FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chen IL et al. | Synthesis and antiproliferative evaluation of amide-containing flavone and isoflavone derivatives. | 2008 | Bioorg. Med. Chem. | pmid:18662883 |
| Dong X et al. | Identification of SVM-based classification model, synthesis and evaluation of prenylated flavonoids as vasorelaxant agents. | 2008 | Bioorg. Med. Chem. | pmid:18678502 |
| Najmus-Saqib Q et al. | Antimicrobial and cytotoxicity activities of the medicinal plant Primula macrophylla. | 2009 | J Enzyme Inhib Med Chem | pmid:18686139 |
| Ji W et al. | Hypolipidaemic mechanisms of action of CM108 (a flavone derivative) in hyperlipidaemic rats. | 2008 | J. Pharm. Pharmacol. | pmid:18718125 |
| Kaur P et al. | Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study. | 2008 | Carcinogenesis | pmid:18725386 |
| Shih CH et al. | Functional characterization of key structural genes in rice flavonoid biosynthesis. | 2008 | Planta | pmid:18726614 |
| Shukla S and Gupta S | Apigenin suppresses insulin-like growth factor I receptor signaling in human prostate cancer: an in vitro and in vivo study. | 2009 | Mol. Carcinog. | pmid:18726972 |
| Russo EB | Cannabinoids in the management of difficult to treat pain. | 2008 | Ther Clin Risk Manag | pmid:18728714 |
| Luo P et al. | Scutellarin isolated from Erigeron multiradiatus inhibits high glucose-mediated vascular inflammation. | 2008 | Yakugaku Zasshi | pmid:18758143 |
| Lawrence CJ et al. | MaizeGDB: The maize model organism database for basic, translational, and applied research. | 2008 | Int J Plant Genomics | pmid:18769488 |
| Lv W et al. | Jaceosidin induces apoptosis in human ovary cancer cells through mitochondrial pathway. | 2008 | J. Biomed. Biotechnol. | pmid:18769496 |
| Meng Y et al. | Flavones and flavone glycosides from Halophila johnsonii. | 2008 | Phytochemistry | pmid:18771781 |
| Wu D et al. | D-Alanine:D-alanine ligase as a new target for the flavonoids quercetin and apigenin. | 2008 | Int. J. Antimicrob. Agents | pmid:18774266 |
| Li G et al. | Effects of elevated CO(2) and O(3) on phenolic compounds in spring wheat and maize leaves. | 2008 | Bull Environ Contam Toxicol | pmid:18781273 |
| Hájek T et al. | Multidimensional LC x LC analysis of phenolic and flavone natural antioxidants with UV-electrochemical coulometric and MS detection. | 2008 | J Sep Sci | pmid:18792009 |
| Wang YZ et al. | In vivo effects of Pain Relieving Plaster on closed soft tissue injury in rabbit ears. | 2008 | BMC Complement Altern Med | pmid:18793392 |
| Martins VP et al. | Mitochondrial function in the yeast form of the pathogenic fungus Paracoccidioides brasiliensis. | 2008 | J. Bioenerg. Biomembr. | pmid:18797987 |
| Lanoë PH et al. | Cyclometallated platinum(II) complexes incorporating ethynyl-flavone ligands: switching between triplet and singlet emission induced by selective binding of Pb2+ ions. | 2008 | Chem. Commun. (Camb.) | pmid:18802561 |
| Cesla P et al. | Optimization of two-dimensional gradient liquid chromatography separations. | 2009 | J Chromatogr A | pmid:18804770 |
| Li GM et al. | [Effects of elevated carbon dioxide and ozone on the growth and secondary metabolism of spring wheat]. | 2008 | Ying Yong Sheng Tai Xue Bao | pmid:18808021 |
| Rezai-Zadeh K et al. | Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression. | 2008 | J Neuroinflammation | pmid:18817573 |
| Aravind SG et al. | Semi-preparative HPLC preparation and HPTLC quantification of tetrahydroamentoflavone as marker in Semecarpus anacardium and its polyherbal formulations. | 2008 | J Pharm Biomed Anal | pmid:18823732 |
| Das B et al. | Diterpenoids from Jatropha multifida. | 2008 | Phytochemistry | pmid:18823921 |
| Guo QS et al. | [Study on dynamic accumulation of flavone in various Chrysanthemum morifolium for medicine]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18831193 |
| Nilsson J et al. | Azaflavones compared to flavones as ligands to the benzodiazepine binding site of brain GABA(A) receptors. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18851913 |
