FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Liu Q et al. | Metabolism profile of scutellarin in urine following oral administration to rats by ultra performance liquid chromatography coupled to time-of-flight mass spectrometry. | 2009 | Talanta | pmid:19782195 |
Yenjai C et al. | Structural modification of 5,7-dimethoxyflavone from Kaempferia parviflora and biological activities. | 2009 | Arch. Pharm. Res. | pmid:19784571 |
Kwak HS et al. | Marked individual variation in isoflavone metabolism after a soy challenge can modulate the skeletal effect of isoflavones in premenopausal women. | 2009 | J. Korean Med. Sci. | pmid:19794985 |
Chang TL | Inhibitory effect of flavonoids on 26S proteasome activity. | 2009 | J. Agric. Food Chem. | pmid:19795881 |
Zhang HM et al. | [Analysis of Belamcanda chinensis with space flight mutagenesis by FTIR]. | 2009 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:19798954 |
Zhao JH et al. | Chemical chaperone and inhibitor discovery: potential treatments for protein conformational diseases. | 2007 | Perspect Medicin Chem | pmid:19812735 |
Kasai N et al. | Atypical kinetics of cytochromes P450 catalysing 3'-hydroxylation of flavone from the white-rot fungus Phanerochaete chrysosporium. | 2010 | J. Biochem. | pmid:19819902 |
Tan M et al. | Synthesis, cytotoxic activity, and DNA binding properties of copper (II) complexes with hesperetin, naringenin, and apigenin. | 2009 | Bioinorg Chem Appl | pmid:19830248 |
Geng X et al. | High selective purification of flavonoids from natural plants based on polymeric adsorbent with hydrogen-bonding interaction. | 2009 | J Chromatogr A | pmid:19837412 |
Jandera P and Hájek T | Utilization of dual retention mechanism on columns with bonded PEG and diol stationary phases for adjusting the separation selectivity of phenolic and flavone natural antioxidants. | 2009 | J Sep Sci | pmid:19839014 |
Duchowicz PR et al. | QSAR analysis on Spodoptera litura antifeedant activities for flavone derivatives. | 2009 | Sci. Total Environ. | pmid:19846206 |
Galla G et al. | Computational annotation of genes differentially expressed along olive fruit development. | 2009 | BMC Plant Biol. | pmid:19852839 |
Seo J et al. | Time-dependent density functional theory-assisted absolute configuration determination of cis-dihydrodiol metabolite produced from isoflavone by biphenyl dioxygenase. | 2010 | Anal. Biochem. | pmid:19854147 |
Rajesh G et al. | Effect of hydroxyl substitution of flavone on angiogenesis and free radical scavenging activities: a structure-activity relationship studies using computational tools. | 2010 | Eur J Pharm Sci | pmid:19874890 |
Jin M et al. | Suppressive effects of T-412, a flavone on interleukin-4 production in T cells. | 2009 | Biol. Pharm. Bull. | pmid:19881301 |
Fekrazad HM et al. | A phase I study of flavopiridol in combination with gemcitabine and irinotecan in patients with metastatic cancer. | 2010 | Am. J. Clin. Oncol. | pmid:19884803 |
Baek I et al. | Flavone Attenuates Vascular Contractions by Inhibiting RhoA/Rho Kinase Pathway. | 2009 | Korean J. Physiol. Pharmacol. | pmid:19885038 |
Ibanez S et al. | Plant chemical defence: a partner control mechanism stabilising plant--seed-eating pollinator mutualisms. | 2009 | BMC Evol. Biol. | pmid:19887006 |
Qian LB et al. | Luteolin reduces high glucose-mediated impairment of endothelium-dependent relaxation in rat aorta by reducing oxidative stress. | 2010 | Pharmacol. Res. | pmid:19892019 |
Szliszka E et al. | Ethanolic Extract of Propolis Augments TRAIL-Induced Apoptotic Death in Prostate Cancer Cells. | 2011 | Evid Based Complement Alternat Med | pmid:19892808 |
Schubert M et al. | Two novel disaccharides, rutinose and methylrutinose, are involved in carbon metabolism in Datisca glomerata. | 2010 | Planta | pmid:19915863 |
Zhang ZF et al. | Separation and purification of two flavone glucuronides from Erigeron multiradiatus (Lindl.) Benth with macroporous resins. | 2009 | J. Biomed. Biotechnol. | pmid:19918373 |
Julião Lde S et al. | Flavones and phenylpropanoids from a sedative extract of Lantana trifolia L. | 2010 | Phytochemistry | pmid:19922967 |
