FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Lu H et al. | Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin. | 2005 | J. Med. Chem. | pmid:15689157 |
Garritano S et al. | Assessment of estrogenic activity of flavonoids from Mediterranean plants using an in vitro short-term test. | 2005 | Phytomedicine | pmid:15693722 |
Zhang J et al. | Threshold dissociation and molecular modeling of transition metal complexes of flavonoids. | 2005 | J. Am. Soc. Mass Spectrom. | pmid:15694764 |
Göker H et al. | Synthesis and potent antimicrobial activity of some novel 2-phenyl or methyl-4H-1-benzopyran-4-ones carrying amidinobenzimidazoles. | 2005 | Bioorg. Med. Chem. | pmid:15698788 |
Likhitwitayawuid K et al. | Phenolics with antiviral activity from Millettia erythrocalyx and Artocarpus lakoocha. | 2005 | Nat. Prod. Res. | pmid:15715263 |
Wenzig E et al. | Flavonolignans from Avena sativa. | 2005 | J. Nat. Prod. | pmid:15730266 |
Kagawa H et al. | Oxidation and rearrangements of flavanones by mammalian cytochrome P450. | 2004 | Xenobiotica | pmid:15742975 |
Zhang J and Brodbelt JS | Silver complexation and tandem mass spectrometry for differentiation of isomeric flavonoid diglycosides. | 2005 | Anal. Chem. | pmid:15762583 |
Ngadjui BT et al. | Prenylated chalcones, flavone and other constituents of the twigs of Dorstenia angusticornis and Dorstenia barteri var. subtriangularis. | 2005 | Phytochemistry | pmid:15771891 |
Malolanarasimhan K et al. | Synthesis and biological study of a flavone acetic acid analogue containing an azido reporting group designed as a multifunctional binding site probe. | 2005 | Bioorg. Med. Chem. | pmid:15781383 |
Wenzel U et al. | Melatonin potentiates flavone-induced apoptosis in human colon cancer cells by increasing the level of glycolytic end products. | 2005 | Int. J. Cancer | pmid:15800915 |
Kanho H et al. | Biotransformation of benzaldehyde-type and acetophenone-type derivatives by Pharbitis nil hairy roots. | 2005 | Chem. Pharm. Bull. | pmid:15802832 |
Sawada Y and Ayabe S | Multiple mutagenesis of P450 isoflavonoid synthase reveals a key active-site residue. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15809082 |
Cai H et al. | Determination of the putative cancer chemopreventive flavone tricin in plasma and tissues of mice by HPLC with UV--visible detection. | 2005 | Biomed. Chromatogr. | pmid:15828058 |
Han Y | Ginkgo terpene component has an anti-inflammatory effect on Candida albicans-caused arthritic inflammation. | 2005 | Int. Immunopharmacol. | pmid:15829420 |
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Fernández SP et al. | Synergistic interaction between hesperidin, a natural flavonoid, and diazepam. | 2005 | Eur. J. Pharmacol. | pmid:15840404 |
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Erhart LM et al. | Flavone initiates a hierarchical activation of the caspase-cascade in colon cancer cells. | 2005 | Apoptosis | pmid:15909122 |
Rothwell JA et al. | Experimental determination of octanol-water partition coefficients of quercetin and related flavonoids. | 2005 | J. Agric. Food Chem. | pmid:15913295 |
Nakagawa-Goto K et al. | Total synthesis and bioactivity of unique flavone desmosdumotin B and its analogs. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15913998 |
Iori F et al. | Theoretical quantitative structure-activity relationships of flavone ligands interacting with cytochrome P450 1A1 and 1A2 isozymes. | 2005 | Bioorg. Med. Chem. | pmid:15914008 |
Åania-Pietrzak B et al. | Modulation of MRP1 protein transport by plant, and synthetically modified flavonoids. | 2005 | Life Sci. | pmid:15916776 |
Jeyabal PV et al. | Apigenin inhibits oxidative stress-induced macromolecular damage in N-nitrosodiethylamine (NDEA)-induced hepatocellular carcinogenesis in Wistar albino rats. | 2005 | Mol. Carcinog. | pmid:15924350 |
Ahmed-Belkacem A et al. | Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2. | 2005 | Cancer Res. | pmid:15930306 |
Ko WC et al. | Mechanisms of relaxant action of luteolin in isolated guinea pig trachea. | 2005 | Planta Med. | pmid:15931576 |
