FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Goettel W and Messing J | Change of gene structure and function by non-homologous end-joining, homologous recombination, and transposition of DNA. | 2009 | PLoS Genet. | pmid:19521498 |
Zhang J et al. | Transposition of reversed Ac element ends generates novel chimeric genes in maize. | 2006 | PLoS Genet. | pmid:17029561 |
Charkoudian LK et al. | In living color: bacterial pigments as an untapped resource in the classroom and beyond. | 2010 | PLoS Biol. | pmid:20957190 |
Bas E et al. | Anti-inflammatory activity of 5-O-demethylnobiletin, a polymethoxyflavone isolated from Sideritis tragoriganum. | 2006 | Planta Med. | pmid:16491449 |
Govindarajan R et al. | Effect of Desmodium gangeticum extract on blood glucose in rats and on insulin secretion in vitro. | 2007 | Planta Med. | pmid:17431824 |
Zhai K et al. | Chrysin induces hyperalgesia via the GABAA receptor in mice. | 2008 | Planta Med. | pmid:18612941 |
Chen JJ et al. | Furoquinoline alkaloids and cytotoxic constituents from the leaves of Melicope semecarpifolia. | 2003 | Planta Med. | pmid:12865974 |
Tsai PL and Tsai TH | Pharmacokinetics of baicalin in rats and its interactions with cyclosporin A, quinidine and SKF-525A: a microdialysis study. | 2004 | Planta Med. | pmid:15549664 |
Untergehrer M et al. | Structure-Dependent Deconjugation of Flavonoid Glucuronides by Human β-Glucuronidase - In Vitro and In Silico Analyses. | 2015 | Planta Med. | pmid:26018917 |
Suyenaga ES et al. | Appraisal of the antichemotactic activity of flavonoids on polymorphonuclear neutrophils. | 2011 | Planta Med. | pmid:21058242 |