FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fernández SP et al. | Synergistic interaction between hesperidin, a natural flavonoid, and diazepam. | 2005 | Eur. J. Pharmacol. | pmid:15840404 |
| Rayyan S et al. | Flavone C-glycosides from leaves of Oxalis triangularis. | 2005 | J. Agric. Food Chem. | pmid:16366694 |
| Yoon JH and Baek SJ | Molecular targets of dietary polyphenols with anti-inflammatory properties. | 2005 | Yonsei Med. J. | pmid:16259055 |
| Sasaki K et al. | Effect of flavones on rat brain and lung matrix metalloproteinase activity measured by film in-situ zymography. | 2005 | J. Pharm. Pharmacol. | pmid:15831206 |
| Zheng W et al. | [Study on extraction of zhuyun 3# by supercritical CO2]. | 2005 | Zhong Yao Cai | pmid:16104514 |
| Griffin RJ et al. | Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro. | 2005 | J. Med. Chem. | pmid:15658870 |
| Ebert B et al. | Induction of phase-1 metabolizing enzymes by oltipraz, flavone and indole-3-carbinol enhance the formation and transport of benzo[a]pyrene sulfate conjugates in intestinal Caco-2 cells. | 2005 | Toxicol. Lett. | pmid:15890477 |
| Erhart LM et al. | Flavone initiates a hierarchical activation of the caspase-cascade in colon cancer cells. | 2005 | Apoptosis | pmid:15909122 |
| Nakagawa-Goto K et al. | Total synthesis and bioactivity of unique flavone desmosdumotin B and its analogs. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15913998 |
| Wang TC et al. | Synthesis, antiproliferative, and antiplatelet activities of oxime- and methyloxime-containing flavone and isoflavone derivatives. | 2005 | Bioorg. Med. Chem. | pmid:15990314 |
| Horvath CR et al. | Identification and quantification of eight flavones in root and shoot tissues of the medicinal plant huang-qin (Scutellaria baicalensis Georgi) using high-performance liquid chromatography with diode array and mass spectrometric detection. | 2005 | J Chromatogr A | pmid:15679157 |
| Wenzel U et al. | Increased mitochondrial palmitoylcarnitine/carnitine countertransport by flavone causes oxidative stress and apoptosis in colon cancer cells. | 2005 | Cell. Mol. Life Sci. | pmid:16314920 |
| Li BH et al. | Structure-activity relationship of polyphenols that inhibit fatty acid synthase. | 2005 | J. Biochem. | pmid:16428296 |
| Melidou M et al. | Protection against nuclear DNA damage offered by flavonoids in cells exposed to hydrogen peroxide: the role of iron chelation. | 2005 | Free Radic. Biol. Med. | pmid:16298684 |
| Ono M et al. | Radioiodinated flavones for in vivo imaging of beta-amyloid plaques in the brain. | 2005 | J. Med. Chem. | pmid:16279784 |
| Wang F et al. | Neuroactive flavonoids interacting with GABAA receptor complex. | 2005 | Curr Drug Targets CNS Neurol Disord | pmid:16266290 |
| Kim H et al. | Effects of naturally occurring compounds on fibril formation and oxidative stress of beta-amyloid. | 2005 | J. Agric. Food Chem. | pmid:16248550 |
| Kovacic P | Fundamental, electron transfer mechanism by pyrylium-type ions for the anticancer drugs 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA). | 2005 | Curr Med Chem Anticancer Agents | pmid:16178775 |
| Ozbey S et al. | Antibacterial 4-amino-N-(5-methylisoxazol-3-yl)-N-[(4-oxo-2-phenyl-4H-1-benzopyran-6-yl)methyl]benzenesulfonamide. | 2005 | Acta Crystallogr C | pmid:16143780 |
| Rothwell JA et al. | Experimental determination of octanol-water partition coefficients of quercetin and related flavonoids. | 2005 | J. Agric. Food Chem. | pmid:15913295 |
| Iori F et al. | Theoretical quantitative structure-activity relationships of flavone ligands interacting with cytochrome P450 1A1 and 1A2 isozymes. | 2005 | Bioorg. Med. Chem. | pmid:15914008 |
| Han Y | Ginkgo terpene component has an anti-inflammatory effect on Candida albicans-caused arthritic inflammation. | 2005 | Int. Immunopharmacol. | pmid:15829420 |
| Sawada Y and Ayabe S | Multiple mutagenesis of P450 isoflavonoid synthase reveals a key active-site residue. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15809082 |
| Malolanarasimhan K et al. | Synthesis and biological study of a flavone acetic acid analogue containing an azido reporting group designed as a multifunctional binding site probe. | 2005 | Bioorg. Med. Chem. | pmid:15781383 |
