| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lymphedema | D008209 | 4 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Vitcheva V et al. | Hepatoprotective effects of saponarin, isolated from Gypsophila trichotoma Wend. on cocaine-induced oxidative stress in rats. | 2011 | Redox Rep. | pmid:21722413 |
| Barrero RA et al. | De novo assembly of Euphorbia fischeriana root transcriptome identifies prostratin pathway related genes. | 2011 | BMC Genomics | pmid:22151917 |
| Walch SG et al. | Antioxidant Capacity and Polyphenolic Composition as Quality Indicators for Aqueous Infusions of Salvia officinalis L. (sage tea). | 2011 | Front Pharmacol | pmid:22194722 |
| Silva RO et al. | Sulfated-polysaccharide fraction from red algae Gracilaria caudata protects mice gut against ethanol-induced damage. | 2011 | Mar Drugs | pmid:22163181 |
| Lee KN et al. | Prevention of NSAID-associated gastroduodenal injury in healthy volunteers-a randomized, double-blind, multicenter study comparing DA-9601 with misoprostol. | 2011 | J. Korean Med. Sci. | pmid:21860559 |
| Klein T et al. | Structural basis for species specific inhibition of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1): computational study and biological validation. | 2011 | PLoS ONE | pmid:21857977 |
| Janovick JA et al. | Therapeutic rescue of misfolded mutants: validation of primary high throughput screens for identification of pharmacoperone drugs. | 2011 | PLoS ONE | pmid:21818389 |
| Seo S et al. | Cyanide, a coproduct of plant hormone ethylene biosynthesis, contributes to the resistance of rice to blast fungus. | 2011 | Plant Physiol. | pmid:21075959 |
| Wootten D et al. | Modulation of the glucagon-like peptide-1 receptor signaling by naturally occurring and synthetic flavonoids. | 2011 | J. Pharmacol. Exp. Ther. | pmid:21075839 |
| Lewin G et al. | Synthesis of antiproliferative flavones from calycopterin, major flavonoid of Calycopteris floribunda Lamk. | 2011 | Bioorg. Med. Chem. | pmid:21146994 |
| Flemmig J et al. | Olea europaea leaf (Ph.Eur.) extract as well as several of its isolated phenolics inhibit the gout-related enzyme xanthine oxidase. | 2011 | Phytomedicine | pmid:21144719 |
| Enomoto R et al. | Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects. | 2011 | Cancer Chemother. Pharmacol. | pmid:20658136 |
| Varma A et al. | Andrographolide: a new plant-derived antineoplastic entity on horizon. | 2011 | Evid Based Complement Alternat Med | pmid:19752167 |
| Phromnoi K et al. | Dihydroxypentamethoxyflavone down-regulates constitutive and inducible signal transducers and activators of transcription-3 through the induction of tyrosine phosphatase SHP-1. | 2011 | Mol. Pharmacol. | pmid:21816954 |
| Xue L et al. | Pd-carbene catalyzed carbonylation reactions of aryl iodides. | 2011 | Dalton Trans | pmid:21677940 |
| Schumacher M et al. | Potential role of P-gp for flavone-induced diminished apoptosis and increased adenoma size in the small intestine of APC(min/+) mice. | 2011 | Cancer Invest. | pmid:21649465 |
| Said SA | Two new special flavones from Uvaria accuminata. | 2011 | Nat. Prod. Res. | pmid:21644179 |
| Seo J et al. | Flavonoids biotransformation by bacterial non-heme dioxygenases, biphenyl and naphthalene dioxygenase. | 2011 | Appl. Microbiol. Biotechnol. | pmid:21626021 |
| Boyle SP et al. | Evaluation of quality control strategies in Scutellaria herbal medicines. | 2011 | J Pharm Biomed Anal | pmid:21163602 |
| Clark ST and Verwoerd WS | A systems approach to identifying correlated gene targets for the loss of colour pigmentation in plants. | 2011 | BMC Bioinformatics | pmid:21849042 |
| Zhao E and Mu Q | Phytoestrogen biological actions on Mammalian reproductive system and cancer growth. | 2011 Jan-Mar | Sci Pharm | pmid:21617769 |
| El-Alfy TS et al. | A New Flavonoid C-Glycoside from Celtis australis L. and Celtis occidentalis L. Leaves and Potential Antioxidant and Cytotoxic Activities. | 2011 Oct-Dec | Sci Pharm | pmid:22145118 |
| Duraipandiyan V et al. | Antimicrobial activity of sesquiterpene lactones isolated from traditional medicinal plant, Costus speciosus (Koen ex.Retz.) Sm. | 2012 | BMC Complement Altern Med | pmid:22397713 |
| Yang Y et al. | Bioactivity-guided fractionation of the triglyceride-lowering component and in vivo and in vitro evaluation of hypolipidemic effects of Calyx seu Fructus Physalis. | 2012 | Lipids Health Dis | pmid:22413998 |
