FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hirvonen T et al. | Intake of flavonols and flavones and risk of coronary heart disease in male smokers. | 2001 | Epidemiology | pmid:11138821 |
| Vermelho AB et al. | Microbial enzyme: applications in industry and in bioremediation. | 2012 | Enzyme Res | pmid:22496966 |
| Vila-Real H et al. | Enzymatic Synthesis of the Flavone Glucosides, Prunin and Isoquercetin, and the Aglycones, Naringenin and Quercetin, with Selective α-L-Rhamnosidase and β-D-Glucosidase Activities of Naringinase. | 2011 | Enzyme Res | pmid:21941631 |
| Marinova MD and Tchorbanov BP | Preparation of antioxidant enzymatic hydrolysates from honeybee-collected pollen using plant enzymes. | 2011 | Enzyme Res | pmid:21318132 |
| Mackenzie CA et al. | Gonadal differentiation in frogs exposed to estrogenic and antiestrogenic compounds. | 2003 | Environ. Toxicol. Chem. | pmid:14552012 |
| Gassmann K et al. | Species-specific differential AhR expression protects human neural progenitor cells against developmental neurotoxicity of PAHs. | 2010 | Environ. Health Perspect. | pmid:20570779 |
| Cesla P et al. | Separation of phenolic acids and flavone natural antioxidants by two-dimensional method combining liquid chromatography and micellar electrokinetic capillary chromatography. | 2010 | Electrophoresis | pmid:20593394 |
| Ruffmann R and Sartani A | Flavoxate, a drug with smooth muscle relaxing activity. | 1987 | Drugs Exp Clin Res | pmid:3595445 |
| Walle UK and Walle T | Bioavailable flavonoids: cytochrome P450-mediated metabolism of methoxyflavones. | 2007 | Drug Metab. Dispos. | pmid:17709371 |
| Kim SK et al. | The mitogen-activated protein kinase kinase (mek) inhibitor PD98059 elevates primary cultured rat hepatocyte glutathione levels independent of inhibiting mek. | 2006 | Drug Metab. Dispos. | pmid:16443668 |
| Khan KK et al. | Homotropic versus heterotopic cooperativity of cytochrome P450eryF: a substrate oxidation and spectral titration study. | 2003 | Drug Metab. Dispos. | pmid:12642459 |
| Chen EP et al. | A mechanism-based mathematical model of aryl hydrocarbon receptor-mediated CYP1A induction in rats using beta-naphthoflavone as a tool compound. | 2010 | Drug Metab. Dispos. | pmid:20843940 |
| Si D et al. | Mechanism of CYP2C9 inhibition by flavones and flavonols. | 2009 | Drug Metab. Dispos. | pmid:19074529 |
| Hosoda K et al. | Plasma profiling of intact isoflavone metabolites by high-performance liquid chromatography and mass spectrometric identification of flavone glycosides daidzin and genistin in human plasma after administration of kinako. | 2008 | Drug Metab. Dispos. | pmid:18443032 |
| Pham MH et al. | Identification of new flavone-8-acetic acid metabolites using mouse microsomes and comparison with human microsomes. | 2007 | Drug Metab. Dispos. | pmid:17664249 |
| Otake Y and Walle T | Oxidation of the flavonoids galangin and kaempferide by human liver microsomes and CYP1A1, CYP1A2, and CYP2C9. | 2002 | Drug Metab. Dispos. | pmid:11792676 |
| Pham MH et al. | Identification and induction of cytochrome P450s involved in the metabolism of flavone-8-acetic acid in mice. | 2011 | Drug Metab Lett | pmid:21457135 |
| Jian J et al. | Bauhinia championii flavone inhibits apoptosis and autophagy via the PI3K/Akt pathway in myocardial ischemia/reperfusion injury in rats. | 2015 | Drug Des Devel Ther | pmid:26604691 |
| Tahanian E et al. | Flavonoids targeting of IκB phosphorylation abrogates carcinogen-induced MMP-9 and COX-2 expression in human brain endothelial cells. | 2011 | Drug Des Devel Ther | pmid:21625419 |
| Tsai IT et al. | Flavone is efficient to protect zebrafish fins from UV-induced damage. | 2012 | Drug Chem Toxicol | pmid:22289409 |
