FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Goyal N et al. | Ethynylflavones, highly potent, and selective inhibitors of cytochrome P450 1A1. | 2014 | Chem. Res. Toxicol. | pmid:25033111 |
Prasad VG et al. | Iminoflavones combat 1,2-dimethyl hydrazine-induced aberrant crypt foci development in colon cancer. | 2014 | Biomed Res Int | pmid:24995310 |
Li LZ et al. | Flavonoids and other constituents from Aletris spicata and their chemotaxonomic significance. | 2014 | Nat. Prod. Res. | pmid:24896299 |
Yan J et al. | GmFNSII-controlled soybean flavone metabolism responds to abiotic stresses and regulates plant salt tolerance. | 2014 | Plant Cell Physiol. | pmid:24192294 |
Barreca D et al. | First evidence of C- and O-glycosyl flavone in blood orange (Citrus sinensis (L.) Osbeck) juice and their influence on antioxidant properties. | 2014 | Food Chem | pmid:24295703 |
Wang MH et al. | A new antioxidant flavone glycoside from Scutellaria baicalensis Georgi. | 2014 | Nat. Prod. Res. | pmid:24995563 |
Ahmed N et al. | Design, synthesis and antiproliferative activity of functionalized flavone-triazole-tetrahydropyran conjugates against human cancer cell lines. | 2014 | Eur J Med Chem | pmid:24941129 |
Raghav N and Garg S | SAR studies of o-hydroxychalcones and their cyclized analogs and study them as novel inhibitors of cathepsin B and cathepsin H. | 2014 | Eur J Pharm Sci | pmid:24780403 |
Berczyński P et al. | Studies on the antioxidant activity of some thiazolidinedione, imidazolidinedione and rhodanine derivatives having a flavone core. | 2014 | Luminescence | pmid:24733694 |
Venditti A et al. | A C-methylated resacetophenone from Cistus monspeliensis L. | 2014 | Fitoterapia | pmid:24685506 |
Lin SH and Shih YW | Antitumor effects of the flavone chalcone: inhibition of invasion and migration through the FAK/JNK signaling pathway in human gastric adenocarcinoma AGS cells. | 2014 | Mol. Cell. Biochem. | pmid:24510324 |
Fan Y et al. | The design of propolis flavone microemulsion and its effect on enhancing the immunity and antioxidant activity in mice. | 2014 | Int. J. Biol. Macromol. | pmid:24463267 |
Modelli A and Pshenichnyuk SA | Gas-phase dissociative electron attachment to flavonoids and possible similarities to their metabolic pathways. | 2013 | Phys Chem Chem Phys | pmid:23243660 |
Golub AG et al. | Discovery and characterization of synthetic 4'-hydroxyflavones-New CK2 inhibitors from flavone family. | 2013 | Bioorg. Med. Chem. | pmid:24011954 |
Wiejak J et al. | Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells. | 2013 | Biochem. J. | pmid:23782265 |
D'Abrosca B et al. | A new acylated flavone glycoside with antioxidant and radical scavenging activities from Teucrium polium leaves. | 2013 | Nat. Prod. Res. | pmid:22708583 |
Choe H et al. | Structure-based design of flavone-based inhibitors of wild-type and T315I mutant of ABL. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23790540 |
Richter D et al. | Effects of phytoestrogen extracts isolated from pumpkin seeds on estradiol production and ER/PR expression in breast cancer and trophoblast tumor cells. | 2013 | Nutr Cancer | pmid:23859042 |
Hapuarachchi SD et al. | Andrographidine G, a new flavone glucoside from Andrographis paniculata. | 2013 | Nat Prod Commun | pmid:23678804 |
Yin FZ et al. | [Optimization of preparation of salt-processed psoraleae fructus medicines with multi-index orthogonal method]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:23668006 |
Zhang JY et al. | [Rapid recognition and identification of chemical constituents in Qinghuo Zhimai tablets by SPE-HPLC-ESI-MS(n)]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:23672039 |
Kalisz S et al. | Stabilization of anthocyanin and skullcap flavone complexes--investigations with computer simulation and experimental methods. | 2013 | Food Chem | pmid:23265516 |
Rane RA et al. | Synthesis and evaluation of novel marine bromopyrrole alkaloid-based hybrids as anticancer agents. | 2013 | Eur J Med Chem | pmid:23584542 |
Sun Y et al. | Enrichment and antioxidant properties of flavone C-glycosides from trollflowers using macroporous resin. | 2013 | Food Chem | pmid:23768390 |
Zhong LR et al. | Radix tetrastigma hemsleyani flavone induces apoptosis in human lung carcinoma a549 cells by modulating the MAPK pathway. | 2013 | Asian Pac. J. Cancer Prev. | pmid:24289612 |
