FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hildebrandt AG et al. | Studies on the mechanism of stimulation of microsomal H2O2 formation and benzo(a)pyrene hydroxylation by substrates and flavone. | 1981 | Adv. Exp. Med. Biol. | pmid:6283811 |
| Paulin JJ et al. | Ultrastructural modifications during the metabolism of metronidazole by Trypanosoma cruzi. | 1983 | J. Submicrosc. Cytol. | pmid:6361276 |
| Elliger CA et al. | Mutagenicity of flavones, chromones and acetophenones in Salmonella typhimurium. New structure-activity relationships. | 1984 | Mutat. Res. | pmid:6363915 |
| Ghosh DK et al. | Microsomal benzo(a)pyrene hydroxylase in Aspergillus ochraceus TS: assay and characterization of the enzyme system. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6409103 |
| Nose K | Inhibition by flavonoids of RNA synthesis in permeable WI-38 cells and of transcription by RNA polymerase II. | 1984 | Biochem. Pharmacol. | pmid:6508836 |
| Ficarra P et al. | Analysis of 2-phenyl-chromon derivatives and chlorogenic acid. II. High-performance thin layer chromatography and high-performance liquid chromatography in flowers, leaves and buds extractives of Crataegus oxyacantha L. | 1984 | Farmaco Prat | pmid:6542533 |
| Dutta D et al. | Induction of benzo(a)pyrene hydroxylase in Aspergillus ochraceus TS: evidences of multiple forms of cytochrome P-450. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6626210 |
| Matern U et al. | Further characterization and regulation of malonyl-coenzyme A: flavonoid glucoside malonyltransferases from parsley cell suspension cultures. | 1983 | Arch. Biochem. Biophys. | pmid:6639051 |
| Hausen BM et al. | 5,8-dihydroxyflavone (primetin) the contact sensitizer of Primula mistassinica Michaux. | 1983 | Arch. Dermatol. Res. | pmid:6660907 |
| Tóth L et al. | [Analysis of flavone derivatives by polyamide layer chromatography]. | 1984 | Acta Pharm Hung | pmid:6711313 |
| Keller G and Leuenberger PM | [Aldose-reductase inhibitors and cataract formation (author's transl)]. | 1980 | Klin Monbl Augenheilkd | pmid:6775130 |
| Okuda J et al. | Inhibition of aldose reductases from rat and bovine lenses by flavonoids. | 1982 | Biochem. Pharmacol. | pmid:6818971 |
| Lasker JM et al. | In vivo activation of zoxazolamine metabolism by flavone. | 1982 | Science | pmid:7089530 |
| Viswanathan T and Alworth WL | Effects of 1-arylpyrroles and naphthoflavones upon cytochrome P-450 dependent monooxygenase activities. | 1981 | J. Med. Chem. | pmid:7277387 |
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| Rossi M et al. | Molecular structures of 5,6- and 7,8-benzoflavones, inhibitors of aryl hydrocarbon hydroxylase. | 1980 | Cancer Res. | pmid:7388828 |
| Alworth WL et al. | Stimulation of mammalian epoxide hydrase activity by flavones. | 1980 | Xenobiotica | pmid:7415221 |
| Iinuma M and Matsuura S | [Synthetic studies of the flavone derivatives. VII. Synthesis of 6,8-dimethoxyflavone derivatives and their 13C-NMR (author's transl)]. | 1980 | Yakugaku Zasshi | pmid:7463312 |
| Shin W et al. | Structure-taste correlations in sweet dihydrochalcone, sweet dihydroisocoumarin, and bitter flavone compounds. | 1995 | J. Med. Chem. | pmid:7473560 |
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| Monici M et al. | Flavone photoreactivity. UV-induced reactions in organic solvents and micellar systems. | 1993 | J. Photochem. Photobiol. B, Biol. | pmid:8271117 |
| Ching LM et al. | Induction of tumor necrosis factor-alpha messenger RNA in human and murine cells by the flavone acetic acid analogue 5,6-dimethylxanthenone-4-acetic acid (NSC 640488). | 1994 | Cancer Res. | pmid:8313372 |
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| Ebel J and Hahlbrock K | Enzymes of flavone and flavonol-glycoside biosynthesis. Coordinated and selective induction in cell-suspension cultures of Petroselinum hortense. | 1977 | Eur. J. Biochem. | pmid:862617 |
| Karton Y et al. | Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. | 1996 | J. Med. Chem. | pmid:8691424 |
| Critchfield JW et al. | Inhibition of HIV activation in latently infected cells by flavonoid compounds. | 1996 | AIDS Res. Hum. Retroviruses | pmid:8825617 |
| Chaumontet C et al. | Lack of tumor-promoting effects of flavonoids: studies on rat liver preneoplastic foci and on in vivo and in vitro gap junctional intercellular communication. | 1996 | Nutr Cancer | pmid:8910908 |
| Canivenc-Lavier MC et al. | Comparative effects of flavonoids and model inducers on drug-metabolizing enzymes in rat liver. | 1996 | Toxicology | pmid:8931757 |
| Siess MH et al. | Time course of induction of rat hepatic drug-metabolizing enzyme activities following dietary administration of flavonoids. | 1996 | J Toxicol Environ Health | pmid:8968409 |
| Harlow GR and Halpert JR | Alanine-scanning mutagenesis of a putative substrate recognition site in human cytochrome P450 3A4. Role of residues 210 and 211 in flavonoid activation and substrate specificity. | 1997 | J. Biol. Chem. | pmid:9038138 |
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| Collins BM et al. | The estrogenic and antiestrogenic activities of phytochemicals with the human estrogen receptor expressed in yeast. | 1997 | Steroids | pmid:9090797 |
| Hollman PC and Katan MB | Absorption, metabolism and health effects of dietary flavonoids in man. | 1997 | Biomed. Pharmacother. | pmid:9436520 |
| Kitajima-Ihara T and Yagi T | Rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria: the enzyme expressed in Escherichia coli acts as a member of the respiratory chain in the host cells. | 1998 | FEBS Lett. | pmid:9462835 |
| Belinky PA et al. | The antioxidative effects of the isoflavan glabridin on endogenous constituents of LDL during its oxidation. | 1998 | Atherosclerosis | pmid:9568736 |
| Zhai S et al. | Inhibition of methoxyresorufin demethylase activity by flavonoids in human liver microsomes. | 1998 | Life Sci. | pmid:9718089 |
| Bai F et al. | Promoter activation and following induction of the p21/WAF1 gene by flavone is involved in G1 phase arrest in A549 lung adenocarcinoma cells. | 1998 | FEBS Lett. | pmid:9804172 |
| Matusuura S et al. | [Synthesis studies of the flavone derivates. III. Photochemical reaction of chalcone derivative (author's transl)]. | 1976 | Yakugaku Zasshi | pmid:986458 |
| Kuo SM | Transepithelial transport and accumulation of flavone in human intestinal Caco-2 cells. | 1998 | Life Sci. | pmid:9877222 |