FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Halbwirth H | The creation and physiological relevance of divergent hydroxylation patterns in the flavonoid pathway. | 2010 | Int J Mol Sci | pmid:20386656 |
Ragab FA et al. | Synthesis and anticonvulsant activity of certain substituted furochromone, benzofuran and flavone derivatives. | 2010 | Chem. Pharm. Bull. | pmid:20823592 |
Stark JL et al. | Solution structure and function of YndB, an AHSA1 protein from Bacillus subtilis. | 2010 | Proteins | pmid:20818668 |
Du Y et al. | Identification of flavone phytoalexins and a pathogen-inducible flavone synthase II gene (SbFNSII) in sorghum. | 2010 | J. Exp. Bot. | pmid:20007684 |
Filak LK et al. | Organometallic indolo[3,2-c]quinolines versus indolo[3,2-d]benzazepines: synthesis, structural and spectroscopic characterization, and biological efficacy. | 2010 | J. Biol. Inorg. Chem. | pmid:20369265 |
Alvarez G et al. | Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity. | 2010 | Eur J Med Chem | pmid:20889239 |
Zhang C et al. | Functional characterization of cis-acting elements mediating flavone-inducible expression of CYP321A1. | 2010 | Insect Biochem. Mol. Biol. | pmid:20854909 |
Zhang Y et al. | Reproducibility and relative validity of a food frequency questionnaire to assess intake of dietary flavonol and flavone in Chinese university campus population. | 2010 | Nutr Res | pmid:20851305 |
Carneiro CD et al. | Effect of flavonoids on 2'-deoxyguanosine and DNA oxidation caused by singlet molecular oxygen. | 2010 Aug-Sep | Food Chem. Toxicol. | pmid:20561949 |
Acharya A et al. | Redox regulation in cancer: a double-edged sword with therapeutic potential. | 2010 Jan-Feb | Oxid Med Cell Longev | pmid:20716925 |
Marczak Å et al. | Fragmentation pathways of acylated flavonoid diglucuronides from leaves of Medicago truncatula. | 2010 May-Jun | Phytochem Anal | pmid:19950391 |
Mafuvadze B et al. | Apigenin blocks induction of vascular endothelial growth factor mRNA and protein in progestin-treated human breast cancer cells. | 2010 Sep-Oct | Menopause | pmid:20551847 |
Sati SC et al. | Bioactive constituents and medicinal importance of genus Alnus. | 2011 | Pharmacogn Rev | pmid:22279375 |
Kloska A et al. | Effects of flavonoids on glycosaminoglycan synthesis: implications for substrate reduction therapy in Sanfilippo disease and other mucopolysaccharidoses. | 2011 | Metab Brain Dis | pmid:21305347 |
Zuk M et al. | Flavonoid engineering of flax potentiate its biotechnological application. | 2011 | BMC Biotechnol. | pmid:21276227 |
Lee SJ et al. | Hypolipidemic and hypoglycemic effects of Orostachys japonicus A. Berger extracts in streptozotocin-induced diabetic rats. | 2011 | Nutr Res Pract | pmid:21994524 |
Asakawa T et al. | PET imaging of nobiletin based on a practical total synthesis. | 2011 | Chem. Commun. (Camb.) | pmid:21243163 |
Xiao J et al. | Noncovalent interaction of dietary polyphenols with common human plasma proteins. | 2011 | J. Agric. Food Chem. | pmid:21863815 |
Raza SS et al. | Silymarin protects neurons from oxidative stress associated damages in focal cerebral ischemia: a behavioral, biochemical and immunohistological study in Wistar rats. | 2011 | J. Neurol. Sci. | pmid:21840019 |
Mohammadi-Motlagh HR et al. | Anticancer and anti-inflammatory activities of shallot (Allium ascalonicum) extract. | 2011 | Arch Med Sci | pmid:22291731 |
Elmann A et al. | Anti-neuroinflammatory effects of the extract of Achillea fragrantissima. | 2011 | BMC Complement Altern Med | pmid:22018032 |
Himi E et al. | Differential expression of three flavanone 3-hydroxylase genes in grains and coleoptiles of wheat. | 2011 | Int J Plant Genomics | pmid:21977025 |
Sumbul S et al. | Role of phenolic compounds in peptic ulcer: An overview. | 2011 | J Pharm Bioallied Sci | pmid:21966156 |
Niazmand S et al. | Cardiovascular effects of Teucrium polium L. extract in rabbit. | 2011 | Pharmacogn Mag | pmid:21969799 |
Ibrahim MH et al. | Effects of nitrogen fertilization on synthesis of primary and secondary metabolites in three varieties of Kacip Fatimah (Labisia pumila Blume). | 2011 | Int J Mol Sci | pmid:21954355 |
Li D et al. | Transcriptional profiling of Medicago truncatula under salt stress identified a novel CBF transcription factor MtCBF4 that plays an important role in abiotic stress responses. | 2011 | BMC Plant Biol. | pmid:21718548 |
