FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Kim JH et al. | Characterization of flavonoid 7-O-glucosyltransferase from Arabidopsis thaliana. | 2006 | Biosci. Biotechnol. Biochem. | pmid:16794327 |
Ferrer-Sueta G et al. | Reduction of manganese porphyrins by flavoenzymes and submitochondrial particles: a catalytic cycle for the reduction of peroxynitrite. | 2006 | Free Radic. Biol. Med. | pmid:16843831 |
Vargo MA et al. | Apigenin-induced-apoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells. | 2006 | Biochem. Pharmacol. | pmid:16844095 |
Hayeshi R et al. | The potential inhibitory effect of antiparasitic drugs and natural products on P-glycoprotein mediated efflux. | 2006 | Eur J Pharm Sci | pmid:16846720 |
Liu S et al. | Tumor inhibition and improved immunity in mice treated with flavone from Cirsium japonicum DC. | 2006 | Int. Immunopharmacol. | pmid:16846832 |
Lévy V et al. | A phase I dose-finding and pharmacokinetic study of subcutaneous semisynthetic homoharringtonine (ssHHT) in patients with advanced acute myeloid leukaemia. | 2006 | Br. J. Cancer | pmid:16847470 |
da Fonseca R et al. | Molecular interactions between human cytochrome P450 1A2 and flavone derivatives. | 2006 | Med Chem | pmid:16848753 |
Nagai S et al. | Kinetic study of the quenching reaction of singlet oxygen by flavonoids in ethanol solution. | 2005 | J Phys Chem B | pmid:16851486 |
Gobbi S et al. | Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme. | 2006 | J. Med. Chem. | pmid:16854084 |
Innocenti G et al. | In vitro estrogenic activity of Achillea millefolium L. | 2007 | Phytomedicine | pmid:16860978 |
Wang D et al. | Immunologic synergism with IL-2 and effects of cCHMIs on mRNA expression of IL-2 and IFN-gamma in chicken peripheral T lymphocyte. | 2006 | Vaccine | pmid:16887240 |
Lameira J et al. | Structure-activity relationship study of flavone compounds with anti-HIV-1 integrase activity: a density functional theory study. | 2006 | Bioorg. Med. Chem. | pmid:16890444 |
González B et al. | Respiratory system of Gluconacetobacter diazotrophicus PAL5. Evidence for a cyanide-sensitive cytochrome bb and cyanide-resistant cytochrome ba quinol oxidases. | 2006 | Biochim. Biophys. Acta | pmid:16934215 |
Iwashina T et al. | Analysis of flavonoids in pubescence of soybean near-isogenic lines for pubescence color loci. | J. Hered. | pmid:16985083 | |
Lotito SB and Frei B | Dietary flavonoids attenuate tumor necrosis factor alpha-induced adhesion molecule expression in human aortic endothelial cells. Structure-function relationships and activity after first pass metabolism. | 2006 | J. Biol. Chem. | pmid:16987811 |
Schutte ME et al. | An in vitro and in silico study on the flavonoid-mediated modulation of the transport of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through Caco-2 monolayers. | 2006 | Toxicol. Appl. Pharmacol. | pmid:16997339 |
Tsuji PA et al. | Accumulation and metabolism of the anticancer flavonoid 5,7-dimethoxyflavone compared to its unmethylated analog chrysin in the Atlantic killifish. | 2006 | Chem. Biol. Interact. | pmid:16999945 |
Moorthy NS et al. | Synthesis, biological evaluation and in silico metabolic and toxicity prediction of some flavanone derivatives. | 2006 | Chem. Pharm. Bull. | pmid:17015974 |
Zhang J et al. | Transposition of reversed Ac element ends generates novel chimeric genes in maize. | 2006 | PLoS Genet. | pmid:17029561 |
Patanasethanont D et al. | Effects of Kaempferia parviflora extracts and their flavone constituents on P-glycoprotein function. | 2007 | J Pharm Sci | pmid:17031860 |
Ono M et al. | Synthesis and characterization of styrylchromone derivatives as beta-amyloid imaging agents. | 2007 | Bioorg. Med. Chem. | pmid:17035032 |
Casadesus G et al. | Targeting gonadotropins: an alternative option for Alzheimer disease treatment. | 2006 | J. Biomed. Biotechnol. | pmid:17047306 |
Ebert B et al. | Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate. | 2007 | Toxicol. Sci. | pmid:17077187 |
Zabala G et al. | Transcriptome changes in the phenylpropanoid pathway of Glycine max in response to Pseudomonas syringae infection. | 2006 | BMC Plant Biol. | pmid:17083738 |
