FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Petroianu G et al. | Monitoring by HPLC of chamomile flavonoids exposed to rat liver microsomal metabolism. | 2009 | Open Med Chem J | pmid:19707521 |
Studholme DJ et al. | A draft genome sequence and functional screen reveals the repertoire of type III secreted proteins of Pseudomonas syringae pathovar tabaci 11528. | 2009 | BMC Genomics | pmid:19703286 |
Yoshimura S et al. | Inhibitory effect of flavonoids on the efflux of N-acetyl 5-aminosalicylic acid intracellularly formed in Caco-2 cells. | 2009 | J. Biomed. Biotechnol. | pmid:19688110 |
Li HQ et al. | Synthesis of C(7) modified chrysin derivatives designing to inhibit beta-ketoacyl-acyl carrier protein synthase III (FabH) as antibiotics. | 2009 | Bioorg. Med. Chem. | pmid:19664929 |
Ryu YB et al. | Structural characteristics of flavanones and flavones from Cudrania tricuspidata for neuraminidase inhibition. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19660948 |
Cai H et al. | Flavones as colorectal cancer chemopreventive agents--phenol-o-methylation enhances efficacy. | 2009 | Cancer Prev Res (Phila) | pmid:19638489 |
Karvela E et al. | Deployment of response surface methodology to optimise recovery of grape (Vitis vinifera) stem polyphenols. | 2009 | Talanta | pmid:19635365 |
Xu F et al. | Quasi-MSn identification of flavanone 7-glycoside isomers in Da Chengqi Tang by high performance liquid chromatography-tandem mass spectrometry. | 2009 | Chin Med | pmid:19630957 |
Medić-Sarić M et al. | From functional food to medicinal product: systematic approach in analysis of polyphenolics from propolis and wine. | 2009 | Nutr J | pmid:19624827 |
Maddocks KJ and Lin TS | Update in the management of chronic lymphocytic leukemia. | 2009 | J Hematol Oncol | pmid:19619273 |
Liu G et al. | On-line strategies for the identification of unknown flavone glycosides in Dracocephalum tanguticum Maxim. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19615954 |
Yamada T et al. | New azaphilones, seco-chaetomugilins A and D, produced by a marine-fish-derived Chaetomium globosum. | 2009 | Mar Drugs | pmid:19597583 |
Chang TS | An updated review of tyrosinase inhibitors. | 2009 | Int J Mol Sci | pmid:19582213 |
Göpfert JC et al. | Identification, functional characterization and developmental regulation of sesquiterpene synthases from sunflower capitate glandular trichomes. | 2009 | BMC Plant Biol. | pmid:19580670 |
Cao H et al. | Arsenic accumulation in Scutellaria baicalensis Georgi and its effects on plant growth and pharmaceutical components. | 2009 | J. Hazard. Mater. | pmid:19577841 |
Shimada T et al. | Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study. | 2009 | Chem. Res. Toxicol. | pmid:19563207 |
Masada S et al. | Functional and structural characterization of a flavonoid glucoside 1,6-glucosyltransferase from Catharanthus roseus. | 2009 | Plant Cell Physiol. | pmid:19561332 |
Xia C et al. | Differential effect of Shenmai injection, a herbal preparation, on the cytochrome P450 3A-mediated 1'-hydroxylation and 4-hydroxylation of midazolam. | 2009 | Chem. Biol. Interact. | pmid:19557931 |
Zhu JT et al. | Estrogenic and neuroprotective properties of scutellarin from Erigeron breviscapus: a drug against postmenopausal symptoms and Alzheimer's disease. | 2009 | Planta Med. | pmid:19533578 |
Simons CC et al. | Dietary flavonol, flavone and catechin intake and risk of colorectal cancer in the Netherlands Cohort Study. | 2009 | Int. J. Cancer | pmid:19530252 |
Goettel W and Messing J | Change of gene structure and function by non-homologous end-joining, homologous recombination, and transposition of DNA. | 2009 | PLoS Genet. | pmid:19521498 |
Jeon YM et al. | Biological synthesis of 7-O-methyl Apigenin from naringenin using escherichia coli expressing two genes. | 2009 | J. Microbiol. Biotechnol. | pmid:19494697 |
Peng H et al. | A novel two mode-acting inhibitor of ABCG2-mediated multidrug transport and resistance in cancer chemotherapy. | 2009 | PLoS ONE | pmid:19479068 |
