FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhang M et al. | FlavonQ: an automated data processing tool for profiling flavone and flavonol glycosides with ultra-high-performance liquid chromatography-diode array detection-high resolution accurate mass-mass spectrometry. | 2015 | Anal. Chem. | pmid:26359695 |
| Real Hernandez LM et al. | Berry Phenolic Compounds Increase Expression of Hepatocyte Nuclear Factor-1α (HNF-1α) in Caco-2 and Normal Colon Cells Due to High Affinities with Transcription and Dimerization Domains of HNF-1α. | 2015 | PLoS ONE | pmid:26413797 |
| Zhang F et al. | Forsythoneosides A-D, Neuroprotective Phenethanoid and Flavone Glycoside Heterodimers from the Fruits of Forsythia suspensa. | 2015 | J. Nat. Prod. | pmid:26422318 |
| Hao B et al. | The biosynthesis of allelopathic di-C-glycosylflavones from the roots of Desmodium incanum (G. Mey.) DC. | 2015 | Org. Biomol. Chem. | pmid:26478440 |
| Imran S et al. | Synthesis of novel flavone hydrazones: in-vitro evaluation of α-glucosidase inhibition, QSAR analysis and docking studies. | 2015 | Eur J Med Chem | pmid:26491979 |
| Li YR et al. | Tangeretin derivative, 5-acetyloxy-6,7,8,4'-tetramethoxyflavone induces G2/M arrest, apoptosis and autophagy in human non-small cell lung cancer cells in vitro and in vivo. | 2016 | Cancer Biol. Ther. | pmid:26569090 |
| Malkhasian AY and Howlin BJ | Docking and DFT studies on ligand binding to Quercetin 2,3-dioxygenase. | 2016 | J. Biomol. Struct. Dyn. | pmid:26599260 |
| Jian J et al. | Bauhinia championii flavone inhibits apoptosis and autophagy via the PI3K/Akt pathway in myocardial ischemia/reperfusion injury in rats. | 2015 | Drug Des Devel Ther | pmid:26604691 |
| LeJeune TM et al. | Mechanism of Action of Two Flavone Isomers Targeting Cancer Cells with Varying Cell Differentiation Status. | 2015 | PLoS ONE | pmid:26606169 |
| Lin CH et al. | Flavones inhibit breast cancer proliferation through the Akt/FOXO3a signaling pathway. | 2015 | BMC Cancer | pmid:26675309 |
| Cummings J and Smyth JF | Flavone 8-acetic acid: our current understanding of its mechanism of action in solid tumours. | 1989 | Cancer Chemother. Pharmacol. | pmid:2667786 |
| Zhang J et al. | A flavone-based turn-on fluorescent probe for intracellular cysteine/homocysteine sensing with high selectivity. | 2016 | Talanta | pmid:26695232 |
| Kerr DJ and Kaye SB | Flavone acetic acid--preclinical and clinical activity. | 1989 | Eur J Cancer Clin Oncol | pmid:2680512 |
| Wang DJ et al. | Effect of Total Flavone of Haw Leaves on Nuclear Factor Erythroid-2 Related Factor and Other Related Factors in Nonalcoholic Steatohepatitis Rats. | 2018 | Chin J Integr Med | pmid:26919834 |
| Kant R et al. | Synthesis of newer 1,2,3-triazole linked chalcone and flavone hybrid compounds and evaluation of their antimicrobial and cytotoxic activities. | 2016 | Eur J Med Chem | pmid:26922227 |
| Kasala ER et al. | Chemopreventive effect of chrysin, a dietary flavone against benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice. | 2016 | Pharmacol Rep | pmid:26922533 |
| Zhu W et al. | Flavone inhibits migration through DLC1/RhoA pathway by decreasing ROS generation in breast cancer cells. | 2016 | In Vitro Cell. Dev. Biol. Anim. | pmid:26935193 |
| Ismail NA and Jusoh SA | Molecular Docking and Molecular Dynamics Simulation Studies to Predict Flavonoid Binding on the Surface of DENV2 E Protein. | 2017 | Interdiscip Sci | pmid:26969331 |
| Lameiras P and Nuzillard JM | Highly Viscous Binary Solvents: DMSO-d6/Glycerol and DMSO-d6/Glycerol-d8 for Polar and Apolar Mixture Analysis by NMR. | 2016 | Anal. Chem. | pmid:27008506 |
| Baguley BC et al. | Comparison of the effects of flavone acetic acid, fostriecin, homoharringtonine and tumour necrosis factor alpha on colon 38 tumours in mice. | 1989 | Eur J Cancer Clin Oncol | pmid:2702981 |
| Lewis CR et al. | Autonomic neuropathy following treatment with flavone acetic acid. | 1989 | Eur J Cancer Clin Oncol | pmid:2703010 |
| Cassidy J et al. | Could interspecies differences in the protein binding of flavone acetic acid contribute to the failure to predict lack of efficacy in patients? | 1989 | Cancer Chemother. Pharmacol. | pmid:2713962 |
| Zhao Q et al. | A specialized flavone biosynthetic pathway has evolved in the medicinal plant, Scutellaria baicalensis. | 2016 | Sci Adv | pmid:27152350 |
