FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Diniz A et al. | Characterization of interactions between polyphenolic compounds and human serum proteins by capillary electrophoresis. | 2008 | Anal Bioanal Chem | pmid:18418586 |
Buszewski B and Noga S | Hydrophilic interaction liquid chromatography (HILIC)--a powerful separation technique. | 2012 | Anal Bioanal Chem | pmid:21879300 |
Bovee TF et al. | Screening of synthetic and plant-derived compounds for (anti)estrogenic and (anti)androgenic activities. | 2008 | Anal Bioanal Chem | pmid:18188547 |
Tabak C et al. | Chronic obstructive pulmonary disease and intake of catechins, flavonols, and flavones: the MORGEN Study. | 2001 | Am. J. Respir. Crit. Care Med. | pmid:11435239 |
Caci E et al. | CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12651632 |
Lin J et al. | Dietary intakes of flavonols and flavones and coronary heart disease in US women. | 2007 | Am. J. Epidemiol. | pmid:17379619 |
Fekrazad HM et al. | A phase I study of flavopiridol in combination with gemcitabine and irinotecan in patients with metastatic cancer. | 2010 | Am. J. Clin. Oncol. | pmid:19884803 |
Cassidy A et al. | Intake of dietary flavonoids and risk of epithelial ovarian cancer. | 2014 | Am. J. Clin. Nutr. | pmid:25332332 |
Rossi M and La Vecchia C | Flavonoids and the risk of ovarian cancer. | 2014 | Am. J. Clin. Nutr. | pmid:25332318 |
Critchfield JW et al. | Inhibition of HIV activation in latently infected cells by flavonoid compounds. | 1996 | AIDS Res. Hum. Retroviruses | pmid:8825617 |
Agbottah E et al. | Two specific drugs, BMS-345541 and purvalanol A induce apoptosis of HTLV-1 infected cells through inhibition of the NF-kappaB and cell cycle pathways. | 2008 | AIDS Res Ther | pmid:18544167 |
Guendel I et al. | Inhibition of human immunodeficiency virus type-1 by cdk inhibitors. | 2010 | AIDS Res Ther | pmid:20334651 |
Al-Rimawi F et al. | ANALYSIS OF PHENOLIC AND FLAVONOIDS OF WILD EPHEDRA ALATA PLANT EXTRACTS BY LC/PDA AND LC/MS AND THEIR ANTIOXIDANT ACTIVITY. | 2017 | Afr J Tradit Complement Altern Med | pmid:28573229 |
Mbouangouere RN et al. | Piptaderol from Piptadenia africana. | 2007 | Afr J Tradit Complement Altern Med | pmid:20161892 |
Jacobson KA et al. | Interactions of flavones and other phytochemicals with adenosine receptors. | 2002 | Adv. Exp. Med. Biol. | pmid:12083460 |
Hildebrandt AG et al. | Studies on the mechanism of stimulation of microsomal H2O2 formation and benzo(a)pyrene hydroxylation by substrates and flavone. | 1981 | Adv. Exp. Med. Biol. | pmid:6283811 |
Gunnarsson D et al. | Effects of dietary phytoestrogens on plasma testosterone and triiodothyronine (T3) levels in male goat kids. | 2009 | Acta Vet. Scand. | pmid:20003293 |
Lakshmi V et al. | Antifilarial activity in vitro and in vivo of some flavonoids tested against Brugia malayi. | 2010 | Acta Trop. | pmid:20609356 |
Tóth L et al. | [Analysis of flavone derivatives by polyamide layer chromatography]. | 1984 | Acta Pharm Hung | pmid:6711313 |
Vetrani C et al. | Association between different dietary polyphenol subclasses and the improvement in cardiometabolic risk factors: evidence from a randomized controlled clinical trial. | 2018 | Acta Diabetol | pmid:29151225 |