Büchner FL et al. | Fruits and vegetables consumption and the risk of histological subtypes of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). | 2010 | Cancer Causes Control | pmid:19924549 |
Mays JR et al. | The synthesis and evaluation of flavone and isoflavone chimeras of novobiocin and derrubone. | 2010 | Bioorg. Med. Chem. | pmid:19932969 |
Oyama T et al. | Dietary tricin suppresses inflammation-related colon carcinogenesis in male Crj: CD-1 mice. | 2009 | Cancer Prev Res (Phila) | pmid:19934339 |
Bacher M et al. | Complete 1H and 13C NMR data assignment of new constituents from Severinia buxifolia. | 2010 | Magn Reson Chem | pmid:19937908 |
Veitch NC et al. | Flavonoid glycosides of the black locust tree, Robinia pseudoacacia (Leguminosae). | 2010 | Phytochemistry | pmid:19948349 |
Marczak Å et al. | Fragmentation pathways of acylated flavonoid diglucuronides from leaves of Medicago truncatula. | 2010 May-Jun | Phytochem Anal | pmid:19950391 |
Liu Z et al. | Protective effect of chrysoeriol against doxorubicin-induced cardiotoxicity in vitro. | 2009 | Chin. Med. J. | pmid:19951587 |
Uchi H et al. | A clinical trial of kampo formulae for the treatment of symptoms of yusho, a poisoning caused by dioxins and related organochlorine compounds. | 2011 | Evid Based Complement Alternat Med | pmid:19996156 |
Gunnarsson D et al. | Effects of dietary phytoestrogens on plasma testosterone and triiodothyronine (T3) levels in male goat kids. | 2009 | Acta Vet. Scand. | pmid:20003293 |
Du Y et al. | Identification of flavone phytoalexins and a pathogen-inducible flavone synthase II gene (SbFNSII) in sorghum. | 2010 | J. Exp. Bot. | pmid:20007684 |
Morant M et al. | Metabolomic, transcriptional, hormonal, and signaling cross-talk in superroot2. | 2010 | Mol Plant | pmid:20008451 |
Yin J et al. | Antioxidant and antidiabetic activities of extracts from Cirsium japonicum roots. | 2008 | Nutr Res Pract | pmid:20016726 |
Bao K et al. | Selective demethylation and debenzylation of aryl ethers by magnesium iodide under solvent-free conditions and its application to the total synthesis of natural products. | 2009 | Org. Biomol. Chem. | pmid:20024102 |
An L et al. | Total flavonoids extracted from xiaobuxin-tang on the hyperactivity of hypothalamic-pituitary-adrenal axis in chronically stressed rats. | 2011 | Evid Based Complement Alternat Med | pmid:20028718 |
Tayarani-Najaran Z et al. | Analyzing Cytotoxic and Apoptogenic Properties of Scutellaria litwinowii Root Extract on Cancer Cell Lines. | 2011 | Evid Based Complement Alternat Med | pmid:20028719 |
Vijayaraghavan R et al. | Comparative evaluation of some flavonoids and tocopherol acetate against the systemic toxicity induced by sulphur mustard. | 2008 | Indian J Pharmacol | pmid:20040938 |
Froyen EB et al. | Regulation of phase II enzymes by genistein and daidzein in male and female Swiss Webster mice. | 2009 | J Med Food | pmid:20041775 |
Smit N et al. | The hunt for natural skin whitening agents. | 2009 | Int J Mol Sci | pmid:20054473 |
Tanaka Y et al. | Recent progress of flower colour modification by biotechnology. | 2009 | Int J Mol Sci | pmid:20054474 |
Bregestovski P et al. | Genetically encoded optical sensors for monitoring of intracellular chloride and chloride-selective channel activity. | 2009 | Front Mol Neurosci | pmid:20057911 |
Xu B and Chang SK | Phenolic substance characterization and chemical and cell-based antioxidant activities of 11 lentils grown in the northern United States. | 2010 | J. Agric. Food Chem. | pmid:20058926 |
Dirscherl K et al. | Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype. | 2010 | J Neuroinflammation | pmid:20074346 |
Walle T | Methylation of dietary flavones increases their metabolic stability and chemopreventive effects. | 2009 | Int J Mol Sci | pmid:20087474 |
Jandera P et al. | Dual hydrophilic interaction-RP retention mechanism on polar columns: structural correlations and implementation for 2-D separations on a single column. | 2010 | J Sep Sci | pmid:20087874 |
Seo J et al. | Location of flavone B-ring controls regioselectivity and stereoselectivity of naphthalene dioxygenase from Pseudomonas sp. strain NCIB 9816-4. | 2010 | Appl. Microbiol. Biotechnol. | pmid:20091026 |