Furuta T et al. | Concise synthesis of chafurosides A and B. | 2009 | Org. Lett. | pmid:19473042 |
Bastos ML et al. | Studies on the antimicrobial activity and brine shrimp toxicity of Zeyheria tuberculosa (Vell.) Bur. (Bignoniaceae) extracts and their main constituents. | 2009 | Ann. Clin. Microbiol. Antimicrob. | pmid:19450272 |
Choi EJ and Kim GH | Apigenin Induces Apoptosis through a Mitochondria/Caspase-Pathway in Human Breast Cancer MDA-MB-453 Cells. | 2009 | J Clin Biochem Nutr | pmid:19430615 |
Otaki N et al. | Distribution and major sources of flavonoid intakes in the middle-aged Japanese women. | 2009 | J Clin Biochem Nutr | pmid:19430611 |
Androutsopoulos VP et al. | Anticancer effects of the flavonoid diosmetin on cell cycle progression and proliferation of MDA-MB 468 breast cancer cells due to CYP1 activation. | 2009 | Oncol. Rep. | pmid:19424633 |
Kang HK et al. | Apigenin, a non-mutagenic dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation for expansion of autoreactive Th1 and Th17 cells. | 2009 | Arthritis Res. Ther. | pmid:19405952 |
Putz MV et al. | Quantum-SAR extension of the spectral-SAR algorithm: application to polyphenolic anticancer bioactivity. | 2009 | Int J Mol Sci | pmid:19399244 |
Fiorentino A et al. | Identification and assessment of antioxidant capacity of phytochemicals from kiwi fruits. | 2009 | J. Agric. Food Chem. | pmid:19358604 |
Li ZF et al. | Emodin and baicalein inhibit pancreatic stromal derived factor-1 expression in rats with acute pancreatitis. | 2009 | HBPD INT | pmid:19357036 |
Chokchaisiri R et al. | Bioactive flavonoids of the flowers of Butea monosperma. | 2009 | Chem. Pharm. Bull. | pmid:19336944 |
Kim KS et al. | Inhibition of overexpressed CDC-25.1 phosphatase activity by flavone in Caenorhabditis elegans. | 2009 | Mol. Cells | pmid:19326082 |
Fassihi A and Sabet R | QSAR study of p56(lck) protein tyrosine kinase inhibitory activity of flavonoid derivatives using MLR and GA-PLS. | 2008 | Int J Mol Sci | pmid:19325836 |
Samee W et al. | 3D-QSAR investigation of synthetic antioxidant chromone derivatives by molecular field analysis. | 2008 | Int J Mol Sci | pmid:19325746 |
Szliszka E et al. | Dietary flavonoids sensitize HeLa cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). | 2008 | Int J Mol Sci | pmid:19325719 |
Wang Y et al. | Inactivation of GSK-3beta by metallothionein prevents diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage, and remodeling. | 2009 | Diabetes | pmid:19324938 |
Parekh HS et al. | A new dawn for the use of traditional Chinese medicine in cancer therapy. | 2009 | Mol. Cancer | pmid:19298677 |
Mohammed MM et al. | New acylated flavone and cyanogenic glycosides from Linum grandiflorum. | 2009 | Nat. Prod. Res. | pmid:19296395 |
Tan WJ et al. | Bioactive compounds of inhibiting xanthine oxidase from Selaginella labordei. | 2009 | Nat. Prod. Res. | pmid:19296380 |
Geraets L et al. | Inhibition of LPS-induced pulmonary inflammation by specific flavonoids. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19292976 |
Marian CM | Spin-forbidden transitions in flavone. | 2009 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:19264543 |
Shin EK et al. | Chrysin, a natural flavone, improves murine inflammatory bowel diseases. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19233127 |
Bjorøy O et al. | C-glycosylanthocyanidins synthesized from C-glycosylflavones. | 2009 | Phytochemistry | pmid:19185884 |
Jeong SH et al. | Tyrosinase inhibitory polyphenols from roots of Morus lhou. | 2009 | J. Agric. Food Chem. | pmid:19166303 |
Wang GH et al. | [Optimal extraction of nuciferine and flavone from lotus leaf based on central composite design and response surface methodology]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19157120 |
López-Lázaro M | Distribution and biological activities of the flavonoid luteolin. | 2009 | Mini Rev Med Chem | pmid:19149659 |
Gong T et al. | Novel benzil and isoflavone derivatives from Millettia dielsiana. | 2009 | Planta Med. | pmid:19140097 |
Lee EA et al. | Robustness of QTLs across germplasm pools using a model quantitative trait. | 2009 | Genome | pmid:19132070 |
