FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kassem ME et al. | A sulphated flavone glycoside from Livistona australis and its antioxidant and cytotoxic activity. | 2012 | Nat. Prod. Res. | pmid:21793764 |
| Tsai IT et al. | Flavone is efficient to protect zebrafish fins from UV-induced damage. | 2012 | Drug Chem Toxicol | pmid:22289409 |
| Adejumo OE et al. | Moringa oleifera Lam. (Moringaceae) grown in Nigeria: In vitro antisickling activity on deoxygenated erythrocyte cells. | 2012 | J Pharm Bioallied Sci | pmid:22557922 |
| Guo AJ et al. | Kaempferol as a flavonoid induces osteoblastic differentiation via estrogen receptor signaling. | 2012 | Chin Med | pmid:22546174 |
| Chen HJ et al. | Determination of phenolic acids and flavonoids in Taraxacum formosanum Kitam by liquid chromatography-tandem mass spectrometry coupled with a post-column derivatization technique. | 2012 | Int J Mol Sci | pmid:22312251 |
| Wink M et al. | Secondary Metabolites from Plants Inhibiting ABC Transporters and Reversing Resistance of Cancer Cells and Microbes to Cytotoxic and Antimicrobial Agents. | 2012 | Front Microbiol | pmid:22536197 |
| Peterson JJ et al. | Associations between flavonoids and cardiovascular disease incidence or mortality in European and US populations. | 2012 | Nutr. Rev. | pmid:22946850 |
| Kim S et al. | Vascular disrupting agent drug classes differ in effects on the cytoskeleton. | 2012 | PLoS ONE | pmid:22848372 |
| Xin HL et al. | Anti-inflammatory and analgesic activity of total flavone of Cunninghamia lanceolata. | 2012 | Molecules | pmid:22832885 |
| Zhou G and Lv G | [Comparative studies on scavenging DPPH free radicals activity of flavone C-glycosides from different parts of Dendrobium officinale]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22993976 |
| Lies B et al. | Flavone potently stimulates an apical transporter for flavonoids in human intestinal Caco-2 cells. | 2012 | Mol Nutr Food Res | pmid:22965487 |
| Lee JH et al. | Flavone reduces the production of virulence factors, staphyloxanthin and α-hemolysin, in Staphylococcus aureus. | 2012 | Curr. Microbiol. | pmid:22965624 |
| Hostetler GL et al. | Endogenous enzymes, heat, and pH affect flavone profiles in parsley (Petroselinum crispum var. neapolitanum) and celery (Apium graveolens) during juice processing. | 2012 | J. Agric. Food Chem. | pmid:22224550 |
| Greeff J et al. | Antioxidant properties of 4-quinolones and structurally related flavones. | 2012 | Bioorg. Med. Chem. | pmid:22197671 |
| Welch A et al. | Habitual flavonoid intakes are positively associated with bone mineral density in women. | 2012 | J. Bone Miner. Res. | pmid:22549983 |
| Yarmolinsky L et al. | Potent antiviral flavone glycosides from Ficus benjamina leaves. | 2012 | Fitoterapia | pmid:22155188 |
| Joshi SC and Mathela CS | Antioxidant and antibacterial activities of the leaf essential oil and its constituents furanodienone and curzerenone from Lindera pulcherrima (Nees.) Benth. ex hook. f. | 2012 | Pharmacognosy Res | pmid:22518079 |
| Chantarudee A et al. | Chemical constituents and free radical scavenging activity of corn pollen collected from Apis mellifera hives compared to floral corn pollen at Nan, Thailand. | 2012 | BMC Complement Altern Med | pmid:22513008 |
| Clark BR et al. | Flavone C-glycosides from Anthurium andraeanum. | 2012 | Nat Prod Commun | pmid:22816298 |
| Soumyanath A et al. | Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease: Investigation of a Possible Mechanism of Action. | 2012 | Int J Alzheimers Dis | pmid:22506133 |
| Niraula NP et al. | Biotransformation of flavone by CYP105P2 from Streptomyces peucetius. | 2012 | J. Microbiol. Biotechnol. | pmid:22713981 |
| Chen LY et al. | Structural elucidation and bioactivity of biflavonoids from the stems of Wikstroemia taiwanensis. | 2012 | Int J Mol Sci | pmid:22312302 |
| Li Y et al. | [Simultaneous determination of five active components in resina draconis and its extract by HPLC]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22792791 |
| Khan R et al. | Chrysin protects against cisplatin-induced colon. toxicity via amelioration of oxidative stress and apoptosis: probable role of p38MAPK and p53. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22155348 |
| Kim HG et al. | Acacetin protects dopaminergic cells against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neuroinflammation in vitro and in vivo. | 2012 | Biol. Pharm. Bull. | pmid:22863927 |