Jahaniani F et al. | Xanthomicrol is the main cytotoxic component of Dracocephalum kotschyii and a potential anti-cancer agent. | 2005 | Phytochemistry | pmid:15949825 |
Park H et al. | Synthesis and inhibition of PGE2 production of 6,8-disubstituted chrysin derivatives. | 2005 | Eur J Med Chem | pmid:15963606 |
Machha A and Mustafa MR | Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta. | 2005 | J. Cardiovasc. Pharmacol. | pmid:15965352 |
Kwon HM et al. | Anti-inflammatory inhibition of endothelial cell adhesion molecule expression by flavone derivatives. | 2005 | J. Agric. Food Chem. | pmid:15969490 |
Kachlicki P et al. | Profiling isoflavone conjugates in root extracts of lupine species with LC/ESI/MSn systems. | 2005 | J Mass Spectrom | pmid:15971291 |
Wang TC et al. | Synthesis, antiproliferative, and antiplatelet activities of oxime- and methyloxime-containing flavone and isoflavone derivatives. | 2005 | Bioorg. Med. Chem. | pmid:15990314 |
Bankova V | Chemical diversity of propolis and the problem of standardization. | 2005 | J Ethnopharmacol | pmid:15993016 |
Verschoyle RD et al. | Preliminary safety evaluation of the putative cancer chemopreventive agent tricin, a naturally occurring flavone. | 2006 | Cancer Chemother. Pharmacol. | pmid:16001171 |
Takeda K et al. | Components of protocyanin, a blue pigment from the blue flowers of Centaurea cyanus. | 2005 | Phytochemistry | pmid:16005311 |
Siess MH et al. | Dietary modification of drug-metabolizing enzyme activities: dose-response effect of flavonoids. | 1992 | J Toxicol Environ Health | pmid:1602520 |
Leonard E et al. | Expression of a soluble flavone synthase allows the biosynthesis of phytoestrogen derivatives in Escherichia coli. | 2006 | Appl. Microbiol. Biotechnol. | pmid:16025328 |
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Woodman OL et al. | Vasorelaxant and antioxidant activity of flavonols and flavones: structure-activity relationships. | 2005 | J. Cardiovasc. Pharmacol. | pmid:16116335 |
Huong DT et al. | A new flavone and cytotoxic activity of flavonoid constituents isolated from Miliusa balansae (Annonaceae). | 2005 | Pharmazie | pmid:16124409 |
Xie F et al. | The osteoprotective effect of Herba epimedii (HEP) extract in vivo and in vitro. | 2005 | Evid Based Complement Alternat Med | pmid:16136213 |
Martens S and Mithöfer A | Flavones and flavone synthases. | 2005 | Phytochemistry | pmid:16137727 |
Ozbey S et al. | Antibacterial 4-amino-N-(5-methylisoxazol-3-yl)-N-[(4-oxo-2-phenyl-4H-1-benzopyran-6-yl)methyl]benzenesulfonamide. | 2005 | Acta Crystallogr C | pmid:16143780 |
UydeÅŸ-DoÄŸan BS et al. | The comparison of the relaxant effects of two methoxylated flavones in rat aortic rings. | 2005 | Vascul. Pharmacol. | pmid:16169284 |
Cai H et al. | The rice bran constituent tricin potently inhibits cyclooxygenase enzymes and interferes with intestinal carcinogenesis in ApcMin mice. | 2005 | Mol. Cancer Ther. | pmid:16170019 |
Kovacic P | Fundamental, electron transfer mechanism by pyrylium-type ions for the anticancer drugs 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA). | 2005 | Curr Med Chem Anticancer Agents | pmid:16178775 |
Cappelli C et al. | Computational study of conformational and chiroptical properties of (2R,3S,4R)-(+)-3,3',4,4',7-flavanpentol. | 2005 | Chirality | pmid:16196026 |
Girish KS and Kemparaju K | Inhibition of Naja naja venom hyaluronidase by plant-derived bioactive components and polysaccharides. | 2005 | Biochemistry Mosc. | pmid:16212553 |
Sandabe UK et al. | Phytochemical screening and effect of aqueous extract of Ficus sycomorus L. (Moraceae) stembark on muscular activity in laboratory animals. | 2006 | J Ethnopharmacol | pmid:16243463 |
Kim H et al. | Effects of naturally occurring compounds on fibril formation and oxidative stress of beta-amyloid. | 2005 | J. Agric. Food Chem. | pmid:16248550 |
Moon BH et al. | Complete assignment of (1)H and (13)C NMR data of dihydroxyflavone derivatives. | 2006 | Magn Reson Chem | pmid:16259053 |
