FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fernández SP et al. | Synergistic interaction between hesperidin, a natural flavonoid, and diazepam. | 2005 | Eur. J. Pharmacol. | pmid:15840404 |
| Furtmueller R et al. | 6,3'-Dinitroflavone is a low efficacy modulator of GABA(A) receptors. | 2008 | Eur. J. Pharmacol. | pmid:18639544 |
| Geraets L et al. | Flavone as PARP-1 inhibitor: its effect on lipopolysaccharide induced gene-expression. | 2007 | Eur. J. Pharmacol. | pmid:17643414 |
| Patanasethanont D et al. | Modulation of function of multidrug resistance associated-proteins by Kaempferia parviflora extracts and their components. | 2007 | Eur. J. Pharmacol. | pmid:17481606 |
| Toton E et al. | The tetramethoxyflavone zapotin selectively activates protein kinase C epsilon, leading to its down-modulation accompanied by Bcl-2, c-Jun and c-Fos decrease. | 2012 | Eur. J. Pharmacol. | pmid:22381066 |
| Cai M et al. | The neuroprotective effect of eupatilin against ischemia/reperfusion-induced delayed neuronal damage in mice. | 2012 | Eur. J. Pharmacol. | pmid:22683875 |
| Guo W et al. | Antagonistic effect of flavonoids on NSC-741909-mediated antitumor activity via scavenging of reactive oxygen species. | 2010 | Eur. J. Pharmacol. | pmid:20854805 |
| Ren L et al. | Effects of flavone 6-substitutions on GABAA receptors efficacy. | 2011 | Eur. J. Pharmacol. | pmid:21914441 |
| Jansakul C et al. | Relaxant mechanisms of 3, 5, 7, 3', 4'-pentamethoxyflavone on isolated human cavernosum. | 2012 | Eur. J. Pharmacol. | pmid:22800934 |
| Yin Y et al. | Jaceosidin inhibits contact hypersensitivity in mice via down-regulating IFN-γ/STAT1/T-bet signaling in T cells. | 2011 | Eur. J. Pharmacol. | pmid:21093428 |
| Hall BJ et al. | Flumazenil-independent positive modulation of gamma-aminobutyric acid action by 6-methylflavone at human recombinant alpha1beta2gamma2L and alpha1beta2 GABAA receptors. | 2004 | Eur. J. Pharmacol. | pmid:15102527 |
| Benabdallah H and Gharzouli K | Effects of flavone on the contractile activity of the circular smooth muscle of the rabbit middle colon in vitro. | 2015 | Eur. J. Pharmacol. | pmid:25895637 |
| Alexandrakis M et al. | Flavones inhibit proliferation and increase mediator content in human leukemic mast cells (HMC-1). | 2003 | Eur. J. Haematol. | pmid:14703695 |
| Hirvonen T et al. | Flavonol and flavone intake and the risk of intermittent claudication in male smokers. | 2004 | Eur. J. Epidemiol. | pmid:15180100 |
| Park HJ et al. | Baicalin induces NAD(P)H:quinone reductase through the transactivation of AP-1 and NF-kappaB in Hepa 1c1c7 cells. | 2004 | Eur. J. Cancer Prev. | pmid:15548947 |
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| Rajesh G et al. | Effect of hydroxyl substitution of flavone on angiogenesis and free radical scavenging activities: a structure-activity relationship studies using computational tools. | 2010 | Eur J Pharm Sci | pmid:19874890 |
| Duchnowicz P et al. | Hypolipidemic and antioxidant effects of hydroxycinnamic acids, quercetin, and cyanidin 3-glucoside in hypercholesterolemic erythrocytes (in vitro study). | 2012 | Eur J Nutr | pmid:21755326 |
| Torres-Piedra M et al. | A comparative study of flavonoid analogues on streptozotocin-nicotinamide induced diabetic rats: quercetin as a potential antidiabetic agent acting via 11beta-hydroxysteroid dehydrogenase type 1 inhibition. | 2010 | Eur J Med Chem | pmid:20346546 |
| Liao SY et al. | QSAR, action mechanism and molecular design of flavone and isoflavone derivatives with cytotoxicity against HeLa. | 2008 | Eur J Med Chem | pmid:18082913 |
| Park H et al. | Synthesis and inhibition of PGE2 production of 6,8-disubstituted chrysin derivatives. | 2005 | Eur J Med Chem | pmid:15963606 |
| Kothandan G et al. | Docking and 3D-QSAR (quantitative structure activity relationship) studies of flavones, the potent inhibitors of p-glycoprotein targeting the nucleotide binding domain. | 2011 | Eur J Med Chem | pmid:21723648 |
| Rane RA et al. | Synthesis and evaluation of novel marine bromopyrrole alkaloid-based hybrids as anticancer agents. | 2013 | Eur J Med Chem | pmid:23584542 |
| Dong JJ et al. | Synthesis, biological evaluation and molecular docking studies of flavone and isoflavone derivatives as a novel class of KSP (kinesin spindle protein) inhibitors. | 2013 | Eur J Med Chem | pmid:24184776 |