Subbarao PG and Ashok P | Antihyperlipidemic effect of Trichilia connaroides in hypercholesterolemic rats and its possible mechanism. | 2011 | J Pharm Bioallied Sci | pmid:21687351 |
Saeidnia S et al. | A review on phytochemistry and medicinal properties of the genus Achillea. | 2011 | Daru | pmid:22615655 |
Garateix A et al. | Antinociception produced by Thalassia testudinum extract BM-21 is mediated by the inhibition of acid sensing ionic channels by the phenolic compound thalassiolin B. | 2011 | Mol Pain | pmid:21261973 |
Casati P et al. | Rapid Maize Leaf and Immature Ear Responses to UV-B Radiation. | 2011 | Front Plant Sci | pmid:22666224 |
Cai H et al. | Pharmacokinetics in mice and metabolism in murine and human liver fractions of the putative cancer chemopreventive agents 3',4',5',5,7-pentamethoxyflavone and tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone). | 2011 | Cancer Chemother. Pharmacol. | pmid:20364427 |
Xia EQ et al. | Microwave-assisted extraction of oleanolic acid and ursolic acid from Ligustrum lucidum Ait. | 2011 | Int J Mol Sci | pmid:21954361 |
Szliszka E et al. | Ethanolic Extract of Propolis Augments TRAIL-Induced Apoptotic Death in Prostate Cancer Cells. | 2011 | Evid Based Complement Alternat Med | pmid:19892808 |
Hämäläinen M et al. | Effects of flavonoids on prostaglandin E2 production and on COX-2 and mPGES-1 expressions in activated macrophages. | 2011 | Planta Med. | pmid:21341175 |
Gao L et al. | 3D QSAR and docking study of flavone derivatives as potent inhibitors of influenza H1N1 virus neuraminidase. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21843936 |
Kundu R et al. | Carlinoside reduces hepatic bilirubin accumulation by stimulating bilirubin-UGT activity through Nrf2 gene expression. | 2011 | Biochem. Pharmacol. | pmid:21801714 |
Wei H et al. | Neuropective constituents from the rhizomes of Abacopteris penangiana. | 2011 | J Asian Nat Prod Res | pmid:21751838 |
Khan SI et al. | Potential utility of natural products as regulators of breast cancer-associated aromatase promoters. | 2011 | Reprod. Biol. Endocrinol. | pmid:21693041 |
Uchi H et al. | A clinical trial of kampo formulae for the treatment of symptoms of yusho, a poisoning caused by dioxins and related organochlorine compounds. | 2011 | Evid Based Complement Alternat Med | pmid:19996156 |
Khan MS et al. | Methylated chrysin induces co-ordinated attenuation of the canonical Wnt and NF-kB signaling pathway and upregulates apoptotic gene expression in the early hepatocarcinogenesis rat model. | 2011 | Chem. Biol. Interact. | pmid:21554863 |
Larroque-Lombard AL et al. | Synthesis and studies on three-compartment flavone-containing combi-molecules designed to target EGFR, DNA, and MEK. | 2011 | Chem Biol Drug Des | pmid:21294849 |
Fan Y et al. | Epimedium polysaccharide and propolis flavone can synergistically inhibit the cellular infectivity of NDV and improve the curative effect of ND in chicken. | 2011 | Int. J. Biol. Macromol. | pmid:21238483 |
Kang KP et al. | Luteolin ameliorates cisplatin-induced acute kidney injury in mice by regulation of p53-dependent renal tubular apoptosis. | 2011 | Nephrol. Dial. Transplant. | pmid:20817674 |
Lefort EC and Blay J | The dietary flavonoid apigenin enhances the activities of the anti-metastatic protein CD26 on human colon carcinoma cells. | 2011 | Clin. Exp. Metastasis | pmid:21298326 |
Wang XX et al. | Simultaneous structural identification of natural products in fractions of crude extract of the rare endangered plant Anoectochilus roxburghii using H NMR/RRLC-MS parallel dynamic spectroscopy. | 2011 | Int J Mol Sci | pmid:21731458 |
Patra JC and Chua BH | Artificial neural network-based drug design for diabetes mellitus using flavonoids. | 2011 | J Comput Chem | pmid:20806262 |
Bensasson RV et al. | Potency of inhibition of human DNA topoisomerase I by flavones assessed through physicochemical parameters. | 2011 | Free Radic. Biol. Med. | pmid:21745563 |
Maher P et al. | Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes. | 2011 | PLoS ONE | pmid:21738623 |
Beg S et al. | Systematic review of herbals as potential anti-inflammatory agents: Recent advances, current clinical status and future perspectives. | 2011 | Pharmacogn Rev | pmid:22279370 |
Fang W et al. | Flavonoids from the aerial parts of Macrothelypteris torresiana. | 2011 | Nat. Prod. Res. | pmid:21240759 |