FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shih CH et al. | Functional characterization of key structural genes in rice flavonoid biosynthesis. | 2008 | Planta | pmid:18726614 |
| Chen IL et al. | Synthesis and antiproliferative evaluation of amide-containing flavone and isoflavone derivatives. | 2008 | Bioorg. Med. Chem. | pmid:18662883 |
| Zhao Z et al. | Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats. | 2008 | Behav. Brain Res. | pmid:18655806 |
| Hara T et al. | Flavopiridol potentiates the cytotoxic effects of radiation in radioresistant tumor cells in which p53 is mutated or Bcl-2 is overexpressed. | 2008 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:18640498 |
| Furtmueller R et al. | 6,3'-Dinitroflavone is a low efficacy modulator of GABA(A) receptors. | 2008 | Eur. J. Pharmacol. | pmid:18639544 |
| Yang L et al. | Compound Chinese herbal medicinal ingredients can enhance immune response and efficacy of RHD vaccine in rabbit. | 2008 | Vaccine | pmid:18602959 |
| Shiono M et al. | Structure of commelinin, a blue complex pigment from the blue flowers of Commelina communis. | 2008 | Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. | pmid:19075517 |
| Campos DA et al. | Gastroprotective effect of a flavone from Lonchocarpus araripensis Benth. (Leguminosae) and the possible mechanism. | 2008 | J. Pharm. Pharmacol. | pmid:18284821 |
| Liao SY et al. | QSAR, action mechanism and molecular design of flavone and isoflavone derivatives with cytotoxicity against HeLa. | 2008 | Eur J Med Chem | pmid:18082913 |
| Gobbo-Neto L and Lopes NP | Online identification of chlorogenic acids, sesquiterpene lactones, and flavonoids in the Brazilian arnica Lychnophora ericoides Mart. (Asteraceae) leaves by HPLC-DAD-MS and HPLC-DAD-MS/MS and a validated HPLC-DAD method for their simultaneous analysis. | 2008 | J. Agric. Food Chem. | pmid:18237124 |
| Winkelmann I et al. | Proteome response in HT-29 human colorectal cancer cells to two apoptosis-inducing compounds with different mode of action. | 2008 | Int. J. Cancer | pmid:18214853 |
| Yamada P et al. | Inhibitory effect of various Tunisian olive oils on chemical mediator release and cytokine production by basophilic cells. | 2008 | J Ethnopharmacol | pmid:18178046 |
| Djeridane A et al. | Inhibition of porcine liver carboxylesterase by a new flavone glucoside isolated from Deverra scoparia. | 2008 | Chem. Biol. Interact. | pmid:18163984 |
| Jandera P et al. | Optimization of separation in two-dimensional high-performance liquid chromatography by adjusting phase system selectivity and using programmed elution techniques. | 2008 | J Chromatogr A | pmid:18067903 |
| Ulanovskaya OA et al. | Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide. | 2008 | Nat. Chem. Biol. | pmid:18516048 |
| Quintieri L et al. | Flavonoids diosmetin and luteolin inhibit midazolam metabolism by human liver microsomes and recombinant CYP 3A4 and CYP3A5 enzymes. | 2008 | Biochem. Pharmacol. | pmid:18191104 |
| Lee YJ et al. | Characterization of flavone synthase I from rice. | 2008 | BMB Rep | pmid:18304453 |
| Mishra KP et al. | Effect of Seabuckthorn (Hippophae rhamnoides) flavone on immune system: an in-vitro approach. | 2008 | Phytother Res | pmid:18570236 |
| Lee YU et al. | Inhibition of developmental processes by flavone in Caenorhabditis elegans and its application to the pinewood nematode, Bursaphelenchus xylophilus. | 2008 | Mol. Cells | pmid:18596412 |
| Zhao C et al. | [Study on anti-diabetes active fraction and constituents from Potentilla chinesis]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18590200 |
| Rudolf JL et al. | The influence of diet composition on phase I and II biotransformation enzyme induction. | 2008 | Arch. Toxicol. | pmid:18488195 |
| Meng Y et al. | Flavones and flavone glycosides from Halophila johnsonii. | 2008 | Phytochemistry | pmid:18771781 |
| Toulmin A et al. | Toward prediction of alkane/water partition coefficients. | 2008 | J. Med. Chem. | pmid:18558667 |
| Dong X et al. | Identification of SVM-based classification model, synthesis and evaluation of prenylated flavonoids as vasorelaxant agents. | 2008 | Bioorg. Med. Chem. | pmid:18678502 |
| Zhai K et al. | Chrysin induces hyperalgesia via the GABAA receptor in mice. | 2008 | Planta Med. | pmid:18612941 |
| Mirzoeva S et al. | Inhibition of HIF-1 alpha and VEGF expression by the chemopreventive bioflavonoid apigenin is accompanied by Akt inhibition in human prostate carcinoma PC3-M cells. | 2008 | Mol. Carcinog. | pmid:18240292 |
