FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Verweij J et al. | Rapid alkalinisation for flavone acetic acid administration: a potentially hazardous procedure. | 1988 | Lancet | pmid:2893206 |
Davis HP et al. | Immune thrombocytopenia caused by flavone-8-acetic acid. | 1988 | Lancet | pmid:2893207 |
Damia G et al. | Dose-dependent pharmacokinetics of flavone acetic acid in mice. | 1988 | Cancer Chemother. Pharmacol. | pmid:3396145 |
Evelhoch JL et al. | Flavone acetic acid (NSC 347512)-induced modulation of murine tumor physiology monitored by in vivo nuclear magnetic resonance spectroscopy. | 1988 | Cancer Res. | pmid:3409216 |
Gouyette A et al. | Flavone acetic acid: a nonlinear pharmacokinetic model. | 1988 | Cancer Chemother. Pharmacol. | pmid:3409441 |
Abdalla S et al. | Effects of hispidulin, a flavone isolated from Inula viscosa, on isolated guinea-pig smooth muscle. | 1988 | Gen. Pharmacol. | pmid:3410278 |
Hornung RL et al. | Immunomodulation of natural killer cell activity by flavone acetic acid: occurrence via induction of interferon alpha/beta. | 1988 | J. Natl. Cancer Inst. | pmid:3418728 |
Oberpichler H et al. | Effects of Ginkgo biloba constituents related to protection against brain damage caused by hypoxia. | 1988 | Pharmacol Res Commun | pmid:3420139 |
Bissery MC et al. | Flavone acetic acid (NSC 347512)-induced DNA damage in Glasgow osteogenic sarcoma in vivo. | 1988 | Cancer Res. | pmid:3422592 |
Finlay GJ et al. | Effect of flavone acetic acid on Lewis lung carcinoma: evidence for an indirect effect. | 1988 | J. Natl. Cancer Inst. | pmid:3351960 |
Giavazzi R et al. | Response to flavone acetic acid (NSC 347512) of primary and metastatic human colorectal carcinoma xenografts. | 1988 | Br. J. Cancer | pmid:3355765 |
Rabinovitz M | The structure of flavone-8-acetic acid, a chemotherapeutic agent, and its application to drug design. | 1988 | J. Enzym. Inhib. | pmid:3236069 |
Robbins RC | Flavones in citrus exhibit antiadhesive action on platelets. | 1988 | Int J Vitam Nutr Res | pmid:3243696 |
Armitage JP et al. | Comparison of the chemotactic behaviour of Rhizobium leguminosarum with and without the nodulation plasmid. | 1988 | Mol. Microbiol. | pmid:3210967 |
Gao F et al. | Sesquiterpene lactones and flavonoids from Helianthus species. | 1987 Jan-Feb | J. Nat. Prod. | pmid:3598595 |
Ohchi H et al. | Effects of dietary xenobiotics on the metabolism of copper, alpha-tocopherol and cholesterol in rats. | 1987 | J. Nutr. Sci. Vitaminol. | pmid:3125311 |
Abdalla SS and Abu Zarga MH | Effects of cirsimaritin, a flavone isolated from Artemisia judaica, on isolated guinea-pig ileum. | 1987 | Planta Med. | pmid:3671552 |
Kerr DJ et al. | Phase I and pharmacokinetic study of flavone acetic acid. | 1987 | Cancer Res. | pmid:3677106 |
Capolongo LS et al. | Antiproliferative properties of flavone acetic acid (NSC 347512) (LM 975), a new anticancer agent. | 1987 | Eur J Cancer Clin Oncol | pmid:3678316 |
O'Dwyer PJ et al. | Flavone acetic acid (LM 975, NSC 347512). A novel antitumor agent. | 1987 | Cancer Chemother. Pharmacol. | pmid:3545524 |