Singh S et al. | 2-(4-Chloro-phen-yl)chromen-4-one. | 2011 | Acta Crystallogr Sect E Struct Rep Online | pmid:22199687 |
Gohain M et al. | Racemic tricarbon-yl[7-meth-oxy-2-(η-phen-yl)chromane]-chromium(0). | 2011 | Acta Crystallogr Sect E Struct Rep Online | pmid:21753961 |
Wera M et al. | 3-Hy-droxy-2-(4-meth-oxy-phen-yl)-4H-chromen-4-one. | 2011 | Acta Crystallogr Sect E Struct Rep Online | pmid:21523104 |
Brito I et al. | 4',5-Dihy-droxy-7-meth-oxy-flavanone dihydrate. | 2012 | Acta Crystallogr Sect E Struct Rep Online | pmid:22259537 |
Wera M et al. | 2-(4-Fluoro-phen-yl)-3-hy-droxy-4H-chromen-4-one. | 2010 | Acta Crystallogr Sect E Struct Rep Online | pmid:21589426 |
van Tonder JH et al. | Racemic tricarbonyl[(4a,5,6,7,8,8a-η)-2-phenyl-3,4-dihydro-2H-1-benzopyran]chromium(0). | 2010 | Acta Crystallogr Sect E Struct Rep Online | pmid:21588503 |
Janeczko T et al. | 2-(4-Bromo-phen-yl)-6-methyl-4H-1-benzopyran-4-one (4'-bromo-6-methyl-flavone). | 2010 | Acta Crystallogr Sect E Struct Rep Online | pmid:21580767 |
Xiong HP et al. | 5,7-Dihydr-oxy-3,6,8-trimethoxy-flavone. | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21578970 |
Aree T and Sawasdee P | 3,5,7-Trimeth-oxy-2-(4-methoxy-phen-yl)-4H-1-benzopyran-4-one. | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21578306 |
Aree T et al. | 5,7-Dimeth-oxy-2-(4-methoxy-phen-yl)-4H-1-benzopyran-4-one methanol solvate monohydrate. | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21578297 |
van Tonder JH et al. | Tricarbon-yl(η-flavone)chromium(0). | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21578102 |
Liu B and Yang BL | Poly[(μ-5,7-dihydr-oxy-4-oxo-2-phenyl-4H-chromene-8-sulfonato)potassium(I)]. | 2008 | Acta Crystallogr Sect E Struct Rep Online | pmid:21581534 |
Liu B and Yang BL | Hexaaqua-(5,7-dihydr-oxy-4-oxo-2-phenyl-4H-chromene-8-sulfonato)calcium(II) 5,7-dihydr-oxy-4-oxo-2-phenyl-4H-chromene-8-sulfonate trihydrate. | 2008 | Acta Crystallogr Sect E Struct Rep Online | pmid:21581174 |
Ramachandran G et al. | 2-(5,7-Dimeth-oxy-4-oxo-4H-chromen-2-yl)phenyl 4-toluene-sulfonate. | 2008 | Acta Crystallogr Sect E Struct Rep Online | pmid:21203275 |
Li WW and Zhang ZT | Hexaquacobalt(II) bis(5-hydroxy-7-methoxy-4-oxo-2-phenyl-4H-chromene-6-sulfonate) tetrahydrate. | 2008 | Acta Crystallogr C | pmid:18391382 |
Ozbey S et al. | Antibacterial 4-amino-N-(5-methylisoxazol-3-yl)-N-[(4-oxo-2-phenyl-4H-1-benzopyran-6-yl)methyl]benzenesulfonamide. | 2005 | Acta Crystallogr C | pmid:16143780 |
Ohba S et al. | Swertisin dihydrate. | 2004 | Acta Crystallogr C | pmid:15579976 |
Hori A and Naganuma K | Fully and partially fluorinated flavone derivatives. | 2010 | Acta Crystallogr C | pmid:20442510 |
Liu B et al. | Biocompatible flavone-based fluorogenic probes for quick wash-free mitochondrial imaging in living cells. | 2014 | ACS Appl Mater Interfaces | pmid:25382851 |
Liu B et al. | Flavone-based ESIPT ratiometric chemodosimeter for detection of cysteine in living cells. | 2014 | ACS Appl Mater Interfaces | pmid:24571859 |
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