FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Tóth L et al. | [Analysis of flavone derivatives by polyamide layer chromatography]. | 1984 | Acta Pharm Hung | pmid:6711313 |
Agosin M | The aerobic metabolism of metronidazole by Trypanosoma cruzi epimastigotes. | 1983 | Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. | pmid:6138198 |
He ZY | [Preliminary study on the treatment of coronary heart disease with total flavone of Caulis piperis Futokadsurae]. | 1983 | Zhong Xi Yi Jie He Za Zhi | pmid:6227404 |
Paulin JJ et al. | Ultrastructural modifications during the metabolism of metronidazole by Trypanosoma cruzi. | 1983 | J. Submicrosc. Cytol. | pmid:6361276 |
Ghosh DK et al. | Microsomal benzo(a)pyrene hydroxylase in Aspergillus ochraceus TS: assay and characterization of the enzyme system. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6409103 |
Dutta D et al. | Induction of benzo(a)pyrene hydroxylase in Aspergillus ochraceus TS: evidences of multiple forms of cytochrome P-450. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6626210 |
Matern U et al. | Further characterization and regulation of malonyl-coenzyme A: flavonoid glucoside malonyltransferases from parsley cell suspension cultures. | 1983 | Arch. Biochem. Biophys. | pmid:6639051 |
Hausen BM et al. | 5,8-dihydroxyflavone (primetin) the contact sensitizer of Primula mistassinica Michaux. | 1983 | Arch. Dermatol. Res. | pmid:6660907 |
Nomura T et al. | Constituents of the Chinese crude drug "sÄng-bái-pÃ" (Morus root bark). | 1983 | Planta Med. | pmid:17405088 |
Lasker JM et al. | In vivo activation of zoxazolamine metabolism by flavone. | 1982 | Science | pmid:7089530 |