FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| DÃaz F et al. | Cytotoxic flavone analogues of vitexicarpin, a constituent of the leaves of Vitex negundo. | 2003 | J. Nat. Prod. | pmid:12828478 |
| Shibata H et al. | Flavone markedly affects phenotypic expression of beta-lactam resistance in methicillin-resistant Staphylococcus aureus strains isolated clinically. | 2003 | Biol. Pharm. Bull. | pmid:14519958 |
| Govindarajan R et al. | Studies on the antioxidant activities of Desmodium gangeticum. | 2003 | Biol. Pharm. Bull. | pmid:14519948 |
| Wenzel U et al. | Nitric oxide suppresses apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions. | 2003 | Int. J. Cancer | pmid:12866025 |
| Caci E et al. | CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12651632 |
| Kesava Reddy M et al. | A new chalcone and a flavone from Andrographis neesiana. | 2003 | Chem. Pharm. Bull. | pmid:12843595 |
| Jameson MB et al. | Clinical aspects of a phase I trial of 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent. | 2003 | Br. J. Cancer | pmid:12799625 |
| Tombola F et al. | Plant polyphenols inhibit VacA, a toxin secreted by the gastric pathogen Helicobacter pylori. | 2003 | FEBS Lett. | pmid:12753930 |
| Rustin GJ et al. | 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent: phase I clinical and pharmacokinetic study. | 2003 | Br. J. Cancer | pmid:12698178 |
| Springsteel MF et al. | Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain. | 2003 | Bioorg. Med. Chem. | pmid:12927873 |
| Beyer G and Melzig MF | Effects of selected flavonoids and caffeic acid derivatives on hypoxanthine-xanthine oxidase-induced toxicity in cultivated human cells. | 2003 | Planta Med. | pmid:14750029 |
| Dias C et al. | Structural elucidation of natural 2-hydroxy di- and tricarboxylic acids and esters, phenylpropanoid esters and a flavonoid from Autonoë madeirensis using gas chromatographic/electron ionization, electrospray ionization and tandem mass spectrometric techniques. | 2003 | J Mass Spectrom | pmid:14696202 |
| Suzuki R et al. | Two flavone C-glycosides from the style of Zea mays with glycation inhibitory activity. | 2003 | J. Nat. Prod. | pmid:12713418 |
| Tunçbilek M et al. | Synthesis and hypoglycemic activity of some substituted flavonyl thiazolidinedione derivatives--fifth communication: flavonyl benzyl substituted 2,4-thiazolidinediones. | 2003 | Farmaco | pmid:12595040 |
| Alonso M et al. | Flavopiridol induces apoptosis in glioma cell lines independent of retinoblastoma and p53 tumor suppressor pathway alterations by a caspase-independent pathway. | 2003 | Mol. Cancer Ther. | pmid:12589031 |
| Artali R et al. | Synthesis, X-ray crystal structure and biological properties of acetylenic flavone derivatives. | 2003 | Farmaco | pmid:13679182 |
| Moreno JA et al. | [Effect of phenolic compounds of virgin olive oil on LDL oxidation resistance]. | 2003 | Med Clin (Barc) | pmid:12605836 |
| Peterson J et al. | Flavonoid intake and breast cancer risk: a case--control study in Greece. | 2003 | Br. J. Cancer | pmid:14520456 |
| Bozdağ-Dündar O et al. | Synthesis and antimicrobial activity of flavone-3'-carboxaldehyde oxime ether derivatives. | 2003 | Arzneimittelforschung | pmid:12918219 |
| Gobbi S et al. | Synthesis and biological evaluation of 3-alkoxy analogues of flavone-8-acetic acid. | 2003 | J. Med. Chem. | pmid:12904070 |
| Aklilu M et al. | Phase II study of flavopiridol in patients with advanced colorectal cancer. | 2003 | Ann. Oncol. | pmid:12881391 |
| Bauvois B et al. | Synthesis and biological evaluation of novel flavone-8-acetic acid derivatives as reversible inhibitors of aminopeptidase N/CD13. | 2003 | J. Med. Chem. | pmid:12930151 |
| van der Logt EM et al. | Induction of rat hepatic and intestinal UDP-glucuronosyltransferases by naturally occurring dietary anticarcinogens. | 2003 | Carcinogenesis | pmid:12869420 |
| Chen JJ et al. | Furoquinoline alkaloids and cytotoxic constituents from the leaves of Melicope semecarpifolia. | 2003 | Planta Med. | pmid:12865974 |
| Gayot S et al. | Modification of flavonoid using lipase in non-conventional media: effect of the water content. | 2003 | J. Biotechnol. | pmid:12523967 |