Dong JJ et al. | Synthesis, biological evaluation and molecular docking studies of flavone and isoflavone derivatives as a novel class of KSP (kinesin spindle protein) inhibitors. | 2013 | Eur J Med Chem | pmid:24184776 |
Cai X et al. | Digitoflavone inhibits IκBα kinase and enhances apoptosis induced by TNFα through downregulation of expression of nuclear factor κB-regulated gene products in human pancreatic cancer cells. | 2013 | PLoS ONE | pmid:24146961 |
Wang KW et al. | A new lignan with anti-tumour activity from Polygonum perfoliatum L. | 2013 | Nat. Prod. Res. | pmid:22533633 |
Kassem ME et al. | A sulphated flavone glycoside from Livistona australis and its antioxidant and cytotoxic activity. | 2012 | Nat. Prod. Res. | pmid:21793764 |
Fong YK et al. | In vitro and in situ evaluation of herb-drug interactions during intestinal metabolism and absorption of baicalein. | 2012 | J Ethnopharmacol | pmid:21906668 |
Tsai IT et al. | Flavone is efficient to protect zebrafish fins from UV-induced damage. | 2012 | Drug Chem Toxicol | pmid:22289409 |
Wei Z et al. | Cardamonin protects septic mice from acute lung injury by preventing endothelial barrier dysfunction. | 2012 | J. Biochem. Mol. Toxicol. | pmid:22696397 |
Shih HC and Yang LL | Relaxant effect induced by wogonin from Scutellaria baicalensis on rat isolated uterine smooth muscle. | 2012 | Pharm Biol | pmid:22471999 |
Duraipandiyan V et al. | Antimicrobial activity of sesquiterpene lactones isolated from traditional medicinal plant, Costus speciosus (Koen ex.Retz.) Sm. | 2012 | BMC Complement Altern Med | pmid:22397713 |
Adejumo OE et al. | Moringa oleifera Lam. (Moringaceae) grown in Nigeria: In vitro antisickling activity on deoxygenated erythrocyte cells. | 2012 | J Pharm Bioallied Sci | pmid:22557922 |
Guo AJ et al. | Kaempferol as a flavonoid induces osteoblastic differentiation via estrogen receptor signaling. | 2012 | Chin Med | pmid:22546174 |
Asadi S and Theoharides TC | Corticotropin-releasing hormone and extracellular mitochondria augment IgE-stimulated human mast-cell vascular endothelial growth factor release, which is inhibited by luteolin. | 2012 | J Neuroinflammation | pmid:22559745 |
Chen HJ et al. | Determination of phenolic acids and flavonoids in Taraxacum formosanum Kitam by liquid chromatography-tandem mass spectrometry coupled with a post-column derivatization technique. | 2012 | Int J Mol Sci | pmid:22312251 |
Wink M et al. | Secondary Metabolites from Plants Inhibiting ABC Transporters and Reversing Resistance of Cancer Cells and Microbes to Cytotoxic and Antimicrobial Agents. | 2012 | Front Microbiol | pmid:22536197 |
Peterson JJ et al. | Associations between flavonoids and cardiovascular disease incidence or mortality in European and US populations. | 2012 | Nutr. Rev. | pmid:22946850 |
Yuqing Z et al. | Flavone ingredients can synergistically inhibit NDV infecting cell and improve ND vaccine's protective rate. | 2012 | Int. J. Biol. Macromol. | pmid:22575392 |
Kim S et al. | Vascular disrupting agent drug classes differ in effects on the cytoskeleton. | 2012 | PLoS ONE | pmid:22848372 |
Xin HL et al. | Anti-inflammatory and analgesic activity of total flavone of Cunninghamia lanceolata. | 2012 | Molecules | pmid:22832885 |
Fan Y et al. | Liposome and epimedium polysaccharide-propolis flavone can synergistically enhance immune effect of vaccine. | 2012 | Int. J. Biol. Macromol. | pmid:22020157 |
Zhou G and Lv G | [Comparative studies on scavenging DPPH free radicals activity of flavone C-glycosides from different parts of Dendrobium officinale]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22993976 |
Resende FA et al. | Mutagenicity of flavonoids assayed by bacterial reverse mutation (Ames) test. | 2012 | Molecules | pmid:22565478 |
Lies B et al. | Flavone potently stimulates an apical transporter for flavonoids in human intestinal Caco-2 cells. | 2012 | Mol Nutr Food Res | pmid:22965487 |
Lee JH et al. | Flavone reduces the production of virulence factors, staphyloxanthin and α-hemolysin, in Staphylococcus aureus. | 2012 | Curr. Microbiol. | pmid:22965624 |
