FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Boyle SP et al. | Evaluation of quality control strategies in Scutellaria herbal medicines. | 2011 | J Pharm Biomed Anal | pmid:21163602 |
pmid:21176927 | ||||
Baxter A et al. | Non-covalent inhibitors of rhinovirus 3C protease. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21183345 |
Ramachandran G et al. | 2-(5,7-Dimeth-oxy-4-oxo-4H-chromen-2-yl)phenyl 4-toluene-sulfonate. | 2008 | Acta Crystallogr Sect E Struct Rep Online | pmid:21203275 |
Duan K et al. | LC-MS/MS determination and pharmacokinetic study of five flavone components after solvent extraction/acid hydrolysis in rat plasma after oral administration of Verbena officinalis L. extract. | 2011 | J Ethnopharmacol | pmid:21220003 |
Gasiorowski K et al. | Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? | 2011 | CNS Neurol Disord Drug Targets | pmid:21222632 |
Jin J et al. | Design, synthesis and biological evaluation of new arylpiperazine derivatives bearing a flavone moiety as α1-adrenoceptor antagonists. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21236664 |
Fan Y et al. | Epimedium polysaccharide and propolis flavone can synergistically inhibit the cellular infectivity of NDV and improve the curative effect of ND in chicken. | 2011 | Int. J. Biol. Macromol. | pmid:21238483 |
Fang W et al. | Flavonoids from the aerial parts of Macrothelypteris torresiana. | 2011 | Nat. Prod. Res. | pmid:21240759 |
Asakawa T et al. | PET imaging of nobiletin based on a practical total synthesis. | 2011 | Chem. Commun. (Camb.) | pmid:21243163 |
Garateix A et al. | Antinociception produced by Thalassia testudinum extract BM-21 is mediated by the inhibition of acid sensing ionic channels by the phenolic compound thalassiolin B. | 2011 | Mol Pain | pmid:21261973 |
Kurian G et al. | A Novel Approach for Oral Delivery of Insulin via Desmodium gangeticum Aqueous Root Extract. | 2010 | J Young Pharm | pmid:21264119 |
Zuk M et al. | Flavonoid engineering of flax potentiate its biotechnological application. | 2011 | BMC Biotechnol. | pmid:21276227 |
Rachchh MA and Jain SM | Gastroprotective effect of Benincasa hispida fruit extract. | 2008 | Indian J Pharmacol | pmid:21279184 |
Larroque-Lombard AL et al. | Synthesis and studies on three-compartment flavone-containing combi-molecules designed to target EGFR, DNA, and MEK. | 2011 | Chem Biol Drug Des | pmid:21294849 |
Lefort EC and Blay J | The dietary flavonoid apigenin enhances the activities of the anti-metastatic protein CD26 on human colon carcinoma cells. | 2011 | Clin. Exp. Metastasis | pmid:21298326 |
Kloska A et al. | Effects of flavonoids on glycosaminoglycan synthesis: implications for substrate reduction therapy in Sanfilippo disease and other mucopolysaccharidoses. | 2011 | Metab Brain Dis | pmid:21305347 |
Marinova MD and Tchorbanov BP | Preparation of antioxidant enzymatic hydrolysates from honeybee-collected pollen using plant enzymes. | 2011 | Enzyme Res | pmid:21318132 |
Zeng YW et al. | [The zonal characteristics and cultivated types difference of functional components in brown rice for core collection of Yunnan rice]. | 2010 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:21322246 |
Perry CN et al. | Xenotransplantation of mitochondrial electron transfer enzyme, Ndi1, in myocardial reperfusion injury. | 2011 | PLoS ONE | pmid:21339825 |
Mazzio EA et al. | The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. | 2011 | Int J Mol Sci | pmid:21340000 |
Hämäläinen M et al. | Effects of flavonoids on prostaglandin E2 production and on COX-2 and mPGES-1 expressions in activated macrophages. | 2011 | Planta Med. | pmid:21341175 |
Schmidt A et al. | Polymethylated myricetin in trichomes of the wild tomato species Solanum habrochaites and characterization of trichome-specific 3'/5'- and 7/4'-myricetin O-methyltransferases. | 2011 | Plant Physiol. | pmid:21343428 |
Masoodi TA and Alhamdanz AH | Inhibitory effect of flavonoids on mutant H-Rasp protein. | 2010 | Bioinformation | pmid:21346872 |
