FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Brauch D et al. | Changes in isovitexin-O-glycosylation during the development of young barley plants. | 2018 | Phytochemistry | pmid:29421507 |
Yamada K et al. | A lipase inhibitor monoterpene and monoterpene glycosides from Monarda punctata. | 2010 | Phytochemistry | pmid:20832830 |
Das B et al. | Diterpenoids from Jatropha multifida. | 2008 | Phytochemistry | pmid:18823921 |
Murakami S et al. | Purification and characterization of three neutral extracellular isoperoxidases from rye leaves. | 2007 | Phytochemistry | pmid:17266998 |
Rodrigues J et al. | An unusual C6-C6" linked flavonoid from Miconia cabucu (Melastomataceae). | 2007 | Phytochemistry | pmid:17540417 |
Fossen T et al. | Covalent anthocyanin-flavone dimer from leaves of Oxalis triangularis. | 2007 | Phytochemistry | pmid:17182069 |
Martens S and Mithöfer A | Flavones and flavone synthases. | 2005 | Phytochemistry | pmid:16137727 |
Ngadjui BT et al. | Prenylated chalcones, flavone and other constituents of the twigs of Dorstenia angusticornis and Dorstenia barteri var. subtriangularis. | 2005 | Phytochemistry | pmid:15771891 |
Ono E et al. | Co-pigmentation and flavonoid glycosyltransferases in blue Veronica persica flowers. | 2010 | Phytochemistry | pmid:20223486 |
Kong C et al. | Two compounds from allelopathic rice accession and their inhibitory activity on weeds and fungal pathogens. | 2004 | Phytochemistry | pmid:15110693 |
Reddy MK et al. | A flavone and an unusual 23-carbon terpenoid from Andrographis paniculata. | 2003 | Phytochemistry | pmid:12648550 |
Wang HB et al. | Flavone glucosides with immunomodulatory activity from the leaves of Pleioblastus amarus. | 2004 | Phytochemistry | pmid:15081303 |
Franke K et al. | Flavone-coumarin hybrids from Gnidia socotrana. | 2002 | Phytochemistry | pmid:12453582 |
Lee MH et al. | Bioactive constituents of Spatholobus suberectus in regulating tyrosinase-related proteins and mRNA in HEMn cells. | 2006 | Phytochemistry | pmid:16782143 |
DomÃnguez M et al. | Pensteminoside, an unusual catalpol-type iridoid from Penstemon gentianoides HBK (Plantaginaceae). | 2007 | Phytochemistry | pmid:17507063 |
Albach DC et al. | Acylated flavone glycosides from Veronica. | 2003 | Phytochemistry | pmid:14599528 |
Takeda K et al. | Components of protocyanin, a blue pigment from the blue flowers of Centaurea cyanus. | 2005 | Phytochemistry | pmid:16005311 |
Stochmal A et al. | Acylated apigenin glycosides from alfalfa (Medicago sativa L.) var. Artal. | 2001 | Phytochemistry | pmid:11454348 |
Valant-Vetschera KM et al. | Chemodiversity of exudate flavonoids in Dionysia (Primulaceae): a comparative study. | 2010 | Phytochemistry | pmid:20378133 |
Matsuda H et al. | Inhibitory effects of thunberginols A and B isolated from Hydrangeae Dulcis Folium on mRNA expression of cytokines and on activation of activator protein-1 in RBL-2H3 cells. | 2008 | Phytomedicine | pmid:17950587 |
Borges-Argáez R et al. | Cytotoxic and antiprotozoal activity of flavonoids from Lonchocarpus spp. | 2007 | Phytomedicine | pmid:17291734 |
Varga Z et al. | Structure prerequisite for antioxidant activity of silybin in different biochemical systems in vitro. | 2006 | Phytomedicine | pmid:16360937 |
Perez RM et al. | Isolation and hypoglycemic activity of 5, 7,3'-trihydroxy-3,6,4'-trimethoxyflavone from Brickellia veronicaefolia. | 2000 | Phytomedicine | pmid:10782487 |
Flemmig J et al. | Olea europaea leaf (Ph.Eur.) extract as well as several of its isolated phenolics inhibit the gout-related enzyme xanthine oxidase. | 2011 | Phytomedicine | pmid:21144719 |
Ulrich-Merzenich G et al. | Novel neurological and immunological targets for salicylate-based phytopharmaceuticals and for the anti-depressant imipramine. | 2012 | Phytomedicine | pmid:22743246 |
Garritano S et al. | Assessment of estrogenic activity of flavonoids from Mediterranean plants using an in vitro short-term test. | 2005 | Phytomedicine | pmid:15693722 |