| Zhou X et al. | Flavone and isoflavone derivatives of terrestrial plants as larval settlement inhibitors of the barnacle Balanus amphitrite. | 2009 | Biofouling | pmid:18855151 |
| Seelinger G et al. | Anti-oxidant, anti-inflammatory and anti-allergic activities of luteolin. | 2008 | Planta Med. | pmid:18937165 |
| Alipieva KI et al. | An iridoid and a flavonoid from Sideritis lanata L. | 2009 | Fitoterapia | pmid:18938229 |
| Soriano IR et al. | Inducible Flavone in Oats (Avena sativa) Is a Novel Defense Against Plant-Parasitic Nematodes. | 2004 | Phytopathology | pmid:18944456 |
| Chen HQ et al. | Luteolin protects dopaminergic neurons from inflammation-induced injury through inhibition of microglial activation. | 2008 | Neurosci. Lett. | pmid:18952146 |
| Perumal Samy R and Gopalakrishnakone P | Therapeutic Potential of Plants as Anti-microbials for Drug Discovery. | 2010 | Evid Based Complement Alternat Med | pmid:18955349 |
| Baranowska I and Raróg D | Application of derivative spectrophotometry to determination of flavonoid mixtures. | 2001 | Talanta | pmid:18968363 |
| Toyo'oka T et al. | On-line screening methods for antioxidants scavenging superoxide anion radical and hydrogen peroxide by liquid chromatography with indirect chemiluminescence detection. | 2003 | Talanta | pmid:18969068 |
| Chen LL et al. | [Effect of nebulized TFG on Th1/Th2 imbalance in mouse model with asthma]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19007018 |
| Brunskole M et al. | Trihydroxynaphthalene reductase of Curvularia lunata--a target for flavonoid action? | 2009 | Chem. Biol. Interact. | pmid:19010313 |
| Horvath DP et al. | Transcriptome analysis identifies novel responses and potential regulatory genes involved in seasonal dormancy transitions of leafy spurge (Euphorbia esula L.). | 2008 | BMC Genomics | pmid:19014493 |
| Gupta PJ and Kalaskar S | Ligation and mucopexy for prolapsing hemorrhoids--a ten year experience. | 2008 | Ann Surg Innov Res | pmid:19038061 |
| Jiang L et al. | Analysis of flavonoids in propolis and Ginkgo biloba by micellar electrokinetic capillary chromatography. | 2008 | J. Agric. Food Chem. | pmid:19053353 |
| Si D et al. | Mechanism of CYP2C9 inhibition by flavones and flavonols. | 2009 | Drug Metab. Dispos. | pmid:19074529 |
| Shiono M et al. | Structure of commelinin, a blue complex pigment from the blue flowers of Commelina communis. | 2008 | Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. | pmid:19075517 |
| Justino GC et al. | Electrospray ionization tandem mass spectrometry fragmentation of protonated flavone and flavonol aglycones: a re-examination. | 2009 | Rapid Commun. Mass Spectrom. | pmid:19089862 |
| Wang Y et al. | Screening Antitumor Compounds Psoralen and Isopsoralen from Psoralea corylifolia L. Seeds. | 2011 | Evid Based Complement Alternat Med | pmid:19131395 |
| Lee EA et al. | Robustness of QTLs across germplasm pools using a model quantitative trait. | 2009 | Genome | pmid:19132070 |
| Gong T et al. | Novel benzil and isoflavone derivatives from Millettia dielsiana. | 2009 | Planta Med. | pmid:19140097 |
| López-Lázaro M | Distribution and biological activities of the flavonoid luteolin. | 2009 | Mini Rev Med Chem | pmid:19149659 |
| Wang GH et al. | [Optimal extraction of nuciferine and flavone from lotus leaf based on central composite design and response surface methodology]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19157120 |
| Jeong SH et al. | Tyrosinase inhibitory polyphenols from roots of Morus lhou. | 2009 | J. Agric. Food Chem. | pmid:19166303 |
| Bjorøy O et al. | C-glycosylanthocyanidins synthesized from C-glycosylflavones. | 2009 | Phytochemistry | pmid:19185884 |
| Shin EK et al. | Chrysin, a natural flavone, improves murine inflammatory bowel diseases. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19233127 |
| Marian CM | Spin-forbidden transitions in flavone. | 2009 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:19264543 |