FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Chen IL et al. | Synthesis and antiproliferative evaluation of amide-containing flavone and isoflavone derivatives. | 2008 | Bioorg. Med. Chem. | pmid:18662883 |
Ullah Mughal E et al. | Synthesis and antibacterial activity of substituted flavones, 4-thioflavones and 4-iminoflavones. | 2006 | Bioorg. Med. Chem. | pmid:16603364 |
Dong X et al. | Identification of SVM-based classification model, synthesis and evaluation of prenylated flavonoids as vasorelaxant agents. | 2008 | Bioorg. Med. Chem. | pmid:18678502 |
Marder M et al. | Molecular modeling and QSAR analysis of the interaction of flavone derivatives with the benzodiazepine binding site of the GABA(A) receptor complex. | 2001 | Bioorg. Med. Chem. | pmid:11249125 |
Lewin G et al. | Influence of the skeleton on the cytotoxicity of flavonoids. | 2012 | Bioorg. Med. Chem. | pmid:22257529 |
Li Z et al. | Up-regulation of Toll-like receptor 4 was suppressed by emodin and baicalin in the setting of acute pancreatitis. | 2009 | Biomed. Pharmacother. | pmid:18343629 |
Miyata Y et al. | In vitro studies on nobiletin isolated from citrus plants and the bioactive metabolites, inhibitory action against gelatinase enzymatic activity and the molecular mechanisms in human retinal Müller cell line. | 2017 | Biomed. Pharmacother. | pmid:28623785 |
Hollman PC and Katan MB | Absorption, metabolism and health effects of dietary flavonoids in man. | 1997 | Biomed. Pharmacother. | pmid:9436520 |
Huang L et al. | Autophagy induction by hispidulin provides protection against sevoflurane-induced neuronal apoptosis in aged rats. | 2018 | Biomed. Pharmacother. | pmid:29287193 |
Thangaraj K and Vaiyapuri M | Orientin, a C-glycosyl dietary flavone, suppresses colonic cell proliferation and mitigates NF-κB mediated inflammatory response in 1,2-dimethylhydrazine induced colorectal carcinogenesis. | 2017 | Biomed. Pharmacother. | pmid:29198745 |
Buset H and Scheline RR | Identification of urinary metabolites of flavanone in the rat. | 1979 | Biomed. Mass Spectrom. | pmid:476285 |
Cai H et al. | Determination of the flavone tricin in human plasma by high-performance liquid chromatography. | 2003 | Biomed. Chromatogr. | pmid:14598326 |
Cai H et al. | Determination of the putative cancer chemopreventive flavone tricin in plasma and tissues of mice by HPLC with UV--visible detection. | 2005 | Biomed. Chromatogr. | pmid:15828058 |
Kanaze FI et al. | A validated HPLC determination of the flavone aglycone diosmetin in human plasma. | 2004 | Biomed. Chromatogr. | pmid:15386576 |
Prasad VG et al. | Iminoflavones combat 1,2-dimethyl hydrazine-induced aberrant crypt foci development in colon cancer. | 2014 | Biomed Res Int | pmid:24995310 |
Mizoyama Y et al. | Inhibitory effect of flavonoids on N-acetylation of 5-aminosalicylic acid in cultured rat hepatocytes. | 2004 | Biol. Pharm. Bull. | pmid:15340238 |
Shibata H et al. | Flavone markedly affects phenotypic expression of beta-lactam resistance in methicillin-resistant Staphylococcus aureus strains isolated clinically. | 2003 | Biol. Pharm. Bull. | pmid:14519958 |
Govindarajan R et al. | Studies on the antioxidant activities of Desmodium gangeticum. | 2003 | Biol. Pharm. Bull. | pmid:14519948 |
Chatuphonprasert W et al. | Potent modification of inducible CYP1A1 expression by flavonoids. | 2010 | Biol. Pharm. Bull. | pmid:20930378 |
Lai MY et al. | Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of Scutellariae Radix in humans. | 2003 | Biol. Pharm. Bull. | pmid:12520178 |
Morimitsu Y et al. | Inhibitory effect of flavonoids on sulfo- and glucurono-conjugation of acetaminophen in rat cultured hepatocytes and liver subcellular preparations. | 2004 | Biol. Pharm. Bull. | pmid:15133252 |
Jin M et al. | Suppressive effects of T-412, a flavone on interleukin-4 production in T cells. | 2009 | Biol. Pharm. Bull. | pmid:19881301 |
Doronicheva N et al. | Chemical structure-dependent differential effects of flavonoids on the catalase activity as evaluated by a chemiluminescent method. | 2007 | Biol. Pharm. Bull. | pmid:17268053 |
Nakamura K et al. | Effects of Hydroxy Groups in the A-Ring on the Anti-proteasome Activity of Flavone. | 2015 | Biol. Pharm. Bull. | pmid:25810454 |
Kim HG et al. | Acacetin protects dopaminergic cells against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neuroinflammation in vitro and in vivo. | 2012 | Biol. Pharm. Bull. | pmid:22863927 |
