FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Zhao L et al. | The antitumour activity of 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF receptor-1 knockout mice. | 2002 | Br. J. Cancer | pmid:12177785 |
Kahnberg P et al. | Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA(A) receptor. | 2002 | J. Med. Chem. | pmid:12213060 |
Han DH et al. | Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12224631 |
Van Hoorn DE et al. | Accurate prediction of xanthine oxidase inhibition based on the structure of flavonoids. | 2002 | Eur. J. Pharmacol. | pmid:12231379 |
Manthey JA and Guthrie N | Antiproliferative activities of citrus flavonoids against six human cancer cell lines. | 2002 | J. Agric. Food Chem. | pmid:12358447 |
Po LS et al. | Baicalein and genistein display differential actions on estrogen receptor (ER) transactivation and apoptosis in MCF-7 cells. | 2002 | Cancer Lett. | pmid:12359348 |
Böcker D and Verspohl EJ | Role of protein kinase C, PI3-kinase and tyrosine kinase in activation of MAP kinase by glucose and agonists of G-protein coupled receptors in INS-1 cells. | 2001 | Int. J. Exp. Diabetes Res. | pmid:12369712 |
Ogawa M and Ogihara Y | [Studies on the constituents of Enkianthus nudipes. IV. A new flavone glucoside from the stems (author's transl)]. | 1975 | Yakugaku Zasshi | pmid:1237562 |
Vrielynck L et al. | Self-modelling analysis applied to nanosecond transient absorption spectroscopy of flavone: an aid to elucidate and characterise reaction intermediates. | 2002 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:12396046 |
Sampson L et al. | Flavonol and flavone intakes in US health professionals. | 2002 | J Am Diet Assoc | pmid:12396158 |
Thomas JP et al. | Phase I clinical and pharmacokinetic trial of the cyclin-dependent kinase inhibitor flavopiridol. | 2002 | Cancer Chemother. Pharmacol. | pmid:12451473 |
Franke K et al. | Flavone-coumarin hybrids from Gnidia socotrana. | 2002 | Phytochemistry | pmid:12453582 |
Mihara M et al. | Flavopiridol, a cyclin dependent kinase (CDK) inhibitor, induces apoptosis by regulating Bcl-x in oral cancer cells. | 2003 | Oral Oncol. | pmid:12457721 |
Horsman MR and Murata R | Combination of vascular targeting agents with thermal or radiation therapy. | 2002 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:12459380 |
Zuo L et al. | 2D-IR correlation analysis of deteriorative process of traditional Chinese medicine 'Qing Kai Ling' injection. | 2003 | J Pharm Biomed Anal | pmid:12467920 |
Choi MH et al. | Determination of non-steroidal estrogens in breast milk, plasma, urine and hair by gas chromatography/mass spectrometry. | 2002 | Rapid Commun. Mass Spectrom. | pmid:12478564 |
Huang HS et al. | [Advances in the research on pharmacological actions of flavone compounds]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12516448 |
Morimoto M et al. | Insect antifeedant activity of flavones and chromones against Spodoptera litura. | 2003 | J. Agric. Food Chem. | pmid:12517100 |
Lai MY et al. | Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of Scutellariae Radix in humans. | 2003 | Biol. Pharm. Bull. | pmid:12520178 |
Gayot S et al. | Modification of flavonoid using lipase in non-conventional media: effect of the water content. | 2003 | J. Biotechnol. | pmid:12523967 |
Nørbaek R et al. | Flavone C-glycoside, phenolic acid, and nitrogen contents in leaves of barley subject to organic fertilization treatments. | 2003 | J. Agric. Food Chem. | pmid:12537462 |
Hyup YH et al. | 2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12565941 |
Qian S and Chen L | [Studies on the chemical constituents of Citrus reticulata]. | 1998 | Zhong Yao Cai | pmid:12567525 |
Lin L et al. | [A study on the quality of various species of Dalbergia]. | 1997 | Zhong Yao Cai | pmid:12572437 |
Phrutivorapongkul A et al. | Studies on the chemical constituents of stem bark of Millettia leucantha: isolation of new chalcones with cytotoxic, anti-herpes simplex virus and anti-inflammatory activities. | 2003 | Chem. Pharm. Bull. | pmid:12576653 |
Goutman JD et al. | Flavonoid modulation of ionic currents mediated by GABA(A) and GABA(C) receptors. | 2003 | Eur. J. Pharmacol. | pmid:12586201 |