| Takahashi-Ando N et al. | A screening system for inhibitors of trichothecene biosynthesis: hydroxylation of trichodiene as a target. | 2008 | Biotechnol. Lett. | pmid:18239857 |
| Kumar S et al. | Pharmacological evaluation of Bioactive Principle of Turnera aphrodisiaca. | 2008 | Indian J Pharm Sci | pmid:21369434 |
| Puckette MC et al. | Transcriptomic changes induced by acute ozone in resistant and sensitive Medicago truncatula accessions. | 2008 | BMC Plant Biol. | pmid:18433496 |
| Shukla S and Gupta S | Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation. | 2008 | Free Radic. Biol. Med. | pmid:18342637 |
| Yun CS et al. | Expression of parsley flavone synthase I establishes the flavone biosynthetic pathway in Arabidopsis thaliana. | 2008 | Biosci. Biotechnol. Biochem. | pmid:18391443 |
| Tarling CA et al. | The search for novel human pancreatic alpha-amylase inhibitors: high-throughput screening of terrestrial and marine natural product extracts. | 2008 | Chembiochem | pmid:18214874 |
| Wu D et al. | D-Alanine:D-alanine ligase as a new target for the flavonoids quercetin and apigenin. | 2008 | Int. J. Antimicrob. Agents | pmid:18774266 |
| Wu B et al. | Metabonomic study on ageing: NMR-based investigation into rat urinary metabolites and the effect of the total flavone of Epimedium. | 2008 | Mol Biosyst | pmid:18633487 |
| Herath W et al. | Microbial metabolism part 9. Structure and antioxidant significance of the metabolites of 5,7-dihydroxyflavone (chrysin), and 5- and 6-hydroxyflavones. | 2008 | Chem. Pharm. Bull. | pmid:18379084 |
| Barbera M et al. | The ability of coumarin-, flavanon- and flavonol-analogues of flavone acetic acid to stimulate human monocytes. | 2008 | Oncol. Rep. | pmid:18097594 |
| Ryu YB et al. | Inhibitory effects on mushroom tyrosinase by flavones from the stem barks of Morus lhou (S.) Koidz. | 2008 | J Enzyme Inhib Med Chem | pmid:18608767 |
| Ji W et al. | Hypolipidaemic mechanisms of action of CM108 (a flavone derivative) in hyperlipidaemic rats. | 2008 | J. Pharm. Pharmacol. | pmid:18718125 |
| Gupta PJ and Kalaskar S | Ligation and mucopexy for prolapsing hemorrhoids--a ten year experience. | 2008 | Ann Surg Innov Res | pmid:19038061 |
| Horvath DP et al. | Transcriptome analysis identifies novel responses and potential regulatory genes involved in seasonal dormancy transitions of leafy spurge (Euphorbia esula L.). | 2008 | BMC Genomics | pmid:19014493 |
| Rachchh MA and Jain SM | Gastroprotective effect of Benincasa hispida fruit extract. | 2008 | Indian J Pharmacol | pmid:21279184 |
| Heller G et al. | Transcriptional analysis of Pinus sylvestris roots challenged with the ectomycorrhizal fungus Laccaria bicolor. | 2008 | BMC Plant Biol. | pmid:18298811 |
| Henry EC and Gasiewicz TA | Molecular determinants of species-specific agonist and antagonist activity of a substituted flavone towards the aryl hydrocarbon receptor. | 2008 | Arch. Biochem. Biophys. | pmid:18294953 |
| Takada Y et al. | Flavopiridol suppresses tumor necrosis factor-induced activation of activator protein-1, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase (MAPK), p44/p42 MAPK, and Akt, inhibits expression of antiapoptotic gene products, and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells. | 2008 | Mol. Pharmacol. | pmid:18287248 |
| Bovee TF et al. | Screening of synthetic and plant-derived compounds for (anti)estrogenic and (anti)androgenic activities. | 2008 | Anal Bioanal Chem | pmid:18188547 |
| Liu B and Yang BL | Poly[(μ-5,7-dihydr-oxy-4-oxo-2-phenyl-4H-chromene-8-sulfonato)potassium(I)]. | 2008 | Acta Crystallogr Sect E Struct Rep Online | pmid:21581534 |
| Liu B and Yang BL | Hexaaqua-(5,7-dihydr-oxy-4-oxo-2-phenyl-4H-chromene-8-sulfonato)calcium(II) 5,7-dihydr-oxy-4-oxo-2-phenyl-4H-chromene-8-sulfonate trihydrate. | 2008 | Acta Crystallogr Sect E Struct Rep Online | pmid:21581174 |
| Shanmugam K et al. | Plant-derived polyphenols attenuate lipopolysaccharide-induced nitric oxide and tumour necrosis factor production in murine microglia and macrophages. | 2008 | Mol Nutr Food Res | pmid:18186104 |
| Wang XL et al. | Effects of eleven flavonoids from the osteoprotective fraction of Drynaria fortunei (KUNZE) J. SM. on osteoblastic proliferation using an osteoblast-like cell line. | 2008 | Chem. Pharm. Bull. | pmid:18175973 |
| Wang GH et al. | [Optimal extraction of nuciferine and flavone from lotus leaf based on central composite design and response surface methodology]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19157120 |