Cai H et al. | Tissue distribution in mice and metabolism in murine and human liver of apigenin and tricin, flavones with putative cancer chemopreventive properties. | 2007 | Cancer Chemother. Pharmacol. | pmid:17089164 |
Hamada M et al. | TCDD-induced CYP1A1 expression, an index of dioxin toxicity, is suppressed by flavonoids permeating the human intestinal Caco-2 cell monolayers. | 2006 | J. Agric. Food Chem. | pmid:17090139 |
He YM et al. | [Effects of Pollen Typhae total flavone on glucose and lipid metabolism in 3T3-L1 adipocytes]. | 2006 | Zhong Xi Yi Jie He Xue Bao | pmid:17090374 |
Gidda SK and Varin L | Biochemical and molecular characterization of flavonoid 7-sulfotransferase from Arabidopsis thaliana. | Plant Physiol. Biochem. | pmid:17095238 | |
Chen J et al. | Phospholipase C/diacylglycerol kinase-mediated signalling is required for benzothiadiazole-induced oxidative burst and hypersensitive cell death in rice suspension-cultured cells. | 2007 | Protoplasma | pmid:17111096 |
Hui RH et al. | [Simultaneous determination of total flavone and total saponin in Gynostemma pentaphyllum by signal multiplier spectrophotometry]. | 2006 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:17112063 |
Pikulski M et al. | Tunable transition metal-ligand complexation for enhanced elucidation of flavonoid diglycosides by electrospray ionization mass spectrometry. | 2007 | J. Am. Soc. Mass Spectrom. | pmid:17112735 |
Kumar R et al. | A new chromone from Cassia nodosa. | J Asian Nat Prod Res | pmid:17135042 | |
Patel D et al. | Apigenin and cancer chemoprevention: progress, potential and promise (review). | 2007 | Int. J. Oncol. | pmid:17143534 |
Auffret G et al. | Synthesis and antimalarial evaluation of a series of piperazinyl flavones. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17166718 |
Fossen T et al. | Covalent anthocyanin-flavone dimer from leaves of Oxalis triangularis. | 2007 | Phytochemistry | pmid:17182069 |
Wang TC et al. | Synthesis, and cytotoxic and antiplatelet activities of oxime- and methyloxime-containing flavone, isoflavone, and xanthone derivatives. | 2005 | Chem. Biodivers. | pmid:17191978 |
Feng Y et al. | Iridoid glucosides and flavones from the aerial parts of Avicennia marina. | 2006 | Chem. Biodivers. | pmid:17193312 |
Opassiri R et al. | Analysis of rice glycosyl hydrolase family 1 and expression of Os4bglu12 beta-glucosidase. | 2006 | BMC Plant Biol. | pmid:17196101 |
Burns DC et al. | A combined nuclear magnetic resonance and computational study of monohydroxyflavones applied to product ion mass spectra. | 2007 | Rapid Commun. Mass Spectrom. | pmid:17216597 |
Akao T et al. | Efflux of baicalin, a flavone glucuronide of Scutellariae Radix, on Caco-2 cells through multidrug resistance-associated protein 2. | 2007 | J. Pharm. Pharmacol. | pmid:17227625 |
Perry JD et al. | Evaluation of novel chromogenic substrates for the detection of bacterial beta-glucosidase. | 2007 | J. Appl. Microbiol. | pmid:17241346 |
Fisher RF et al. | Extended Region of Nodulation Genes in Rhizobium meliloti 1021. II. Nucleotide Sequence, Transcription Start Sites and Protein Products. | 1987 | Genetics | pmid:17246400 |
Walle T et al. | Cancer chemopreventive properties of orally bioavailable flavonoids--methylated versus unmethylated flavones. | 2007 | Biochem. Pharmacol. | pmid:17250812 |
Iida N et al. | A new flavone xyloside and two new flavan-3-ol glucosides from Juniperus communis var. depressa. | 2007 | Chem. Biodivers. | pmid:17256732 |
Ferrari F et al. | Structures of three new flavone derivatives, brosimones G, H, and I, from Brosimopsis oblongifolia. | 1989 | Planta Med. | pmid:17262259 |
Murakami S et al. | Purification and characterization of three neutral extracellular isoperoxidases from rye leaves. | 2007 | Phytochemistry | pmid:17266998 |
Doronicheva N et al. | Chemical structure-dependent differential effects of flavonoids on the catalase activity as evaluated by a chemiluminescent method. | 2007 | Biol. Pharm. Bull. | pmid:17268053 |
Sarkar K et al. | Antibody response against neem leaf preparation recognizes carcinoembryonic antigen. | 2007 | Int. Immunopharmacol. | pmid:17276888 |
Borges-Argáez R et al. | Cytotoxic and antiprotozoal activity of flavonoids from Lonchocarpus spp. | 2007 | Phytomedicine | pmid:17291734 |