Blonska M et al. | Effect of flavone derivatives on interleukin-1beta (IL-1beta) mRNA expression and IL-1beta protein synthesis in stimulated RAW 264.7 macrophages. | 2003 | Scand. J. Immunol. | pmid:12588662 |
Alonso M et al. | Flavopiridol induces apoptosis in glioma cell lines independent of retinoblastoma and p53 tumor suppressor pathway alterations by a caspase-independent pathway. | 2003 | Mol. Cancer Ther. | pmid:12589031 |
Tunçbilek M et al. | Synthesis and hypoglycemic activity of some substituted flavonyl thiazolidinedione derivatives--fifth communication: flavonyl benzyl substituted 2,4-thiazolidinediones. | 2003 | Farmaco | pmid:12595040 |
Moreno JA et al. | [Effect of phenolic compounds of virgin olive oil on LDL oxidation resistance]. | 2003 | Med Clin (Barc) | pmid:12605836 |
Lai MY et al. | Comparison of metabolic pharmacokinetics of baicalin and baicalein in rats. | 2003 | J. Pharm. Pharmacol. | pmid:12631413 |
Khan KK et al. | Homotropic versus heterotopic cooperativity of cytochrome P450eryF: a substrate oxidation and spectral titration study. | 2003 | Drug Metab. Dispos. | pmid:12642459 |
Zhou JG et al. | Species-specific transcriptional activity of synthetic flavonoids in guinea pig and mouse cells as a result of differential activation of the aryl hydrocarbon receptor to interact with dioxin-responsive elements. | 2003 | Mol. Pharmacol. | pmid:12644593 |
Reddy MK et al. | A flavone and an unusual 23-carbon terpenoid from Andrographis paniculata. | 2003 | Phytochemistry | pmid:12648550 |
Caci E et al. | CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12651632 |
Wu SN et al. | Differential effects of quercetin, a natural polyphenolic flavonoid, on L-type calcium current in pituitary tumor (GH3) cells and neuronal NG108-15 cells. | 2003 | J. Cell. Physiol. | pmid:12652656 |
Fukui Y et al. | A rationale for the shift in colour towards blue in transgenic carnation flowers expressing the flavonoid 3',5'-hydroxylase gene. | 2003 | Phytochemistry | pmid:12657292 |
Kang KW et al. | Activation of CCAAT/enhancer-binding protein beta by 2'-amino-3'-methoxyflavone (PD98059) leads to the induction of glutathione S-transferase A2. | 2003 | Carcinogenesis | pmid:12663507 |
López-Lázaro M | Flavonoids as anticancer agents: structure-activity relationship study. | 2002 | Curr Med Chem Anticancer Agents | pmid:12678721 |
Vaher M and Koel M | Separation of polyphenolic compounds extracted from plant matrices using capillary electrophoresis. | 2003 | J Chromatogr A | pmid:12685601 |
Pepper C et al. | Flavopiridol induces apoptosis in B-cell chronic lymphocytic leukaemia cells through a p38 and ERK MAP kinase-dependent mechanism. | 2003 | Leuk. Lymphoma | pmid:12688354 |
Schauber J et al. | Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes: relevance of signalling pathways. | 2003 | Gut | pmid:12692061 |
Rustin GJ et al. | 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent: phase I clinical and pharmacokinetic study. | 2003 | Br. J. Cancer | pmid:12698178 |
Boué SM et al. | Identification of flavone aglycones and glycosides in soybean pods by liquid chromatography-tandem mass spectrometry. | 2003 | J Chromatogr A | pmid:12703901 |
Selloum L et al. | Anti-inflammatory effect of rutin on rat paw oedema, and on neutrophils chemotaxis and degranulation. | 2003 | Exp. Toxicol. Pathol. | pmid:12710715 |
Gafner S et al. | Inhibition of [3H]-LSD binding to 5-HT7 receptors by flavonoids from Scutellaria lateriflora. | 2003 | J. Nat. Prod. | pmid:12713409 |
Suzuki R et al. | Two flavone C-glycosides from the style of Zea mays with glycation inhibitory activity. | 2003 | J. Nat. Prod. | pmid:12713418 |
Tombola F et al. | Plant polyphenols inhibit VacA, a toxin secreted by the gastric pathogen Helicobacter pylori. | 2003 | FEBS Lett. | pmid:12753930 |
Gleye C et al. | Acaricidal activity of tonka bean extracts. Synthesis and structure-activity relationships of bioactive derivatives. | 2003 | J. Nat. Prod. | pmid:12762809 |
MartÃnez-Richa A and Joseph-Nathan P | Carbon-13 CP-MAS nuclear magnetic resonance studies of teas. | 2003 | Solid State Nucl Magn Reson | pmid:12763559 |