FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Berthier A et al. | Effect of 7-O-beta-D-glucopyranosylchrysin and its aglycone chrysin isolated from Podocytisus caramanicus on estrogen receptor alpha transcriptional activity. | 2007 | Planta Med. | pmid:17948189 |
Bas E et al. | Anti-inflammatory activity of 5-O-demethylnobiletin, a polymethoxyflavone isolated from Sideritis tragoriganum. | 2006 | Planta Med. | pmid:16491449 |
Imre S | [Additional anthraquinone and flavone compounds from the leaves of Digitalis viridiflora. 3. Flavone and anthraquinone dyes of digitalis species]. | 1972 | Planta Med. | pmid:5047478 |
Barberán FA et al. | Highly Methylated 6-Hydroxyflavones and Other Flavonoids from Thymus piperella. | 1985 | Planta Med. | pmid:17342612 |
Saxena M et al. | A New Flavone from Sapium insigne. | 1986 | Planta Med. | pmid:17345426 |
Jiménez MJ et al. | Anti-Inflammatory Activity of a Flavone from Sideritis leucantha. | 1986 | Planta Med. | pmid:17345496 |
Tanaka S et al. | Influence of natural and synthetic compounds on cell surface expression of cell adhesion molecules, ICAM-1 and VCAM-1. | 2001 | Planta Med. | pmid:11301853 |
Ferrari F et al. | Structures of three new flavone derivatives, brosimones G, H, and I, from Brosimopsis oblongifolia. | 1989 | Planta Med. | pmid:17262259 |
Beyer G and Melzig MF | Effects of selected flavonoids and caffeic acid derivatives on hypoxanthine-xanthine oxidase-induced toxicity in cultivated human cells. | 2003 | Planta Med. | pmid:14750029 |
Govindarajan R et al. | Effect of Desmodium gangeticum extract on blood glucose in rats and on insulin secretion in vitro. | 2007 | Planta Med. | pmid:17431824 |
Corradi E et al. | Metabolite Profile and Antiproliferative Effects in HaCaT Cells of a Salix reticulata Extract. | 2017 | Planta Med. | pmid:28449181 |
Zhu JT et al. | Estrogenic and neuroprotective properties of scutellarin from Erigeron breviscapus: a drug against postmenopausal symptoms and Alzheimer's disease. | 2009 | Planta Med. | pmid:19533578 |
Nguyen MT et al. | Xanthine oxidase inhibitors from the flowers of Chrysanthemum sinense. | 2006 | Planta Med. | pmid:16450295 |
Zhai K et al. | Chrysin induces hyperalgesia via the GABAA receptor in mice. | 2008 | Planta Med. | pmid:18612941 |
Goppel M and Franz G | Stability control of senna leaves and senna extracts. | 2004 | Planta Med. | pmid:15124088 |
Haraguchi H et al. | A flavone from Manilkara indica as a specific inhibitor against aldose reductase in vitro. | 2003 | Planta Med. | pmid:14598214 |
Chen JJ et al. | Furoquinoline alkaloids and cytotoxic constituents from the leaves of Melicope semecarpifolia. | 2003 | Planta Med. | pmid:12865974 |
Ko WC et al. | Mechanisms of relaxant action of luteolin in isolated guinea pig trachea. | 2005 | Planta Med. | pmid:15931576 |
Tsai PL and Tsai TH | Pharmacokinetics of baicalin in rats and its interactions with cyclosporin A, quinidine and SKF-525A: a microdialysis study. | 2004 | Planta Med. | pmid:15549664 |
Wang Y et al. | Flavone C-glycosides from the leaves of Lophatherum gracile and their in vitro antiviral activity. | 2012 | Planta Med. | pmid:21870321 |
Untergehrer M et al. | Structure-Dependent Deconjugation of Flavonoid Glucuronides by Human β-Glucuronidase - In Vitro and In Silico Analyses. | 2015 | Planta Med. | pmid:26018917 |
Abdalla SS and Abu Zarga MH | Effects of cirsimaritin, a flavone isolated from Artemisia judaica, on isolated guinea-pig ileum. | 1987 | Planta Med. | pmid:3671552 |
Chang TL et al. | 5,6,3',4'-Tetrahydroxy-7-methoxyflavone as a novel potential proteasome inhibitor. | 2010 | Planta Med. | pmid:20195959 |
Suyenaga ES et al. | Appraisal of the antichemotactic activity of flavonoids on polymorphonuclear neutrophils. | 2011 | Planta Med. | pmid:21058242 |
Gong T et al. | Novel benzil and isoflavone derivatives from Millettia dielsiana. | 2009 | Planta Med. | pmid:19140097 |
Topcu G et al. | Studies on di- and triterpenoids from Salvia staminea with cytotoxic activity. | 2003 | Planta Med. | pmid:12802732 |
