FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Baguley BC | Preclinical efficacy of vascular disrupting agents in non-small-cell lung cancer. | 2011 | Clin Lung Cancer | pmid:21550553 |
Yan H et al. | Treating senile dementia with traditional Chinese medicine. | 2007 | Clin Interv Aging | pmid:18044136 |
Goto S and Handa S | Antithrombotic effects of flavonoid. | 2001 | Circulation | pmid:11157735 |
Li GR et al. | Acacetin, a natural flavone, selectively inhibits human atrial repolarization potassium currents and prevents atrial fibrillation in dogs. | 2008 | Circulation | pmid:18458165 |
Mruk JS et al. | Flavone-8-acetic acid (Flavonoid) profoundly reduces platelet-dependent thrombosis and vasoconstriction after deep arterial injury In vivo. | 2000 | Circulation | pmid:10645930 |
Cappelli C et al. | Computational study of conformational and chiroptical properties of (2R,3S,4R)-(+)-3,3',4,4',7-flavanpentol. | 2005 | Chirality | pmid:16196026 |
Liu Z et al. | Protective effect of chrysoeriol against doxorubicin-induced cardiotoxicity in vitro. | 2009 | Chin. Med. J. | pmid:19951587 |
Guo AJ et al. | Kaempferol as a flavonoid induces osteoblastic differentiation via estrogen receptor signaling. | 2012 | Chin Med | pmid:22546174 |
Xu F et al. | Quasi-MSn identification of flavanone 7-glycoside isomers in Da Chengqi Tang by high performance liquid chromatography-tandem mass spectrometry. | 2009 | Chin Med | pmid:19630957 |
Tan W et al. | Anti-cancer natural products isolated from chinese medicinal herbs. | 2011 | Chin Med | pmid:21777476 |
Tang W et al. | Simultaneous determination of eight major bioactive compounds in Dachengqi Tang (DT) by high-performance liquid chromatography. | 2008 | Chin Med | pmid:18445276 |
Wang DJ et al. | Effect of Total Flavone of Haw Leaves on Nuclear Factor Erythroid-2 Related Factor and Other Related Factors in Nonalcoholic Steatohepatitis Rats. | 2018 | Chin J Integr Med | pmid:26919834 |
Tarling CA et al. | The search for novel human pancreatic alpha-amylase inhibitors: high-throughput screening of terrestrial and marine natural product extracts. | 2008 | Chembiochem | pmid:18214874 |
Goettert M et al. | Biological evaluation and structural determinants of p38α mitogen-activated-protein kinase and c-Jun-N-terminal kinase 3 inhibition by flavonoids. | 2010 | Chembiochem | pmid:21108268 |
Goyal N et al. | Ethynylflavones, highly potent, and selective inhibitors of cytochrome P450 1A1. | 2014 | Chem. Res. Toxicol. | pmid:25033111 |
Fang H et al. | Structure-activity relationships for a large diverse set of natural, synthetic, and environmental estrogens. | 2001 | Chem. Res. Toxicol. | pmid:11258977 |
Fang H et al. | Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor. | 2003 | Chem. Res. Toxicol. | pmid:14565775 |
Shimada T et al. | Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives. | 2010 | Chem. Res. Toxicol. | pmid:21053930 |
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Kanho H et al. | Biotransformation of benzaldehyde-type and acetophenone-type derivatives by Pharbitis nil hairy roots. | 2005 | Chem. Pharm. Bull. | pmid:15802832 |
Kesava Reddy M et al. | A new chalcone and a flavone from Andrographis neesiana. | 2003 | Chem. Pharm. Bull. | pmid:12843595 |
Wu LZ et al. | Two new flavone C-glycosides from Trollius ledebourii. | 2011 | Chem. Pharm. Bull. | pmid:22041076 |
Phrutivorapongkul A et al. | Studies on the chemical constituents of stem bark of Millettia leucantha: isolation of new chalcones with cytotoxic, anti-herpes simplex virus and anti-inflammatory activities. | 2003 | Chem. Pharm. Bull. | pmid:12576653 |
Herath W et al. | Microbial metabolism. Part 6. Metabolites of 3- and 7-hydroxyflavones. | 2006 | Chem. Pharm. Bull. | pmid:16508185 |
Maheswara M et al. | Two new 5-deoxyflavonoids from Calliandra inermis. | 2004 | Chem. Pharm. Bull. | pmid:15304993 |
Waki T et al. | Key role of chemical hardness to compare 2,2-diphenyl-1-picrylhydrazyl radical scavenging power of flavone and flavonol O-glycoside and C-glycoside derivatives. | 2012 | Chem. Pharm. Bull. | pmid:22223373 |
