FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ahmed N et al. | Design, synthesis and antiproliferative activity of functionalized flavone-triazole-tetrahydropyran conjugates against human cancer cell lines. | 2014 | Eur J Med Chem | pmid:24941129 |
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| Wang MH et al. | A new antioxidant flavone glycoside from Scutellaria baicalensis Georgi. | 2014 | Nat. Prod. Res. | pmid:24995563 |
| Lee DW and Park KH | Testosterone metabolism by microsomal cytochrome P-450 in liver of rats treated with some inducers. | 1989 | Int. J. Biochem. | pmid:2502444 |
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| Berim A et al. | Unexpected roles for ancient proteins: flavone 8-hydroxylase in sweet basil trichomes is a Rieske-type, PAO-family oxygenase. | 2014 | Plant J. | pmid:25139498 |
| Zhang C et al. | Common and unique cis-acting elements mediate xanthotoxin and flavone induction of the generalist P450 CYP321A1. | 2014 | Sci Rep | pmid:25262756 |
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| Xu S et al. | A novel flavone-based fluorescent probe for relay recognition of HSO3(-) and Al(3+). | 2015 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:25965168 |
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| Ting Y et al. | Viscoelastic Emulsion Improved the Bioaccessibility and Oral Bioavailability of Crystalline Compound: A Mechanistic Study Using in Vitro and in Vivo Models. | 2015 | Mol. Pharm. | pmid:25984595 |
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| Liu B et al. | A step toward simplified detection of serum albumin on SDS-PAGE using an environment-sensitive flavone sensor. | 2015 | Chem. Commun. (Camb.) | pmid:26068596 |
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| Almeida JR et al. | 3,6-Dimethoxy-6″,6″-Dimethyl-(7,8,2″,3″)-Chromeneflavone, a Flavonoid Isolated from Lonchocarpus Araripensis Benth. (Fabaceae), Reduces Nociceptive Behaviour in Mice. | 2015 | Phytother Res | pmid:26172339 |
| Boesten DM et al. | Protective Pleiotropic Effect of Flavonoids on NAD⺠Levels in Endothelial Cells Exposed to High Glucose. | 2015 | Oxid Med Cell Longev | pmid:26180598 |
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| Yan J et al. | The soybean R2R3 MYB transcription factor GmMYB100 negatively regulates plant flavonoid biosynthesis. | 2015 | Plant Mol. Biol. | pmid:26231207 |
| Desoize B et al. | Response of primary tumour, spontaneous metastases and recurrence of Lewis lung carcinoma (3LL) to flavone acetic acid (FAA, LM975). | 1989 Nov-Dec | Anticancer Res. | pmid:2627123 |
| Zhao W et al. | Ammonium Iodide Induced Nonradical Regioselective Sulfenylation of Flavones via a C-H Functionalization Process. | 2015 | J. Org. Chem. | pmid:26291122 |
| Fan Y et al. | The activation of Epimedium polysaccharide-propolis flavone liposome on Kupffer cells. | 2015 | Carbohydr Polym | pmid:26344320 |