FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Wu Y et al. | [Effects of the total flavone of radix puerariae on apoptotic cell and apoptotic related-gene in atherosclerotic plaques of apoE gene deficiency mice]. | 2007 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:17711723 |
Huang HS et al. | [Advances in the research on pharmacological actions of flavone compounds]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12516448 |
Guo QS et al. | [Study on dynamic accumulation of flavone in various Chrysanthemum morifolium for medicine]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18831193 |
Chen LL et al. | [Effect of nebulized TFG on Th1/Th2 imbalance in mouse model with asthma]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19007018 |
Wang GH et al. | [Optimal extraction of nuciferine and flavone from lotus leaf based on central composite design and response surface methodology]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19157120 |
Wang C et al. | [Advances in chemical components and pharmacology of genus Gentiana]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:20222408 |
Geng XF et al. | [The progress of research on ginlcgobiobal flavone]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15015321 |
Zhang YJ et al. | [Identification and evaluation of TCM shayuanzi]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15015323 |
Zhao C et al. | [Study on anti-diabetes active fraction and constituents from Potentilla chinesis]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18590200 |
Zhou G and Lv G | [Comparative studies on scavenging DPPH free radicals activity of flavone C-glycosides from different parts of Dendrobium officinale]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22993976 |
Li Y et al. | [Simultaneous determination of five active components in resina draconis and its extract by HPLC]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22792791 |
Yin FZ et al. | [Optimization of preparation of salt-processed psoraleae fructus medicines with multi-index orthogonal method]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:23668006 |
Zhang JY et al. | [Rapid recognition and identification of chemical constituents in Qinghuo Zhimai tablets by SPE-HPLC-ESI-MS(n)]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:23672039 |
Qiao Y et al. | [Chemical constituents of n-BuOH extract of Comastoma pedunculatum]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23234130 |
Zhao HN et al. | [A new flavone C-glycoside from leaves of Lophatherum gracile]. | 2014 | Zhongguo Zhong Yao Za Zhi | pmid:24761639 |
He R et al. | [Chemical constituents of leaves of Panax japonicus var. major]. | 2014 | Zhongguo Zhong Yao Za Zhi | pmid:25095375 |
Chen JC et al. | [Anti-arrhythmic action of 4'-methyl-7-([2-hydroxy-3-(beta-propinamidoethyl)amino]propoxy) flavone hydrochloride (SIPI-644)]. | 1988 | Zhongguo Yao Li Xue Bao | pmid:3188948 |
Li XF | [Effects of flavone II of Piper wallichii on the isolated rabbit heart]. | 1985 | Zhong Yao Tong Bao | pmid:2934172 |
Qian S and Chen L | [Studies on the chemical constituents of Citrus reticulata]. | 1998 | Zhong Yao Cai | pmid:12567525 |
Ouyang P et al. | [Effects of flavone from leaves of Diospyros kaki on adventitial fibroblasts proliferation by advanced oxidation protein products in vitro]. | 2004 | Zhong Yao Cai | pmid:15272781 |