| Neves MP et al. | Prenylated derivatives of baicalein and 3,7-dihydroxyflavone: synthesis and study of their effects on tumor cell lines growth, cell cycle and apoptosis. | 2011 | Eur J Med Chem | pmid:21496973 |
| Kant R et al. | Synthesis of newer 1,2,3-triazole linked chalcone and flavone hybrid compounds and evaluation of their antimicrobial and cytotoxic activities. | 2016 | Eur J Med Chem | pmid:26922227 |
| Imran S et al. | Synthesis of novel flavone hydrazones: in-vitro evaluation of α-glucosidase inhibition, QSAR analysis and docking studies. | 2015 | Eur J Med Chem | pmid:26491979 |
| Ahmed N et al. | Design, synthesis and antiproliferative activity of functionalized flavone-triazole-tetrahydropyran conjugates against human cancer cell lines. | 2014 | Eur J Med Chem | pmid:24941129 |
| Mitra I et al. | Chemometric modeling of free radical scavenging activity of flavone derivatives. | 2010 | Eur J Med Chem | pmid:20800321 |
| Alvarez G et al. | Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity. | 2010 | Eur J Med Chem | pmid:20889239 |
| Ilboudo O et al. | Targeting structural motifs of flavonoid diglycosides using collision-induced dissociation experiments on flavonoid/Pb2+ complexes. | 2012 | Eur J Mass Spectrom (Chichester, Eng) | pmid:23221119 |
| Kammalla AK et al. | Comparative pharmacokinetic interactions of Quercetin and Rutin in rats after oral administration of European patented formulation containing Hipphophae rhamnoides and Co-administration of Quercetin and Rutin. | 2015 | Eur J Drug Metab Pharmacokinet | pmid:24888486 |
| Kerr DJ and Kaye SB | Flavone acetic acid--preclinical and clinical activity. | 1989 | Eur J Cancer Clin Oncol | pmid:2680512 |
| Hill S et al. | Vascular collapse after flavone acetic acid: a possible mechanism of its anti-tumour action. | 1989 | Eur J Cancer Clin Oncol | pmid:2591434 |
| Ching LM and Baguley BC | Hyporesponsiveness of macrophages from C3H/HeJ (endotoxin-resistant) mice to the antitumour agent flavone acetic acid (NSC 347512). | 1989 | Eur J Cancer Clin Oncol | pmid:2591444 |
| Ching LM and Baguley BC | Reduction of cytotoxic effector cell activity in colon 38 tumours following treatment with flavone acetic acid. | 1989 | Eur J Cancer Clin Oncol | pmid:2597283 |
| Baguley BC et al. | Comparison of the effects of flavone acetic acid, fostriecin, homoharringtonine and tumour necrosis factor alpha on colon 38 tumours in mice. | 1989 | Eur J Cancer Clin Oncol | pmid:2702981 |
| Lewis CR et al. | Autonomic neuropathy following treatment with flavone acetic acid. | 1989 | Eur J Cancer Clin Oncol | pmid:2703010 |
| Ching LM and Baguley BC | Effect of flavone acetic acid (NSC 347,512) on splenic cytotoxic effector cells and their role in tumour necrosis. | 1989 | Eur J Cancer Clin Oncol | pmid:2737219 |
| Ching LM and Baguley BC | Enhancement of in vitro cytotoxicity of mouse peritoneal exudate cells by flavone acetic acid (NSC 347512). | 1988 | Eur J Cancer Clin Oncol | pmid:3181272 |
| Dodion P et al. | Sensitivity of normal human bone marrow myeloid progenitor cells to anthracycline, cisplatin, anthracene and flavone acetic acid derivatives, and its relevance for the prediction of human plasma concentrations of anticancer drugs. | 1987 | Eur J Cancer Clin Oncol | pmid:3436354 |
| Ching LM and Baguley BC | Induction of natural killer cell activity by the antitumour compound flavone acetic acid (NSC 347 512). | 1987 | Eur J Cancer Clin Oncol | pmid:3665989 |
| Capolongo LS et al. | Antiproliferative properties of flavone acetic acid (NSC 347512) (LM 975), a new anticancer agent. | 1987 | Eur J Cancer Clin Oncol | pmid:3678316 |
| Dodion PF et al. | Clinical and pharmacokinetic phase I trial with the diethylaminoester of flavone acetic acid (LM985, NSC 293015). | 1987 | Eur J Cancer Clin Oncol | pmid:3653200 |
| Schroyens WA et al. | In vitro chemosensitivity testing of flavone acetic acid (LM975; NSC 347512) and its diethylaminoethyl ester derivative (LM985; NSC 293015). | 1987 | Eur J Cancer Clin Oncol | pmid:3653209 |
| Smith GP et al. | Flavone acetic acid (NSC 347512) induces haemorrhagic necrosis of mouse colon 26 and 38 tumours. | 1987 | Eur J Cancer Clin Oncol | pmid:3653213 |