Lohner K et al. | Flavonoids alter P-gp expression in intestinal epithelial cells in vitro and in vivo. | 2007 | Mol Nutr Food Res | pmid:17295420 |
Boumendjel A et al. | Acridone derivatives: design, synthesis, and inhibition of breast cancer resistance protein ABCG2. | 2007 | Bioorg. Med. Chem. | pmid:17317193 |
Ajay M et al. | Modulation of vascular reactivity in normal, hypertensive and diabetic rat aortae by a non-antioxidant flavonoid. | 2007 | Pharmacol. Res. | pmid:17317209 |
Park H et al. | Anti-inflammatory activity of the synthetic C-C biflavonoids. | 2006 | J. Pharm. Pharmacol. | pmid:17331331 |
Cacciola F et al. | Comprehensive two-dimensional liquid chromatography with parallel gradients for separation of phenolic and flavone antioxidants. | 2007 | J Chromatogr A | pmid:17331519 |
Kunnumakkara AB et al. | Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis. | 2007 | Blood | pmid:17332240 |
Barberán FA et al. | Highly Methylated 6-Hydroxyflavones and Other Flavonoids from Thymus piperella. | 1985 | Planta Med. | pmid:17342612 |
Saxena M et al. | A New Flavone from Sapium insigne. | 1986 | Planta Med. | pmid:17345426 |
Jiménez MJ et al. | Anti-Inflammatory Activity of a Flavone from Sideritis leucantha. | 1986 | Planta Med. | pmid:17345496 |
Winkelmann I et al. | The suppression of aberrant crypt multiplicity in colonic tissue of 1,2-dimethylhydrazine-treated C57BL/6J mice by dietary flavone is associated with an increased expression of Krebs cycle enzymes. | 2007 | Carcinogenesis | pmid:17347140 |
Duarte-Almeida JM et al. | Antiproliferative and antioxidant activities of a tricin acylated glycoside from sugarcane (Saccharum officinarum) juice. | 2007 | Phytochemistry | pmid:17350657 |
Ko JH et al. | Four glucosyltransferases from rice: cDNA cloning, expression, and characterization. | 2008 | J. Plant Physiol. | pmid:17363107 |
Joshi KS et al. | P276-00, a novel cyclin-dependent inhibitor induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models. | 2007 | Mol. Cancer Ther. | pmid:17363487 |
Ono M | [Molecular imaging of beta-amyloid plaques in the brain]. | 2007 | Brain Nerve | pmid:17370649 |
Aboul-Enein HY et al. | Scavenging effects of phenolic compounds on reactive oxygen species. | 2007 | Biopolymers | pmid:17373654 |
Han X et al. | Isolation of high-purity casticin from Artemisia annua L. by high-speed counter-current chromatography. | 2007 | J Chromatogr A | pmid:17374377 |
Hinnen P and Eskens FA | Vascular disrupting agents in clinical development. | 2007 | Br. J. Cancer | pmid:17375046 |
Ahmed N et al. | Synthesis, characterization, and estrogen receptor binding affinity of flavone-, indole-, and furan-estradiol conjugates. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17379515 |
Lin J et al. | Dietary intakes of flavonols and flavones and coronary heart disease in US women. | 2007 | Am. J. Epidemiol. | pmid:17379619 |
Chen S and Li X | Transposable elements are enriched within or in close proximity to xenobiotic-metabolizing cytochrome P450 genes. | 2007 | BMC Evol. Biol. | pmid:17381843 |
Cabrera M et al. | Synthetic chalcones, flavanones, and flavones as antitumoral agents: biological evaluation and structure-activity relationships. | 2007 | Bioorg. Med. Chem. | pmid:17383189 |
Odebiyi OO | Isolation of a new flavone and some essential oils with antimicrobial and antifungal properties from the stem bark of Jatropha podagrica. | 1982 | Planta Med. | pmid:17396821 |
Hurabielle M et al. | [Flavonoids of Artemisia campestris, ssp. glutinosa]. | 1982 | Planta Med. | pmid:17396957 |
Forgacs P et al. | [Flavones and Sesquiterpene Lactones of Volutarella divaricata]. | 1981 | Planta Med. | pmid:17401976 |
Enomoto R et al. | Wogonin prevents immunosuppressive action but not anti-inflammatory effect induced by glucocorticoid. | 2007 | Ann. N. Y. Acad. Sci. | pmid:17404053 |
Jeong MA et al. | Jaceosidin, a pharmacologically active flavone derived from Artemisia argyi, inhibits phorbol-ester-induced upregulation of COX-2 and MMP-9 by blocking phosphorylation of ERK-1 and -2 in cultured human mammary epithelial cells. | 2007 | Ann. N. Y. Acad. Sci. | pmid:17404058 |
Kim MJ et al. | Jaceosidin induces apoptosis in ras-transformed human breast epithelial cells through generation of reactive oxygen species. | 2007 | Ann. N. Y. Acad. Sci. | pmid:17404061 |