| Li H et al. | De novo transcriptome of safflower and the identification of putative genes for oleosin and the biosynthesis of flavonoids. | 2012 | PLoS ONE | pmid:22363528 |
| Hostetler G et al. | Flavone deglycosylation increases their anti-inflammatory activity and absorption. | 2012 | Mol Nutr Food Res | pmid:22351119 |
| Yang WS et al. | Nanostructured, self-assembling peptide K5 blocks TNF-α and PGE₂ production by suppression of the AP-1/p38 pathway. | 2012 | Mediators Inflamm. | pmid:22315508 |
| Zielińska D et al. | Evaluation of flavonoid contents and antioxidant capacity of the aerial parts of common and tartary buckwheat plants. | 2012 | Molecules | pmid:22890171 |
| Bandaruk Y et al. | Evaluation of the inhibitory effects of quercetin-related flavonoids and tea catechins on the monoamine oxidase-A reaction in mouse brain mitochondria. | 2012 | J. Agric. Food Chem. | pmid:23009399 |
| Berim A et al. | A set of regioselective O-methyltransferases gives rise to the complex pattern of methoxylated flavones in sweet basil. | 2012 | Plant Physiol. | pmid:22923679 |
| Hatnapure GD et al. | Synthesis and biological evaluation of novel piperazine derivatives of flavone as potent anti-inflammatory and antimicrobial agent. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22981334 |
| Hamilton ML et al. | Elucidation of the biosynthesis of the di-C-glycosylflavone isoschaftoside, an allelopathic component from Desmodium spp. that inhibits Striga spp. development. | 2012 | Phytochemistry | pmid:22959223 |
| Klier L et al. | Lewis acid-triggered selective zincation of chromones, quinolones, and thiochromones: application to the preparation of natural flavones and isoflavones. | 2012 | J. Am. Chem. Soc. | pmid:22860983 |
| Kim D et al. | Synthetic approach to flavanones and flavones via ligand-free palladium(II)-catalyzed conjugate addition of arylboronic acids to chromones. | 2012 | Org. Biomol. Chem. | pmid:22850763 |
| Jansakul C et al. | Relaxant mechanisms of 3, 5, 7, 3', 4'-pentamethoxyflavone on isolated human cavernosum. | 2012 | Eur. J. Pharmacol. | pmid:22800934 |
| Kanda K et al. | Nobiletin suppresses adipocyte differentiation of 3T3-L1 cells by an insulin and IBMX mixture induction. | 2012 | Biochim. Biophys. Acta | pmid:22172985 |
| Lewin G et al. | Influence of the skeleton on the cytotoxicity of flavonoids. | 2012 | Bioorg. Med. Chem. | pmid:22257529 |
| Kongkum N et al. | DNA topoisomerase IIα inhibitory and anti-HIV-1 flavones from leaves and twigs of Gardenia carinata. | 2012 | Fitoterapia | pmid:22155186 |
| Buchanan CM et al. | DMXAA (Vadimezan, ASA404) is a multi-kinase inhibitor targeting VEGFR2 in particular. | 2012 | Clin. Sci. | pmid:22142330 |
| Park NI et al. | Enhancement of rutin in Fagopyrum esculentum hairy root cultures by the Arabidopsis transcription factor AtMYB12. | 2012 | Biotechnol. Lett. | pmid:22113884 |
| Qin S et al. | Gene expression profiling and pathway network analysis of hepatic metabolic enzymes targeted by baicalein. | 2012 | J Ethnopharmacol | pmid:22265932 |
| Patel CA et al. | Remedial Prospective of Hippophae rhamnoides Linn. (Sea Buckthorn). | 2012 | ISRN Pharmacol | pmid:22530142 |
| Rahigude A et al. | Participation of antioxidant and cholinergic system in protective effect of naringenin against type-2 diabetes-induced memory dysfunction in rats. | 2012 | Neuroscience | pmid:22999973 |
| Xiao L et al. | Transcriptome of protoplasts reprogrammed into stem cells in Physcomitrella patens. | 2012 | PLoS ONE | pmid:22545152 |
| Huang WY et al. | Survey of antioxidant capacity and phenolic composition of blueberry, blackberry, and strawberry in Nanjing. | 2012 | J Zhejiang Univ Sci B | pmid:22302422 |
| Zbidah M et al. | Apigenin-induced suicidal erythrocyte death. | 2012 | J. Agric. Food Chem. | pmid:22132906 |
| Xie C et al. | The açaà flavonoid velutin is a potent anti-inflammatory agent: blockade of LPS-mediated TNF-α and IL-6 production through inhibiting NF-κB activation and MAPK pathway. | 2012 | J. Nutr. Biochem. | pmid:22137267 |
| Duchnowicz P et al. | Hypolipidemic and antioxidant effects of hydroxycinnamic acids, quercetin, and cyanidin 3-glucoside in hypercholesterolemic erythrocytes (in vitro study). | 2012 | Eur J Nutr | pmid:21755326 |
| Palmieri D et al. | Apigenin inhibits the TNFα-induced expression of eNOS and MMP-9 via modulating Akt signalling through oestrogen receptor engagement. | 2012 | Mol. Cell. Biochem. | pmid:22899172 |