| Ngadjui BT et al. | Prenylated chalcones, flavone and other constituents of the twigs of Dorstenia angusticornis and Dorstenia barteri var. subtriangularis. | 2005 | Phytochemistry | pmid:15771891 |
| Zhang J and Brodbelt JS | Silver complexation and tandem mass spectrometry for differentiation of isomeric flavonoid diglycosides. | 2005 | Anal. Chem. | pmid:15762583 |
| Göker H et al. | Synthesis and potent antimicrobial activity of some novel 2-phenyl or methyl-4H-1-benzopyran-4-ones carrying amidinobenzimidazoles. | 2005 | Bioorg. Med. Chem. | pmid:15698788 |
| Nagai S et al. | Kinetic study of the quenching reaction of singlet oxygen by flavonoids in ethanol solution. | 2005 | J Phys Chem B | pmid:16851486 |
| Likhitwitayawuid K et al. | Phenolics with antiviral activity from Millettia erythrocalyx and Artocarpus lakoocha. | 2005 | Nat. Prod. Res. | pmid:15715263 |
| Furuya H et al. | Some flavonoids and DHEA-S prevent the cis-effect of expanded CTG repeats in a stable PC12 cell transformant. | 2005 | Biochem. Pharmacol. | pmid:15652241 |
| Wenzig E et al. | Flavonolignans from Avena sativa. | 2005 | J. Nat. Prod. | pmid:15730266 |
| Budzianowski J et al. | Lipophilic flavones of Primula veris L. from field cultivation and in vitro cultures. | 2005 | Phytochemistry | pmid:15896373 |
| Wenzel U et al. | Activation of mitochondrial lactate uptake by flavone induces apoptosis in human colon cancer cells. | 2005 | J. Cell. Physiol. | pmid:15452831 |
| Garritano S et al. | Assessment of estrogenic activity of flavonoids from Mediterranean plants using an in vitro short-term test. | 2005 | Phytomedicine | pmid:15693722 |
| Åania-Pietrzak B et al. | Modulation of MRP1 protein transport by plant, and synthetically modified flavonoids. | 2005 | Life Sci. | pmid:15916776 |
| UydeÅŸ-DoÄŸan BS et al. | The comparison of the relaxant effects of two methoxylated flavones in rat aortic rings. | 2005 | Vascul. Pharmacol. | pmid:16169284 |
| Simons AL et al. | Human gut microbial degradation of flavonoids: structure-function relationships. | 2005 | J. Agric. Food Chem. | pmid:15884869 |
| Lu H et al. | Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin. | 2005 | J. Med. Chem. | pmid:15689157 |
| Capodice JL et al. | Complementary and alternative medicine for chronic prostatitis/chronic pelvic pain syndrome. | 2005 | Evid Based Complement Alternat Med | pmid:16322807 |
| Carrara M et al. | Mono- or di-fluorinated analogues of flavone-8-acetic acid: synthesis and in vitro biological activity. | 2005 Mar-Apr | Anticancer Res. | pmid:15868960 |
| Feng Y et al. | Iridoid glucosides and flavones from the aerial parts of Avicennia marina. | 2006 | Chem. Biodivers. | pmid:17193312 |
| Cheng XP et al. | Inhibitory effect of total flavone of Abelmoschus manihot L. Medic on NMDA receptor-mediated current in cultured rat hippocampal neurons. | 2006 | Neurosci. Res. | pmid:16616791 |
| Stipcevic T et al. | Effect of different flavonoids on collagen synthesis in human fibroblasts. | 2006 | Plant Foods Hum Nutr | pmid:16642409 |
| Gupta A et al. | Influence of sea buckthorn (Hippophae rhamnoides L.) flavone on dermal wound healing in rats. | 2006 | Mol. Cell. Biochem. | pmid:16633732 |
| Ullah Mughal E et al. | Synthesis and antibacterial activity of substituted flavones, 4-thioflavones and 4-iminoflavones. | 2006 | Bioorg. Med. Chem. | pmid:16603364 |
| Wurglics M and Schubert-Zsilavecz M | Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. | 2006 | Clin Pharmacokinet | pmid:16640452 |
| Stintzing FC et al. | Thermal degradation kinetics of isoflavone aglycones from soy and red clover. | 2006 | Mol Nutr Food Res | pmid:16598813 |
| Leonard E et al. | Expression of a soluble flavone synthase allows the biosynthesis of phytoestrogen derivatives in Escherichia coli. | 2006 | Appl. Microbiol. Biotechnol. | pmid:16025328 |
| Sen N et al. | Leishmania donovani: intracellular ATP level regulates apoptosis-like death in luteolin induced dyskinetoplastid cells. | 2006 | Exp. Parasitol. | pmid:16707127 |
| Kostova I et al. | Structure-Activity Relationships of Synthetic Coumarins as HIV-1 Inhibitors. | 2006 | Bioinorg Chem Appl | pmid:17497014 |