Wang Y et al. | Screening Antitumor Compounds Psoralen and Isopsoralen from Psoralea corylifolia L. Seeds. | 2011 | Evid Based Complement Alternat Med | pmid:19131395 |
Justino GC et al. | Electrospray ionization tandem mass spectrometry fragmentation of protonated flavone and flavonol aglycones: a re-examination. | 2009 | Rapid Commun. Mass Spectrom. | pmid:19089862 |
Shiono M et al. | Structure of commelinin, a blue complex pigment from the blue flowers of Commelina communis. | 2008 | Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. | pmid:19075517 |
Si D et al. | Mechanism of CYP2C9 inhibition by flavones and flavonols. | 2009 | Drug Metab. Dispos. | pmid:19074529 |
Jiang L et al. | Analysis of flavonoids in propolis and Ginkgo biloba by micellar electrokinetic capillary chromatography. | 2008 | J. Agric. Food Chem. | pmid:19053353 |
Gupta PJ and Kalaskar S | Ligation and mucopexy for prolapsing hemorrhoids--a ten year experience. | 2008 | Ann Surg Innov Res | pmid:19038061 |
Horvath DP et al. | Transcriptome analysis identifies novel responses and potential regulatory genes involved in seasonal dormancy transitions of leafy spurge (Euphorbia esula L.). | 2008 | BMC Genomics | pmid:19014493 |
Brunskole M et al. | Trihydroxynaphthalene reductase of Curvularia lunata--a target for flavonoid action? | 2009 | Chem. Biol. Interact. | pmid:19010313 |
Chen LL et al. | [Effect of nebulized TFG on Th1/Th2 imbalance in mouse model with asthma]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19007018 |
Toyo'oka T et al. | On-line screening methods for antioxidants scavenging superoxide anion radical and hydrogen peroxide by liquid chromatography with indirect chemiluminescence detection. | 2003 | Talanta | pmid:18969068 |
Baranowska I and Raróg D | Application of derivative spectrophotometry to determination of flavonoid mixtures. | 2001 | Talanta | pmid:18968363 |
Perumal Samy R and Gopalakrishnakone P | Therapeutic Potential of Plants as Anti-microbials for Drug Discovery. | 2010 | Evid Based Complement Alternat Med | pmid:18955349 |
Chen HQ et al. | Luteolin protects dopaminergic neurons from inflammation-induced injury through inhibition of microglial activation. | 2008 | Neurosci. Lett. | pmid:18952146 |
Soriano IR et al. | Inducible Flavone in Oats (Avena sativa) Is a Novel Defense Against Plant-Parasitic Nematodes. | 2004 | Phytopathology | pmid:18944456 |
Alipieva KI et al. | An iridoid and a flavonoid from Sideritis lanata L. | 2009 | Fitoterapia | pmid:18938229 |
Seelinger G et al. | Anti-oxidant, anti-inflammatory and anti-allergic activities of luteolin. | 2008 | Planta Med. | pmid:18937165 |
Zhou X et al. | Flavone and isoflavone derivatives of terrestrial plants as larval settlement inhibitors of the barnacle Balanus amphitrite. | 2009 | Biofouling | pmid:18855151 |
Nilsson J et al. | Azaflavones compared to flavones as ligands to the benzodiazepine binding site of brain GABA(A) receptors. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18851913 |
Guo QS et al. | [Study on dynamic accumulation of flavone in various Chrysanthemum morifolium for medicine]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18831193 |
Das B et al. | Diterpenoids from Jatropha multifida. | 2008 | Phytochemistry | pmid:18823921 |
Aravind SG et al. | Semi-preparative HPLC preparation and HPTLC quantification of tetrahydroamentoflavone as marker in Semecarpus anacardium and its polyherbal formulations. | 2008 | J Pharm Biomed Anal | pmid:18823732 |
Rezai-Zadeh K et al. | Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression. | 2008 | J Neuroinflammation | pmid:18817573 |
Li GM et al. | [Effects of elevated carbon dioxide and ozone on the growth and secondary metabolism of spring wheat]. | 2008 | Ying Yong Sheng Tai Xue Bao | pmid:18808021 |
Cesla P et al. | Optimization of two-dimensional gradient liquid chromatography separations. | 2009 | J Chromatogr A | pmid:18804770 |
