FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Barrellier MT | [Lymphedema: is there a treatment?]. | 1992 Jan-Feb | Rev Med Interne | pmid:1410875 |
Blonska M et al. | Effect of flavone derivatives on interleukin-1beta (IL-1beta) mRNA expression and IL-1beta protein synthesis in stimulated RAW 264.7 macrophages. | 2003 | Scand. J. Immunol. | pmid:12588662 |
Zhao Q et al. | A specialized flavone biosynthetic pathway has evolved in the medicinal plant, Scutellaria baicalensis. | 2016 | Sci Adv | pmid:27152350 |
Zhao E and Mu Q | Phytoestrogen biological actions on Mammalian reproductive system and cancer growth. | 2011 Jan-Mar | Sci Pharm | pmid:21617769 |
El-Alfy TS et al. | A New Flavonoid C-Glycoside from Celtis australis L. and Celtis occidentalis L. Leaves and Potential Antioxidant and Cytotoxic Activities. | 2011 Oct-Dec | Sci Pharm | pmid:22145118 |
Zhang C et al. | Common and unique cis-acting elements mediate xanthotoxin and flavone induction of the generalist P450 CYP321A1. | 2014 | Sci Rep | pmid:25262756 |
Yan X et al. | 58-F, a flavanone from Ophiopogon japonicus, prevents hepatocyte death by decreasing lysosomal membrane permeability. | 2016 | Sci Rep | pmid:27306715 |
Duchowicz PR et al. | QSAR analysis on Spodoptera litura antifeedant activities for flavone derivatives. | 2009 | Sci. Total Environ. | pmid:19846206 |
Lasker JM et al. | In vivo activation of zoxazolamine metabolism by flavone. | 1982 | Science | pmid:7089530 |
Gooda Sahib N et al. | Plants' metabolites as potential antiobesity agents. | 2012 | ScientificWorldJournal | pmid:22666121 |
de-Faria FM et al. | Antioxidant action of mangrove polyphenols against gastric damage induced by absolute ethanol and ischemia-reperfusion in the rat. | 2012 | ScientificWorldJournal | pmid:22654592 |
Kostrzewa-Susłow E and Janeczko T | Microbial transformations of 7-hydroxyflavanone. | 2012 | ScientificWorldJournal | pmid:22654578 |
Xiao Z et al. | [The inhibitory effect of total flavonoids of hippophae on the activation of NF-kappa B by stretching cultured cardiac myocytes]. | 2003 | Sichuan Da Xue Xue Bao Yi Xue Ban | pmid:12947714 |
MartÃnez-Richa A and Joseph-Nathan P | Carbon-13 CP-MAS nuclear magnetic resonance studies of teas. | 2003 | Solid State Nucl Magn Reson | pmid:12763559 |
Marian CM | Spin-forbidden transitions in flavone. | 2009 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:19264543 |
Mitra A et al. | Studies on the interaction of a synthetic nitro-flavone derivative with DNA: A multi-spectroscopic and molecular docking approach. | 2018 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:29885634 |
Vrielynck L et al. | Self-modelling analysis applied to nanosecond transient absorption spectroscopy of flavone: an aid to elucidate and characterise reaction intermediates. | 2002 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:12396046 |
Xu S et al. | A novel flavone-based fluorescent probe for relay recognition of HSO3(-) and Al(3+). | 2015 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:25965168 |
Chen Q et al. | Measurement of total flavone content in snow lotus (Saussurea involucrate) using near infrared spectroscopy combined with interval PLS and genetic algorithm. | 2010 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:20338806 |
Collins BM et al. | The estrogenic and antiestrogenic activities of phytochemicals with the human estrogen receptor expressed in yeast. | 1997 | Steroids | pmid:9090797 |
Baranowska I and Raróg D | Application of derivative spectrophotometry to determination of flavonoid mixtures. | 2001 | Talanta | pmid:18968363 |
Liu Q et al. | Metabolism profile of scutellarin in urine following oral administration to rats by ultra performance liquid chromatography coupled to time-of-flight mass spectrometry. | 2009 | Talanta | pmid:19782195 |
Toyo'oka T et al. | On-line screening methods for antioxidants scavenging superoxide anion radical and hydrogen peroxide by liquid chromatography with indirect chemiluminescence detection. | 2003 | Talanta | pmid:18969068 |
Zhang J et al. | A flavone-based turn-on fluorescent probe for intracellular cysteine/homocysteine sensing with high selectivity. | 2016 | Talanta | pmid:26695232 |
