FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

Cross Reference

Introduction

To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with FLAVONE?

FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with FLAVONE

MeSH term MeSH ID Detail
Weight Loss D015431 56 associated lipids
Stomach Ulcer D013276 75 associated lipids
Osteosarcoma D012516 50 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Pain D010146 64 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Melanoma D008545 69 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Lymphedema D008209 4 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Leukemia P388 D007941 43 associated lipids
Hypertension D006973 115 associated lipids
Hyperlipidemias D006949 73 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hemolysis D006461 131 associated lipids
Glioma D005910 112 associated lipids
Encephalitis D004660 15 associated lipids
Edema D004487 152 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Cystitis D003556 23 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Body Weight D001835 333 associated lipids
Asthma D001249 52 associated lipids
Adenoma D000236 40 associated lipids
Adenocarcinoma D000230 166 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with FLAVONE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with FLAVONE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with FLAVONE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with FLAVONE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with FLAVONE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with FLAVONE?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Disease model

Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Animal Disease Models

Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with FLAVONE

Download all related citations
Per page 10 20 50 100 | Total 1492
Authors Title Published Journal PubMed Link
Meydani M and Hasan ST Dietary polyphenols and obesity. 2010 Nutrients pmid:22254051
Torres-Piedra M et al. A comparative study of flavonoid analogues on streptozotocin-nicotinamide induced diabetic rats: quercetin as a potential antidiabetic agent acting via 11beta-hydroxysteroid dehydrogenase type 1 inhibition. 2010 Eur J Med Chem pmid:20346546
Jeong HJ et al. Chungsim-Yeunja-Tang decreases the inflammatory response in peripheral blood mononuclear cells from patients with cerebral infarction through an NF-κB dependent mechanism. 2010 J Neuroinflammation pmid:21108840
Ansó E et al. Flavonoids inhibit hypoxia-induced vascular endothelial growth factor expression by a HIF-1 independent mechanism. 2010 Biochem. Pharmacol. pmid:20153296
Ghasemzadeh A et al. Effect of different light intensities on total phenolics and flavonoids synthesis and anti-oxidant activities in young ginger varieties (Zingiber officinale Roscoe). 2010 Int J Mol Sci pmid:21152306
Medjakovic S et al. Potential health-modulating effects of isoflavones and metabolites via activation of PPAR and AhR. 2010 Nutrients pmid:22254019
Liao Z et al. Antidiabetic effect of flavones from Cirsium japonicum DC in diabetic rats. 2010 Arch. Pharm. Res. pmid:20361298
Khoo BY et al. Apoptotic effects of chrysin in human cancer cell lines. 2010 Int J Mol Sci pmid:20559509
Ono E et al. Co-pigmentation and flavonoid glycosyltransferases in blue Veronica persica flowers. 2010 Phytochemistry pmid:20223486
Villaflores OB et al. Phytoconstituents from Alpinia purpurata and their in vitro inhibitory activity against Mycobacterium tuberculosis. 2010 Pharmacogn Mag pmid:21120040
Kim MJ et al. TNF-α induces expression of urokinase-type plasminogen activator and β-catenin activation through generation of ROS in human breast epithelial cells. 2010 Biochem. Pharmacol. pmid:20804741
Vidyalakshmi K et al. Antinociceptive effect of certain dihydroxy flavones in mice. 2010 Pharmacol. Biochem. Behav. pmid:20346369
Joe EJ et al. Engineering of flavonoid O-methyltransferase for a novel regioselectivity. 2010 Mol. Cells pmid:20680484
Pichichero E et al. Acacia honey and chrysin reduce proliferation of melanoma cells through alterations in cell cycle progression. 2010 Int. J. Oncol. pmid:20811719
Shukla S and Gupta S Apigenin: a promising molecule for cancer prevention. 2010 Pharm. Res. pmid:20306120
