FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Goettert M et al. | Biological evaluation and structural determinants of p38α mitogen-activated-protein kinase and c-Jun-N-terminal kinase 3 inhibition by flavonoids. | 2010 | Chembiochem | pmid:21108268 |
Yang Y et al. | Binding research on flavones as ligands of β-amyloid aggregates by fluorescence and their 3D-QSAR, docking studies. | 2010 | J. Mol. Graph. Model. | pmid:21094069 |
Yin Y et al. | Jaceosidin inhibits contact hypersensitivity in mice via down-regulating IFN-γ/STAT1/T-bet signaling in T cells. | 2011 | Eur. J. Pharmacol. | pmid:21093428 |
Seo S et al. | Cyanide, a coproduct of plant hormone ethylene biosynthesis, contributes to the resistance of rice to blast fungus. | 2011 | Plant Physiol. | pmid:21075959 |
Wootten D et al. | Modulation of the glucagon-like peptide-1 receptor signaling by naturally occurring and synthetic flavonoids. | 2011 | J. Pharmacol. Exp. Ther. | pmid:21075839 |
Madeira PJ et al. | Electrospray ionization Fourier transform ion cyclotron resonance mass spectrometric and semi-empirical calculations study of five isoflavone aglycones. | 2010 | Rapid Commun. Mass Spectrom. | pmid:21072799 |
Guttikonda SK et al. | Whole genome co-expression analysis of soybean cytochrome P450 genes identifies nodulation-specific P450 monooxygenases. | 2010 | BMC Plant Biol. | pmid:21062474 |
Baguley BC and McKeage MJ | ASA404: a tumor vascular-disrupting agent with broad potential for cancer therapy. | 2010 | Future Oncol | pmid:21062153 |
Kumar GS et al. | Synthesis and biological evaluation of novel benzyl-substituted flavones as free radical (DPPH) scavengers and α-glucosidase inhibitors. | 2010 | J Asian Nat Prod Res | pmid:21061220 |
Suyenaga ES et al. | Appraisal of the antichemotactic activity of flavonoids on polymorphonuclear neutrophils. | 2011 | Planta Med. | pmid:21058242 |
Zhang Y et al. | Dietary flavonol and flavone intakes and their major food sources in Chinese adults. | 2010 | Nutr Cancer | pmid:21058200 |
Yen JH et al. | Glycine tomentella Hayata inhibits IL-1β and IL-6 production, inhibits MMP-9 activity, and enhances RAW264.7 macrophage clearance of apoptotic cells. | 2010 | J. Biomed. Sci. | pmid:21054849 |
Shimada T et al. | Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives. | 2010 | Chem. Res. Toxicol. | pmid:21053930 |
Son MJ et al. | Chrysosplenol C increases contraction in rat ventricular myocytes. | 2011 | J. Cardiovasc. Pharmacol. | pmid:21052017 |
Attimarad M | Liquid Chromatographic Determination of Flavoxate HCl in Pharmaceutical Formulation. | 2010 | J Young Pharm | pmid:21042486 |
Yamagata K et al. | Apigenin inhibits tumor necrosis factor alpha plus high glucose-induced LOX-1 expression in human endothelial cells. | 2011 | Microvasc. Res. | pmid:21040737 |
Chen CC et al. | Calcium- and phosphatidylinositol 3-kinase/Akt-dependent activation of endothelial nitric oxide synthase by apigenin. | 2010 | Life Sci. | pmid:21034748 |
Kundu S and Roy D | Structural study of biologically significant ligands with major birch pollen allergen Betv1 by docking and molecular dynamics simulation. | 2010 | Bioinformation | pmid:20978606 |
Meng X et al. | Effects of Various Flavonoids on the α-Synuclein Fibrillation Process. | 2010 | Parkinsons Dis | pmid:20976092 |
Charkoudian LK et al. | In living color: bacterial pigments as an untapped resource in the classroom and beyond. | 2010 | PLoS Biol. | pmid:20957190 |
Jayaraman P et al. | Activity and interactions of antibiotic and phytochemical combinations against Pseudomonas aeruginosa in vitro. | 2010 | Int. J. Biol. Sci. | pmid:20941374 |
Gülcemal D et al. | Phenolic Glycosides with antiproteasomal activity from Centaurea urvillei DC. subsp. urvillei. | 2010 | Carbohydr. Res. | pmid:20937505 |
Cai RL et al. | Antihypertensive effect of total flavone extracts from Puerariae Radix. | 2011 | J Ethnopharmacol | pmid:20933075 |
Wang SQ et al. | Flavonoids from Dracocephalum tanguticum and their cardioprotective effects against doxorubicin-induced toxicity in H9c2 cells. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20932762 |
Chatuphonprasert W et al. | Potent modification of inducible CYP1A1 expression by flavonoids. | 2010 | Biol. Pharm. Bull. | pmid:20930378 |