Innocenti G et al. | In vitro estrogenic activity of Achillea millefolium L. | 2007 | Phytomedicine | pmid:16860978 |
Soriano IR et al. | Inducible Flavone in Oats (Avena sativa) Is a Novel Defense Against Plant-Parasitic Nematodes. | 2004 | Phytopathology | pmid:18944456 |
Nitoda T et al. | Effects of phenolic compounds isolated from Rabdosia japonica on B16-F10 melanoma cells. | 2008 | Phytother Res | pmid:18567053 |
Mishra KP et al. | Effect of Seabuckthorn (Hippophae rhamnoides) flavone on immune system: an in-vitro approach. | 2008 | Phytother Res | pmid:18570236 |
Takano-Ishikawa Y et al. | Inhibitory effects of several flavonoids on E-selectin expression on human umbilical vein endothelial cells stimulated by tumor necrosis factor-alpha. | 2003 | Phytother Res | pmid:14669262 |
Blatt CT et al. | Cytotoxic flavonoids from the stem bark of Lonchocarpus aff. fluvialis. | 2002 | Phytother Res | pmid:12112286 |
Shi Y et al. | Analgesic and uterine relaxant effects of isoliquiritigenin, a flavone from Glycyrrhiza glabra. | 2012 | Phytother Res | pmid:22389128 |
Almeida JR et al. | 3,6-Dimethoxy-6″,6″-Dimethyl-(7,8,2″,3″)-Chromeneflavone, a Flavonoid Isolated from Lonchocarpus Araripensis Benth. (Fabaceae), Reduces Nociceptive Behaviour in Mice. | 2015 | Phytother Res | pmid:26172339 |
Zhao J et al. | MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula. | 2011 | Plant Cell | pmid:21467581 |
Martin C et al. | How can research on plants contribute to promoting human health? | 2011 | Plant Cell | pmid:21586682 |
Akhtar TA et al. | Photosynthetic redox imbalance influences flavonoid biosynthesis in Lemna gibba. | 2010 | Plant Cell Environ. | pmid:20199616 |
Yan J et al. | GmFNSII-controlled soybean flavone metabolism responds to abiotic stresses and regulates plant salt tolerance. | 2014 | Plant Cell Physiol. | pmid:24192294 |
Masada S et al. | Functional and structural characterization of a flavonoid glucoside 1,6-glucosyltransferase from Catharanthus roseus. | 2009 | Plant Cell Physiol. | pmid:19561332 |
Berim A et al. | Identification of a unique 2-oxoglutarate-dependent flavone 7-O-demethylase completes the elucidation of the lipophilic flavone network in basil. | 2015 | Plant Cell Physiol. | pmid:25378691 |
Stipcevic T et al. | Effect of different flavonoids on collagen synthesis in human fibroblasts. | 2006 | Plant Foods Hum Nutr | pmid:16642409 |
Stracke R et al. | Differential regulation of closely related R2R3-MYB transcription factors controls flavonol accumulation in different parts of the Arabidopsis thaliana seedling. | 2007 | Plant J. | pmid:17419845 |
Berim A et al. | Unexpected roles for ancient proteins: flavone 8-hydroxylase in sweet basil trichomes is a Rieske-type, PAO-family oxygenase. | 2014 | Plant J. | pmid:25139498 |
Goodger JQ et al. | Isolation of intact sub-dermal secretory cavities from Eucalyptus. | 2010 | Plant Methods | pmid:20807444 |
Zhang P et al. | A maize QTL for silk maysin levels contains duplicated Myb-homologous genes which jointly regulate flavone biosynthesis. | 2003 | Plant Mol. Biol. | pmid:12825685 |
Yan J et al. | The soybean R2R3 MYB transcription factor GmMYB100 negatively regulates plant flavonoid biosynthesis. | 2015 | Plant Mol. Biol. | pmid:26231207 |
Schmidt A et al. | Polymethylated myricetin in trichomes of the wild tomato species Solanum habrochaites and characterization of trichome-specific 3'/5'- and 7/4'-myricetin O-methyltransferases. | 2011 | Plant Physiol. | pmid:21343428 |
Lan W et al. | Maize Tricin-Oligolignol Metabolites and Their Implications for Monocot Lignification. | 2016 | Plant Physiol. | pmid:27208246 |
Ray H et al. | Expression of anthocyanins and proanthocyanidins after transformation of alfalfa with maize Lc. | 2003 | Plant Physiol. | pmid:12857826 |
Dobritsa AA et al. | LAP5 and LAP6 encode anther-specific proteins with similarity to chalcone synthase essential for pollen exine development in Arabidopsis. | 2010 | Plant Physiol. | pmid:20442277 |