Echeverry C et al. | Pretreatment with natural flavones and neuronal cell survival after oxidative stress: a structure-activity relationship study. | 2010 | J. Agric. Food Chem. | pmid:20095615 |
Gokara M et al. | Molecular interaction studies of trimethoxy flavone with human serum albumin. | 2010 | PLoS ONE | pmid:20098677 |
Ramful D et al. | Bioactive phenolics and antioxidant propensity of flavedo extracts of Mauritian citrus fruits: potential prophylactic ingredients for functional foods application. | 2010 | Toxicology | pmid:20100535 |
Kaneko T et al. | Inhibition of prostaglandin E2 production by flavone and its related compounds. | In Vivo | pmid:20133976 | |
Saleem A et al. | A RP-HPLC-DAD-APCI/MSD method for the characterisation of medicinal Ericaceae used by the Eeyou Istchee Cree First Nations. | Phytochem Anal | pmid:20135709 | |
Basile A et al. | Antibacterial and antifungal properties of acetonic extract of Feijoa sellowiana fruits and its effect on Helicobacter pylori growth. | 2010 | J Med Food | pmid:20136454 |
Ansó E et al. | Flavonoids inhibit hypoxia-induced vascular endothelial growth factor expression by a HIF-1 independent mechanism. | 2010 | Biochem. Pharmacol. | pmid:20153296 |
Mbouangouere RN et al. | Piptaderol from Piptadenia africana. | 2007 | Afr J Tradit Complement Altern Med | pmid:20161892 |
Cheung FW et al. | Geoditin A induces oxidative stress and apoptosis on human colon HT29 cells. | 2010 | Mar Drugs | pmid:20161972 |
McKeage MJ and Baguley BC | Disrupting established tumor blood vessels: an emerging therapeutic strategy for cancer. | 2010 | Cancer | pmid:20166210 |
Kim JM et al. | Morin modulates the oxidative stress-induced NF-kappaB pathway through its anti-oxidant activity. | 2010 | Free Radic. Res. | pmid:20187708 |
Chang TL et al. | 5,6,3',4'-Tetrahydroxy-7-methoxyflavone as a novel potential proteasome inhibitor. | 2010 | Planta Med. | pmid:20195959 |
Song WY et al. | Effect of ethanol extracts from red pepper seeds on antioxidative defense system and oxidative stress in rats fed high-fat . high-cholesterol diet. | 2010 | Nutr Res Pract | pmid:20198203 |
Akhtar TA et al. | Photosynthetic redox imbalance influences flavonoid biosynthesis in Lemna gibba. | 2010 | Plant Cell Environ. | pmid:20199616 |
Galabov AS | Virucidal agents in the eve of manorapid synergy. | 2007 | GMS Krankenhhyg Interdiszip | pmid:20200679 |
Tamura S et al. | New inhibitors for expression of IgE receptor on human mast cell. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20202836 |
Zhang A et al. | Anti-HER-2 engineering antibody ChA21 inhibits growth and induces apoptosis of SK-OV-3 cells. | 2010 | J. Exp. Clin. Cancer Res. | pmid:20214830 |
Yashiroda Y et al. | A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20214890 |
Wang J et al. | Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation. | 2010 | PLoS ONE | pmid:20221395 |
Wang C et al. | [Advances in chemical components and pharmacology of genus Gentiana]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:20222408 |
Ono E et al. | Co-pigmentation and flavonoid glycosyltransferases in blue Veronica persica flowers. | 2010 | Phytochemistry | pmid:20223486 |
Parravicini C et al. | Forced unbinding of GPR17 ligands from wild type and R255I mutant receptor models through a computational approach. | 2010 | BMC Struct. Biol. | pmid:20233425 |
Shukla S and Gupta S | Apigenin: a promising molecule for cancer prevention. | 2010 | Pharm. Res. | pmid:20306120 |
Xiao J et al. | Structure-affinity relationship of flavones on binding to serum albumins: effect of hydroxyl groups on ring A. | 2010 | Mol Nutr Food Res | pmid:20306480 |
Guendel I et al. | Inhibition of human immunodeficiency virus type-1 by cdk inhibitors. | 2010 | AIDS Res Ther | pmid:20334651 |
Zou GA et al. | Flavonoids from the stems of Croton caudatus Geisel. var. tomentosus Hook. | 2010 | Molecules | pmid:20335965 |
Chen Q et al. | Measurement of total flavone content in snow lotus (Saussurea involucrate) using near infrared spectroscopy combined with interval PLS and genetic algorithm. | 2010 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:20338806 |
Vidyalakshmi K et al. | Antinociceptive effect of certain dihydroxy flavones in mice. | 2010 | Pharmacol. Biochem. Behav. | pmid:20346369 |