Hostetler GL et al. | Endogenous enzymes, heat, and pH affect flavone profiles in parsley (Petroselinum crispum var. neapolitanum) and celery (Apium graveolens) during juice processing. | 2012 | J. Agric. Food Chem. | pmid:22224550 |
Greeff J et al. | Antioxidant properties of 4-quinolones and structurally related flavones. | 2012 | Bioorg. Med. Chem. | pmid:22197671 |
Welch A et al. | Habitual flavonoid intakes are positively associated with bone mineral density in women. | 2012 | J. Bone Miner. Res. | pmid:22549983 |
Yarmolinsky L et al. | Potent antiviral flavone glycosides from Ficus benjamina leaves. | 2012 | Fitoterapia | pmid:22155188 |
Joshi SC and Mathela CS | Antioxidant and antibacterial activities of the leaf essential oil and its constituents furanodienone and curzerenone from Lindera pulcherrima (Nees.) Benth. ex hook. f. | 2012 | Pharmacognosy Res | pmid:22518079 |
Chantarudee A et al. | Chemical constituents and free radical scavenging activity of corn pollen collected from Apis mellifera hives compared to floral corn pollen at Nan, Thailand. | 2012 | BMC Complement Altern Med | pmid:22513008 |
Clark BR et al. | Flavone C-glycosides from Anthurium andraeanum. | 2012 | Nat Prod Commun | pmid:22816298 |
Soumyanath A et al. | Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease: Investigation of a Possible Mechanism of Action. | 2012 | Int J Alzheimers Dis | pmid:22506133 |
Niraula NP et al. | Biotransformation of flavone by CYP105P2 from Streptomyces peucetius. | 2012 | J. Microbiol. Biotechnol. | pmid:22713981 |
Chen LY et al. | Structural elucidation and bioactivity of biflavonoids from the stems of Wikstroemia taiwanensis. | 2012 | Int J Mol Sci | pmid:22312302 |
Watts SD et al. | A sensitive membrane-targeted biosensor for monitoring changes in intracellular chloride in neuronal processes. | 2012 | PLoS ONE | pmid:22506078 |
Li Y et al. | [Simultaneous determination of five active components in resina draconis and its extract by HPLC]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22792791 |
Balboni G et al. | Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22487176 |
Zandi K et al. | Flavone enhances dengue virus type-2 (NGC strain) infectivity and replication in vero cells. | 2012 | Molecules | pmid:22374315 |
Furukawa Y et al. | Isolation and characterization of activators of ERK/MAPK from citrus plants. | 2012 | Int J Mol Sci | pmid:22408427 |
Kim HG et al. | Acacetin protects dopaminergic cells against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neuroinflammation in vitro and in vivo. | 2012 | Biol. Pharm. Bull. | pmid:22863927 |
Li H et al. | De novo transcriptome of safflower and the identification of putative genes for oleosin and the biosynthesis of flavonoids. | 2012 | PLoS ONE | pmid:22363528 |
Hostetler G et al. | Flavone deglycosylation increases their anti-inflammatory activity and absorption. | 2012 | Mol Nutr Food Res | pmid:22351119 |
Zhang H and Zhang C | Vasoprotection by dietary supplements and exercise: role of TNFα signaling. | 2012 | Exp Diabetes Res | pmid:22110483 |
Shi L et al. | Gossypin induces G2/M arrest in human malignant glioma U251 cells by the activation of Chk1/Cdc25C pathway. | 2012 | Cell. Mol. Neurobiol. | pmid:21984341 |
Yang WS et al. | Nanostructured, self-assembling peptide K5 blocks TNF-α and PGE₂ production by suppression of the AP-1/p38 pathway. | 2012 | Mediators Inflamm. | pmid:22315508 |
Toton E et al. | The tetramethoxyflavone zapotin selectively activates protein kinase C epsilon, leading to its down-modulation accompanied by Bcl-2, c-Jun and c-Fos decrease. | 2012 | Eur. J. Pharmacol. | pmid:22381066 |
Skizim NJ et al. | Metabolic pathways for photobiological hydrogen production by nitrogenase- and hydrogenase-containing unicellular cyanobacteria Cyanothece. | 2012 | J. Biol. Chem. | pmid:22128188 |
Fasinu PS et al. | An overview of the evidence and mechanisms of herb-drug interactions. | 2012 | Front Pharmacol | pmid:22557968 |
Zielińska D et al. | Evaluation of flavonoid contents and antioxidant capacity of the aerial parts of common and tartary buckwheat plants. | 2012 | Molecules | pmid:22890171 |
Engelbertz J et al. | Bioassay-guided fractionation of a thymol-deprived hydrophilic thyme extract and its antispasmodic effect. | 2012 | J Ethnopharmacol | pmid:22465593 |
