FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Cong Y et al. | A new flavonoside from Leonurus heterophyllus. | 2005 | J Asian Nat Prod Res | pmid:15621638 |
Tao SH and Wu FE | A new flavone from Hypericum wightianum. | 2004 | J Asian Nat Prod Res | pmid:15621592 |
Schütz K et al. | Characterization of phenolic acids and flavonoids in dandelion (Taraxacum officinale WEB. ex WIGG.) root and herb by high-performance liquid chromatography/electrospray ionization mass spectrometry. | 2005 | Rapid Commun. Mass Spectrom. | pmid:15593267 |
Chi YS and Kim HP | Suppression of cyclooxygenase-2 expression of skin fibroblasts by wogonin, a plant flavone from Scutellaria radix. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15589400 |
Akao T et al. | Enteric excretion of baicalein, a flavone of Scutellariae Radix, via glucuronidation in rat: involvement of multidrug resistance-associated protein 2. | 2004 | Pharm. Res. | pmid:15587936 |
Ohba S et al. | Swertisin dihydrate. | 2004 | Acta Crystallogr C | pmid:15579976 |
Sato S et al. | Flavopiridol as a radio-sensitizer for esophageal cancer cell lines. | 2004 | Dis. Esophagus | pmid:15569374 |
David JP et al. | A new sesquiterpene from the fruits of Allophylus laevigatus. | 2004 | Fitoterapia | pmid:15567269 |
Marrero-Ponce Y | Linear indices of the "molecular pseudograph's atom adjacency matrix": definition, significance-interpretation, and application to QSAR analysis of flavone derivatives as HIV-1 integrase inhibitors. | J Chem Inf Comput Sci | pmid:15554670 | |
Tsai PL and Tsai TH | Pharmacokinetics of baicalin in rats and its interactions with cyclosporin A, quinidine and SKF-525A: a microdialysis study. | 2004 | Planta Med. | pmid:15549664 |
Park HJ et al. | Baicalin induces NAD(P)H:quinone reductase through the transactivation of AP-1 and NF-kappaB in Hepa 1c1c7 cells. | 2004 | Eur. J. Cancer Prev. | pmid:15548947 |
Kim HP et al. | Anti-inflammatory plant flavonoids and cellular action mechanisms. | 2004 | J. Pharmacol. Sci. | pmid:15539763 |
Kanho H et al. | Glucosylation of phenolic compounds by Pharbitis nil hairy roots: I. Glucosylation of coumarin and flavone derivatives. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15502347 |
Ruberto G and Tringali C | Secondary metabolites from the leaves of Feijoa sellowiana Berg. | 2004 | Phytochemistry | pmid:15501265 |
Arakaki N et al. | Induction of G1 cell cycle arrest in human umbilical vein endothelial cells by flavone's inhibition of the extracellular signal regulated kinase cascade. | 2004 | Biochem. Cell Biol. | pmid:15499387 |
Most MM | Estimated phytochemical content of the dietary approaches to stop hypertension (DASH) diet is higher than in the Control Study Diet. | 2004 | J Am Diet Assoc | pmid:15499362 |
Kim SJ et al. | Inhibition of nitric oxide production from lipopolysaccharide-treated RAW 264.7 cells by synthetic flavones: structure-activity relationship and action mechanism. | 2004 | Arch. Pharm. Res. | pmid:15473664 |
Silvério CA and Okano LT | Laser flash photolysis and time-resolved fluorescence measurements of the aggregation number of SDS-biopolymer complexes. | 2004 | Colloids Surf B Biointerfaces | pmid:15465303 |
Kim DO and Lee CY | Comprehensive study on vitamin C equivalent antioxidant capacity (VCEAC) of various polyphenolics in scavenging a free radical and its structural relationship. | 2004 | Crit Rev Food Sci Nutr | pmid:15462129 |
Wu W et al. | Studies on the flavones using liquid chromatography-electrospray ionization tandem mass spectrometry. | 2004 | J Chromatogr A | pmid:15460251 |
Wang QE et al. | Isolation and purification of inflacoumarin A and licochalcone A from licorice by high-speed counter-current chromatography. | 2004 | J Chromatogr A | pmid:15453418 |
Wenzel U et al. | Activation of mitochondrial lactate uptake by flavone induces apoptosis in human colon cancer cells. | 2005 | J. Cell. Physiol. | pmid:15452831 |
BOHR DF et al. | The effects of various flavone glucosides on the rate of passage of Evans blue through the damaged capillary wall. | 1949 | J. Pharmacol. Exp. Ther. | pmid:15391936 |
Kanaze FI et al. | A validated HPLC determination of the flavone aglycone diosmetin in human plasma. | 2004 | Biomed. Chromatogr. | pmid:15386576 |
Badria FA and Zidan OA | Natural products for dental caries prevention. | 2004 | J Med Food | pmid:15383236 |