Karvela E et al. | Deployment of response surface methodology to optimise recovery of grape (Vitis vinifera) stem polyphenols. | 2009 | Talanta | pmid:19635365 |
Meyer JD et al. | Quantitative trait loci for maysin synthesis in maize (Zea mays L.) lines selected for high silk maysin content. | 2007 | Theor. Appl. Genet. | pmid:17486311 |
Russo EB | Cannabinoids in the management of difficult to treat pain. | 2008 | Ther Clin Risk Manag | pmid:18728714 |
Kamata R et al. | Agonistic effects of diverse xenobiotics on the constitutive androstane receptor as detected in a recombinant yeast-cell assay. | 2018 | Toxicol In Vitro | pmid:28927721 |
Lim H et al. | Flavonoids interfere with NLRP3 inflammasome activation. | 2018 | Toxicol. Appl. Pharmacol. | pmid:29960001 |
Khan R et al. | Chrysin protects against cisplatin-induced colon. toxicity via amelioration of oxidative stress and apoptosis: probable role of p38MAPK and p53. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22155348 |
Schutte ME et al. | An in vitro and in silico study on the flavonoid-mediated modulation of the transport of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through Caco-2 monolayers. | 2006 | Toxicol. Appl. Pharmacol. | pmid:16997339 |
Lin TY et al. | Hispidulin inhibits the release of glutamate in rat cerebrocortical nerve terminals. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22759588 |
Ebert B et al. | Induction of phase-1 metabolizing enzymes by oltipraz, flavone and indole-3-carbinol enhance the formation and transport of benzo[a]pyrene sulfate conjugates in intestinal Caco-2 cells. | 2005 | Toxicol. Lett. | pmid:15890477 |
Ebert B et al. | Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate. | 2007 | Toxicol. Sci. | pmid:17077187 |
Sanderson JT et al. | Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells. | 2004 | Toxicol. Sci. | pmid:15319488 |
Bugel SM et al. | Comparative Developmental Toxicity of Flavonoids Using an Integrative Zebrafish System. | 2016 | Toxicol. Sci. | pmid:27492224 |
van Duursen MB et al. | Phytochemicals inhibit catechol-O-methyltransferase activity in cytosolic fractions from healthy human mammary tissues: implications for catechol estrogen-induced DNA damage. | 2004 | Toxicol. Sci. | pmid:15254334 |
Hong H et al. | Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein. | 2015 | Toxicol. Sci. | pmid:25349334 |
Canivenc-Lavier MC et al. | Comparative effects of flavonoids and model inducers on drug-metabolizing enzymes in rat liver. | 1996 | Toxicology | pmid:8931757 |
Ramful D et al. | Bioactive phenolics and antioxidant propensity of flavedo extracts of Mauritian citrus fruits: potential prophylactic ingredients for functional foods application. | 2010 | Toxicology | pmid:20100535 |
Schrader KK | Plant Natural compounds with antibacterial activity towards common pathogens of pond-cultured channel catfish (Ictalurus punctatus). | 2010 | Toxins (Basel) | pmid:22069655 |
Yang L et al. | Compound Chinese herbal medicinal ingredients can enhance immune response and efficacy of RHD vaccine in rabbit. | 2008 | Vaccine | pmid:18602959 |
Wang D et al. | Immunologic synergism with IL-2 and effects of cCHMIs on mRNA expression of IL-2 and IFN-gamma in chicken peripheral T lymphocyte. | 2006 | Vaccine | pmid:16887240 |
Sun JL et al. | Immunologic enhancement of compound Chinese herbal medicinal ingredients and their efficacy comparison with compound Chinese herbal medicines. | 2006 | Vaccine | pmid:16378665 |
UydeÅŸ-DoÄŸan BS et al. | The comparison of the relaxant effects of two methoxylated flavones in rat aortic rings. | 2005 | Vascul. Pharmacol. | pmid:16169284 |
Zandi K et al. | Antiviral activity of four types of bioflavonoid against dengue virus type-2. | 2011 | Virol. J. | pmid:22201648 |
Madan V et al. | Requirement of the vesicular system for membrane permeabilization by Sindbis virus. | 2005 | Virology | pmid:15661162 |
Chang CW et al. | Daphne Genkwa sieb. Et zucc. Water-soluble extracts act on enterovirus 71 by inhibiting viral entry. | 2012 | Viruses | pmid:22590685 |
Ibrahim AR and Abul-Hajj YJ | Microbiological transformation of flavone and isoflavone. | 1990 | Xenobiotica | pmid:2346033 |
Lee HS et al. | In vitro metabolism of eupatilin by multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes. | 2007 | Xenobiotica | pmid:17701830 |