| Maçanita AL et al. | Photochemistry of flavothione and hydroxyflavothiones: mechanisms and kinetics. | 2003 | Photochem. Photobiol. | pmid:12856878 |
| Vieira RF et al. | Chemical profiling of Ocimum americanum using external flavonoids. | 2003 | Phytochemistry | pmid:12809716 |
| Gabrieli C and Kokkalou E | A new acetylated glucoside of luteolin and two flavone glucosides from Lavandula stoechas ssp. stoechas. | 2003 | Pharmazie | pmid:12857010 |
| Chi YS et al. | Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression. | 2003 | Biochem. Pharmacol. | pmid:14505806 |
| Ray H et al. | Expression of anthocyanins and proanthocyanidins after transformation of alfalfa with maize Lc. | 2003 | Plant Physiol. | pmid:12857826 |
| Albach DC et al. | Acylated flavone glycosides from Veronica. | 2003 | Phytochemistry | pmid:14599528 |
| Mackenzie CA et al. | Gonadal differentiation in frogs exposed to estrogenic and antiestrogenic compounds. | 2003 | Environ. Toxicol. Chem. | pmid:14552012 |
| Newell DR et al. | Professor Tom Connors and the development of novel cancer therapies by the Phase I/II Clinical Trials Committee of Cancer Research UK. | 2003 | Br. J. Cancer | pmid:12888809 |
| Schauber J et al. | Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes: relevance of signalling pathways. | 2003 | Gut | pmid:12692061 |
| Suetsugi M et al. | Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors. | 2003 | Mol. Cancer Res. | pmid:14638870 |
| Alexandrakis M et al. | Flavones inhibit proliferation and increase mediator content in human leukemic mast cells (HMC-1). | 2003 | Eur. J. Haematol. | pmid:14703695 |
| Kragh M et al. | Acute effects of vascular modifying agents in solid tumors assessed by noninvasive laser Doppler flowmetry and near infrared spectroscopy. | 2002 May-Jun | Neoplasia | pmid:11988846 |
| Zhao L et al. | The antitumour activity of 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF receptor-1 knockout mice. | 2002 | Br. J. Cancer | pmid:12177785 |
| Hori K et al. | A novel combretastatin A-4 derivative, AC7700, strongly stanches tumour blood flow and inhibits growth of tumours developing in various tissues and organs. | 2002 | Br. J. Cancer | pmid:12085211 |
| Ching LM et al. | Induction of endothelial cell apoptosis by the antivascular agent 5,6-Dimethylxanthenone-4-acetic acid. | 2002 | Br. J. Cancer | pmid:12085190 |
| Jacobson KA et al. | Interactions of flavones and other phytochemicals with adenosine receptors. | 2002 | Adv. Exp. Med. Biol. | pmid:12083460 |
| Kuffel MJ et al. | Activation of the antitumor agent aminoflavone (NSC 686288) is mediated by induction of tumor cell cytochrome P450 1A1/1A2. | 2002 | Mol. Pharmacol. | pmid:12065765 |
| Hadjokas NE et al. | Arginine to lysine 108 substitution in recombinant CYP1A2 abolishes methoxyresorufin metabolism in lymphoblastoid cells. | 2002 | Br. J. Pharmacol. | pmid:12023936 |
| Isobe T et al. | [Antibacterial constituents against Helicobacter pylori of Brazilian medicinal plant, Pariparoba]. | 2002 | Yakugaku Zasshi | pmid:11968842 |
| Han DH et al. | Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12224631 |
| Matsui T et al. | Luteolin, a flavone, does not suppress postprandial glucose absorption through an inhibition of alpha-glucosidase action. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12005074 |
| Cai H et al. | A straightforward means of coupling preparative high-performance liquid chromatography and mass spectrometry. | 2002 | Rapid Commun. Mass Spectrom. | pmid:11870892 |
| Kahnberg P et al. | Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA(A) receptor. | 2002 | J. Med. Chem. | pmid:12213060 |
| Vrielynck L et al. | Self-modelling analysis applied to nanosecond transient absorption spectroscopy of flavone: an aid to elucidate and characterise reaction intermediates. | 2002 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:12396046 |
| López-Lázaro M | Flavonoids as anticancer agents: structure-activity relationship study. | 2002 | Curr Med Chem Anticancer Agents | pmid:12678721 |