Zhou JM et al. Structure-function relationships of wheat flavone O-methyltransferase: Homology modeling and site-directed mutagenesis. 2010 BMC Plant Biol. pmid:20670441
Tamura S et al. New inhibitors for expression of IgE receptor on human mast cell. 2010 Bioorg. Med. Chem. Lett. pmid:20202836
Kurian G et al. A Novel Approach for Oral Delivery of Insulin via Desmodium gangeticum Aqueous Root Extract. 2010 J Young Pharm pmid:21264119
Yi Lau GT and Leung LK The dietary flavonoid apigenin blocks phorbol 12-myristate 13-acetate-induced COX-2 transcriptional activity in breast cell lines. 2010 Food Chem. Toxicol. pmid:20691240
Ghasemzadeh A et al. Synthesis of phenolics and flavonoids in ginger (Zingiber officinale Roscoe) and their effects on photosynthesis rate. 2010 Int J Mol Sci pmid:21151455
Goettel W and Messing J Divergence of gene regulation through chromosomal rearrangements. 2010 BMC Genomics pmid:21118519
Guttikonda SK et al. Whole genome co-expression analysis of soybean cytochrome P450 genes identifies nodulation-specific P450 monooxygenases. 2010 BMC Plant Biol. pmid:21062474
Zou GA et al. Flavonoids from the stems of Croton caudatus Geisel. var. tomentosus Hook. 2010 Molecules pmid:20335965
Schubert M et al. Two novel disaccharides, rutinose and methylrutinose, are involved in carbon metabolism in Datisca glomerata. 2010 Planta pmid:19915863
Kim JM et al. Morin modulates the oxidative stress-induced NF-kappaB pathway through its anti-oxidant activity. 2010 Free Radic. Res. pmid:20187708
Zhang A et al. Augmented inhibition of angiogenesis by combination of HER2 antibody chA21 and trastuzumab in human ovarian carcinoma xenograft. 2010 J Ovarian Res pmid:20723224
Du Y et al. CYP93G2 is a flavanone 2-hydroxylase required for C-glycosylflavone biosynthesis in rice. 2010 Plant Physiol. pmid:20647377
Gassmann K et al. Species-specific differential AhR expression protects human neural progenitor cells against developmental neurotoxicity of PAHs. 2010 Environ. Health Perspect. pmid:20570779
Morreel K et al. Mass spectrometry-based sequencing of lignin oligomers. 2010 Plant Physiol. pmid:20554692
Parravicini C et al. Forced unbinding of GPR17 ligands from wild type and R255I mutant receptor models through a computational approach. 2010 BMC Struct. Biol. pmid:20233425
Zhang A et al. Anti-HER-2 engineering antibody ChA21 inhibits growth and induces apoptosis of SK-OV-3 cells. 2010 J. Exp. Clin. Cancer Res. pmid:20214830
Akhtar TA et al. Photosynthetic redox imbalance influences flavonoid biosynthesis in Lemna gibba. 2010 Plant Cell Environ. pmid:20199616
Khalafalah AK et al. Chemical constituents of Tephrosia purpurea. 2010 Pharmacognosy Res pmid:21808544
McKeage MJ and Baguley BC Disrupting established tumor blood vessels: an emerging therapeutic strategy for cancer. 2010 Cancer pmid:20166210
Cheung FW et al. Geoditin A induces oxidative stress and apoptosis on human colon HT29 cells. 2010 Mar Drugs pmid:20161972
Yang JM et al. Hispidulin sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by AMPK activation leading to Mcl-1 block in translation. 2010 J. Agric. Food Chem. pmid:20734985
Lin YC et al. Hispidulin potently inhibits human glioblastoma multiforme cells through activation of AMP-activated protein kinase (AMPK). 2010 J. Agric. Food Chem. pmid:20698539
Büchner FL et al. Fruits and vegetables consumption and the risk of histological subtypes of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). 2010 Cancer Causes Control pmid:19924549
Aparicio S A systematic computational study on flavonoids. 2010 Int J Mol Sci pmid:20559499
Song WY et al. Effect of ethanol extracts from red pepper seeds on antioxidative defense system and oxidative stress in rats fed high-fat . high-cholesterol diet. 2010 Nutr Res Pract pmid:20198203
Mays JR et al. The synthesis and evaluation of flavone and isoflavone chimeras of novobiocin and derrubone. 2010 Bioorg. Med. Chem. pmid:19932969
Choi CW et al. Yeast α-glucosidase inhibition by isoflavones from plants of Leguminosae as an in vitro alternative to acarbose. 2010 J. Agric. Food Chem. pmid:20734984
Lewin G et al. Semisynthesis of natural flavones inhibiting tubulin polymerization, from hesperidin. 2010 J. Nat. Prod. pmid:20356063