| Collins-Burow BM et al. | Antiestrogenic activity of flavonoid phytochemicals mediated via the c-Jun N-terminal protein kinase pathway. Cell-type specific regulation of estrogen receptor alpha. | 2012 | J. Steroid Biochem. Mol. Biol. | pmid:22634477 |
| Yuqing Z et al. | Flavone ingredients can synergistically inhibit NDV infecting cell and improve ND vaccine's protective rate. | 2012 | Int. J. Biol. Macromol. | pmid:22575392 |
| Fan Y et al. | Liposome and epimedium polysaccharide-propolis flavone can synergistically enhance immune effect of vaccine. | 2012 | Int. J. Biol. Macromol. | pmid:22020157 |
| Chang CW et al. | Daphne Genkwa sieb. Et zucc. Water-soluble extracts act on enterovirus 71 by inhibiting viral entry. | 2012 | Viruses | pmid:22590685 |
| Zhou G and Lv G | [Comparative studies on scavenging DPPH free radicals activity of flavone C-glycosides from different parts of Dendrobium officinale]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22993976 |
| Resende FA et al. | Mutagenicity of flavonoids assayed by bacterial reverse mutation (Ames) test. | 2012 | Molecules | pmid:22565478 |
| Furukawa Y et al. | Isolation and characterization of activators of ERK/MAPK from citrus plants. | 2012 | Int J Mol Sci | pmid:22408427 |
| Khan R et al. | Chrysin protects against cisplatin-induced colon. toxicity via amelioration of oxidative stress and apoptosis: probable role of p38MAPK and p53. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22155348 |
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| Skizim NJ et al. | Metabolic pathways for photobiological hydrogen production by nitrogenase- and hydrogenase-containing unicellular cyanobacteria Cyanothece. | 2012 | J. Biol. Chem. | pmid:22128188 |
| Ni Q et al. | Seasonal variations of the antioxidant composition in ground bamboo Sasa argenteastriatus leaves. | 2012 | Int J Mol Sci | pmid:22408451 |
| Chung MJ et al. | Suppressive effects of Schizandra chinensis Baillon water extract on allergy-related cytokine generation and degranulation in IgE-antigen complex-stimulated RBL-2H3 cells. | 2012 | Nutr Res Pract | pmid:22586497 |
| Bandaruk Y et al. | Evaluation of the inhibitory effects of quercetin-related flavonoids and tea catechins on the monoamine oxidase-A reaction in mouse brain mitochondria. | 2012 | J. Agric. Food Chem. | pmid:23009399 |
| Hatnapure GD et al. | Synthesis and biological evaluation of novel piperazine derivatives of flavone as potent anti-inflammatory and antimicrobial agent. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22981334 |
| Hamilton ML et al. | Elucidation of the biosynthesis of the di-C-glycosylflavone isoschaftoside, an allelopathic component from Desmodium spp. that inhibits Striga spp. development. | 2012 | Phytochemistry | pmid:22959223 |
| Kanda K et al. | Nobiletin suppresses adipocyte differentiation of 3T3-L1 cells by an insulin and IBMX mixture induction. | 2012 | Biochim. Biophys. Acta | pmid:22172985 |
| Guo F et al. | Effect of the citrus lycopene β-cyclase transgene on carotenoid metabolism in transgenic tomato fruits. | 2012 | PLoS ONE | pmid:22384184 |
| Kongkum N et al. | DNA topoisomerase IIα inhibitory and anti-HIV-1 flavones from leaves and twigs of Gardenia carinata. | 2012 | Fitoterapia | pmid:22155186 |
| Buchanan CM et al. | DMXAA (Vadimezan, ASA404) is a multi-kinase inhibitor targeting VEGFR2 in particular. | 2012 | Clin. Sci. | pmid:22142330 |
| Zhang T et al. | Inhibitory effects and underlying mechanism of 7-hydroxyflavone phosphate ester in HeLa cells. | 2012 | PLoS ONE | pmid:22574207 |
| Rahigude A et al. | Participation of antioxidant and cholinergic system in protective effect of naringenin against type-2 diabetes-induced memory dysfunction in rats. | 2012 | Neuroscience | pmid:22999973 |
| Xie C et al. | The açaà flavonoid velutin is a potent anti-inflammatory agent: blockade of LPS-mediated TNF-α and IL-6 production through inhibiting NF-κB activation and MAPK pathway. | 2012 | J. Nutr. Biochem. | pmid:22137267 |
| Shukla S et al. | Apigenin attenuates insulin-like growth factor-I signaling in an autochthonous mouse prostate cancer model. | 2012 | Pharm. Res. | pmid:22139534 |
| Hirohata M et al. | Anti-amyloidogenic effects of soybean isoflavones in vitro: Fluorescence spectroscopy demonstrating direct binding to Aβ monomers, oligomers and fibrils. | 2012 | Biochim. Biophys. Acta | pmid:22587837 |
| Tsui KH et al. | Upregulation of prostate-derived Ets factor by luteolin causes inhibition of cell proliferation and cell invasion in prostate carcinoma cells. | 2012 | Int. J. Cancer | pmid:21780100 |
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