Torres-Piedra M et al. | A comparative study of flavonoid analogues on streptozotocin-nicotinamide induced diabetic rats: quercetin as a potential antidiabetic agent acting via 11beta-hydroxysteroid dehydrogenase type 1 inhibition. | 2010 | Eur J Med Chem | pmid:20346546 |
Lewin G et al. | Semisynthesis of natural flavones inhibiting tubulin polymerization, from hesperidin. | 2010 | J. Nat. Prod. | pmid:20356063 |
Han Y et al. | Ectopic expression of apple F3'H genes contributes to anthocyanin accumulation in the Arabidopsis tt7 mutant grown under nitrogen stress. | 2010 | Plant Physiol. | pmid:20357139 |
Liao Z et al. | Antidiabetic effect of flavones from Cirsium japonicum DC in diabetic rats. | 2010 | Arch. Pharm. Res. | pmid:20361298 |
Cai H et al. | Pharmacokinetics in mice and metabolism in murine and human liver fractions of the putative cancer chemopreventive agents 3',4',5',5,7-pentamethoxyflavone and tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone). | 2011 | Cancer Chemother. Pharmacol. | pmid:20364427 |
Filak LK et al. | Organometallic indolo[3,2-c]quinolines versus indolo[3,2-d]benzazepines: synthesis, structural and spectroscopic characterization, and biological efficacy. | 2010 | J. Biol. Inorg. Chem. | pmid:20369265 |
Valant-Vetschera KM et al. | Chemodiversity of exudate flavonoids in Dionysia (Primulaceae): a comparative study. | 2010 | Phytochemistry | pmid:20378133 |
Halbwirth H | The creation and physiological relevance of divergent hydroxylation patterns in the flavonoid pathway. | 2010 | Int J Mol Sci | pmid:20386656 |
Xia EQ et al. | Biological activities of polyphenols from grapes. | 2010 | Int J Mol Sci | pmid:20386657 |
Xiang H et al. | Synthesis and biological evaluation of isoflavone fatty acid esters with potential weight loss and hypolipidemic activities. | 2010 | Bioorg. Med. Chem. | pmid:20392645 |
Chung KS et al. | Eupafolin, a flavonoid isolated from Artemisia princeps, induced apoptosis in human cervical adenocarcinoma HeLa cells. | 2010 | Mol Nutr Food Res | pmid:20397191 |
Knjazeva T and Kaljurand M | Capillary electrophoresis frontal analysis for the study of flavonoid interactions with human serum albumin. | 2010 | Anal Bioanal Chem | pmid:20422159 |
Kosmider B et al. | Structure-activity relationship and apoptosis induction in A549 cells by the potential anticancer compound cis-bis(3-aminoflavone)dichloroplatinum(II). | 2010 | Arzneimittelforschung | pmid:20422947 |
Neveu V et al. | Phenol-Explorer: an online comprehensive database on polyphenol contents in foods. | 2010 | Database (Oxford) | pmid:20428313 |
Picon PD et al. | Randomized clinical trial of a phytotherapic compound containing Pimpinella anisum, Foeniculum vulgare, Sambucus nigra, and Cassia augustifolia for chronic constipation. | 2010 | BMC Complement Altern Med | pmid:20433751 |
Wang H et al. | Xeno-oestrogens and phyto-oestrogens are alternative ligands for the androgen receptor. | 2010 | Asian J. Androl. | pmid:20436506 |
Suttana W et al. | Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols. | 2010 | Mol. Cancer | pmid:20438634 |
Dobritsa AA et al. | LAP5 and LAP6 encode anther-specific proteins with similarity to chalcone synthase essential for pollen exine development in Arabidopsis. | 2010 | Plant Physiol. | pmid:20442277 |
Hori A and Naganuma K | Fully and partially fluorinated flavone derivatives. | 2010 | Acta Crystallogr C | pmid:20442510 |
Kyrgidis A et al. | Melanoma: Stem cells, sun exposure and hallmarks for carcinogenesis, molecular concepts and future clinical implications. | 2010 | J Carcinog | pmid:20442802 |
Mukai R et al. | Suppression mechanisms of flavonoids on aryl hydrocarbon receptor-mediated signal transduction. | 2010 | Arch. Biochem. Biophys. | pmid:20450880 |
Tian Y et al. | Anti-HBV active flavone glucosides from Euphorbia humifusa Willd. | 2010 | Fitoterapia | pmid:20450964 |
Gao LM and Meléndez E | Cytotoxic properties of titanocenyl amides on breast cancer cell line mcf-7. | 2010 | Met Based Drugs | pmid:20454639 |
Jeng YJ et al. | Subchronic exposure to phytoestrogens alone and in combination with diethylstilbestrol - pituitary tumor induction in Fischer 344 rats. | 2010 | Nutr Metab (Lond) | pmid:20459739 |