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| Xue L et al. | Pd-carbene catalyzed carbonylation reactions of aryl iodides. | 2011 | Dalton Trans | pmid:21677940 |
| Lee JH et al. | Flavone reduces the production of virulence factors, staphyloxanthin and α-hemolysin, in Staphylococcus aureus. | 2012 | Curr. Microbiol. | pmid:22965624 |
| Manthey JA et al. | Biological properties of citrus flavonoids pertaining to cancer and inflammation. | 2001 | Curr. Med. Chem. | pmid:11172671 |
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| Kovacic P | Fundamental, electron transfer mechanism by pyrylium-type ions for the anticancer drugs 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA). | 2005 | Curr Med Chem Anticancer Agents | pmid:16178775 |
| López-Lázaro M | Flavonoids as anticancer agents: structure-activity relationship study. | 2002 | Curr Med Chem Anticancer Agents | pmid:12678721 |
| Wang F et al. | Neuroactive flavonoids interacting with GABAA receptor complex. | 2005 | Curr Drug Targets CNS Neurol Disord | pmid:16266290 |
| Kim DO and Lee CY | Comprehensive study on vitamin C equivalent antioxidant capacity (VCEAC) of various polyphenolics in scavenging a free radical and its structural relationship. | 2004 | Crit Rev Food Sci Nutr | pmid:15462129 |
| Kanth BK et al. | Homology modeling, binding site identification and docking in flavone hydroxylase CYP105P2 in Streptomyces peucetius ATCC 27952. | 2010 | Comput Biol Chem | pmid:20889382 |
| Agosin M | The aerobic metabolism of metronidazole by Trypanosoma cruzi epimastigotes. | 1983 | Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. | pmid:6138198 |
| Silvério CA and Okano LT | Laser flash photolysis and time-resolved fluorescence measurements of the aggregation number of SDS-biopolymer complexes. | 2004 | Colloids Surf B Biointerfaces | pmid:15465303 |
| Das S et al. | Antioxidant flavone analog functionalized fluorescent silica nanoparticles: Synthesis and exploration of their possible use as biomolecule sensor. | 2017 | Colloids Surf B Biointerfaces | pmid:28601757 |
| Gasiorowski K et al. | Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? | 2011 | CNS Neurol Disord Drug Targets | pmid:21222632 |
| Samarghandian S et al. | Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3. | 2011 | Clinics (Sao Paulo) | pmid:21808878 |
| Buchanan CM et al. | DMXAA (Vadimezan, ASA404) is a multi-kinase inhibitor targeting VEGFR2 in particular. | 2012 | Clin. Sci. | pmid:22142330 |
| Jeon SB et al. | Flavone inhibits vascular contraction by decreasing phosphorylation of the myosin phosphatase target subunit. | 2007 | Clin. Exp. Pharmacol. Physiol. | pmid:17880363 |
| Lefort EC and Blay J | The dietary flavonoid apigenin enhances the activities of the anti-metastatic protein CD26 on human colon carcinoma cells. | 2011 | Clin. Exp. Metastasis | pmid:21298326 |
| Kestell P et al. | Measurement of plasma 5-hydroxyindoleacetic acid as a possible clinical surrogate marker for the action of antivascular agents. | 2001 | Clin. Chim. Acta | pmid:11718691 |
| Li Y et al. | Induction of apoptosis and inhibition of c-erbB-2 in breast cancer cells by flavopiridol. | 2000 | Clin. Cancer Res. | pmid:10656453 |
| Motwani M et al. | Flavopiridol, a cyclin-dependent kinase inhibitor, prevents spindle inhibitor-induced endoreduplication in human cancer cells. | 2000 | Clin. Cancer Res. | pmid:10741717 |
| Manna SK et al. | Morin (3,5,7,2',4'-Pentahydroxyflavone) abolishes nuclear factor-kappaB activation induced by various carcinogens and inflammatory stimuli, leading to suppression of nuclear factor-kappaB-regulated gene expression and up-regulation of apoptosis. | 2007 | Clin. Cancer Res. | pmid:17404114 |
| Wurglics M and Schubert-Zsilavecz M | Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. | 2006 | Clin Pharmacokinet | pmid:16640452 |