Yoon JH and Baek SJ | Molecular targets of dietary polyphenols with anti-inflammatory properties. | 2005 | Yonsei Med. J. | pmid:16259055 |
Mavel S et al. | Synthesis and biological evaluation of a series of flavone derivatives as potential radioligands for imaging the multidrug resistance-associated protein 1 (ABCC1/MRP1). | 2006 | Bioorg. Med. Chem. | pmid:16263302 |
Wang F et al. | Neuroactive flavonoids interacting with GABAA receptor complex. | 2005 | Curr Drug Targets CNS Neurol Disord | pmid:16266290 |
Ono M et al. | Radioiodinated flavones for in vivo imaging of beta-amyloid plaques in the brain. | 2005 | J. Med. Chem. | pmid:16279784 |
Melidou M et al. | Protection against nuclear DNA damage offered by flavonoids in cells exposed to hydrogen peroxide: the role of iron chelation. | 2005 | Free Radic. Biol. Med. | pmid:16298684 |
Wenzel U et al. | Increased mitochondrial palmitoylcarnitine/carnitine countertransport by flavone causes oxidative stress and apoptosis in colon cancer cells. | 2005 | Cell. Mol. Life Sci. | pmid:16314920 |
Capodice JL et al. | Complementary and alternative medicine for chronic prostatitis/chronic pelvic pain syndrome. | 2005 | Evid Based Complement Alternat Med | pmid:16322807 |
Kite GC et al. | Data-directed scan sequence for the general assignment of C-glycosylflavone O-glycosides in plant extracts by liquid chromatography-ion trap mass spectrometry. | 2006 | J Chromatogr A | pmid:16360661 |
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Zgórka G | Retention behavior of silica-bonded and novel polymeric reversed-phase sorbents in studies on flavones as chemotaxonomic markers of Scutellaria L. genus. | 2006 | J Chromatogr A | pmid:16364344 |
Rayyan S et al. | Flavone C-glycosides from leaves of Oxalis triangularis. | 2005 | J. Agric. Food Chem. | pmid:16366694 |
Sun JL et al. | Immunologic enhancement of compound Chinese herbal medicinal ingredients and their efficacy comparison with compound Chinese herbal medicines. | 2006 | Vaccine | pmid:16378665 |
Meyer H et al. | Bioavailability of apigenin from apiin-rich parsley in humans. | 2006 | Ann. Nutr. Metab. | pmid:16407641 |
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Le Bon AM et al. | Inhibition of microsome-mediated binding of benzo[a]pyrene to DNA by flavonoids either in vitro or after dietary administration to rats. | 1992 | Chem. Biol. Interact. | pmid:1643669 |
Kim SK et al. | The mitogen-activated protein kinase kinase (mek) inhibitor PD98059 elevates primary cultured rat hepatocyte glutathione levels independent of inhibiting mek. | 2006 | Drug Metab. Dispos. | pmid:16443668 |
Sandabe UK et al. | Phytochemical screening and effect of aqueous extract of Ficus sycomorus L. (Moraceae) stem bark on muscular activity in laboratory animals. | 2006 | J Ethnopharmacol | pmid:16448793 |
Nguyen MT et al. | Xanthine oxidase inhibitors from the flowers of Chrysanthemum sinense. | 2006 | Planta Med. | pmid:16450295 |
Qi S et al. | Simultaneous determination of bioactive flavone derivatives in Chinese herb extraction by capillary electrophoresis used different electrolyte systems--borate and ionic liquids. | 2006 | J Chromatogr A | pmid:16464459 |
Bas E et al. | Anti-inflammatory activity of 5-O-demethylnobiletin, a polymethoxyflavone isolated from Sideritis tragoriganum. | 2006 | Planta Med. | pmid:16491449 |
Li H et al. | Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | 2006 | J. Mol. Graph. Model. | pmid:16497524 |
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Stintzing FC et al. | Thermal degradation kinetics of isoflavone aglycones from soy and red clover. | 2006 | Mol Nutr Food Res | pmid:16598813 |
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Sen N et al. | Leishmania donovani: intracellular ATP level regulates apoptosis-like death in luteolin induced dyskinetoplastid cells. | 2006 | Exp. Parasitol. | pmid:16707127 |
Kim BG et al. | Regioselectivity of 7-O-methyltransferase of poplar to flavones. | 2006 | J. Biotechnol. | pmid:16713650 |
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