Guo SS et al. | [The cytology mechanism of anti-parainfluenza virus infection of total flavone of Scutellaria barbata]. | 2009 | Yao Xue Xue Bao | pmid:21351467 |
Bredebach M et al. | Three 2-oxoglutarate-dependent dioxygenase activities of Equisetum arvense L. forming flavone and flavonol from (2S)-naringenin. | 2011 | Phytochemistry | pmid:21353683 |
Semwal RB et al. | Chemical constituents from the stem bark of Symplocos paniculata Thunb. with antimicrobial, analgesic and anti-inflammatory activities. | 2011 | J Ethnopharmacol | pmid:21354288 |
Pick A et al. | Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP). | 2011 | Bioorg. Med. Chem. | pmid:21354800 |
Kumar S et al. | Pharmacological evaluation of Bioactive Principle of Turnera aphrodisiaca. | 2008 | Indian J Pharm Sci | pmid:21369434 |
Shi G et al. | Molecular characteristics and antitumor capacity of Glycan extracted from Cynomorium songaricum. | 2011 | Int. J. Biol. Macromol. | pmid:21396396 |
Zhang JW et al. | Structural elucidation of a new flavone from Sarcopyramis nepalensis. | 2011 | J Asian Nat Prod Res | pmid:21409688 |
Rasoanaivo P et al. | Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions. | 2011 | Malar. J. | pmid:21411015 |
Manhita A et al. | Extracting natural dyes from wool--an evaluation of extraction methods. | 2011 | Anal Bioanal Chem | pmid:21416400 |
Novy P et al. | In vitro synergistic effects of baicalin with oxytetracycline and tetracycline against Staphylococcus aureus. | 2011 | J. Antimicrob. Chemother. | pmid:21421582 |
Kim JY et al. | Isolation of cholinesterase-inhibiting flavonoids from Morus lhou. | 2011 | J. Agric. Food Chem. | pmid:21434689 |
Kochevenko A and Fernie AR | The genetic architecture of branched-chain amino acid accumulation in tomato fruits. | 2011 | J. Exp. Bot. | pmid:21436187 |
Mladěnka P et al. | In vitro analysis of iron chelating activity of flavonoids. | 2011 | J. Inorg. Biochem. | pmid:21450273 |
Pham MH et al. | Identification and induction of cytochrome P450s involved in the metabolism of flavone-8-acetic acid in mice. | 2011 | Drug Metab Lett | pmid:21457135 |
Li LJ et al. | Flavans from the leaf of Ilex centrochinensis. | 2011 | J Asian Nat Prod Res | pmid:21462042 |
Zhao J et al. | MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula. | 2011 | Plant Cell | pmid:21467581 |
Zhang J et al. | Studies on the active components and antioxidant activities of the extracts of Mimosa pudica Linn. from southern China. | 2011 | Pharmacogn Mag | pmid:21472077 |
Zolkipli Z et al. | Vulnerability to oxidative stress in vitro in pathophysiology of mitochondrial short-chain acyl-CoA dehydrogenase deficiency: response to antioxidants. | 2011 | PLoS ONE | pmid:21483766 |
Neves MP et al. | Prenylated derivatives of baicalein and 3,7-dihydroxyflavone: synthesis and study of their effects on tumor cell lines growth, cell cycle and apoptosis. | 2011 | Eur J Med Chem | pmid:21496973 |
Etinski M et al. | Time-dependent approaches for the calculation of intersystem crossing rates. | 2011 | J Chem Phys | pmid:21513373 |
Wera M et al. | 3-Hy-droxy-2-(4-meth-oxy-phen-yl)-4H-chromen-4-one. | 2011 | Acta Crystallogr Sect E Struct Rep Online | pmid:21523104 |
Zhou T et al. | Study of polyethylene glycol as a green solvent in the microwave-assisted extraction of flavone and coumarin compounds from medicinal plants. | 2011 | J Chromatogr A | pmid:21531418 |
Huang CH et al. | Natural flavone kaempferol suppresses chemokines expression in human monocyte THP-1 cells through MAPK pathways. | 2010 | J. Food Sci. | pmid:21535503 |
Park NI et al. | Enhancement of flavone levels through overexpression of chalcone isomerase in hairy root cultures of Scutellaria baicalensis. | 2011 | Funct. Integr. Genomics | pmid:21538138 |
Vandeputte OM et al. | The flavanone naringenin reduces the production of quorum sensing-controlled virulence factors in Pseudomonas aeruginosa PAO1. | 2011 | Microbiology (Reading, Engl.) | pmid:21546585 |
Baguley BC | Preclinical efficacy of vascular disrupting agents in non-small-cell lung cancer. | 2011 | Clin Lung Cancer | pmid:21550553 |