Lanoë PH et al. | Cyclometallated platinum(II) complexes incorporating ethynyl-flavone ligands: switching between triplet and singlet emission induced by selective binding of Pb2+ ions. | 2008 | Chem. Commun. (Camb.) | pmid:18802561 |
Martins VP et al. | Mitochondrial function in the yeast form of the pathogenic fungus Paracoccidioides brasiliensis. | 2008 | J. Bioenerg. Biomembr. | pmid:18797987 |
Wang YZ et al. | In vivo effects of Pain Relieving Plaster on closed soft tissue injury in rabbit ears. | 2008 | BMC Complement Altern Med | pmid:18793392 |
Hájek T et al. | Multidimensional LC x LC analysis of phenolic and flavone natural antioxidants with UV-electrochemical coulometric and MS detection. | 2008 | J Sep Sci | pmid:18792009 |
Li G et al. | Effects of elevated CO(2) and O(3) on phenolic compounds in spring wheat and maize leaves. | 2008 | Bull Environ Contam Toxicol | pmid:18781273 |
Wu D et al. | D-Alanine:D-alanine ligase as a new target for the flavonoids quercetin and apigenin. | 2008 | Int. J. Antimicrob. Agents | pmid:18774266 |
Meng Y et al. | Flavones and flavone glycosides from Halophila johnsonii. | 2008 | Phytochemistry | pmid:18771781 |
Lv W et al. | Jaceosidin induces apoptosis in human ovary cancer cells through mitochondrial pathway. | 2008 | J. Biomed. Biotechnol. | pmid:18769496 |
Lawrence CJ et al. | MaizeGDB: The maize model organism database for basic, translational, and applied research. | 2008 | Int J Plant Genomics | pmid:18769488 |
Luo P et al. | Scutellarin isolated from Erigeron multiradiatus inhibits high glucose-mediated vascular inflammation. | 2008 | Yakugaku Zasshi | pmid:18758143 |
Russo EB | Cannabinoids in the management of difficult to treat pain. | 2008 | Ther Clin Risk Manag | pmid:18728714 |
Shukla S and Gupta S | Apigenin suppresses insulin-like growth factor I receptor signaling in human prostate cancer: an in vitro and in vivo study. | 2009 | Mol. Carcinog. | pmid:18726972 |
Shih CH et al. | Functional characterization of key structural genes in rice flavonoid biosynthesis. | 2008 | Planta | pmid:18726614 |
Kaur P et al. | Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study. | 2008 | Carcinogenesis | pmid:18725386 |
Ji W et al. | Hypolipidaemic mechanisms of action of CM108 (a flavone derivative) in hyperlipidaemic rats. | 2008 | J. Pharm. Pharmacol. | pmid:18718125 |
Najmus-Saqib Q et al. | Antimicrobial and cytotoxicity activities of the medicinal plant Primula macrophylla. | 2009 | J Enzyme Inhib Med Chem | pmid:18686139 |
Dong X et al. | Identification of SVM-based classification model, synthesis and evaluation of prenylated flavonoids as vasorelaxant agents. | 2008 | Bioorg. Med. Chem. | pmid:18678502 |
Chen IL et al. | Synthesis and antiproliferative evaluation of amide-containing flavone and isoflavone derivatives. | 2008 | Bioorg. Med. Chem. | pmid:18662883 |
Zhao Z et al. | Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats. | 2008 | Behav. Brain Res. | pmid:18655806 |
Hara T et al. | Flavopiridol potentiates the cytotoxic effects of radiation in radioresistant tumor cells in which p53 is mutated or Bcl-2 is overexpressed. | 2008 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:18640498 |
Furtmueller R et al. | 6,3'-Dinitroflavone is a low efficacy modulator of GABA(A) receptors. | 2008 | Eur. J. Pharmacol. | pmid:18639544 |
Wu B et al. | Metabonomic study on ageing: NMR-based investigation into rat urinary metabolites and the effect of the total flavone of Epimedium. | 2008 | Mol Biosyst | pmid:18633487 |
Zhai K et al. | Chrysin induces hyperalgesia via the GABAA receptor in mice. | 2008 | Planta Med. | pmid:18612941 |
Ryu YB et al. | Inhibitory effects on mushroom tyrosinase by flavones from the stem barks of Morus lhou (S.) Koidz. | 2008 | J Enzyme Inhib Med Chem | pmid:18608767 |
Yang L et al. | Compound Chinese herbal medicinal ingredients can enhance immune response and efficacy of RHD vaccine in rabbit. | 2008 | Vaccine | pmid:18602959 |
Lee YU et al. | Inhibition of developmental processes by flavone in Caenorhabditis elegans and its application to the pinewood nematode, Bursaphelenchus xylophilus. | 2008 | Mol. Cells | pmid:18596412 |