2010 Met Based Drugs pmid:20454639
Jeng YJ et al. Subchronic exposure to phytoestrogens alone and in combination with diethylstilbestrol - pituitary tumor induction in Fischer 344 rats. 2010 Nutr Metab (Lond) pmid:20459739