| MeSH term | MeSH ID | Detail |
|---|---|---|
| Glioma | D005910 | 112 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Pain | D010146 | 64 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nilsson J et al. | Azaflavones compared to flavones as ligands to the benzodiazepine binding site of brain GABA(A) receptors. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18851913 |
| Chen WQ et al. | A new antifungal and cytotoxic C-methylated flavone glycoside from Picea neoveitchii. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22901896 |
| Nakagawa-Goto K et al. | Total synthesis and bioactivity of unique flavone desmosdumotin B and its analogs. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15913998 |
| Auffret G et al. | Synthesis and antimalarial evaluation of a series of piperazinyl flavones. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17166718 |
| Ryu YB et al. | Structural characteristics of flavanones and flavones from Cudrania tricuspidata for neuraminidase inhibition. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19660948 |
| Balboni G et al. | Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22487176 |
| Choe H et al. | Structure-based design of flavone-based inhibitors of wild-type and T315I mutant of ABL. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23790540 |
| Hyup YH et al. | 2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12565941 |
| Tamura S et al. | New inhibitors for expression of IgE receptor on human mast cell. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20202836 |
| Kang Y et al. | Inhibitory potential of flavonoids on PtdIns(3,4,5)P3 binding with the phosphoinositide-dependent kinase 1 pleckstrin homology domain. | 2017 | Bioorg. Med. Chem. Lett. | pmid:28049590 |
| Hatnapure GD et al. | Synthesis and biological evaluation of novel piperazine derivatives of flavone as potent anti-inflammatory and antimicrobial agent. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22981334 |
| Gao L et al. | 3D QSAR and docking study of flavone derivatives as potent inhibitors of influenza H1N1 virus neuraminidase. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21843936 |
| Jin J et al. | Design, synthesis and biological evaluation of new arylpiperazine derivatives bearing a flavone moiety as α1-adrenoceptor antagonists. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21236664 |
| Baxter A et al. | Non-covalent inhibitors of rhinovirus 3C protease. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21183345 |
| Cabrera M et al. | Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. | 2010 | Bioorg. Med. Chem. | pmid:20639112 |
| Betti L et al. | Design, synthesis, and alpha(1)-adrenoceptor binding properties of new arylpiperazine derivatives bearing a flavone nucleus as the terminal heterocyclic molecular portion. | 2004 | Bioorg. Med. Chem. | pmid:15018926 |
| Ono M et al. | Synthesis and characterization of styrylchromone derivatives as beta-amyloid imaging agents. | 2007 | Bioorg. Med. Chem. | pmid:17035032 |
| Lameira J et al. | Structure-activity relationship study of flavone compounds with anti-HIV-1 integrase activity: a density functional theory study. | 2006 | Bioorg. Med. Chem. | pmid:16890444 |
| Iori F et al. | Theoretical quantitative structure-activity relationships of flavone ligands interacting with cytochrome P450 1A1 and 1A2 isozymes. | 2005 | Bioorg. Med. Chem. | pmid:15914008 |
| Valenti P et al. | Synthesis and biological activity of some rigid analogues of flavone-8-acetic acid. | 2000 | Bioorg. Med. Chem. | pmid:10968283 |