Schrader KK Plant Natural compounds with antibacterial activity towards common pathogens of pond-cultured channel catfish (Ictalurus punctatus). 2010 Toxins (Basel) pmid:22069655
Mitra I et al. Chemometric modeling of free radical scavenging activity of flavone derivatives. 2010 Eur J Med Chem pmid:20800321
Xiao J et al. Structure-affinity relationship of flavones on binding to serum albumins: effect of hydroxyl groups on ring A. 2010 Mol Nutr Food Res pmid:20306480
Chang TL et al. 5,6,3',4'-Tetrahydroxy-7-methoxyflavone as a novel potential proteasome inhibitor. 2010 Planta Med. pmid:20195959
Goettert M et al. Biological evaluation and structural determinants of p38α mitogen-activated-protein kinase and c-Jun-N-terminal kinase 3 inhibition by flavonoids. 2010 Chembiochem pmid:21108268
Wang J et al. Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation. 2010 PLoS ONE pmid:20221395
Nessa F et al. Xanthine oxidase inhibitory activities of extracts and flavonoids of the leaves of Blumea balsamifera. 2010 Pharm Biol pmid:20738223
Liu H et al. New synthetic flavone derivatives induce apoptosis of hepatocarcinoma cells. 2010 Bioorg. Med. Chem. pmid:20674374
Guendel I et al. Inhibition of human immunodeficiency virus type-1 by cdk inhibitors. 2010 AIDS Res Ther pmid:20334651
Gokara M et al. Molecular interaction studies of trimethoxy flavone with human serum albumin. 2010 PLoS ONE pmid:20098677
Chen Q et al. Measurement of total flavone content in snow lotus (Saussurea involucrate) using near infrared spectroscopy combined with interval PLS and genetic algorithm. 2010 Spectrochim Acta A Mol Biomol Spectrosc pmid:20338806
Yashiroda Y et al. A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor. 2010 Biochem. Biophys. Res. Commun. pmid:20214890
Bacher M et al. Complete 1H and 13C NMR data assignment of new constituents from Severinia buxifolia. 2010 Magn Reson Chem pmid:19937908
Kasai N et al. Atypical kinetics of cytochromes P450 catalysing 3'-hydroxylation of flavone from the white-rot fungus Phanerochaete chrysosporium. 2010 J. Biochem. pmid:19819902
Rajesh G et al. Effect of hydroxyl substitution of flavone on angiogenesis and free radical scavenging activities: a structure-activity relationship studies using computational tools. 2010 Eur J Pharm Sci pmid:19874890
Carneiro CD et al. Effect of flavonoids on 2'-deoxyguanosine and DNA oxidation caused by singlet molecular oxygen. 2010 Aug-Sep Food Chem. Toxicol. pmid:20561949
Acharya A et al. Redox regulation in cancer: a double-edged sword with therapeutic potential. 2010 Jan-Feb Oxid Med Cell Longev pmid:20716925
Marczak Ł et al. Fragmentation pathways of acylated flavonoid diglucuronides from leaves of Medicago truncatula. 2010 May-Jun Phytochem Anal pmid:19950391
Mafuvadze B et al. Apigenin blocks induction of vascular endothelial growth factor mRNA and protein in progestin-treated human breast cancer cells. 2010 Sep-Oct Menopause pmid:20551847
Bredebach M et al. Three 2-oxoglutarate-dependent dioxygenase activities of Equisetum arvense L. forming flavone and flavonol from (2S)-naringenin. 2011 Phytochemistry pmid:21353683
Wu LZ et al. Two new flavone C-glycosides from Trollius ledebourii. 2011 Chem. Pharm. Bull. pmid:22041076
Park SR et al. Enhanced flavonoid production in Streptomyces venezuelae via metabolic engineering. 2011 J. Microbiol. Biotechnol. pmid:22127124
Vandeputte OM et al. The flavanone naringenin reduces the production of quorum sensing-controlled virulence factors in Pseudomonas aeruginosa PAO1. 2011 Microbiology (Reading, Engl.) pmid:21546585
Luo H et al. Analysis of the transcriptome of Panax notoginseng root uncovers putative triterpene saponin-biosynthetic genes and genetic markers. 2011 BMC Genomics pmid:22369100
Jeon JG et al. Natural products in caries research: current (limited) knowledge, challenges and future perspective. 2011 Caries Res. pmid:21576957
Lima de Medeiros BJ et al. Liver protective activity of a hydroethanolic extract of Arrabidaea chica (Humb. and Bonpl.) B. Verl. (pariri). 2011 Pharmacognosy Res pmid:21772750
Park NI et al. Enhancement of flavone levels through overexpression of chalcone isomerase in hairy root cultures of Scutellaria baicalensis. 2011 Funct. Integr. Genomics pmid:21538138