Chokchaisiri R et al. | Bioactive flavonoids of the flowers of Butea monosperma. | 2009 | Chem. Pharm. Bull. | pmid:19336944 |
Murata T et al. | Hyaluronidase inhibitors from Keiskea japonica. | 2012 | Chem. Pharm. Bull. | pmid:22223383 |
Ragab FA et al. | Synthesis and anticonvulsant activity of certain substituted furochromone, benzofuran and flavone derivatives. | 2010 | Chem. Pharm. Bull. | pmid:20823592 |
Herath W et al. | Microbial metabolism part 9. Structure and antioxidant significance of the metabolites of 5,7-dihydroxyflavone (chrysin), and 5- and 6-hydroxyflavones. | 2008 | Chem. Pharm. Bull. | pmid:18379084 |
Alam MS and Lee DU | Facile synthesis and antibacterial activity of naturally occurring 5-methoxyfuroflavone. | 2010 | Chem. Pharm. Bull. | pmid:21139271 |
Fernandes DC et al. | Myeloperoxidase inhibitory and radical scavenging activities of flavones from Pterogyne nitens. | 2008 | Chem. Pharm. Bull. | pmid:18451567 |
Hayashi T et al. | A cytotoxic flavone from Scoparia dulcis L. | 1988 | Chem. Pharm. Bull. | pmid:3246045 |
Wang XL et al. | Effects of eleven flavonoids from the osteoprotective fraction of Drynaria fortunei (KUNZE) J. SM. on osteoblastic proliferation using an osteoblast-like cell line. | 2008 | Chem. Pharm. Bull. | pmid:18175973 |
Moorthy NS et al. | Synthesis, biological evaluation and in silico metabolic and toxicity prediction of some flavanone derivatives. | 2006 | Chem. Pharm. Bull. | pmid:17015974 |
Lanoë PH et al. | Cyclometallated platinum(II) complexes incorporating ethynyl-flavone ligands: switching between triplet and singlet emission induced by selective binding of Pb2+ ions. | 2008 | Chem. Commun. (Camb.) | pmid:18802561 |
Liu B et al. | A step toward simplified detection of serum albumin on SDS-PAGE using an environment-sensitive flavone sensor. | 2015 | Chem. Commun. (Camb.) | pmid:26068596 |
Asakawa T et al. | PET imaging of nobiletin based on a practical total synthesis. | 2011 | Chem. Commun. (Camb.) | pmid:21243163 |
Khoobi M et al. | A facile route to flavone and neoflavone backbones via a regioselective palladium catalyzed oxidative Heck reaction. | 2012 | Chem. Commun. (Camb.) | pmid:22318701 |
Xia C et al. | Differential effect of Shenmai injection, a herbal preparation, on the cytochrome P450 3A-mediated 1'-hydroxylation and 4-hydroxylation of midazolam. | 2009 | Chem. Biol. Interact. | pmid:19557931 |
Tsuji PA et al. | Accumulation and metabolism of the anticancer flavonoid 5,7-dimethoxyflavone compared to its unmethylated analog chrysin in the Atlantic killifish. | 2006 | Chem. Biol. Interact. | pmid:16999945 |
Tsuji PA and Walle T | Benzo[a]pyrene-induced cytochrome P450 1A and DNA binding in cultured trout hepatocytes - inhibition by plant polyphenols. | 2007 | Chem. Biol. Interact. | pmid:17583686 |
Djeridane A et al. | Inhibition of porcine liver carboxylesterase by a new flavone glucoside isolated from Deverra scoparia. | 2008 | Chem. Biol. Interact. | pmid:18163984 |
Valdameri G et al. | Importance of the core structure of flavones in promoting inhibition of the mitochondrial respiratory chain. | 2010 | Chem. Biol. Interact. | pmid:20654598 |
Brunskole M et al. | Trihydroxynaphthalene reductase of Curvularia lunata--a target for flavonoid action? | 2009 | Chem. Biol. Interact. | pmid:19010313 |
Khan MS et al. | Methylated chrysin induces co-ordinated attenuation of the canonical Wnt and NF-kB signaling pathway and upregulates apoptotic gene expression in the early hepatocarcinogenesis rat model. | 2011 | Chem. Biol. Interact. | pmid:21554863 |
Le Bon AM et al. | Inhibition of microsome-mediated binding of benzo[a]pyrene to DNA by flavonoids either in vitro or after dietary administration to rats. | 1992 | Chem. Biol. Interact. | pmid:1643669 |
Martin HJ et al. | The inhibitory effects of flavonoids and antiestrogens on the Glut1 glucose transporter in human erythrocytes. | 2003 | Chem. Biol. Interact. | pmid:14642735 |
Wu B and Wang J | Phenolic compounds from Selaginella moellendorfii. | 2011 | Chem. Biodivers. | pmid:21922662 |
Iida N et al. | A new flavone xyloside and two new flavan-3-ol glucosides from Juniperus communis var. depressa. | 2007 | Chem. Biodivers. | pmid:17256732 |