FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

Cross Reference

Introduction

To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with FLAVONE?

FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with FLAVONE

MeSH term MeSH ID Detail
Lymphedema D008209 4 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Leukemia P388 D007941 43 associated lipids
Hypertension D006973 115 associated lipids
Hyperlipidemias D006949 73 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hemolysis D006461 131 associated lipids
Glioma D005910 112 associated lipids
Encephalitis D004660 15 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with FLAVONE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with FLAVONE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with FLAVONE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with FLAVONE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with FLAVONE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with FLAVONE?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Disease model

Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Animal Disease Models

Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with FLAVONE

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Per page 10 20 50 100 | Total 1492
Authors Title Published Journal PubMed Link
Zhao L et al. The antitumour activity of 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF receptor-1 knockout mice. 2002 Br. J. Cancer pmid:12177785
Hori K et al. A novel combretastatin A-4 derivative, AC7700, strongly stanches tumour blood flow and inhibits growth of tumours developing in various tissues and organs. 2002 Br. J. Cancer pmid:12085211
Ching LM et al. Induction of endothelial cell apoptosis by the antivascular agent 5,6-Dimethylxanthenone-4-acetic acid. 2002 Br. J. Cancer pmid:12085190
Jones DJ et al. Characterisation of metabolites of the putative cancer chemopreventive agent quercetin and their effect on cyclo-oxygenase activity. 2004 Br. J. Cancer pmid:15292928
Cai H et al. Growth-inhibitory and cell cycle-arresting properties of the rice bran constituent tricin in human-derived breast cancer cells in vitro and in nude mice in vivo. 2004 Br. J. Cancer pmid:15316567
Murray JC et al. Flavone acetic acid induces a coagulopathy in mice. 1989 Br. J. Cancer pmid:2803949
Giavazzi R et al. Response to flavone acetic acid (NSC 347512) of primary and metastatic human colorectal carcinoma xenografts. 1988 Br. J. Cancer pmid:3355765
Lévy V et al. A phase I dose-finding and pharmacokinetic study of subcutaneous semisynthetic homoharringtonine (ssHHT) in patients with advanced acute myeloid leukaemia. 2006 Br. J. Cancer pmid:16847470
Pepper C et al. Flavopiridol circumvents Bcl-2 family mediated inhibition of apoptosis and drug resistance in B-cell chronic lymphocytic leukaemia. 2001 Br. J. Haematol. pmid:11472347
Mursu J et al. Flavonoid intake and the risk of ischaemic stroke and CVD mortality in middle-aged Finnish men: the Kuopio Ischaemic Heart Disease Risk Factor Study. 2008 Br. J. Nutr. pmid:18377681
Leung LK et al. Effect of dietary flavonols on oestrogen receptor transactivation and cell death induction. 2004 Br. J. Nutr. pmid:15182386
Hadjokas NE et al. Arginine to lysine 108 substitution in recombinant CYP1A2 abolishes methoxyresorufin metabolism in lymphoblastoid cells. 2002 Br. J. Pharmacol. pmid:12023936
Kavvadias D et al. The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects. 2004 Br. J. Pharmacol. pmid:15231642
Ono M [Molecular imaging of beta-amyloid plaques in the brain]. 2007 Brain Nerve pmid:17370649
Zeng Y et al. Baicalin reduces the severity of experimental autoimmune encephalomyelitis. 2007 Braz. J. Med. Biol. Res. pmid:17653455
Atkinson C et al. Red-clover-derived isoflavones and mammographic breast density: a double-blind, randomized, placebo-controlled trial [ISRCTN42940165]. 2004 Breast Cancer Res. pmid:15084240
Androutsopoulos V et al. Antiproliferative and cytostatic effects of the natural product eupatorin on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism. 2008 Breast Cancer Res. pmid:18454852
Bonnay M et al. [Flavone acetic acid and LY 186641 interfere in various ways in Jaffé's reaction]. 1989 Bull Cancer pmid:2620109
Tranchand B et al. [Phase I pharmacokinetics of flavone-acetic acid]. 1989 Bull Cancer pmid:2620114
Li G et al. Effects of elevated CO(2) and O(3) on phenolic compounds in spring wheat and maize leaves. 2008 Bull Environ Contam Toxicol pmid:18781273
Quéval P and Beaumatin J [Study of the inductor effect of 5,6-benzoflavone on the activity of pulmonary benzopyrene monoxidase. Comparison with other chemical or physical agents]. 1979 C. R. Acad. Sci., D, Sci. Nat. pmid:111845
