FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Forgacs P et al. | [Flavones and Sesquiterpene Lactones of Volutarella divaricata]. | 1981 | Planta Med. | pmid:17401976 |
Nomura T et al. | Constituents of the Chinese crude drug "sÄng-bái-pÃ" (Morus root bark). | 1983 | Planta Med. | pmid:17405088 |
Barberán FA et al. | Highly Methylated 6-Hydroxyflavones and Other Flavonoids from Thymus piperella. | 1985 | Planta Med. | pmid:17342612 |
Saxena M et al. | A New Flavone from Sapium insigne. | 1986 | Planta Med. | pmid:17345426 |
Jiménez MJ et al. | Anti-Inflammatory Activity of a Flavone from Sideritis leucantha. | 1986 | Planta Med. | pmid:17345496 |
Tanaka S et al. | Influence of natural and synthetic compounds on cell surface expression of cell adhesion molecules, ICAM-1 and VCAM-1. | 2001 | Planta Med. | pmid:11301853 |
Corradi E et al. | Metabolite Profile and Antiproliferative Effects in HaCaT Cells of a Salix reticulata Extract. | 2017 | Planta Med. | pmid:28449181 |
Goppel M and Franz G | Stability control of senna leaves and senna extracts. | 2004 | Planta Med. | pmid:15124088 |
Chang TL et al. | 5,6,3',4'-Tetrahydroxy-7-methoxyflavone as a novel potential proteasome inhibitor. | 2010 | Planta Med. | pmid:20195959 |
Gong T et al. | Novel benzil and isoflavone derivatives from Millettia dielsiana. | 2009 | Planta Med. | pmid:19140097 |