| Lan W et al. | Maize Tricin-Oligolignol Metabolites and Their Implications for Monocot Lignification. | 2016 | Plant Physiol. | pmid:27208246 |
| Yan X et al. | 58-F, a flavanone from Ophiopogon japonicus, prevents hepatocyte death by decreasing lysosomal membrane permeability. | 2016 | Sci Rep | pmid:27306715 |
| Cummings J et al. | Characterization of the major metabolites of flavone acetic acid and comparison of their disposition in humans and mice. | 1989 | Cancer Res. | pmid:2731178 |
| Bibby MC et al. | Influence of site on the chemosensitivity of transplantable murine colon tumours to flavone acetic acid (LM975, NSC 347512). | 1989 | Cancer Chemother. Pharmacol. | pmid:2731316 |
| Rabinovitz M | Flavone-8-acetic acid and the natural flavonoids. | 1989 | J. Natl. Cancer Inst. | pmid:2733041 |
| Zwi LJ et al. | Blood flow failure as a major determinant in the antitumor action of flavone acetic acid. | 1989 | J. Natl. Cancer Inst. | pmid:2733044 |
| Roy D and Liehr JG | Metabolic oxidation of diethylstilbestrol to diethylstilbestrol-4',4"-quinone in Syrian hamsters. | 1989 | Carcinogenesis | pmid:2736717 |
| Ching LM and Baguley BC | Effect of flavone acetic acid (NSC 347,512) on splenic cytotoxic effector cells and their role in tumour necrosis. | 1989 | Eur J Cancer Clin Oncol | pmid:2737219 |
| Bugel SM et al. | Comparative Developmental Toxicity of Flavonoids Using an Integrative Zebrafish System. | 2016 | Toxicol. Sci. | pmid:27492224 |
| Ertan R et al. | Synthesis of new annellated flavonoid derivatives possessing spasmolytic activity--VII. | 1989 | Arch. Pharm. (Weinheim) | pmid:2751412 |
| Chabot GG et al. | Flavone acetic acid (LM-975; NSC-347512) activation to cytotoxic species in vivo and in vitro. | 1989 | Cancer Chemother. Pharmacol. | pmid:2758556 |
| Nagai T et al. | Inhibition of mouse liver sialidase by plant flavonoids. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2775264 |
| Sun JR and Brown JM | Enhancement of the antitumor effect of flavone acetic acid by the bioreductive cytotoxic drug SR 4233 in a murine carcinoma. | 1989 | Cancer Res. | pmid:2790784 |
| Kamto EL et al. | Alternating isocratic and step gradient elution high-speed counter-current chromatography for the isolation of minor phenolics from Ormocarpum kirkii bark. | 2017 | J Chromatogr A | pmid:27988077 |
| Atwell GJ et al. | Synthesis and anti-tumour activity of topologically-related analogues of flavoneacetic acid. | 1989 | Anticancer Drug Des. | pmid:2803464 |
| Kerr DJ et al. | Phase II trials of flavone acetic acid in advanced malignant melanoma and colorectal carcinoma. | 1989 | Br. J. Cancer | pmid:2803908 |
| Murray JC et al. | Flavone acetic acid induces a coagulopathy in mice. | 1989 | Br. J. Cancer | pmid:2803949 |
| Kang Y et al. | Inhibitory potential of flavonoids on PtdIns(3,4,5)P3 binding with the phosphoinositide-dependent kinase 1 pleckstrin homology domain. | 2017 | Bioorg. Med. Chem. Lett. | pmid:28049590 |
| Li YP et al. | Three new C-alkylated flavonoids from Desmodium oblongum. | 2017 | J Asian Nat Prod Res | pmid:28145124 |
| Yang Y et al. | Encapsulation of Polymethoxyflavones in Citrus Oil Emulsion-Based Delivery Systems. | 2017 | J. Agric. Food Chem. | pmid:28182421 |
| Lonchampt M et al. | Protective effect of a purified flavonoid fraction against reactive oxygen radicals. In vivo and in vitro study. | 1989 | Arzneimittelforschung | pmid:2818676 |
| Li S et al. | Chemical profiling of Fufang-Xialian-Capsule by UHPLC-Q-TOF-MS and its antioxidant activity evaluated by in vitro method. | 2017 | J Pharm Biomed Anal | pmid:28235732 |
| Tsai YF et al. | 6-Hydroxy-5,7-dimethoxy-flavone suppresses the neutrophil respiratory burst via selective PDE4 inhibition to ameliorate acute lung injury. | 2017 | Free Radic. Biol. Med. | pmid:28263828 |
| An JY et al. | Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE2 in LPS-induced RAW 264.7 cells. | 2017 | Bioorg. Med. Chem. Lett. | pmid:28408221 |
| Corradi E et al. | Metabolite Profile and Antiproliferative Effects in HaCaT Cells of a Salix reticulata Extract. | 2017 | Planta Med. | pmid:28449181 |
| Bourdillat B et al. | Mechanism of action of hispidulin, a natural flavone, on human platelets. | 1988 | Prog. Clin. Biol. Res. | pmid:2845433 |
| Qu Y et al. | Expression of Root Genes in Arabidopsis Seedlings Grown by Standard and Improved Growing Methods. | 2017 | Int J Mol Sci | pmid:28467358 |