Jung SH et al. | Aldose reductase and advanced glycation endproducts inhibitory effect of Phyllostachys nigra. | 2007 | Biol. Pharm. Bull. | pmid:17666823 |
Tan M et al. | Synthesis, cytotoxic activity, and DNA binding properties of copper (II) complexes with hesperetin, naringenin, and apigenin. | 2009 | Bioinorg Chem Appl | pmid:19830248 |
Kostova I et al. | Structure-Activity Relationships of Synthetic Coumarins as HIV-1 Inhibitors. | 2006 | Bioinorg Chem Appl | pmid:17497014 |
Kundu S and Roy D | Structural study of biologically significant ligands with major birch pollen allergen Betv1 by docking and molecular dynamics simulation. | 2010 | Bioinformation | pmid:20978606 |
Masoodi TA and Alhamdanz AH | Inhibitory effect of flavonoids on mutant H-Rasp protein. | 2010 | Bioinformation | pmid:21346872 |
Zhou X et al. | Flavone and isoflavone derivatives of terrestrial plants as larval settlement inhibitors of the barnacle Balanus amphitrite. | 2009 | Biofouling | pmid:18855151 |
Siess MH et al. | Mechanisms involved in the chemoprevention of flavonoids. | 2000 | Biofactors | pmid:11216486 |
González B et al. | Respiratory system of Gluconacetobacter diazotrophicus PAL5. Evidence for a cyanide-sensitive cytochrome bb and cyanide-resistant cytochrome ba quinol oxidases. | 2006 | Biochim. Biophys. Acta | pmid:16934215 |
Zhou JM et al. | Sequential O-methylation of tricetin by a single gene product in wheat. | 2006 | Biochim. Biophys. Acta | pmid:16730127 |
Scheidt HA et al. | Investigation of the membrane localization and distribution of flavonoids by high-resolution magic angle spinning NMR spectroscopy. | 2004 | Biochim. Biophys. Acta | pmid:15157612 |
Chan LP et al. | Apigenin induces apoptosis via tumor necrosis factor receptor- and Bcl-2-mediated pathway and enhances susceptibility of head and neck squamous cell carcinoma to 5-fluorouracil and cisplatin. | 2012 | Biochim. Biophys. Acta | pmid:22554915 |
Choi J et al. | Flavones from Scutellaria baicalensis Georgi attenuate apoptosis and protein oxidation in neuronal cell lines. | 2002 | Biochim. Biophys. Acta | pmid:12090934 |
Kanda K et al. | Nobiletin suppresses adipocyte differentiation of 3T3-L1 cells by an insulin and IBMX mixture induction. | 2012 | Biochim. Biophys. Acta | pmid:22172985 |
Hirohata M et al. | Anti-amyloidogenic effects of soybean isoflavones in vitro: Fluorescence spectroscopy demonstrating direct binding to Aβ monomers, oligomers and fibrils. | 2012 | Biochim. Biophys. Acta | pmid:22587837 |
Kim J et al. | In vitro characterization of CYP102G4 from Streptomyces cattleya: A self-sufficient P450 naturally producing indigo. | 2018 | Biochim Biophys Acta Proteins Proteom | pmid:28821467 |
Girish KS and Kemparaju K | Inhibition of Naja naja venom hyaluronidase by plant-derived bioactive components and polysaccharides. | 2005 | Biochemistry Mosc. | pmid:16212553 |
Fang J and Beattie DS | Novel FMN-containing rotenone-insensitive NADH dehydrogenase from Trypanosoma brucei mitochondria: isolation and characterization. | 2002 | Biochemistry | pmid:11863445 |
Lolli G et al. | Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight. | 2012 | Biochemistry | pmid:22794353 |
Cutroneo KR et al. | Induction of benzpyrene hydroxylase by flavone and its derivatives in fetal rat liver explants. | 1972 | Biochem. Pharmacol. | pmid:5064734 |
Walle T et al. | Cancer chemopreventive properties of orally bioavailable flavonoids--methylated versus unmethylated flavones. | 2007 | Biochem. Pharmacol. | pmid:17250812 |
Verbeek R et al. | The flavones luteolin and apigenin inhibit in vitro antigen-specific proliferation and interferon-gamma production by murine and human autoimmune T cells. | 2004 | Biochem. Pharmacol. | pmid:15276069 |
Huen MS et al. | Naturally occurring 2'-hydroxyl-substituted flavonoids as high-affinity benzodiazepine site ligands. | 2003 | Biochem. Pharmacol. | pmid:14637197 |
Dertinger SD et al. | Effect of 3'-methoxy-4'-nitroflavone on benzo[a]pyrene toxicity. Aryl hydrocarbon receptor-dependent and -independent mechanisms. | 2000 | Biochem. Pharmacol. | pmid:10825463 |
Niisato N et al. | Cross talk of cAMP and flavone in regulation of cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel and Na+/K+/2Cl- cotransporter in renal epithelial A6 cells. | 2004 | Biochem. Pharmacol. | pmid:14757180 |
Nose K | Inhibition by flavonoids of RNA synthesis in permeable WI-38 cells and of transcription by RNA polymerase II. | 1984 | Biochem. Pharmacol. | pmid:6508836 |