Cavé A et al. [Pachypodol (5,4'-dihydroxy 3,7,3'-trimethoxy flavone or 3,7,3'-quercetol trimethylether), a new flavonoid isolated from Pachypodanthium confine Engler and Diels (annonaceae)]. 1973 C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. pmid:4201538
McKeage MJ and Baguley BC Disrupting established tumor blood vessels: an emerging therapeutic strategy for cancer. 2010 Cancer pmid:20166210
Li YR et al. Tangeretin derivative, 5-acetyloxy-6,7,8,4'-tetramethoxyflavone induces G2/M arrest, apoptosis and autophagy in human non-small cell lung cancer cells in vitro and in vivo. 2016 Cancer Biol. Ther. pmid:26569090
Lagiou P et al. Flavonoid intake and liver cancer: a case-control study in Greece. 2008 Cancer Causes Control pmid:18350370
Hirvonen T et al. Flavonol and flavone intake and the risk of cancer in male smokers (Finland). 2001 Cancer Causes Control pmid:11714106
Büchner FL et al. Fruits and vegetables consumption and the risk of histological subtypes of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). 2010 Cancer Causes Control pmid:19924549
Weiss GR et al. New anticancer agents. 1988 Cancer Chemother Biol Response Modif pmid:2484323
Weiss GR et al. New anticancer agents. 1987 Cancer Chemother Biol Response Modif pmid:2484330
Cai H et al. Tissue distribution in mice and metabolism in murine and human liver of apigenin and tricin, flavones with putative cancer chemopreventive properties. 2007 Cancer Chemother. Pharmacol. pmid:17089164
Cummings J and Smyth JF Flavone 8-acetic acid: our current understanding of its mechanism of action in solid tumours. 1989 Cancer Chemother. Pharmacol. pmid:2667786
Chabot GG et al. Pharmacodynamics and causes of dose-dependent pharmacokinetics of flavone-8-acetic acid (LM-975; NSC-347512) in mice. 1989 Cancer Chemother. Pharmacol. pmid:2597279
Thomas JP et al. Phase I clinical and pharmacokinetic trial of the cyclin-dependent kinase inhibitor flavopiridol. 2002 Cancer Chemother. Pharmacol. pmid:12451473
Cassidy J et al. Could interspecies differences in the protein binding of flavone acetic acid contribute to the failure to predict lack of efficacy in patients? 1989 Cancer Chemother. Pharmacol. pmid:2713962
Chabot GG et al. Flavone acetic acid (LM-975; NSC-347512) activation to cytotoxic species in vivo and in vitro. 1989 Cancer Chemother. Pharmacol. pmid:2758556
Bibby MC et al. Influence of site on the chemosensitivity of transplantable murine colon tumours to flavone acetic acid (LM975, NSC 347512). 1989 Cancer Chemother. Pharmacol. pmid:2731316
Cai H et al. Pharmacokinetics in mice and metabolism in murine and human liver fractions of the putative cancer chemopreventive agents 3',4',5',5,7-pentamethoxyflavone and tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone). 2011 Cancer Chemother. Pharmacol. pmid:20364427
Verschoyle RD et al. Preliminary safety evaluation of the putative cancer chemopreventive agent tricin, a naturally occurring flavone. 2006 Cancer Chemother. Pharmacol. pmid:16001171
Enomoto R et al. Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects. 2011 Cancer Chemother. Pharmacol. pmid:20658136
Damia G et al. Dose-dependent pharmacokinetics of flavone acetic acid in mice. 1988 Cancer Chemother. Pharmacol. pmid:3396145
Gouyette A et al. Flavone acetic acid: a nonlinear pharmacokinetic model. 1988 Cancer Chemother. Pharmacol. pmid:3409441
O'Dwyer PJ et al. Flavone acetic acid (LM 975, NSC 347512). A novel antitumor agent. 1987 Cancer Chemother. Pharmacol. pmid:3545524
Ullmannova V and Popescu NC Inhibition of cell proliferation, induction of apoptosis, reactivation of DLC1, and modulation of other gene expression by dietary flavone in breast cancer cell lines. 2007 Cancer Detect. Prev. pmid:17418982
Schumacher M et al. Potential role of P-gp for flavone-induced diminished apoptosis and increased adenoma size in the small intestine of APC(min/+) mice. 2011 Cancer Invest. pmid:21649465
Po LS et al. Baicalein and genistein display differential actions on estrogen receptor (ER) transactivation and apoptosis in MCF-7 cells. 2002 Cancer Lett. pmid:12359348
Cai H et al. Flavones as colorectal cancer chemopreventive agents--phenol-o-methylation enhances efficacy. 2009 Cancer Prev Res (Phila) pmid:19638489
Oyama T et al. Dietary tricin suppresses inflammation-related colon carcinogenesis in male Crj: CD-1 mice. 2009 Cancer Prev Res (Phila) pmid:19934339
Shukla S et al. Blockade of beta-catenin signaling by plant flavonoid apigenin suppresses prostate carcinogenesis in TRAMP mice. 2007 Cancer Res. pmid:17638904
Wenzel U et al. Dietary flavone is a potent apoptosis inducer in human colon carcinoma cells. 2000 Cancer Res. pmid:10919656
Weiss RB et al. Phase I and clinical pharmacology study of intravenous flavone acetic acid (NSC 347512). 1988 Cancer Res. pmid:3167843