Chan LP et al. | Apigenin induces apoptosis via tumor necrosis factor receptor- and Bcl-2-mediated pathway and enhances susceptibility of head and neck squamous cell carcinoma to 5-fluorouracil and cisplatin. | 2012 | Biochim. Biophys. Acta | pmid:22554915 |
Cai M et al. | The neuroprotective effect of eupatilin against ischemia/reperfusion-induced delayed neuronal damage in mice. | 2012 | Eur. J. Pharmacol. | pmid:22683875 |
Wang Y et al. | Flavone C-glycosides from the leaves of Lophatherum gracile and their in vitro antiviral activity. | 2012 | Planta Med. | pmid:21870321 |
Sharma M et al. | Expression of flavonoid 3'-hydroxylase is controlled by P1, the regulator of 3-deoxyflavonoid biosynthesis in maize. | 2012 | BMC Plant Biol. | pmid:23113982 |
Hammoud L et al. | A new flavonoid and other constituents from Centaurea nicaeensis All. var. walliana M. | 2012 | Nat. Prod. Res. | pmid:21815723 |
Chung MJ et al. | Suppressive effects of Schizandra chinensis Baillon water extract on allergy-related cytokine generation and degranulation in IgE-antigen complex-stimulated RBL-2H3 cells. | 2012 | Nutr Res Pract | pmid:22586497 |
Berim A et al. | A set of regioselective O-methyltransferases gives rise to the complex pattern of methoxylated flavones in sweet basil. | 2012 | Plant Physiol. | pmid:22923679 |
Seki N et al. | Tricin inhibits proliferation of human hepatic stellate cells in vitro by blocking tyrosine phosphorylation of PDGF receptor and its signaling pathways. | 2012 | J. Cell. Biochem. | pmid:22359269 |
Ulrich-Merzenich G et al. | Novel neurological and immunological targets for salicylate-based phytopharmaceuticals and for the anti-depressant imipramine. | 2012 | Phytomedicine | pmid:22743246 |
Shi Y et al. | Analgesic and uterine relaxant effects of isoliquiritigenin, a flavone from Glycyrrhiza glabra. | 2012 | Phytother Res | pmid:22389128 |
Wilczańska-Barska A et al. | Enhanced accumulation of secondary metabolites in hairy root cultures of Scutellaria lateriflora following elicitation. | 2012 | Biotechnol. Lett. | pmid:22639092 |
Mijangos MV et al. | Microwave-assisted C-3 selective oxidative radical alkylation of flavones. | 2012 | Org. Biomol. Chem. | pmid:22395456 |
Surichan S et al. | Bioactivation of the citrus flavonoid nobiletin by CYP1 enzymes in MCF7 breast adenocarcinoma cells. | 2012 | Food Chem. Toxicol. | pmid:22743247 |
Guo F et al. | Effect of the citrus lycopene β-cyclase transgene on carotenoid metabolism in transgenic tomato fruits. | 2012 | PLoS ONE | pmid:22384184 |
Fatima T et al. | Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed. | 2012 | PLoS ONE | pmid:22558083 |
Lolli G et al. | Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight. | 2012 | Biochemistry | pmid:22794353 |
Kim YW et al. | DA6034 promotes gastric epithelial cell migration and wound-healing through the mTOR pathway. | 2012 | J. Gastroenterol. Hepatol. | pmid:21793913 |
Zhang T et al. | Inhibitory effects and underlying mechanism of 7-hydroxyflavone phosphate ester in HeLa cells. | 2012 | PLoS ONE | pmid:22574207 |
Patel CA et al. | Remedial Prospective of Hippophae rhamnoides Linn. (Sea Buckthorn). | 2012 | ISRN Pharmacol | pmid:22530142 |
Lin TY et al. | Hispidulin inhibits the release of glutamate in rat cerebrocortical nerve terminals. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22759588 |
Pohanka M | Antioxidants countermeasures against sulfur mustard. | 2012 | Mini Rev Med Chem | pmid:22512566 |
Xiao L et al. | Transcriptome of protoplasts reprogrammed into stem cells in Physcomitrella patens. | 2012 | PLoS ONE | pmid:22545152 |
Begum N et al. | Apigenin ameliorates gamma radiation-induced cytogenetic alterations in cultured human blood lymphocytes. | 2012 | Mutat. Res. | pmid:22516036 |
Huang WY et al. | Survey of antioxidant capacity and phenolic composition of blueberry, blackberry, and strawberry in Nanjing. | 2012 | J Zhejiang Univ Sci B | pmid:22302422 |
Duchnowicz P et al. | Hypolipidemic and antioxidant effects of hydroxycinnamic acids, quercetin, and cyanidin 3-glucoside in hypercholesterolemic erythrocytes (in vitro study). | 2012 | Eur J Nutr | pmid:21755326 |
Tsui KH et al. | Upregulation of prostate-derived Ets factor by luteolin causes inhibition of cell proliferation and cell invasion in prostate carcinoma cells. | 2012 | Int. J. Cancer | pmid:21780100 |