Lee E et al. | Wogonin, a plant flavone, potentiates etoposide-induced apoptosis in cancer cells. | 2007 | Ann. N. Y. Acad. Sci. | pmid:17404065 |
Manna SK et al. | Morin (3,5,7,2',4'-Pentahydroxyflavone) abolishes nuclear factor-kappaB activation induced by various carcinogens and inflammatory stimuli, leading to suppression of nuclear factor-kappaB-regulated gene expression and up-regulation of apoptosis. | 2007 | Clin. Cancer Res. | pmid:17404114 |
Nomura T et al. | Constituents of the Chinese crude drug "sÄng-bái-pÃ" (Morus root bark). | 1983 | Planta Med. | pmid:17405088 |
Ullmannova V and Popescu NC | Inhibition of cell proliferation, induction of apoptosis, reactivation of DLC1, and modulation of other gene expression by dietary flavone in breast cancer cell lines. | 2007 | Cancer Detect. Prev. | pmid:17418982 |
Stracke R et al. | Differential regulation of closely related R2R3-MYB transcription factors controls flavonol accumulation in different parts of the Arabidopsis thaliana seedling. | 2007 | Plant J. | pmid:17419845 |
do Nascimento AM and de Oliveira DC | A new 5-deoxyflavone glycoside from the aerial parts of Calea clausseniana. | 2007 | Carbohydr. Res. | pmid:17420009 |
Govindarajan R et al. | Effect of Desmodium gangeticum extract on blood glucose in rats and on insulin secretion in vitro. | 2007 | Planta Med. | pmid:17431824 |
Zhang J et al. | Flavone synthases from Medicago truncatula are flavanone-2-hydroxylases and are important for nodulation. | 2007 | Plant Physiol. | pmid:17434990 |
Gates MA et al. | A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer. | 2007 | Int. J. Cancer | pmid:17471564 |
Patanasethanont D et al. | Modulation of function of multidrug resistance associated-proteins by Kaempferia parviflora extracts and their components. | 2007 | Eur. J. Pharmacol. | pmid:17481606 |
Meyer JD et al. | Quantitative trait loci for maysin synthesis in maize (Zea mays L.) lines selected for high silk maysin content. | 2007 | Theor. Appl. Genet. | pmid:17486311 |
Yao N et al. | Synthesis of flavonoid analogues as scaffolds for natural product-based combinatorial libraries. | J Comb Chem | pmid:17487987 | |
Ohtani H et al. | Effects of various methoxyflavones on vincristine uptake and multidrug resistance to vincristine in P-gp-overexpressing K562/ADM cells. | 2007 | Pharm. Res. | pmid:17492365 |
Kostova I et al. | Structure-Activity Relationships of Synthetic Coumarins as HIV-1 Inhibitors. | 2006 | Bioinorg Chem Appl | pmid:17497014 |
Zamora RodrÃguez ZB et al. | Antioxidant mechanism is involved in the gastroprotective effects of ozonized sunflower oil in ethanol-induced ulcers in rats. | 2007 | Mediators Inflamm. | pmid:17497036 |
Mitchell AE et al. | Isozyme- and gender-specific induction of glutathione S-transferases by flavonoids. | 2007 | Arch. Toxicol. | pmid:17503020 |
DomÃnguez M et al. | Pensteminoside, an unusual catalpol-type iridoid from Penstemon gentianoides HBK (Plantaginaceae). | 2007 | Phytochemistry | pmid:17507063 |
Kikuchi K et al. | Flavonoids induce germination of basidiospores of the ectomycorrhizal fungus Suillus bovinus. | 2007 | Mycorrhiza | pmid:17516095 |
Sarkar M and Samanta A | Photophysical and density functional studies of the interaction of a flavone derivative with the halides. | 2007 | J Phys Chem B | pmid:17523624 |
Snijman PW et al. | The antimutagenic activity of the major flavonoids of rooibos (Aspalathus linearis): some dose-response effects on mutagen activation-flavonoid interactions. | 2007 | Mutat. Res. | pmid:17537670 |
Rodrigues J et al. | An unusual C6-C6" linked flavonoid from Miconia cabucu (Melastomataceae). | 2007 | Phytochemistry | pmid:17540417 |
Rossi A et al. | Inhibition of inducible nitric oxide synthase expression by an acetonic extract from Feijoa sellowiana Berg. fruits. | 2007 | J. Agric. Food Chem. | pmid:17550270 |
Fukuda I et al. | Interaction between the aryl hydrocarbon receptor and its antagonists, flavonoids. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17560542 |
Wan L et al. | Quantitative determination of apigenin and its metabolism in rat plasma after intravenous bolus administration by HPLC coupled with tandem mass spectrometry. | 2007 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:17561454 |