Yang C et al. Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-κB/COX-2 pathway. 2011 PLoS ONE pmid:21779360
Son MJ et al. Chrysosplenol C increases contraction in rat ventricular myocytes. 2011 J. Cardiovasc. Pharmacol. pmid:21052017
Han S et al. Herbal extract THI improves metabolic abnormality in mice fed a high-fat diet. 2011 Nutr Res Pract pmid:21779522
Martin C et al. How can research on plants contribute to promoting human health? 2011 Plant Cell pmid:21586682
Tan W et al. Anti-cancer natural products isolated from chinese medicinal herbs. 2011 Chin Med pmid:21777476
Ono M and Saji H SPECT Imaging Agents for Detecting Cerebral β-Amyloid Plaques. 2011 Int J Mol Imaging pmid:21603239
Yao N et al. Novel flavonoids with antiproliferative activities against breast cancer cells. 2011 J. Med. Chem. pmid:21599001
Wera M et al. 3-Hy-droxy-2-(4-meth-oxy-phen-yl)-4H-chromen-4-one. 2011 Acta Crystallogr Sect E Struct Rep Online pmid:21523104
Zolkipli Z et al. Vulnerability to oxidative stress in vitro in pathophysiology of mitochondrial short-chain acyl-CoA dehydrogenase deficiency: response to antioxidants. 2011 PLoS ONE pmid:21483766
Zhang J et al. Studies on the active components and antioxidant activities of the extracts of Mimosa pudica Linn. from southern China. 2011 Pharmacogn Mag pmid:21472077
Theoharides TC and Zhang B Neuro-inflammation, blood-brain barrier, seizures and autism. 2011 J Neuroinflammation pmid:22129087
Lin CC et al. Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. 2011 Int. J. Oncol. pmid:21573491
Seo YJ et al. Apoptotic effects of genistein, biochanin-A and apigenin on LNCaP and PC-3 cells by p21 through transcriptional inhibition of polo-like kinase-1. 2011 J. Korean Med. Sci. pmid:22065906
Yob NJ et al. Zingiber zerumbet (L.) Smith: A Review of Its Ethnomedicinal, Chemical, and Pharmacological Uses. 2011 Evid Based Complement Alternat Med pmid:21584247
Vitalini S et al. Primula spectabilis Tratt. aerial parts: morphology, volatile compounds and flavonoids. 2011 Phytochemistry pmid:21612805
Yin Y et al. Jaceosidin inhibits contact hypersensitivity in mice via down-regulating IFN-γ/STAT1/T-bet signaling in T cells. 2011 Eur. J. Pharmacol. pmid:21093428
Fletcher JN et al. In vitro evaluation of flavonoids from Eriodictyon californicum for antagonist activity against the bitterness receptor hTAS2R31. 2011 J. Agric. Food Chem. pmid:22059530
Phromnoi K et al. A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents. 2011 Mol. Pharmacol. pmid:20930110
Yamagata K et al. Apigenin inhibits tumor necrosis factor alpha plus high glucose-induced LOX-1 expression in human endothelial cells. 2011 Microvasc. Res. pmid:21040737
Shi G et al. Molecular characteristics and antitumor capacity of Glycan extracted from Cynomorium songaricum. 2011 Int. J. Biol. Macromol. pmid:21396396
Chou ST et al. Zanthoxylum ailanthoides Sieb and Zucc. extract inhibits growth and induces cell death through G2/M-phase arrest and activation of apoptotic signals in colo 205 human colon adenocarcinoma cells. 2011 Anticancer Res. pmid:21617225
Baguley BC Preclinical efficacy of vascular disrupting agents in non-small-cell lung cancer. 2011 Clin Lung Cancer pmid:21550553
Zhou T et al. Study of polyethylene glycol as a green solvent in the microwave-assisted extraction of flavone and coumarin compounds from medicinal plants. 2011 J Chromatogr A pmid:21531418
Etinski M et al. Time-dependent approaches for the calculation of intersystem crossing rates. 2011 J Chem Phys pmid:21513373
Polier G et al. Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1. 2011 Cell Death Dis pmid:21776020
Mehla R et al. A flavonoid, luteolin, cripples HIV-1 by abrogation of tat function. 2011 PLoS ONE pmid:22140483
Suyenaga ES et al. Appraisal of the antichemotactic activity of flavonoids on polymorphonuclear neutrophils. 2011 Planta Med. pmid:21058242
Pan SY et al. New perspectives on chinese herbal medicine (zhong-yao) research and development. 2011 Evid Based Complement Alternat Med pmid:21785622
Chahar MK et al. Flavonoids: A versatile source of anticancer drugs. 2011 Pharmacogn Rev pmid:22096313
Samarghandian S et al. Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3. 2011 Clinics (Sao Paulo) pmid:21808878