Phromnoi K et al. | A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents. | 2011 | Mol. Pharmacol. | pmid:20930110 |
Lakhan SE and Vieira KF | Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review. | 2010 | Nutr J | pmid:20929532 |
Fransen HP et al. | Assessment of health claims, content, and safety of herbal supplements containing Ginkgo biloba. | 2010 | Food Nutr Res | pmid:20927202 |
Wang YJ et al. | Computational analysis for hepatic safety signals of constituents present in botanical extracts widely used by women in the United States for treatment of menopausal symptoms. | 2011 | Regul. Toxicol. Pharmacol. | pmid:20920542 |
Kanth BK et al. | Homology modeling, binding site identification and docking in flavone hydroxylase CYP105P2 in Streptomyces peucetius ATCC 27952. | 2010 | Comput Biol Chem | pmid:20889382 |
Alvarez G et al. | Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity. | 2010 | Eur J Med Chem | pmid:20889239 |
Chirumbolo S | The role of quercetin, flavonols and flavones in modulating inflammatory cell function. | 2010 | Inflamm Allergy Drug Targets | pmid:20887269 |
Cao H et al. | Binding Citrus flavanones to human serum albumin: effect of structure on affinity. | 2011 | Mol. Biol. Rep. | pmid:20878474 |
Sasaki K et al. | Functional divergence within class B MADS-box genes TfGLO and TfDEF in Torenia fournieri Lind. | 2010 | Mol. Genet. Genomics | pmid:20872230 |
Wang XH et al. | Screen of micro-organisms for inducing the production of dragon's blood by leaf of Dracaena cochinchinensis. | 2010 | Lett. Appl. Microbiol. | pmid:20860774 |
Zhang C et al. | Functional characterization of cis-acting elements mediating flavone-inducible expression of CYP321A1. | 2010 | Insect Biochem. Mol. Biol. | pmid:20854909 |
Guo W et al. | Antagonistic effect of flavonoids on NSC-741909-mediated antitumor activity via scavenging of reactive oxygen species. | 2010 | Eur. J. Pharmacol. | pmid:20854805 |
Luo H et al. | Comparison of 454-ESTs from Huperzia serrata and Phlegmariurus carinatus reveals putative genes involved in lycopodium alkaloid biosynthesis and developmental regulation. | 2010 | BMC Plant Biol. | pmid:20854695 |
Zhang Y et al. | Reproducibility and relative validity of a food frequency questionnaire to assess intake of dietary flavonol and flavone in Chinese university campus population. | 2010 | Nutr Res | pmid:20851305 |
Chen EP et al. | A mechanism-based mathematical model of aryl hydrocarbon receptor-mediated CYP1A induction in rats using beta-naphthoflavone as a tool compound. | 2010 | Drug Metab. Dispos. | pmid:20843940 |
Perez-Vizcaino F and Duarte J | Flavonols and cardiovascular disease. | 2010 | Mol. Aspects Med. | pmid:20837053 |
Yamada K et al. | A lipase inhibitor monoterpene and monoterpene glycosides from Monarda punctata. | 2010 | Phytochemistry | pmid:20832830 |
Ragab FA et al. | Synthesis and anticonvulsant activity of certain substituted furochromone, benzofuran and flavone derivatives. | 2010 | Chem. Pharm. Bull. | pmid:20823592 |
Stark JL et al. | Solution structure and function of YndB, an AHSA1 protein from Bacillus subtilis. | 2010 | Proteins | pmid:20818668 |
Kang KP et al. | Luteolin ameliorates cisplatin-induced acute kidney injury in mice by regulation of p53-dependent renal tubular apoptosis. | 2011 | Nephrol. Dial. Transplant. | pmid:20817674 |
Pichichero E et al. | Acacia honey and chrysin reduce proliferation of melanoma cells through alterations in cell cycle progression. | 2010 | Int. J. Oncol. | pmid:20811719 |
Wang P et al. | Structural basis for certain naturally occurring bioflavonoids to function as reducing co-substrates of cyclooxygenase I and II. | 2010 | PLoS ONE | pmid:20808785 |
Goodger JQ et al. | Isolation of intact sub-dermal secretory cavities from Eucalyptus. | 2010 | Plant Methods | pmid:20807444 |
Patra JC and Chua BH | Artificial neural network-based drug design for diabetes mellitus using flavonoids. | 2011 | J Comput Chem | pmid:20806262 |
Kim MJ et al. | TNF-α induces expression of urokinase-type plasminogen activator and β-catenin activation through generation of ROS in human breast epithelial cells. | 2010 | Biochem. Pharmacol. | pmid:20804741 |