Shih CH et al. | Functional characterization of key structural genes in rice flavonoid biosynthesis. | 2008 | Planta | pmid:18726614 |
Schwalm K et al. | Flavonoid-related regulation of auxin accumulation in Agrobacterium tumefaciens-induced plant tumors. | 2003 | Planta | pmid:14523649 |
Sue M et al. | Purification and characterization of a hydroxamic acid glucoside beta-glucosidase from wheat (Triticum aestivum L.) seedlings. | 2000 | Planta | pmid:10750901 |
Schubert M et al. | Two novel disaccharides, rutinose and methylrutinose, are involved in carbon metabolism in Datisca glomerata. | 2010 | Planta | pmid:19915863 |
Kim DH et al. | Molecular characterization of flavonoid malonyltransferase from Oryza sativa. | 2009 Nov-Dec | Plant Physiol. Biochem. | pmid:19733090 |
Gidda SK and Varin L | Biochemical and molecular characterization of flavonoid 7-sulfotransferase from Arabidopsis thaliana. | Plant Physiol. Biochem. | pmid:17095238 | |
Schmidt A et al. | Polymethylated myricetin in trichomes of the wild tomato species Solanum habrochaites and characterization of trichome-specific 3'/5'- and 7/4'-myricetin O-methyltransferases. | 2011 | Plant Physiol. | pmid:21343428 |
Han Y et al. | Ectopic expression of apple F3'H genes contributes to anthocyanin accumulation in the Arabidopsis tt7 mutant grown under nitrogen stress. | 2010 | Plant Physiol. | pmid:20357139 |
Lan W et al. | Maize Tricin-Oligolignol Metabolites and Their Implications for Monocot Lignification. | 2016 | Plant Physiol. | pmid:27208246 |
Heller W et al. | Enzymes of General Phenylpropanoid Metabolism and of Flavonoid Glycoside Biosynthesis in Parsley: Differential Inducibility by Light during the Growth of Cell Suspension Cultures. | 1979 | Plant Physiol. | pmid:16660968 |
Larson RL and Bussard JB | Microsomal flavonoid 3'-monooxygenase from maize seedlings. | 1986 | Plant Physiol. | pmid:16664648 |
Kapulnik Y et al. | Flavone limitations to root nodulation and symbiotic nitrogen fixation in alfalfa. | 1987 | Plant Physiol. | pmid:16665583 |
Seo S et al. | Cyanide, a coproduct of plant hormone ethylene biosynthesis, contributes to the resistance of rice to blast fungus. | 2011 | Plant Physiol. | pmid:21075959 |
Ray H et al. | Expression of anthocyanins and proanthocyanidins after transformation of alfalfa with maize Lc. | 2003 | Plant Physiol. | pmid:12857826 |
Du Y et al. | CYP93G2 is a flavanone 2-hydroxylase required for C-glycosylflavone biosynthesis in rice. | 2010 | Plant Physiol. | pmid:20647377 |
Morreel K et al. | Mass spectrometry-based sequencing of lignin oligomers. | 2010 | Plant Physiol. | pmid:20554692 |
Berim A et al. | A set of regioselective O-methyltransferases gives rise to the complex pattern of methoxylated flavones in sweet basil. | 2012 | Plant Physiol. | pmid:22923679 |
Dobritsa AA et al. | LAP5 and LAP6 encode anther-specific proteins with similarity to chalcone synthase essential for pollen exine development in Arabidopsis. | 2010 | Plant Physiol. | pmid:20442277 |
Frangne N et al. | Flavone glucoside uptake into barley mesophyll and Arabidopsis cell culture vacuoles. Energization occurs by H(+)-antiport and ATP-binding cassette-type mechanisms. | 2002 | Plant Physiol. | pmid:11842175 |
Zhang J et al. | Flavone synthases from Medicago truncatula are flavanone-2-hydroxylases and are important for nodulation. | 2007 | Plant Physiol. | pmid:17434990 |
Zhang P et al. | A maize QTL for silk maysin levels contains duplicated Myb-homologous genes which jointly regulate flavone biosynthesis. | 2003 | Plant Mol. Biol. | pmid:12825685 |
Yan J et al. | The soybean R2R3 MYB transcription factor GmMYB100 negatively regulates plant flavonoid biosynthesis. | 2015 | Plant Mol. Biol. | pmid:26231207 |
Goodger JQ et al. | Isolation of intact sub-dermal secretory cavities from Eucalyptus. | 2010 | Plant Methods | pmid:20807444 |
Berim A et al. | Unexpected roles for ancient proteins: flavone 8-hydroxylase in sweet basil trichomes is a Rieske-type, PAO-family oxygenase. | 2014 | Plant J. | pmid:25139498 |