Saracoglu I et al. | Acylated flavonoids and phenol glycosides from Veronica thymoides subsp. pseudocinerea. | 2004 | Phytochemistry | pmid:15381011 |
Mizoyama Y et al. | Inhibitory effect of flavonoids on N-acetylation of 5-aminosalicylic acid in cultured rat hepatocytes. | 2004 | Biol. Pharm. Bull. | pmid:15340238 |
Sato Y et al. | Variation in synergistic activity by flavone and its related compounds on the increased susceptibility of various strains of methicillin-resistant Staphylococcus aureus to beta-lactam antibiotics. | 2004 | Int. J. Antimicrob. Agents | pmid:15325425 |
Chen CC et al. | Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: structure-activity relationships. | 2004 | Mol. Pharmacol. | pmid:15322261 |
Sanderson JT et al. | Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells. | 2004 | Toxicol. Sci. | pmid:15319488 |
Cai H et al. | Growth-inhibitory and cell cycle-arresting properties of the rice bran constituent tricin in human-derived breast cancer cells in vitro and in nude mice in vivo. | 2004 | Br. J. Cancer | pmid:15316567 |
Burns SA et al. | Direct liquid chromatography-mass spectrometry method for the detection of glutathione S-transferase isozymes and investigation of their expression in response to dietary flavone. | 2004 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:15315784 |
Kim DH et al. | Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces cell cycle arrest in ras-transformed human mammary epithelial cells. | 2004 | Biochem. Pharmacol. | pmid:15313404 |
Maheswara M et al. | Two new 5-deoxyflavonoids from Calliandra inermis. | 2004 | Chem. Pharm. Bull. | pmid:15304993 |
Wu W et al. | Structural analysis of selected characteristic flavones by electrospray tandem mass spectrometry. | 2004 | Anal Sci | pmid:15293412 |
Jones DJ et al. | Characterisation of metabolites of the putative cancer chemopreventive agent quercetin and their effect on cyclo-oxygenase activity. | 2004 | Br. J. Cancer | pmid:15292928 |
del Baño MJ et al. | Flavonoid distribution during the development of leaves, flowers, stems, and roots of Rosmarinus officinalis. postulation of a biosynthetic pathway. | 2004 | J. Agric. Food Chem. | pmid:15291464 |
Chen YC et al. | Flavone inhibition of tumor growth via apoptosis in vitro and in vivo. | 2004 | Int. J. Oncol. | pmid:15289867 |
Verbeek R et al. | The flavones luteolin and apigenin inhibit in vitro antigen-specific proliferation and interferon-gamma production by murine and human autoimmune T cells. | 2004 | Biochem. Pharmacol. | pmid:15276069 |
Herzog A et al. | Pleiotropic molecular effects of the pro-apoptotic dietary constituent flavone in human colon cancer cells identified by protein and mRNA expression profiling. | 2004 | Proteomics | pmid:15274140 |
Ouyang P et al. | [Effects of flavone from leaves of Diospyros kaki on adventitial fibroblasts proliferation by advanced oxidation protein products in vitro]. | 2004 | Zhong Yao Cai | pmid:15272781 |
Kim YW et al. | Synthesis and aromatase inhibitory activity of novel pyridine-containing isoflavones. | 2004 | J. Med. Chem. | pmid:15267241 |
van Duursen MB et al. | Phytochemicals inhibit catechol-O-methyltransferase activity in cytosolic fractions from healthy human mammary tissues: implications for catechol estrogen-induced DNA damage. | 2004 | Toxicol. Sci. | pmid:15254334 |
Ambrozin AR et al. | Trypanocidal activity of Meliaceae and Rutaceae plant extracts. | 2004 | Mem. Inst. Oswaldo Cruz | pmid:15250481 |
Kong X et al. | Effects of Chinese herbal medicinal ingredients on peripheral lymphocyte proliferation and serum antibody titer after vaccination in chicken. | 2004 | Int. Immunopharmacol. | pmid:15233143 |
Kavvadias D et al. | The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects. | 2004 | Br. J. Pharmacol. | pmid:15231642 |
O'Leary KA et al. | Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription. | 2004 | Mutat. Res. | pmid:15225597 |
McMullen MD et al. | Salmon silk genes contribute to the elucidation of the flavone pathway in maize (Zea mays L.). | 2004 May-Jun | J. Hered. | pmid:15220389 |
Quiney C et al. | Flavones and polyphenols inhibit the NO pathway during apoptosis of leukemia B-cells. | 2004 | Leuk. Res. | pmid:15203283 |
Son D et al. | Neuroprotective effect of wogonin in hippocampal slice culture exposed to oxygen and glucose deprivation. | 2004 | Eur. J. Pharmacol. | pmid:15189769 |