FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

Cross Reference

Introduction

To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with FLAVONE?

FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with FLAVONE

MeSH term MeSH ID Detail
Diabetes Mellitus D003920 90 associated lipids
Glioma D005910 112 associated lipids
Hypertension D006973 115 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Edema D004487 152 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 | Total 32

PubChem Associated disorders and diseases

What pathways are associated with FLAVONE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with FLAVONE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with FLAVONE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with FLAVONE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with FLAVONE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with FLAVONE?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Disease model

Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Animal Disease Models

Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with FLAVONE

Download all related citations
Per page 10 20 50 100 | Total 1492
Authors Title Published Journal PubMed Link
Cabrera M et al. Synthetic chalcones, flavanones, and flavones as antitumoral agents: biological evaluation and structure-activity relationships. 2007 Bioorg. Med. Chem. pmid:17383189
Kuemmerle J et al. Synthesis of caged 2,3,3a,7a-tetrahydro-3,6-methanobenzofuran-7(6H)-ones: Evaluating the minimum structure for apoptosis induction by gambogic acid. 2008 Bioorg. Med. Chem. pmid:18337106
Betti L et al. Design, synthesis, and alpha(1)-adrenoceptor binding properties of new arylpiperazine derivatives bearing a flavone nucleus as the terminal heterocyclic molecular portion. 2004 Bioorg. Med. Chem. pmid:15018926
Wang TC et al. Synthesis, antiproliferative, and antiplatelet activities of oxime- and methyloxime-containing flavone and isoflavone derivatives. 2005 Bioorg. Med. Chem. pmid:15990314
Boumendjel A et al. Acridone derivatives: design, synthesis, and inhibition of breast cancer resistance protein ABCG2. 2007 Bioorg. Med. Chem. pmid:17317193
Dei S et al. Design and synthesis of aminoester heterodimers containing flavone or chromone moieties as modulators of P-glycoprotein-based multidrug resistance (MDR). 2018 Bioorg. Med. Chem. pmid:29162309
Lameira J et al. Structure-activity relationship study of flavone compounds with anti-HIV-1 integrase activity: a density functional theory study. 2006 Bioorg. Med. Chem. pmid:16890444
Xiang H et al. Synthesis and biological evaluation of isoflavone fatty acid esters with potential weight loss and hypolipidemic activities. 2010 Bioorg. Med. Chem. pmid:20392645
Greeff J et al. Antioxidant properties of 4-quinolones and structurally related flavones. 2012 Bioorg. Med. Chem. pmid:22197671
Iori F et al. Theoretical quantitative structure-activity relationships of flavone ligands interacting with cytochrome P450 1A1 and 1A2 isozymes. 2005 Bioorg. Med. Chem. pmid:15914008
Malolanarasimhan K et al. Synthesis and biological study of a flavone acetic acid analogue containing an azido reporting group designed as a multifunctional binding site probe. 2005 Bioorg. Med. Chem. pmid:15781383
Göker H et al. Synthesis and potent antimicrobial activity of some novel 2-phenyl or methyl-4H-1-benzopyran-4-ones carrying amidinobenzimidazoles. 2005 Bioorg. Med. Chem. pmid:15698788
Amato E et al. Investigation of fluorinated and bifunctionalized 3-phenylchroman-4-one (isoflavanone) aromatase inhibitors. 2014 Bioorg. Med. Chem. pmid:24345481
Valenti P et al. Synthesis and biological activity of some rigid analogues of flavone-8-acetic acid. 2000 Bioorg. Med. Chem. pmid:10968283
Mavel S et al. Synthesis and biological evaluation of a series of flavone derivatives as potential radioligands for imaging the multidrug resistance-associated protein 1 (ABCC1/MRP1). 2006 Bioorg. Med. Chem. pmid:16263302
Pick A et al. Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP). 2011 Bioorg. Med. Chem. pmid:21354800
Li HQ et al. Synthesis of C(7) modified chrysin derivatives designing to inhibit beta-ketoacyl-acyl carrier protein synthase III (FabH) as antibiotics. 2009 Bioorg. Med. Chem. pmid:19664929
Mays JR et al. The synthesis and evaluation of flavone and isoflavone chimeras of novobiocin and derrubone. 2010 Bioorg. Med. Chem. pmid:19932969
Chen WQ et al. A new antifungal and cytotoxic C-methylated flavone glycoside from Picea neoveitchii. 2012 Bioorg. Med. Chem. Lett. pmid:22901896
Tamura S et al. New inhibitors for expression of IgE receptor on human mast cell. 2010 Bioorg. Med. Chem. Lett. pmid:20202836