FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Siess MH et al. | Mechanisms involved in the chemoprevention of flavonoids. | 2000 | Biofactors | pmid:11216486 |
Zhou X et al. | Flavone and isoflavone derivatives of terrestrial plants as larval settlement inhibitors of the barnacle Balanus amphitrite. | 2009 | Biofouling | pmid:18855151 |
Kundu S and Roy D | Structural study of biologically significant ligands with major birch pollen allergen Betv1 by docking and molecular dynamics simulation. | 2010 | Bioinformation | pmid:20978606 |
Masoodi TA and Alhamdanz AH | Inhibitory effect of flavonoids on mutant H-Rasp protein. | 2010 | Bioinformation | pmid:21346872 |
Tan M et al. | Synthesis, cytotoxic activity, and DNA binding properties of copper (II) complexes with hesperetin, naringenin, and apigenin. | 2009 | Bioinorg Chem Appl | pmid:19830248 |
Kostova I et al. | Structure-Activity Relationships of Synthetic Coumarins as HIV-1 Inhibitors. | 2006 | Bioinorg Chem Appl | pmid:17497014 |
Mizoyama Y et al. | Inhibitory effect of flavonoids on N-acetylation of 5-aminosalicylic acid in cultured rat hepatocytes. | 2004 | Biol. Pharm. Bull. | pmid:15340238 |
Shibata H et al. | Flavone markedly affects phenotypic expression of beta-lactam resistance in methicillin-resistant Staphylococcus aureus strains isolated clinically. | 2003 | Biol. Pharm. Bull. | pmid:14519958 |
Govindarajan R et al. | Studies on the antioxidant activities of Desmodium gangeticum. | 2003 | Biol. Pharm. Bull. | pmid:14519948 |
Chatuphonprasert W et al. | Potent modification of inducible CYP1A1 expression by flavonoids. | 2010 | Biol. Pharm. Bull. | pmid:20930378 |
Lai MY et al. | Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of Scutellariae Radix in humans. | 2003 | Biol. Pharm. Bull. | pmid:12520178 |
Morimitsu Y et al. | Inhibitory effect of flavonoids on sulfo- and glucurono-conjugation of acetaminophen in rat cultured hepatocytes and liver subcellular preparations. | 2004 | Biol. Pharm. Bull. | pmid:15133252 |
Jin M et al. | Suppressive effects of T-412, a flavone on interleukin-4 production in T cells. | 2009 | Biol. Pharm. Bull. | pmid:19881301 |
Doronicheva N et al. | Chemical structure-dependent differential effects of flavonoids on the catalase activity as evaluated by a chemiluminescent method. | 2007 | Biol. Pharm. Bull. | pmid:17268053 |
Nakamura K et al. | Effects of Hydroxy Groups in the A-Ring on the Anti-proteasome Activity of Flavone. | 2015 | Biol. Pharm. Bull. | pmid:25810454 |
Kim HG et al. | Acacetin protects dopaminergic cells against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neuroinflammation in vitro and in vivo. | 2012 | Biol. Pharm. Bull. | pmid:22863927 |
Jung SH et al. | Aldose reductase and advanced glycation endproducts inhibitory effect of Phyllostachys nigra. | 2007 | Biol. Pharm. Bull. | pmid:17666823 |
Prasad VG et al. | Iminoflavones combat 1,2-dimethyl hydrazine-induced aberrant crypt foci development in colon cancer. | 2014 | Biomed Res Int | pmid:24995310 |
Cai H et al. | Determination of the putative cancer chemopreventive flavone tricin in plasma and tissues of mice by HPLC with UV--visible detection. | 2005 | Biomed. Chromatogr. | pmid:15828058 |
Kanaze FI et al. | A validated HPLC determination of the flavone aglycone diosmetin in human plasma. | 2004 | Biomed. Chromatogr. | pmid:15386576 |